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Q8WS25

- Q8WS25_TRYCR

UniProt

Q8WS25 - Q8WS25_TRYCR

Protein
Submitted name:

Farnesyl diphosphate synthase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi52 – 521MagnesiumImported
    Metal bindingi56 – 561MagnesiumImported
    Metal bindingi124 – 1241MagnesiumImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotation

    Keywords - Ligandi

    MagnesiumImported, Metal-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Farnesyl diphosphate synthaseImported
    OrganismiTrypanosoma cruziImported
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ID0X-ray2.81A1-316[»]
    ProteinModelPortaliQ8WS25.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WS25.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.UniRule annotation

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR000092. Polyprenyl_synt.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8WS25-1 [UniParc]FASTAAdd to Basket

    « Hide

    GKYFRGMTVV NVAEGFLAVT QHDEATKERI LHDACVGGWM IEFLQAHYLV    50
    EDDIMDGSVM RRGKPCWYRF PGVTTQCAIN DGIILKSWTQ IMAWHYFADR 100
    PFLKDLLCLF QKVDYATAVG QMYDVTSMCD SNKLDPEVAQ PMTTDFAEFT 150
    PAIYKRIVKY KTTFYTYLLP LVMGLFVSEA AASVEMNLVE RVAHLIGEYF 200
    QVQDDVMDCF TPPEQLGKVG TDIEDAKCSW LAVTFLGKAN AAQVAEFKAN 250
    YGDKDPAKVA VVKRLYSEAN LQADFAAYEA EVVREVESLI EQLKVKSPTF 300
    AESVAVVWEK THKRKK 316
    Length:316
    Mass (Da):35,735
    Last modified:March 1, 2002 - v1
    Checksum:i890D21A9AE9BE454
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF386103 mRNA. Translation: AAL73358.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF386103 mRNA. Translation: AAL73358.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ID0 X-ray 2.81 A 1-316 [» ]
    ProteinModelPortali Q8WS25.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q8WS25.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR000092. Polyprenyl_synt.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and characterization of a mitochondrial farnesyl diphosphate synthase of Trypanosoma cruzi."
      Ferella M.A., Bontempi E.J.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer."
      Huang C.H., Gabelli S.B., Oldfield E., Amzel L.M.
      Proteins 78:888-899(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

    Entry informationi

    Entry nameiQ8WS25_TRYCR
    AccessioniPrimary (citable) accession number: Q8WS25
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3