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Q8WNW4

- Q8WNW4_PIG

UniProt

Q8WNW4 - Q8WNW4_PIG

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Protein
Submitted name:

Beta-catenin

Gene

CTNNB1

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. double-stranded DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: Ensembl
  4. transcription coactivator activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. adherens junction assembly Source: UniProtKB
  2. anterior/posterior axis specification Source: Ensembl
  3. bone resorption Source: Ensembl
  4. branching involved in ureteric bud morphogenesis Source: Ensembl
  5. canonical Wnt signaling pathway Source: UniProtKB
  6. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: Ensembl
  7. canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Source: Ensembl
  8. canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition Source: UniProtKB
  9. cell adhesion Source: UniProtKB
  10. cell fate specification Source: Ensembl
  11. cell-matrix adhesion Source: Ensembl
  12. cell maturation Source: Ensembl
  13. cellular response to growth factor stimulus Source: UniProtKB
  14. cellular response to indole-3-methanol Source: UniProtKB
  15. central nervous system vasculogenesis Source: Ensembl
  16. dorsal/ventral axis specification Source: Ensembl
  17. ectoderm development Source: Ensembl
  18. embryonic axis specification Source: Ensembl
  19. embryonic digit morphogenesis Source: Ensembl
  20. embryonic foregut morphogenesis Source: Ensembl
  21. embryonic forelimb morphogenesis Source: Ensembl
  22. embryonic heart tube development Source: Ensembl
  23. embryonic hindlimb morphogenesis Source: Ensembl
  24. embryonic skeletal limb joint morphogenesis Source: Ensembl
  25. endodermal cell fate commitment Source: Ensembl
  26. endothelial tube morphogenesis Source: UniProtKB
  27. epithelial cell differentiation involved in prostate gland development Source: Ensembl
  28. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  29. fungiform papilla formation Source: Ensembl
  30. gastrulation with mouth forming second Source: Ensembl
  31. genitalia morphogenesis Source: Ensembl
  32. glial cell fate determination Source: Ensembl
  33. hair follicle morphogenesis Source: Ensembl
  34. hair follicle placode formation Source: Ensembl
  35. in utero embryonic development Source: Ensembl
  36. layer formation in cerebral cortex Source: Ensembl
  37. lens morphogenesis in camera-type eye Source: Ensembl
  38. lung-associated mesenchyme development Source: Ensembl
  39. lung cell differentiation Source: Ensembl
  40. lung induction Source: Ensembl
  41. male genitalia development Source: Ensembl
  42. mesenchymal cell proliferation involved in lung development Source: Ensembl
  43. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  44. negative regulation of apoptotic signaling pathway Source: Ensembl
  45. negative regulation of cell proliferation Source: UniProtKB
  46. negative regulation of chondrocyte differentiation Source: Ensembl
  47. negative regulation of neuron death Source: Ensembl
  48. negative regulation of oligodendrocyte differentiation Source: Ensembl
  49. negative regulation of osteoclast differentiation Source: Ensembl
  50. negative regulation of protein sumoylation Source: Ensembl
  51. negative regulation of transcription, DNA-templated Source: UniProtKB
  52. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  53. nephron tubule formation Source: Ensembl
  54. neural plate development Source: Ensembl
  55. neuron migration Source: Ensembl
  56. odontogenesis of dentin-containing tooth Source: Ensembl
  57. oocyte development Source: Ensembl
  58. osteoclast differentiation Source: Ensembl
  59. oviduct development Source: Ensembl
  60. pancreas development Source: Ensembl
  61. patterning of blood vessels Source: Ensembl
  62. positive regulation of apoptotic process Source: UniProtKB
  63. positive regulation of branching involved in lung morphogenesis Source: Ensembl
  64. positive regulation of determination of dorsal identity Source: Ensembl
  65. positive regulation of endothelial cell differentiation Source: Ensembl
  66. positive regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  67. positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  68. positive regulation of heparan sulfate proteoglycan biosynthetic process Source: UniProtKB
  69. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  70. positive regulation of MAPK cascade Source: Ensembl
  71. positive regulation of mesenchymal cell proliferation Source: Ensembl
  72. positive regulation of neuroblast proliferation Source: Ensembl
  73. positive regulation of osteoblast differentiation Source: Ensembl
  74. positive regulation of transcription, DNA-templated Source: UniProtKB
  75. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  76. protein localization to cell surface Source: UniProtKB
  77. proximal/distal pattern formation Source: Ensembl
  78. regulation of calcium ion import Source: UniProtKB
  79. regulation of centriole-centriole cohesion Source: UniProtKB
  80. regulation of centromeric sister chromatid cohesion Source: UniProtKB
  81. regulation of myelination Source: Ensembl
  82. regulation of nephron tubule epithelial cell differentiation Source: Ensembl
  83. regulation of protein localization to cell surface Source: UniProtKB
  84. regulation of secondary heart field cardioblast proliferation Source: Ensembl
  85. regulation of smooth muscle cell proliferation Source: UniProtKB
  86. regulation of T cell proliferation Source: Ensembl
  87. renal inner medulla development Source: Ensembl
  88. renal outer medulla development Source: Ensembl
  89. renal vesicle formation Source: Ensembl
  90. response to drug Source: Ensembl
  91. response to estradiol Source: UniProtKB
  92. single organismal cell-cell adhesion Source: UniProtKB
  93. smooth muscle cell differentiation Source: Ensembl
  94. synapse organization Source: Ensembl
  95. synaptic vesicle transport Source: Ensembl
  96. T cell differentiation in thymus Source: Ensembl
  97. thymus development Source: Ensembl
  98. trachea formation Source: Ensembl
  99. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_191877. Ca2+ pathway.
REACT_203275. deactivation of the beta-catenin transactivating complex.
REACT_208383. Apoptotic cleavage of cell adhesion proteins.
REACT_209721. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
REACT_210788. Beta-catenin phosphorylation cascade.
REACT_212348. Degradation of beta-catenin by the destruction complex.
REACT_212592. formation of the beta-catenin:TCF transactivating complex.
REACT_221357. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_221864. Adherens junctions interactions.
REACT_222474. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
REACT_226209. TCF dependent signaling in response to WNT.
REACT_227335. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-cateninImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:CTNNB1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. beta-catenin destruction complex Source: UniProtKB
  4. beta-catenin-TCF7L2 complex Source: UniProtKB
  5. catenin complex Source: UniProtKB
  6. cell-cell adherens junction Source: UniProtKB
  7. cell-cell junction Source: UniProtKB
  8. cell cortex Source: UniProtKB
  9. cell junction Source: UniProtKB
  10. cell periphery Source: BHF-UCL
  11. centrosome Source: UniProtKB
  12. cytoplasm Source: UniProtKB
  13. cytosol Source: UniProtKB
  14. extracellular vesicular exosome Source: Ensembl
  15. fascia adherens Source: Ensembl
  16. lamellipodium Source: Ensembl
  17. lateral plasma membrane Source: Ensembl
  18. microvillus membrane Source: Ensembl
  19. nucleus Source: UniProtKB
  20. perinuclear region of cytoplasm Source: UniProtKB
  21. plasma membrane Source: UniProtKB
  22. protein-DNA complex Source: UniProtKB
  23. Scrib-APC-beta-catenin complex Source: Ensembl
  24. tight junction Source: Ensembl
  25. transcription factor complex Source: UniProtKB
  26. Z disc Source: Ensembl
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012019.

Structurei

3D structure databases

ProteinModelPortaliQ8WNW4.
SMRiQ8WNW4. Positions 19-44, 142-691.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ8WNW4.
KOiK02105.
OMAiRESHNRA.
OrthoDBiEOG7X9G6B.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WNW4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG
60 70 80 90 100
NPEEEDVDTT QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP
110 120 130 140 150
ETLDEGMQIP STQFDAAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT
160 170 180 190 200
RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR
210 220 230 240 250
TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS
260 270 280 290 300
VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC
310 320 330 340 350
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC
360 370 380 390 400
SSNKPAIVEA GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG
410 420 430 440 450
LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT
460 470 480 490 500
VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP
510 520 530 540 550
PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR
560 570 580 590 600
TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV
610 620 630 640 650
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG
660 670 680 690 700
VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI
710 720 730 740 750
GAQGEPLGYR QDDPSYRSFH SGGYGQDALG MDPMMEHEMG GHHPGADYPV
760 770 780
DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L
Length:781
Mass (Da):85,511
Last modified:March 1, 2002 - v1
Checksum:i6148652F953F0723
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU861524 Genomic DNA. No translation available.
EU431333 mRNA. Translation: ACA03158.1.
AB046171 mRNA. Translation: BAB82984.1.
RefSeqiNP_999532.1. NM_214367.1.
XP_005669434.1. XM_005669377.1.
UniGeneiSsc.25839.

Genome annotation databases

EnsembliENSSSCT00000012342; ENSSSCP00000012019; ENSSSCG00000011274.
GeneIDi397657.
KEGGissc:397657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU861524 Genomic DNA. No translation available.
EU431333 mRNA. Translation: ACA03158.1 .
AB046171 mRNA. Translation: BAB82984.1 .
RefSeqi NP_999532.1. NM_214367.1.
XP_005669434.1. XM_005669377.1.
UniGenei Ssc.25839.

3D structure databases

ProteinModelPortali Q8WNW4.
SMRi Q8WNW4. Positions 19-44, 142-691.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000012019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000012342 ; ENSSSCP00000012019 ; ENSSSCG00000011274 .
GeneIDi 397657.
KEGGi ssc:397657.

Organism-specific databases

CTDi 1499.

Phylogenomic databases

eggNOGi NOG297695.
GeneTreei ENSGT00730000110821.
HOGENOMi HOG000230958.
HOVERGENi HBG000919.
InParanoidi Q8WNW4.
KOi K02105.
OMAi RESHNRA.
OrthoDBi EOG7X9G6B.
TreeFami TF317997.

Enzyme and pathway databases

Reactomei REACT_191877. Ca2+ pathway.
REACT_203275. deactivation of the beta-catenin transactivating complex.
REACT_208383. Apoptotic cleavage of cell adhesion proteins.
REACT_209721. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
REACT_210788. Beta-catenin phosphorylation cascade.
REACT_212348. Degradation of beta-catenin by the destruction complex.
REACT_212592. formation of the beta-catenin:TCF transactivating complex.
REACT_221357. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_221864. Adherens junctions interactions.
REACT_222474. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
REACT_226209. TCF dependent signaling in response to WNT.
REACT_227335. CDO in myogenesis.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
Pfami PF00514. Arm. 4 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells."
    Hirano M., Niiro N., Hirano K., Nishimura J., Hartshorne D.J., Kanaide H.
    Biochem. Biophys. Res. Commun. 254:490-496(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Transcriptional upregulation of p27Kip1 during contact-induced growth arrest in endotehlial cells."
    Hirano M., Hirano K., Nishimura J., Kanaide H.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Tumour necrosis factor-alpha inhibits differentiation of porcine preadipocytes via Wnt/beta-catenin signaling pathway."
    Luo X., Li H.X., Wu Z.S., Yang G.S.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ8WNW4_PIG
AccessioniPrimary (citable) accession number: Q8WNW4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3