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Q8WP15

- GRK7_PIG

UniProt

Q8WP15 - GRK7_PIG

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Protein

G protein-coupled receptor kinase 7

Gene
GRK7
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO) By similarity.

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.

Enzyme regulationi

Inhibited by phosphorylation of Ser-36 By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei220 – 2201ATP By similarity
Active sitei316 – 3161Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi197 – 2059ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
  3. rhodopsin kinase activity Source: UniProtKB

GO - Biological processi

  1. protein autophosphorylation Source: Ensembl
  2. signal transduction Source: InterPro
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
  4. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 7 (EC:2.7.11.14, EC:2.7.11.16)
Alternative name(s):
G protein-coupled receptor kinase GRK7
Gene namesi
Name:GRK7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 13

Subcellular locationi

Membrane; Lipid-anchor By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550G protein-coupled receptor kinase 7PRO_0000024334Add
BLAST
Propeptidei551 – 5533Removed in mature form By similarityPRO_0000024335

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361Phosphoserine; by PKA1 Publication
Modified residuei550 – 5501Cysteine methyl ester Reviewed prediction
Lipidationi550 – 5501S-geranylgeranyl cysteine Reviewed prediction

Post-translational modificationi

Autophosphorylated in vitro at Ser-490 By similarity. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012443.

Structurei

3D structure databases

ProteinModelPortaliQ8WP15.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 176121RGSAdd
BLAST
Domaini191 – 454264Protein kinaseAdd
BLAST
Domaini455 – 52066AGC-kinase C-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110751.
HOGENOMiHOG000006742.
HOVERGENiHBG004532.
KOiK00909.
OMAiAYAFESK.
OrthoDBiEOG7V1FQK.
TreeFamiTF313940.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WP15-1 [UniParc]FASTAAdd to Basket

« Hide

MVDMGGLDNL IANTAYLQAR KTSDADSKEL QRRRRSLMLP GPQSCEQLRQ    50
AMPADFNSLC EQQPIGRRLF RDFLATVPAY QEAMGFLEEV QSWELAEEGP 100
AKGSTLQALV ATCAVAPNPG QPHSFLSPAL VTKCQAATTD EERASLVEQA 150
KAEAMAFLQD QPFREFLVSP FYDKFLQWKV FEMQPVSDKY FEEFRVLGKG 200
GFGEVCAVQV KNTGKMYACK KLDKKRLKKK SGEKMALSEK EILEKVSSPF 250
VVSLAYAFES KSHLCLVMSL MNGGDLKFHI YSVGERGLDM NRVIFYSAQM 300
TCGVLHLHSL GIVYRDLKPE NVLLDDLGNC RLSDLGLAVQ IQDGKPVTQR 350
AGTNGYMAPE ILMEKASYSY PVDWFAMGCS IYEMVAGRTP FKDYKEKISK 400
EDLKQRTLKE EVRFQHQSFT EEAKDICRLF LAKTPEQRLG SREKSDDPRK 450
HHFFKTINFP RLEAGLVDPP FVPDPSVVYA KDVDEIEDFS EVRGVEFDDK 500
DKQFFQRFAT GAVPIAWQEE IIETGLFEEL NDPNRPAGCG EGNSSRSGVC 550
LLL 553
Length:553
Mass (Da):62,299
Last modified:March 1, 2002 - v1
Checksum:i9BAD6E91BF31D33E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282270 mRNA. Translation: AAL33881.1.
RefSeqiNP_999212.1. NM_214047.1.
UniGeneiSsc.165.

Genome annotation databases

EnsembliENSSSCT00000012780; ENSSSCP00000012443; ENSSSCG00000011675.
GeneIDi397114.
KEGGissc:397114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282270 mRNA. Translation: AAL33881.1 .
RefSeqi NP_999212.1. NM_214047.1.
UniGenei Ssc.165.

3D structure databases

ProteinModelPortali Q8WP15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000012443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000012780 ; ENSSSCP00000012443 ; ENSSSCG00000011675 .
GeneIDi 397114.
KEGGi ssc:397114.

Organism-specific databases

CTDi 131890.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110751.
HOGENOMi HOG000006742.
HOVERGENi HBG004532.
KOi K00909.
OMAi AYAFESK.
OrthoDBi EOG7V1FQK.
TreeFami TF313940.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR00717. GPCRKINASE.
SMARTi SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction."
    Weiss E.R., Ducceschi M.H., Horner T.J., Li A., Craft C.M., Osawa S.
    J. Neurosci. 21:9175-9184(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light."
    Osawa S., Jo R., Weiss E.R.
    J. Neurochem. 107:1314-1324(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-36.

Entry informationi

Entry nameiGRK7_PIG
AccessioniPrimary (citable) accession number: Q8WP15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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