Q8WS25 (Q8WS25_TRYCR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Farnesyl diphosphate synthase EMBL AAL73358.1
Organism	Trypanosoma cruzi EMBL AAL73358.1
Taxonomic identifier	5693 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	316 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FPP/GGPP synthase family. RuleBase RU004466

Ontologies

Keywords
Biological process	Isoprene biosynthesis RuleBase RU004466
Ligand	Magnesium PDB 3ICZ PDB 3ICK PDB 3ID0 PDB 3ICM PDB 3IBA PDB 3ICN Metal-binding PDB 3ICZ PDB 3ICK PDB 3ID0 PDB 3ICM PDB 3IBA PDB 3ICN
Molecular function	Transferase RuleBase RU004466
Technical term	3D-structure PDB 3ICZ PDB 3ICK PDB 3ID0 PDB 3ICM PDB 3IBA PDB 3ICN
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	52	1	Magnesium PDB 3ID0
	Metal binding	56	1	Magnesium PDB 3ID0
	Metal binding	124	1	Magnesium PDB 3ID0
Experimental info
	Non-terminal residue	1	1	EMBL AAL73358.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WS25 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 890D21A9AE9BE454	FASTA	316	35,735
	10 20 30 40 50 60 GKYFRGMTVV NVAEGFLAVT QHDEATKERI LHDACVGGWM IEFLQAHYLV EDDIMDGSVM 70 80 90 100 110 120 RRGKPCWYRF PGVTTQCAIN DGIILKSWTQ IMAWHYFADR PFLKDLLCLF QKVDYATAVG 130 140 150 160 170 180 QMYDVTSMCD SNKLDPEVAQ PMTTDFAEFT PAIYKRIVKY KTTFYTYLLP LVMGLFVSEA 190 200 210 220 230 240 AASVEMNLVE RVAHLIGEYF QVQDDVMDCF TPPEQLGKVG TDIEDAKCSW LAVTFLGKAN 250 260 270 280 290 300 AAQVAEFKAN YGDKDPAKVA VVKRLYSEAN LQADFAAYEA EVVREVESLI EQLKVKSPTF 310 AESVAVVWEK THKRKK

References

[1]	"Sequencing and characterization of a mitochondrial farnesyl diphosphate synthase of Trypanosoma cruzi." Ferella M.A., Bontempi E.J. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer." Huang C.H., Gabelli S.B., Oldfield E., Amzel L.M. Proteins 78:888-899(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF386103 mRNA. Translation: AAL73358.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3IBA	X-ray	2.40	A	1-316	[»]
3ICK	X-ray	2.40	A	1-316	[»]
3ICM	X-ray	2.20	A	1-316	[»]
3ICN	X-ray	2.40	A	1-316	[»]
3ICZ	X-ray	2.15	A	1-316	[»]
3ID0	X-ray	2.81	A	1-316	[»]

ProteinModelPortal

Q8WS25.

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

Gene3D

1.10.600.10. 1 hit.

InterPro

IPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]

Pfam

PF00348. polyprenyl_synt. 1 hit.
[Graphical view]

SUPFAM

SSF48576. Terpenoid_synth. 1 hit.

PROSITE

PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

ProtoNet

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Other

EvolutionaryTrace

Q8WS25.

Entry information

Entry name

Q8WS25_TRYCR

Accession

Primary (citable) accession number: Q8WS25

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	March 6, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)