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Q8WNW4 (Q8WNW4_PIG) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Uncharacterized protein Ensembl ENSSSCP00000012019
Gene names
Name:CTNNB1 Ensembl ENSSSCP00000012019
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length781 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

adherens junction assembly

Inferred from sequence or structural similarity. Source: UniProtKB

anterior/posterior axis specification

Inferred from electronic annotation. Source: Ensembl

bone resorption

Inferred from electronic annotation. Source: Ensembl

branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition

Inferred from sequence or structural similarity. Source: UniProtKB

cell adhesion

Inferred from sequence or structural similarity. Source: UniProtKB

cell fate specification

Inferred from electronic annotation. Source: Ensembl

cell maturation

Inferred from electronic annotation. Source: Ensembl

cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

cellular response to growth factor stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to indole-3-methanol

Inferred from sequence or structural similarity. Source: UniProtKB

central nervous system vasculogenesis

Inferred from electronic annotation. Source: Ensembl

dorsal/ventral axis specification

Inferred from electronic annotation. Source: Ensembl

ectoderm development

Inferred from electronic annotation. Source: Ensembl

embryonic axis specification

Inferred from electronic annotation. Source: Ensembl

embryonic digit morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic foregut morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic forelimb morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic heart tube development

Inferred from electronic annotation. Source: Ensembl

embryonic hindlimb morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal limb joint morphogenesis

Inferred from electronic annotation. Source: Ensembl

endodermal cell fate commitment

Inferred from electronic annotation. Source: Ensembl

endothelial tube morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

epithelial cell differentiation involved in prostate gland development

Inferred from electronic annotation. Source: Ensembl

epithelial tube branching involved in lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

fungiform papilla formation

Inferred from electronic annotation. Source: Ensembl

gastrulation with mouth forming second

Inferred from electronic annotation. Source: Ensembl

genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

glial cell fate determination

Inferred from electronic annotation. Source: Ensembl

hair follicle morphogenesis

Inferred from electronic annotation. Source: Ensembl

hair follicle placode formation

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

layer formation in cerebral cortex

Inferred from electronic annotation. Source: Ensembl

lens morphogenesis in camera-type eye

Inferred from electronic annotation. Source: Ensembl

lung cell differentiation

Inferred from electronic annotation. Source: Ensembl

lung induction

Inferred from electronic annotation. Source: Ensembl

lung-associated mesenchyme development

Inferred from electronic annotation. Source: Ensembl

male genitalia development

Inferred from electronic annotation. Source: Ensembl

mesenchymal cell proliferation involved in lung development

Inferred from electronic annotation. Source: Ensembl

mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of oligodendrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein sumoylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

nephron tubule formation

Inferred from electronic annotation. Source: Ensembl

neural plate development

Inferred from electronic annotation. Source: Ensembl

neuron migration

Inferred from electronic annotation. Source: Ensembl

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

oocyte development

Inferred from electronic annotation. Source: Ensembl

osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

oviduct development

Inferred from electronic annotation. Source: Ensembl

pancreas development

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of branching involved in lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of determination of dorsal identity

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation involved in prostate gland development

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of heparan sulfate proteoglycan biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

protein localization to cell surface

Inferred from sequence or structural similarity. Source: UniProtKB

proximal/distal pattern formation

Inferred from electronic annotation. Source: Ensembl

regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of calcium ion import

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of centriole-centriole cohesion

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of centromeric sister chromatid cohesion

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of myelination

Inferred from electronic annotation. Source: Ensembl

regulation of nephron tubule epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of protein localization to cell surface

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of secondary heart field cardioblast proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of smooth muscle cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

renal inner medulla development

Inferred from electronic annotation. Source: Ensembl

renal outer medulla development

Inferred from electronic annotation. Source: Ensembl

renal vesicle formation

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from sequence or structural similarity. Source: UniProtKB

single organismal cell-cell adhesion

Inferred from sequence or structural similarity. Source: UniProtKB

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

synapse organization

Inferred from electronic annotation. Source: Ensembl

synaptic vesicle transport

Inferred from electronic annotation. Source: Ensembl

thymus development

Inferred from electronic annotation. Source: Ensembl

trachea formation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentScrib-APC-beta-catenin complex

Inferred from electronic annotation. Source: Ensembl

Z disc

Inferred from electronic annotation. Source: Ensembl

apical junction complex

Inferred from electronic annotation. Source: Ensembl

apical part of cell

Inferred from electronic annotation. Source: Ensembl

basolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

beta-catenin destruction complex

Inferred from sequence or structural similarity. Source: UniProtKB

beta-catenin-TCF7L2 complex

Inferred from sequence or structural similarity. Source: UniProtKB

catenin complex

Inferred from sequence or structural similarity. Source: UniProtKB

cell cortex

Inferred from sequence or structural similarity. Source: UniProtKB

cell junction

Inferred from sequence or structural similarity. Source: UniProtKB

cell periphery

Inferred from sequence or structural similarity. Source: BHF-UCL

cell-cell adherens junction

Inferred from sequence or structural similarity. Source: UniProtKB

cell-cell junction

Inferred from sequence or structural similarity. Source: UniProtKB

centrosome

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

fascia adherens

Inferred from electronic annotation. Source: Ensembl

lamellipodium

Inferred from electronic annotation. Source: Ensembl

lateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

microvillus membrane

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

protein-DNA complex

Inferred from sequence or structural similarity. Source: UniProtKB

transcription factor complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionchromatin binding

Inferred from electronic annotation. Source: Ensembl

double-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

transcription coactivator activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8WNW4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6148652F953F0723

FASTA78185,511
        10         20         30         40         50         60 
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTT 

        70         80         90        100        110        120 
QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT 

       130        140        150        160        170        180 
NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 

       190        200        210        220        230        240 
KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 

       250        260        270        280        290        300 
VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 

       310        320        330        340        350        360 
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA 

       370        380        390        400        410        420 
GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 

       430        440        450        460        470        480 
AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 

       490        500        510        520        530        540 
AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 

       550        560        570        580        590        600 
VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 

       610        620        630        640        650        660 
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 

       670        680        690        700        710        720 
RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEPLGYR QDDPSYRSFH 

       730        740        750        760        770        780 
SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD 


L 

« Hide

References

« Hide 'large scale' references
[1]"Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells."
Hirano M., Niiro N., Hirano K., Nishimura J., Hartshorne D.J., Kanaide H.
Biochem. Biophys. Res. Commun. 254:490-496(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Transcriptional upregulation of p27Kip1 during contact-induced growth arrest in endotehlial cells."
Hirano M., Hirano K., Nishimura J., Kanaide H.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Tumour necrosis factor-alpha inhibits differentiation of porcine preadipocytes via Wnt/beta-catenin signaling pathway."
Luo X., Li H.X., Wu Z.S., Yang G.S.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]Porcine genome sequencing project
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Ensembl
Submitted (JUN-2011) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU861524 Genomic DNA. No translation available.
EU431333 mRNA. Translation: ACA03158.1.
AB046171 mRNA. Translation: BAB82984.1.
RefSeqNP_999532.1. NM_214367.1.
XP_005669434.1. XM_005669377.1.
UniGeneSsc.25839.

3D structure databases

ProteinModelPortalQ8WNW4.
SMRQ8WNW4. Positions 19-44, 142-691.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000012019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000012342; ENSSSCP00000012019; ENSSSCG00000011274.
GeneID397657.
KEGGssc:397657.

Organism-specific databases

CTD1499.

Phylogenomic databases

eggNOGNOG297695.
GeneTreeENSGT00730000110821.
HOGENOMHOG000230958.
HOVERGENHBG000919.
KOK02105.
OMARESHNRA.
OrthoDBEOG7X9G6B.
TreeFamTF317997.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamPF00514. Arm. 4 hits.
[Graphical view]
PRINTSPR01869. BCATNINFAMLY.
SMARTSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8WNW4_PIG
AccessionPrimary (citable) accession number: Q8WNW4
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)