Q8WR53 (Q8WR53_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hephaestus EMBL AAL57860.1

Submitted name:
Hephaestus, isoform A EMBL AAN14297.2
Submitted name:
Hephaestus, isoform B EMBL AAF57208.2
Submitted name:
Hephaestus, isoform D EMBL AAO41620.1
Submitted name:
Hephaestus, isoform E EMBL AAO41621.1
Submitted name:
Hephaestus, isoform F EMBL AAO41622.1
Submitted name:
Hephaestus, isoform I EMBL AAO41624.1
Submitted name:
Hephaestus, isoform J EMBL AAO41625.1
Submitted name:
Hephaestus, isoform N EMBL ABW08818.1
Submitted name:
Hephaestus, isoform V EMBL ACZ95087.1

Gene names

Name:	heph FlyBase FBgn0011224 EMBL AAF57208.2
Synonyms:	CG31000-RN EMBL ACD81846.1
ORF Names:	CG31000 FlyBase FBgn0011224, Dmel_CG31000 EMBL AAF57208.2

Organism

Drosophila melanogaster (Fruit fly) EMBL AAL57860.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	608 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	imaginal disc-derived wing margin morphogenesis Inferred from mutant phenotype. Source: FlyBase imaginal disc-derived wing vein morphogenesis Inferred from mutant phenotype. Source: FlyBase mRNA processing Inferred from electronic annotation. Source: InterPro negative regulation of oskar mRNA translation Inferred from mutant phenotype. Source: FlyBase oocyte microtubule cytoskeleton polarization Inferred from mutant phenotype. Source: FlyBase sperm individualization Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytoplasm Inferred from direct assay. Source: FlyBase nucleus Inferred from electronic annotation. Source: InterPro ribonucleoprotein complex Inferred from direct assay. Source: FlyBase
Molecular function	mRNA 3'-UTR binding Inferred from direct assay. Source: FlyBase nucleotide binding Inferred from electronic annotation. Source: InterPro translation repressor activity, nucleic acid binding Inferred from mutant phenotype. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8WR53 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 7A20BEB8802CBF04	FASTA	608	65,512
	10 20 30 40 50 60 MMSCPIPMPM PISSLHKSEF EPVNIGVKRG SDELLSQAAV MAPASDNNNQ DLATKKAKLE 70 80 90 100 110 120 PGTVLAGGIA KASKVIHLRN IPNESGEADV IALGIPFGRV TNVLVLKGKN QAFIEMADEI 130 140 150 160 170 180 SATSMVSCYT VTPPQMRGRM VYVQFSNHRE LKTDQGHNNS TAHSDYSVQS PASGSPLPLS 190 200 210 220 230 240 AAANATSNNA NSSSDSNSAM GILQNTSAVN AGGNTNAAGG PNTVLRVIVE SLMYPVSLDI 250 260 270 280 290 300 LHQIFQRYGK VLKIVTFTKN NSFQALIQYP DANSAQHAKS LLDGQNIYNG CCTLRIDNSK 310 320 330 340 350 360 LTALNVKYNN DKSRDFTNPA LPPGEPGVDI MPTAGGLMNT NDLLLIAARQ RPSLSGDKIV 370 380 390 400 410 420 NGLGAPGVLP PFALGLGTPL TGGYNNALPN LAAFSLANSG ALQTTAPAMR GYSNVLLVSN 430 440 450 460 470 480 LNEEMVTPDA LFTLFGVYGD VQRVKILYNK KDSALIQMAE PQQAYLAMSH LDKLRLWGKP 490 500 510 520 530 540 IRVMASKHQA VQLPKEGQPD AGLTRDYSQN PLHRFKKPGS KNYQNIYPPS ATLHLSNIPS 550 560 570 580 590 600 SCSEDDIKEA FTSNSFEVKA FKFFPKDRKM ALLQLLSVEE AVLALIKMHN HQLSESNHLR VSFSKSNI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Smith C.D., Shu S., Mungall C.J., Karpen G.H. Science 316:1586-1591(2007) [PubMed: 17569856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E. Science 316:1625-1628(2007) [PubMed: 17569867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Combined evidence annotation of transposable elements in genome sequences." Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D. PLoS Comput. Biol. 1:166-175(2005) [PubMed: 16110336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[6]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002) [PubMed: 12537574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J.W., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E. Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed: 12537573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M. Genome Biol. 3 (12), RESEARCH0079 (2002) Cited for: NUCLEOTIDE SEQUENCE.
[9]	Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL ACD81846.1.
[10]	Drosophila Heterochromatin Genome Project Smith C.D., Shu S., Mungall C.J., Karpen G.H. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[11]	FlyBase Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[12]	"Drosophila melanogaster release 4 sequence." Berkeley Drosophila Genome Project Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[13]	Celniker S., Carlson J., Kennedy C., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Karpen G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[14]	Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[15]	"Drosophila melanogaster hephaestus mRNA, testes splice form." Schulz C., Fuller M.T. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAF57208.2. AF455053 mRNA. Translation: AAL57860.1. AE014297 Genomic DNA. Translation: AAN14297.2. AE014297 Genomic DNA. Translation: AAO41620.1. AE014297 Genomic DNA. Translation: AAO41621.1. AE014297 Genomic DNA. Translation: AAO41622.1. AE014297 Genomic DNA. Translation: AAO41624.1. AE014297 Genomic DNA. Translation: AAO41625.1. AE014297 Genomic DNA. Translation: AAO41626.1. AE014297 Genomic DNA. Translation: ABW08818.1. BT032832 mRNA. Translation: ACD81846.1. AE014297 Genomic DNA. Translation: ACZ95081.1. AE014297 Genomic DNA. Translation: ACZ95087.1.
RefSeq	NP_001097994.1. NM_001104524.2. NP_001163788.1. NM_001170317.1. NP_001163794.1. NM_001170323.1. NP_733460.1. NM_170581.2. NP_733461.2. NM_170582.3. NP_788773.1. NM_176596.2. NP_788774.1. NM_176597.2. NP_788775.1. NM_176598.2. NP_788777.1. NM_176600.2. NP_788778.1. NM_176601.2. NP_788779.1. NM_176602.2.
UniGene	Dm.19417.
3D structure databases
HSSP	HSSP built from PDB template 1QM9 based on UniProtKB P26599.
ProteinModelPortal	Q8WR53.
SMR	Q8WR53. Positions 70-155, 219-325, 413-608.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WR53. 3 interactions.
MINT	MINT-298225.
STRING	Q8WR53.
Proteomic databases
PRIDE	Q8WR53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085878; FBpp0085237; FBgn0011224. FBtr0085879; FBpp0085238; FBgn0011224. FBtr0085882; FBpp0085241; FBgn0011224. FBtr0085883; FBpp0085242; FBgn0011224. FBtr0085884; FBpp0085243; FBgn0011224. FBtr0085885; FBpp0085244; FBgn0011224. FBtr0085886; FBpp0085245; FBgn0011224. FBtr0085888; FBpp0085247; FBgn0011224. FBtr0112866; FBpp0111779; FBgn0011224. FBtr0300264; FBpp0289492; FBgn0011224. FBtr0300270; FBpp0289498; FBgn0011224.
GeneID	48571.
KEGG	dme:Dmel_CG31000.
UCSC	CG31000-RA. d. melanogaster.
Organism-specific databases
CTD	9843.
FlyBase	FBgn0011224. heph.
Phylogenomic databases
GeneTree	EMGT00050000000537.
InParanoid	Q8WR53.
PhylomeDB	Q8WR53.
Gene expression databases
ArrayExpress	Q8WR53.
Bgee	Q8WR53.
Family and domain databases
InterPro	IPR006536. HnRNP-L_PTB. IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 4 hits.
KO	K14948.
Pfam	PF00076. RRM_1. 2 hits. [Graphical view]
SMART	SM00360. RRM. 4 hits. [Graphical view]
TIGRFAMs	TIGR01649. HnRNP-L_PTB. 1 hit.
PROSITE	PS50102. RRM. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	839481.

Entry information

Entry name

Q8WR53_DROME

Accession

Primary (citable) accession number: Q8WR53
Secondary accession number(s): Q8IMF7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)