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Protein

Boophilin-H2

Gene

H2

Organism
Rhipicephalus microplus (Cattle tick) (Boophilus microplus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents blood clot formation to allow successful feeding and digestion through its inhibition activity of thrombin and other host anticoagulating factors like kallikrein, coagulation factor VII, or plasmin.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Boophilin-H2
Gene namesi
Name:H2
OrganismiRhipicephalus microplus (Cattle tick) (Boophilus microplus)
Taxonomic identifieri6941 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusBoophilus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 142127Boophilin-H2PRO_5000066993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 71PROSITE-ProRule annotation1 Publication
Disulfide bondi30 ↔ 54PROSITE-ProRule annotation1 Publication
Disulfide bondi46 ↔ 67PROSITE-ProRule annotation1 Publication
Disulfide bondi89 ↔ 139PROSITE-ProRule annotation1 Publication
Disulfide bondi98 ↔ 122PROSITE-ProRule annotation1 Publication
Disulfide bondi114 ↔ 135PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts with host thrombin and trypsin.1 Publication

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 224Combined sources
Beta strandi34 – 407Combined sources
Turni41 – 444Combined sources
Beta strandi45 – 517Combined sources
Beta strandi61 – 633Combined sources
Helixi64 – 718Combined sources
Helixi85 – 884Combined sources
Beta strandi102 – 1087Combined sources
Turni109 – 1124Combined sources
Beta strandi113 – 1197Combined sources
Beta strandi129 – 1313Combined sources
Helixi132 – 1398Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ODYX-ray2.35E/F16-142[»]
ProteinModelPortaliQ8WPI2.
SMRiQ8WPI2. Positions 16-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WPI2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 7151BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd
BLAST
Domaini89 – 13951BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 BPTI/Kunitz inhibitor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di4.10.410.10. 2 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 2 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 2 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 2 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WPI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCIILLAVL GTAFAQRNGF CRLPADEGIC KALIPRFYFN TETGKCTMFS
60 70 80 90 100
YGGCGGNENN FETIEECQKA CGAPERVNDF ESADFKTGCE PAADSGSCAG
110 120 130 140
QLERWFYNVQ SGECETFVYG GCGGNDNNYE SEEECELVCK NM
Length:142
Mass (Da):15,538
Last modified:March 1, 2002 - v1
Checksum:i88BF0008BBD42010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ304447 mRNA. Translation: CAC82583.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ304447 mRNA. Translation: CAC82583.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ODYX-ray2.35E/F16-142[»]
ProteinModelPortaliQ8WPI2.
SMRiQ8WPI2. Positions 16-142.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI02.020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WPI2.

Family and domain databases

Gene3Di4.10.410.10. 2 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 2 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 2 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 2 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBOOH2_RHIMP
AccessioniPrimary (citable) accession number: Q8WPI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2002
Last modified: October 14, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.