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Protein
Submitted name:

Beta-catenin

Gene

CTNNB1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-195253. Degradation of beta-catenin by the destruction complex.
R-SSC-196299. Beta-catenin phosphorylation cascade.
R-SSC-201681. TCF dependent signaling in response to WNT.
R-SSC-201722. Formation of the beta-catenin:TCF transactivating complex.
R-SSC-3134973. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
R-SSC-351906. Apoptotic cleavage of cell adhesion proteins.
R-SSC-375170. CDO in myogenesis.
R-SSC-3769402. Deactivation of the beta-catenin transactivating complex.
R-SSC-4086398. Ca2+ pathway.
R-SSC-418990. Adherens junctions interactions.
R-SSC-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
R-SSC-5218920. VEGFR2 mediated vascular permeability.
R-SSC-5626467. RHO GTPases activate IQGAPs.
R-SSC-8951430. RUNX3 regulates WNT signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-cateninImported
Gene namesi
Name:CTNNB1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSSSCG00000011274.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012019.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati151 – 191ARMPROSITE-ProRule annotationAdd BLAST41
Repeati193 – 236ARMPROSITE-ProRule annotationAdd BLAST44
Repeati235 – 277ARMPROSITE-ProRule annotationAdd BLAST43
Repeati277 – 319ARMPROSITE-ProRule annotationAdd BLAST43
Repeati319 – 362ARMPROSITE-ProRule annotationAdd BLAST44
Repeati400 – 442ARMPROSITE-ProRule annotationAdd BLAST43
Repeati442 – 484ARMPROSITE-ProRule annotationAdd BLAST43
Repeati489 – 532ARMPROSITE-ProRule annotationAdd BLAST44
Repeati594 – 636ARMPROSITE-ProRule annotationAdd BLAST43

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
KOiK02105.
OMAiWEQGFNQ.
OrthoDBiEOG091G03A5.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
PfamiView protein in Pfam
PF00514. Arm. 4 hits.
PRINTSiPR01869. BCATNINFAMLY.
SMARTiView protein in SMART
SM00185. ARM. 12 hits.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 9 hits.

Sequencei

Sequence statusi: Complete.

Q8WNW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG
60 70 80 90 100
NPEEEDVDTT QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP
110 120 130 140 150
ETLDEGMQIP STQFDAAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT
160 170 180 190 200
RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR
210 220 230 240 250
TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS
260 270 280 290 300
VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC
310 320 330 340 350
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC
360 370 380 390 400
SSNKPAIVEA GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG
410 420 430 440 450
LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT
460 470 480 490 500
VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP
510 520 530 540 550
PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR
560 570 580 590 600
TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV
610 620 630 640 650
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG
660 670 680 690 700
VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI
710 720 730 740 750
GAQGEPLGYR QDDPSYRSFH SGGYGQDALG MDPMMEHEMG GHHPGADYPV
760 770 780
DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L
Length:781
Mass (Da):85,511
Last modified:March 1, 2002 - v1
Checksum:i6148652F953F0723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000085 Genomic DNA. No translation available.
EU431333 mRNA. Translation: ACA03158.1.
AB046171 mRNA. Translation: BAB82984.1.
RefSeqiNP_999532.1. NM_214367.1.
XP_005669434.1. XM_005669377.2.
XP_013836946.1. XM_013981492.1.
UniGeneiSsc.25839.

Genome annotation databases

EnsembliENSSSCT00000012342; ENSSSCP00000012019; ENSSSCG00000011274.
ENSSSCT00000041383; ENSSSCP00000043940; ENSSSCG00000011274.
ENSSSCT00000050538; ENSSSCP00000047580; ENSSSCG00000011274.
ENSSSCT00000057283; ENSSSCP00000031836; ENSSSCG00000011274.
GeneIDi397657.
KEGGissc:397657.

Similar proteinsi

Entry informationi

Entry nameiQ8WNW4_PIG
AccessioniPrimary (citable) accession number: Q8WNW4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported