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Q8WNW4

- Q8WNW4_PIG

UniProt

Q8WNW4 - Q8WNW4_PIG

Protein
Submitted name:

Beta-catenin

Gene

CTNNB1

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: Ensembl
    4. transcription coactivator activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. adherens junction assembly Source: UniProtKB
    2. anterior/posterior axis specification Source: Ensembl
    3. bone resorption Source: Ensembl
    4. branching involved in ureteric bud morphogenesis Source: Ensembl
    5. canonical Wnt signaling pathway Source: UniProtKB
    6. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: Ensembl
    7. canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Source: Ensembl
    8. canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition Source: UniProtKB
    9. cell adhesion Source: UniProtKB
    10. cell fate specification Source: Ensembl
    11. cell-matrix adhesion Source: Ensembl
    12. cell maturation Source: Ensembl
    13. cellular response to growth factor stimulus Source: UniProtKB
    14. cellular response to indole-3-methanol Source: UniProtKB
    15. central nervous system vasculogenesis Source: Ensembl
    16. dorsal/ventral axis specification Source: Ensembl
    17. ectoderm development Source: Ensembl
    18. embryonic axis specification Source: Ensembl
    19. embryonic digit morphogenesis Source: Ensembl
    20. embryonic foregut morphogenesis Source: Ensembl
    21. embryonic forelimb morphogenesis Source: Ensembl
    22. embryonic heart tube development Source: Ensembl
    23. embryonic hindlimb morphogenesis Source: Ensembl
    24. embryonic skeletal limb joint morphogenesis Source: Ensembl
    25. endodermal cell fate commitment Source: Ensembl
    26. endothelial tube morphogenesis Source: UniProtKB
    27. epithelial cell differentiation involved in prostate gland development Source: Ensembl
    28. epithelial tube branching involved in lung morphogenesis Source: Ensembl
    29. fungiform papilla formation Source: Ensembl
    30. gastrulation with mouth forming second Source: Ensembl
    31. genitalia morphogenesis Source: Ensembl
    32. glial cell fate determination Source: Ensembl
    33. hair follicle morphogenesis Source: Ensembl
    34. hair follicle placode formation Source: Ensembl
    35. in utero embryonic development Source: Ensembl
    36. layer formation in cerebral cortex Source: Ensembl
    37. lens morphogenesis in camera-type eye Source: Ensembl
    38. lung-associated mesenchyme development Source: Ensembl
    39. lung cell differentiation Source: Ensembl
    40. lung induction Source: Ensembl
    41. male genitalia development Source: Ensembl
    42. mesenchymal cell proliferation involved in lung development Source: Ensembl
    43. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
    44. negative regulation of apoptotic signaling pathway Source: Ensembl
    45. negative regulation of cell proliferation Source: UniProtKB
    46. negative regulation of chondrocyte differentiation Source: Ensembl
    47. negative regulation of oligodendrocyte differentiation Source: Ensembl
    48. negative regulation of osteoclast differentiation Source: Ensembl
    49. negative regulation of protein sumoylation Source: Ensembl
    50. negative regulation of transcription, DNA-templated Source: UniProtKB
    51. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    52. nephron tubule formation Source: Ensembl
    53. neural plate development Source: Ensembl
    54. neuron migration Source: Ensembl
    55. odontogenesis of dentin-containing tooth Source: Ensembl
    56. oocyte development Source: Ensembl
    57. osteoclast differentiation Source: Ensembl
    58. oviduct development Source: Ensembl
    59. pancreas development Source: Ensembl
    60. patterning of blood vessels Source: Ensembl
    61. positive regulation of apoptotic process Source: UniProtKB
    62. positive regulation of branching involved in lung morphogenesis Source: Ensembl
    63. positive regulation of determination of dorsal identity Source: Ensembl
    64. positive regulation of endothelial cell differentiation Source: Ensembl
    65. positive regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
    66. positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
    67. positive regulation of heparan sulfate proteoglycan biosynthetic process Source: UniProtKB
    68. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    69. positive regulation of MAPK cascade Source: Ensembl
    70. positive regulation of mesenchymal cell proliferation Source: Ensembl
    71. positive regulation of neuroblast proliferation Source: Ensembl
    72. positive regulation of osteoblast differentiation Source: Ensembl
    73. positive regulation of transcription, DNA-templated Source: UniProtKB
    74. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    75. protein localization to cell surface Source: UniProtKB
    76. proximal/distal pattern formation Source: Ensembl
    77. regulation of calcium ion import Source: UniProtKB
    78. regulation of centriole-centriole cohesion Source: UniProtKB
    79. regulation of centromeric sister chromatid cohesion Source: UniProtKB
    80. regulation of myelination Source: Ensembl
    81. regulation of nephron tubule epithelial cell differentiation Source: Ensembl
    82. regulation of protein localization to cell surface Source: UniProtKB
    83. regulation of secondary heart field cardioblast proliferation Source: Ensembl
    84. regulation of smooth muscle cell proliferation Source: UniProtKB
    85. regulation of T cell proliferation Source: Ensembl
    86. renal inner medulla development Source: Ensembl
    87. renal outer medulla development Source: Ensembl
    88. renal vesicle formation Source: Ensembl
    89. response to drug Source: Ensembl
    90. response to estradiol Source: UniProtKB
    91. single organismal cell-cell adhesion Source: UniProtKB
    92. smooth muscle cell differentiation Source: Ensembl
    93. synapse organization Source: Ensembl
    94. synaptic vesicle transport Source: Ensembl
    95. T cell differentiation in thymus Source: Ensembl
    96. thymus development Source: Ensembl
    97. trachea formation Source: Ensembl
    98. Wnt signaling pathway Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_191877. Ca2+ pathway.
    REACT_203275. deactivation of the beta-catenin transactivating complex.
    REACT_208383. Apoptotic cleavage of cell adhesion proteins.
    REACT_209721. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
    REACT_210788. Beta-catenin phosphorylation cascade.
    REACT_212348. Degradation of beta-catenin by the destruction complex.
    REACT_212592. formation of the beta-catenin:TCF transactivating complex.
    REACT_221357. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_221864. Adherens junctions interactions.
    REACT_222474. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_226209. TCF dependent signaling in response to WNT.
    REACT_227335. CDO in myogenesis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Beta-cateninImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:CTNNB1Imported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. apical junction complex Source: Ensembl
    2. apical part of cell Source: Ensembl
    3. basolateral plasma membrane Source: Ensembl
    4. beta-catenin destruction complex Source: UniProtKB
    5. beta-catenin-TCF7L2 complex Source: UniProtKB
    6. catenin complex Source: UniProtKB
    7. cell-cell adherens junction Source: UniProtKB
    8. cell-cell junction Source: UniProtKB
    9. cell cortex Source: UniProtKB
    10. cell junction Source: UniProtKB
    11. cell periphery Source: BHF-UCL
    12. centrosome Source: UniProtKB
    13. cytoplasm Source: UniProtKB
    14. cytosol Source: UniProtKB
    15. fascia adherens Source: Ensembl
    16. lamellipodium Source: Ensembl
    17. lateral plasma membrane Source: Ensembl
    18. microvillus membrane Source: Ensembl
    19. nucleus Source: UniProtKB
    20. perinuclear region of cytoplasm Source: UniProtKB
    21. plasma membrane Source: UniProtKB
    22. protein-DNA complex Source: UniProtKB
    23. Scrib-APC-beta-catenin complex Source: Ensembl
    24. transcription factor complex Source: UniProtKB
    25. Z disc Source: Ensembl

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000012019.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WNW4.
    SMRiQ8WNW4. Positions 19-44, 142-691.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG297695.
    GeneTreeiENSGT00730000110821.
    HOGENOMiHOG000230958.
    HOVERGENiHBG000919.
    KOiK02105.
    OMAiRESHNRA.
    OrthoDBiEOG7X9G6B.
    TreeFamiTF317997.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view]
    PfamiPF00514. Arm. 4 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 12 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WNW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG    50
    NPEEEDVDTT QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP 100
    ETLDEGMQIP STQFDAAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT 150
    RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR 200
    TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS 250
    VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300
    LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC 350
    SSNKPAIVEA GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG 400
    LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT 450
    VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP 500
    PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR 550
    TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 600
    QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG 650
    VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI 700
    GAQGEPLGYR QDDPSYRSFH SGGYGQDALG MDPMMEHEMG GHHPGADYPV 750
    DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L 781
    Length:781
    Mass (Da):85,511
    Last modified:March 1, 2002 - v1
    Checksum:i6148652F953F0723
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU861524 Genomic DNA. No translation available.
    EU431333 mRNA. Translation: ACA03158.1.
    AB046171 mRNA. Translation: BAB82984.1.
    RefSeqiNP_999532.1. NM_214367.1.
    XP_005669434.1. XM_005669377.1.
    UniGeneiSsc.25839.

    Genome annotation databases

    EnsembliENSSSCT00000012342; ENSSSCP00000012019; ENSSSCG00000011274.
    GeneIDi397657.
    KEGGissc:397657.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU861524 Genomic DNA. No translation available.
    EU431333 mRNA. Translation: ACA03158.1 .
    AB046171 mRNA. Translation: BAB82984.1 .
    RefSeqi NP_999532.1. NM_214367.1.
    XP_005669434.1. XM_005669377.1.
    UniGenei Ssc.25839.

    3D structure databases

    ProteinModelPortali Q8WNW4.
    SMRi Q8WNW4. Positions 19-44, 142-691.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000012019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000012342 ; ENSSSCP00000012019 ; ENSSSCG00000011274 .
    GeneIDi 397657.
    KEGGi ssc:397657.

    Organism-specific databases

    CTDi 1499.

    Phylogenomic databases

    eggNOGi NOG297695.
    GeneTreei ENSGT00730000110821.
    HOGENOMi HOG000230958.
    HOVERGENi HBG000919.
    KOi K02105.
    OMAi RESHNRA.
    OrthoDBi EOG7X9G6B.
    TreeFami TF317997.

    Enzyme and pathway databases

    Reactomei REACT_191877. Ca2+ pathway.
    REACT_203275. deactivation of the beta-catenin transactivating complex.
    REACT_208383. Apoptotic cleavage of cell adhesion proteins.
    REACT_209721. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
    REACT_210788. Beta-catenin phosphorylation cascade.
    REACT_212348. Degradation of beta-catenin by the destruction complex.
    REACT_212592. formation of the beta-catenin:TCF transactivating complex.
    REACT_221357. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_221864. Adherens junctions interactions.
    REACT_222474. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_226209. TCF dependent signaling in response to WNT.
    REACT_227335. CDO in myogenesis.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view ]
    Pfami PF00514. Arm. 4 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 12 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells."
      Hirano M., Niiro N., Hirano K., Nishimura J., Hartshorne D.J., Kanaide H.
      Biochem. Biophys. Res. Commun. 254:490-496(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Transcriptional upregulation of p27Kip1 during contact-induced growth arrest in endotehlial cells."
      Hirano M., Hirano K., Nishimura J., Kanaide H.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Tumour necrosis factor-alpha inhibits differentiation of porcine preadipocytes via Wnt/beta-catenin signaling pathway."
      Luo X., Li H.X., Wu Z.S., Yang G.S.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Porcine genome sequencing project
      Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ8WNW4_PIG
    AccessioniPrimary (citable) accession number: Q8WNW4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3