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Q8WQ22 (Q8WQ22_LOCMI) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Pacifastin-related serine protease inhibitor EMBL CAD11969.1
Gene names
Name:pp2 EMBL CAD11969.1
OrganismLocusta migratoria migratorioides (African migratory locust) EMBL CAD11969.1
Taxonomic identifier7005 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Orthopteroidea › Orthoptera › Caelifera › Acridomorpha › Acridoidea › Acrididae › Oedipodinae › Locusta

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

Ontologies

Keywords
   DomainSignal EMBL CAD11969.1
   Molecular functionHydrolase
Protease EMBL CAD11969.1
   Technical term3D-structure PDB 2VU8 PDB 1WO9
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionpeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

peptidase inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential EMBL CAD11969.1
Chain23 – 145123 Potential EMBL CAD11969.1
PRO_5000068087
Chain23 – 6644protease inhibitor PI-3 EMBL CAD11969.1
PRO_5000068088
Chain69 – 10638protease inhibitor PI-4 EMBL CAD11969.1
PRO_5000068089
Chain109 – 14537protease inhibitor PI-5 EMBL CAD11969.1
PRO_5000068090

Sequences

Sequence LengthMass (Da)Tools
Q8WQ22 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 4345973893061627

FASTA14515,370
        10         20         30         40         50         60 
MKVTLAIAAA ALLVVMATTV DAAGECTPGQ TKKQDCNTCT CTPTGIWGCT RKACRTTREA 

        70         80         90        100        110        120 
EEPAIVKRQA QQCTPNKSFK KDCNTCTCNK DGTAAICTQI ACLNRGRRQV NCTPGTTFQD 

       130        140 
RCNTCRCSSN GRSAACTLKA CPGFG

« Hide

References

[1]"cDNA cloning of two different serine protease inhibitor precursors in the migratory locust, Locusta migratoria."
Simonet G., Claeys I., Vanderperren H., November T., De Loof A., Vanden Broeck J.
Insect Mol. Biol. 11:249-256(2002) [PubMed: 12000644] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Fat body EMBL CAD11969.1.
[2]"Genomics, evolution and biological functions of the pacifastin peptide family: a conserved serine protease inhibitor family in arthropods."
Simonet G., Claeys I., Franssens V., De Loof A., Broeck J.V.
Peptides 24:1633-1644(2003) [PubMed: 14706543] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Fat body EMBL CAD11969.1.
[3]"Structural and functional properties of a novel serine protease inhibiting peptide family in arthropods."
Simonet G., Claeys I., Vanden Broeck J.
Comp. Biochem. Physiol. 132B:247-255(2002) [PubMed: 11997226] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Fat body EMBL CAD11969.1.
[4]Vanden Broeck J.J.M.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Fat body EMBL CAD11969.1.
[5]"Structure of Locusta migratoria protease inhibitor 3 (LMPI-3) in complex with Fusarium oxysporum trypsin."
Leone P., Roussel A., Kellenberger C.
Acta Crystallogr. D Biol. Crystallogr. 64:1165-1171(2008) [PubMed: 19020355] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 25-57.
[6]"Selective inhibition of trypsins by insect peptides: role of P6-P10 loop."
Kellenberger C., Ferrat G., Leone P., Darbon H., Roussel A.
Biochemistry 42:13605-13612(2003) [PubMed: 14622007] [Abstract]
Cited for: STRUCTURE BY NMR OF 23-57.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ419777 mRNA. Translation: CAD11969.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WO9NMR-A23-57[»]
2VU8X-ray1.80I25-57[»]
ProteinModelPortalQ8WQ22.
SMRQ8WQ22. Positions 23-57, 72-104, 110-143.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020862. Pacifastin_art.
IPR008037. Prot_inh_PMP.
IPR016307. Prtase-inh_pacifastin.
[Graphical view]
PfamPF05375. Pacifastin_I. 3 hits.
[Graphical view]
PIRSFPIRSF001625. Prot_inhib_pacifastin. 1 hit.
SUPFAMSSF57283. PMP_SGCI. 3 hits.
PROSITEPS51446. PACIFASTIN. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8WQ22_LOCMI
AccessionPrimary (citable) accession number: Q8WQ22
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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