Pacifastin-related serine protease inhibitor precursor - Locusta migratoria migratorioides (African migratory locust)

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Unreviewed, UniProtKB/TrEMBL Q8WQ22 (Q8WQ22_LOCMI)

Last modified January 19, 2010. Version 35. History...

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Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
Pacifastin-related serine protease inhibitor EMBL CAD11969.1

Gene names

Name:

pp2 EMBL CAD11969.1

Organism

Locusta migratoria migratorioides (African migratory locust) EMBL CAD11969.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Orthopteroidea › Orthoptera › Caelifera › Acridomorpha › Acridoidea › Acrididae › Oedipodinae › Locusta

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Domain	Signal EMBL CAD11969.1
Molecular function	Hydrolase Protease EMBL CAD11969.1
Gene Ontology (GO)
Molecular function	peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW peptidase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

22

Potential EMBL CAD11969.1

Chain

123

Potential EMBL CAD11969.1

PRO_5000068087

Chain

44

protease inhibitor PI-3 EMBL CAD11969.1

PRO_5000068088

Chain

38

protease inhibitor PI-4 EMBL CAD11969.1

PRO_5000068089

Chain

37

protease inhibitor PI-5 EMBL CAD11969.1

PRO_5000068090

Sequences

Sequence

Length

Mass (Da)

Tools

Q8WQ22-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 4345973893061627
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145

15,370

        10         20         30         40         50         60 
MKVTLAIAAA ALLVVMATTV DAAGECTPGQ TKKQDCNTCT CTPTGIWGCT RKACRTTREA 

        70         80         90        100        110        120 
EEPAIVKRQA QQCTPNKSFK KDCNTCTCNK DGTAAICTQI ACLNRGRRQV NCTPGTTFQD 

       130        140 
RCNTCRCSSN GRSAACTLKA CPGFG

References

[1]	"cDNA cloning of two different serine protease inhibitor precursors in the migratory locust, Locusta migratoria." Simonet G., Claeys I., Vanderperren H., November T., De Loof A., Vanden Broeck J. Insect Mol. Biol. 11:249-256(2002) [PubMed: 12000644] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Fat body EMBL CAD11969.1.
[2]	"Genomics, evolution and biological functions of the pacifastin peptide family: a conserved serine protease inhibitor family in arthropods." Simonet G., Claeys I., Franssens V., De Loof A., Broeck J.V. Peptides 24:1633-1644(2003) [PubMed: 14706543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Fat body EMBL CAD11969.1.
[3]	"Structural and functional properties of a novel serine protease inhibiting peptide family in arthropods." Simonet G., Claeys I., Vanden Broeck J. Comp. Biochem. Physiol. 132B:247-255(2002) [PubMed: 11997226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Fat body EMBL CAD11969.1.
[4]	Vanden Broeck J.J.M. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Fat body EMBL CAD11969.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ419777 mRNA. Translation: CAD11969.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WO9	NMR	-	A	23-57	[»]
2VU8	X-ray	1.80	I	25-57	[»]

SMR

Q8WQ22. Positions 72-104, 110-143.

ModBase

Protein family/group databases

MEROPS

I19.001.
I19.011.

Family and domain databases

InterPro

IPR020862. Pacifastin_art.
IPR008037. Prot_inh_PMP.
IPR016307. Prtase-inh_pacifastin.
[Graphical view]

Pfam

PF05375. Pacifastin_I. 3 hits.
[Graphical view]

PIRSF

PIRSF001625. Prot_inhib_pacifastin. 1 hit.

PROSITE

PS51446. PACIFASTIN. 3 hits.
[Graphical view]

ProtoNet

Entry information

Entry name

Q8WQ22_LOCMI

Accession

Primary (citable) accession number: Q8WQ22

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information