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Protein
Submitted name:

Beta-catenin

Gene

CTNNB1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_277755. Degradation of beta-catenin by the destruction complex.
REACT_282029. formation of the beta-catenin:TCF transactivating complex.
REACT_287922. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
REACT_290958. Ca2+ pathway.
REACT_293345. CDO in myogenesis.
REACT_301634. Adherens junctions interactions.
REACT_302889. Beta-catenin phosphorylation cascade.
REACT_322611. TCF dependent signaling in response to WNT.
REACT_323562. deactivation of the beta-catenin transactivating complex.
REACT_325768. VEGFR2 mediated vascular permeability.
REACT_344535. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_351571. Apoptotic cleavage of cell adhesion proteins.
REACT_358170. RHO GTPases activate IQGAPs.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-cateninImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:CTNNB1Imported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8WNW4.
PRIDEiQ8WNW4.

Expressioni

Gene expression databases

GenevisibleiQ8WNW4. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012019.

Structurei

3D structure databases

ProteinModelPortaliQ8WNW4.
SMRiQ8WNW4. Positions 19-44, 142-691.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ8WNW4.
KOiK02105.
OMAiMRAFQDT.
OrthoDBiEOG7X9G6B.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WNW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG
60 70 80 90 100
NPEEEDVDTT QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP
110 120 130 140 150
ETLDEGMQIP STQFDAAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT
160 170 180 190 200
RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR
210 220 230 240 250
TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS
260 270 280 290 300
VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC
310 320 330 340 350
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC
360 370 380 390 400
SSNKPAIVEA GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG
410 420 430 440 450
LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT
460 470 480 490 500
VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP
510 520 530 540 550
PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR
560 570 580 590 600
TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV
610 620 630 640 650
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG
660 670 680 690 700
VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI
710 720 730 740 750
GAQGEPLGYR QDDPSYRSFH SGGYGQDALG MDPMMEHEMG GHHPGADYPV
760 770 780
DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L
Length:781
Mass (Da):85,511
Last modified:March 1, 2002 - v1
Checksum:i6148652F953F0723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU861524 Genomic DNA. No translation available.
EU431333 mRNA. Translation: ACA03158.1.
AB046171 mRNA. Translation: BAB82984.1.
RefSeqiNP_999532.1. NM_214367.1.
XP_005669434.1. XM_005669377.1.
UniGeneiSsc.25839.

Genome annotation databases

EnsembliENSSSCT00000012342; ENSSSCP00000012019; ENSSSCG00000011274.
GeneIDi397657.
KEGGissc:397657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU861524 Genomic DNA. No translation available.
EU431333 mRNA. Translation: ACA03158.1.
AB046171 mRNA. Translation: BAB82984.1.
RefSeqiNP_999532.1. NM_214367.1.
XP_005669434.1. XM_005669377.1.
UniGeneiSsc.25839.

3D structure databases

ProteinModelPortaliQ8WNW4.
SMRiQ8WNW4. Positions 19-44, 142-691.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012019.

Proteomic databases

PaxDbiQ8WNW4.
PRIDEiQ8WNW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000012342; ENSSSCP00000012019; ENSSSCG00000011274.
GeneIDi397657.
KEGGissc:397657.

Organism-specific databases

CTDi1499.

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ8WNW4.
KOiK02105.
OMAiMRAFQDT.
OrthoDBiEOG7X9G6B.
TreeFamiTF317997.

Enzyme and pathway databases

ReactomeiREACT_277755. Degradation of beta-catenin by the destruction complex.
REACT_282029. formation of the beta-catenin:TCF transactivating complex.
REACT_287922. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
REACT_290958. Ca2+ pathway.
REACT_293345. CDO in myogenesis.
REACT_301634. Adherens junctions interactions.
REACT_302889. Beta-catenin phosphorylation cascade.
REACT_322611. TCF dependent signaling in response to WNT.
REACT_323562. deactivation of the beta-catenin transactivating complex.
REACT_325768. VEGFR2 mediated vascular permeability.
REACT_344535. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_351571. Apoptotic cleavage of cell adhesion proteins.
REACT_358170. RHO GTPases activate IQGAPs.

Gene expression databases

GenevisibleiQ8WNW4. SS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells."
    Hirano M., Niiro N., Hirano K., Nishimura J., Hartshorne D.J., Kanaide H.
    Biochem. Biophys. Res. Commun. 254:490-496(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Transcriptional upregulation of p27Kip1 during contact-induced growth arrest in endotehlial cells."
    Hirano M., Hirano K., Nishimura J., Kanaide H.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Tumour necrosis factor-alpha inhibits differentiation of porcine preadipocytes via Wnt/beta-catenin signaling pathway."
    Luo X., Li H.X., Wu Z.S., Yang G.S.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ8WNW4_PIG
AccessioniPrimary (citable) accession number: Q8WNW4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.