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Q8WS25 (Q8WS25_TRYCR) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismTrypanosoma cruzi EMBL AAL73358.1
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length316 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FPP/GGPP synthase family. RuleBase RU004466

Ontologies

Keywords
   Biological processIsoprene biosynthesis RuleBase RU004466
   LigandMagnesium PDB 3ID0
Metal-binding PDB 3ID0
   Molecular functionTransferase RuleBase RU004466
   Technical term3D-structure PDB 3ID0
Gene Ontology (GO)
   Biological_processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

transferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region2 – 54Sulfate 1 binding PDB 3ID0

Sites

Metal binding521Magnesium PDB 3ID0
Metal binding561Magnesium PDB 3ID0
Metal binding1241Magnesium PDB 3ID0
Binding site621Sulfate 1 PDB 3ID0
Binding site951Sulfate 2 PDB 3ID0

Experimental info

Non-terminal residue11 EMBL AAL73358.1

Sequences

Sequence LengthMass (Da)Tools
Q8WS25 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 890D21A9AE9BE454

FASTA31635,735
        10         20         30         40         50         60 
GKYFRGMTVV NVAEGFLAVT QHDEATKERI LHDACVGGWM IEFLQAHYLV EDDIMDGSVM 

        70         80         90        100        110        120 
RRGKPCWYRF PGVTTQCAIN DGIILKSWTQ IMAWHYFADR PFLKDLLCLF QKVDYATAVG 

       130        140        150        160        170        180 
QMYDVTSMCD SNKLDPEVAQ PMTTDFAEFT PAIYKRIVKY KTTFYTYLLP LVMGLFVSEA 

       190        200        210        220        230        240 
AASVEMNLVE RVAHLIGEYF QVQDDVMDCF TPPEQLGKVG TDIEDAKCSW LAVTFLGKAN 

       250        260        270        280        290        300 
AAQVAEFKAN YGDKDPAKVA VVKRLYSEAN LQADFAAYEA EVVREVESLI EQLKVKSPTF 

       310 
AESVAVVWEK THKRKK 

« Hide

References

[1]"Sequencing and characterization of a mitochondrial farnesyl diphosphate synthase of Trypanosoma cruzi."
Ferella M.A., Bontempi E.J.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer."
Huang C.H., Gabelli S.B., Oldfield E., Amzel L.M.
Proteins 78:888-899(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF386103 mRNA. Translation: AAL73358.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ID0X-ray2.81A1-316[»]
ProteinModelPortalQ8WS25.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8WS25.

Entry information

Entry nameQ8WS25_TRYCR
AccessionPrimary (citable) accession number: Q8WS25
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)