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Protein

Boophilin-H2

Gene

H2

Organism
Rhipicephalus microplus (Cattle tick) (Boophilus microplus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents blood clot formation to allow successful feeding and digestion through its inhibition activity of thrombin and other host anticoagulating factors like kallikrein, coagulation factor VII, or plasmin.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Boophilin-H2
Gene namesi
Name:H2
OrganismiRhipicephalus microplus (Cattle tick) (Boophilus microplus)
Taxonomic identifieri6941 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusBoophilus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_500006699316 – 142Boophilin-H2Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 71PROSITE-ProRule annotation1 Publication
Disulfide bondi30 ↔ 54PROSITE-ProRule annotation1 Publication
Disulfide bondi46 ↔ 67PROSITE-ProRule annotation1 Publication
Disulfide bondi89 ↔ 139PROSITE-ProRule annotation1 Publication
Disulfide bondi98 ↔ 122PROSITE-ProRule annotation1 Publication
Disulfide bondi114 ↔ 135PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts with host thrombin and trypsin.1 Publication

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi19 – 22Combined sources4
Beta strandi34 – 40Combined sources7
Turni41 – 44Combined sources4
Beta strandi45 – 51Combined sources7
Beta strandi61 – 63Combined sources3
Helixi64 – 71Combined sources8
Helixi85 – 88Combined sources4
Beta strandi102 – 108Combined sources7
Turni109 – 112Combined sources4
Beta strandi113 – 119Combined sources7
Beta strandi129 – 131Combined sources3
Helixi132 – 139Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ODYX-ray2.35E/F16-142[»]
ProteinModelPortaliQ8WPI2.
SMRiQ8WPI2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WPI2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 71BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini89 – 139BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Signal

Family and domain databases

CDDicd00109. KU. 2 hits.
Gene3Di4.10.410.10. 2 hits.
InterProiView protein in InterPro
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
PfamiView protein in Pfam
PF00014. Kunitz_BPTI. 2 hits.
PRINTSiPR00759. BASICPTASE.
SMARTiView protein in SMART
SM00131. KU. 2 hits.
SUPFAMiSSF57362. SSF57362. 2 hits.
PROSITEiView protein in PROSITE
PS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WPI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCIILLAVL GTAFAQRNGF CRLPADEGIC KALIPRFYFN TETGKCTMFS
60 70 80 90 100
YGGCGGNENN FETIEECQKA CGAPERVNDF ESADFKTGCE PAADSGSCAG
110 120 130 140
QLERWFYNVQ SGECETFVYG GCGGNDNNYE SEEECELVCK NM
Length:142
Mass (Da):15,538
Last modified:March 1, 2002 - v1
Checksum:i88BF0008BBD42010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ304447 mRNA. Translation: CAC82583.1.

Similar proteinsi

Entry informationi

Entry nameiBOOH2_RHIMP
AccessioniPrimary (citable) accession number: Q8WPI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2002
Last modified: August 30, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references