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Q8WS25

- Q8WS25_TRYCR

UniProt

Q8WS25 - Q8WS25_TRYCR

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Protein
Submitted name:

Farnesyl diphosphate synthase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521MagnesiumImported
Metal bindingi56 – 561MagnesiumImported
Metal bindingi124 – 1241MagnesiumImported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Isoprene biosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumImported, Metal-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Farnesyl diphosphate synthaseImported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ID0X-ray2.81A1-316[»]
ProteinModelPortaliQ8WS25.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WS25.

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.UniRule annotation

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WS25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GKYFRGMTVV NVAEGFLAVT QHDEATKERI LHDACVGGWM IEFLQAHYLV
60 70 80 90 100
EDDIMDGSVM RRGKPCWYRF PGVTTQCAIN DGIILKSWTQ IMAWHYFADR
110 120 130 140 150
PFLKDLLCLF QKVDYATAVG QMYDVTSMCD SNKLDPEVAQ PMTTDFAEFT
160 170 180 190 200
PAIYKRIVKY KTTFYTYLLP LVMGLFVSEA AASVEMNLVE RVAHLIGEYF
210 220 230 240 250
QVQDDVMDCF TPPEQLGKVG TDIEDAKCSW LAVTFLGKAN AAQVAEFKAN
260 270 280 290 300
YGDKDPAKVA VVKRLYSEAN LQADFAAYEA EVVREVESLI EQLKVKSPTF
310
AESVAVVWEK THKRKK
Length:316
Mass (Da):35,735
Last modified:March 1, 2002 - v1
Checksum:i890D21A9AE9BE454
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF386103 mRNA. Translation: AAL73358.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF386103 mRNA. Translation: AAL73358.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ID0 X-ray 2.81 A 1-316 [» ]
ProteinModelPortali Q8WS25.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q8WS25.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and characterization of a mitochondrial farnesyl diphosphate synthase of Trypanosoma cruzi."
    Ferella M.A., Bontempi E.J.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer."
    Huang C.H., Gabelli S.B., Oldfield E., Amzel L.M.
    Proteins 78:888-899(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Entry informationi

Entry nameiQ8WS25_TRYCR
AccessioniPrimary (citable) accession number: Q8WS25
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3