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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1

Gene

mbk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in the function of olfactory neurons.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei357 – 3571ATPPROSITE-ProRule annotationBy similarity
Active sitei456 – 4561Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi334 – 3429ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Olfaction, Sensory transduction

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8WQL7.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1By similarity (EC:2.7.12.1)
Alternative name(s):
Dual specificity Yak1-related kinase mbk-1By similarityImported
Minibrain Kinase 1By similarity
Gene namesi
Name:mbk-1Imported
ORF Names:T04C10.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT04C10.1; CE33442; WBGene00003149; mbk-1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 882882Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1PRO_0000390715Add
BLAST

Proteomic databases

EPDiQ8WQL7.
PaxDbiQ8WQL7.
PRIDEiQ8WQL7.

Expressioni

Tissue specificityi

Expressed in all somatic cells.1 Publication

Developmental stagei

First observed during early cell morphogenesis in the embryo, levels increase during later embryonic development and remain at comparable levels throughout larval and adult stages.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
gei-18Q7K7J03EBI-329013,EBI-2315822

Protein-protein interaction databases

BioGridi46475. 2 interactions.
IntActiQ8WQL7. 3 interactions.
MINTiMINT-1127171.
STRINGi6239.T04C10.1.

Structurei

3D structure databases

ProteinModelPortaliQ8WQL7.
SMRiQ8WQL7. Positions 286-700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini328 – 649322Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 2956Poly-GlnSequence analysis
Compositional biasi668 – 6725Poly-GlnSequence analysis
Compositional biasi738 – 857120Gln-richSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000018329.
InParanoidiQ8WQL7.
KOiK08825.
OMAiVVPMRTE.
OrthoDBiEOG77127N.
PhylomeDBiQ8WQL7.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WQL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTADVPDNL QSWGQQPSSS YSNTQQHSQM TNLPPINHNN LCDTEPMNED
60 70 80 90 100
FQLQDVQADE LQKQQKQQEQ QHIQQQNAQR FIAQSRQPHS NILRFPQPPI
110 120 130 140 150
TSIKTNSHAF YPQQEVTQVR PKKHRVSMTN AEAALTPGMP PEKQAAKKRN
160 170 180 190 200
IGQFSTDTVP AGIGMIGIPF ESTSKPLQIQ QFRNPQDAPV RKLTSDLIKT
210 220 230 240 250
YKAINESFYL RKQVRRDRHK SQDAGKPKGS KDGSGASLTD TFSIHNAIPI
260 270 280 290 300
TSSDNHYQQD AHQNAPPLLD TNAPPTSTMV VPMRTETDLQ QQQRQKSSRG
310 320 330 340 350
GPYNNGYDDQ NYDYILKNGE IFDKRYVILS DTPVGKGSFG QVTKAYDTLN
360 370 380 390 400
KEEVAIKIIK NKKTFFDQAQ IEIHLLELTN AHDKDNKYNI VTLKGHFVHR
410 420 430 440 450
AHLCLVFELL SYNLYDLLKN TSFRGVSLNL ARKFAQQLGK TLLFLSSPEL
460 470 480 490 500
SIIHCDLKPE NVLLVNAKRS QIRVIDFGSS CQTGHRIYQY IQSRFYRSPE
510 520 530 540 550
VLLGIAYDTK IDMWSLGCIL VEMHTGEPLF AGSSEVDQMM KIVEVLGMPP
560 570 580 590 600
KEMLDIGPKT HKYFDKTEDG IYYCKKTRDG YRHTYKAPGA RKLHEILGVT
610 620 630 640 650
SGGPGGRRLG EPGHSVEDYS KFKDLIKRML QFDPKQRISP YYVVRHPFLK
660 670 680 690 700
QKEERVPSQP PVSHSNLQQQ QQLYIQQPSS QMSQVMESPS VGSVYVEDNG
710 720 730 740 750
MYRQAPGSSA NPISVTSSFD EGDAMEVDAG RRRFSAHQQN YHNPNYQYSQ
760 770 780 790 800
PQQQQQQQYQ QTQRTQLEQQ QKQAQLQQQL QQQQMQQQQQ QQQQRQHMPQ
810 820 830 840 850
AQSSSQQHLQ SRARPRQQDQ NEWRNQFELD DTFQQKQRKV DDSVSNQISR
860 870 880
NQFNPQQVSM THGNVNANNR EMEKLDYPNN KL
Length:882
Mass (Da):101,244
Last modified:March 1, 2002 - v1
Checksum:iDD5C9DD354DA7098
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY064464 mRNA. Translation: AAL40874.1.
Z69885 Genomic DNA. Translation: CAA93756.2.
PIRiT24445.
RefSeqiNP_510460.2. NM_078059.4.
UniGeneiCel.22462.

Genome annotation databases

EnsemblMetazoaiT04C10.1; T04C10.1; WBGene00003149.
GeneIDi181578.
KEGGicel:CELE_T04C10.1.
UCSCiT04C10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY064464 mRNA. Translation: AAL40874.1.
Z69885 Genomic DNA. Translation: CAA93756.2.
PIRiT24445.
RefSeqiNP_510460.2. NM_078059.4.
UniGeneiCel.22462.

3D structure databases

ProteinModelPortaliQ8WQL7.
SMRiQ8WQL7. Positions 286-700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46475. 2 interactions.
IntActiQ8WQL7. 3 interactions.
MINTiMINT-1127171.
STRINGi6239.T04C10.1.

Proteomic databases

EPDiQ8WQL7.
PaxDbiQ8WQL7.
PRIDEiQ8WQL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT04C10.1; T04C10.1; WBGene00003149.
GeneIDi181578.
KEGGicel:CELE_T04C10.1.
UCSCiT04C10.1. c. elegans.

Organism-specific databases

CTDi181578.
WormBaseiT04C10.1; CE33442; WBGene00003149; mbk-1.

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000018329.
InParanoidiQ8WQL7.
KOiK08825.
OMAiVVPMRTE.
OrthoDBiEOG77127N.
PhylomeDBiQ8WQL7.

Enzyme and pathway databases

SignaLinkiQ8WQL7.

Miscellaneous databases

PROiQ8WQL7.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A."
    Raich W.B., Moorman C., Lacefield C.O., Lehrer J., Bartsch D., Plasterk R.H., Kandel E.R., Hobert O.
    Genetics 163:571-580(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiMBK1_CAEEL
AccessioniPrimary (citable) accession number: Q8WQL7
Secondary accession number(s): Q22155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.