Q8WNW4 (Q8WNW4_PIG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Beta-catenin EMBL BAB82984.1

Submitted name:
Uncharacterized protein Ensembl ENSSSCP00000012019

Gene names

Name:

CTNNB1 Ensembl ENSSSCP00000012019

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	781 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell differentiation in thymus Inferred from electronic annotation. Source: Compara adherens junction assembly Inferred from sequence or structural similarity. Source: UniProtKB anterior/posterior axis specification Inferred from electronic annotation. Source: Compara apoptotic process Inferred from electronic annotation. Source: Compara bone resorption Inferred from electronic annotation. Source: Compara branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition Inferred from sequence or structural similarity. Source: UniProtKB cell fate specification Inferred from electronic annotation. Source: Compara cell maturation Inferred from electronic annotation. Source: Compara cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cell-matrix adhesion Inferred from electronic annotation. Source: Compara cellular response to growth factor stimulus Inferred from sequence or structural similarity. Source: UniProtKB cellular response to indole-3-methanol Inferred from sequence or structural similarity. Source: UniProtKB central nervous system vasculogenesis Inferred from electronic annotation. Source: Compara dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara ectoderm development Inferred from electronic annotation. Source: Compara embryonic axis specification Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic foregut morphogenesis Inferred from electronic annotation. Source: Compara embryonic forelimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic heart tube development Inferred from electronic annotation. Source: Compara embryonic hindlimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal limb joint morphogenesis Inferred from electronic annotation. Source: Compara endodermal cell fate commitment Inferred from electronic annotation. Source: Compara endothelial tube morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB epithelial cell differentiation involved in prostate gland development Inferred from electronic annotation. Source: Compara epithelial tube branching involved in lung morphogenesis Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara fungiform papilla formation Inferred from electronic annotation. Source: Compara gastrulation with mouth forming second Inferred from electronic annotation. Source: Compara genitalia morphogenesis Inferred from electronic annotation. Source: Compara glial cell fate determination Inferred from electronic annotation. Source: Compara hair follicle morphogenesis Inferred from electronic annotation. Source: Compara hair follicle placode formation Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara lens morphogenesis in camera-type eye Inferred from electronic annotation. Source: Compara lung cell differentiation Inferred from electronic annotation. Source: Compara lung induction Inferred from electronic annotation. Source: Compara lung-associated mesenchyme development Inferred from electronic annotation. Source: Compara male genitalia development Inferred from electronic annotation. Source: Compara mesenchymal cell proliferation involved in lung development Inferred from electronic annotation. Source: Compara mesenchymal to epithelial transition involved in metanephros morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of chondrocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of osteoclast differentiation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB nephron tubule formation Inferred from electronic annotation. Source: Compara neural plate development Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara oocyte development Inferred from electronic annotation. Source: Compara osteoclast differentiation Inferred from electronic annotation. Source: Compara oviduct development Inferred from electronic annotation. Source: Compara pancreas development Inferred from electronic annotation. Source: Compara patterning of blood vessels Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of branching involved in lung morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of determination of dorsal identity Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell proliferation involved in prostate gland development Inferred from electronic annotation. Source: Compara positive regulation of fibroblast growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of heparan sulfate proteoglycan biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of neuroblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB protein localization to cell surface Inferred from sequence or structural similarity. Source: UniProtKB proximal/distal pattern formation Inferred from electronic annotation. Source: Compara regulation of T cell proliferation Inferred from electronic annotation. Source: Compara regulation of calcium ion import Inferred from sequence or structural similarity. Source: UniProtKB regulation of centriole-centriole cohesion Inferred from sequence or structural similarity. Source: UniProtKB regulation of centromeric sister chromatid cohesion Inferred from sequence or structural similarity. Source: UniProtKB regulation of myelination Inferred from electronic annotation. Source: Compara regulation of nephron tubule epithelial cell differentiation Inferred from electronic annotation. Source: Compara regulation of protein localization to cell surface Inferred from sequence or structural similarity. Source: UniProtKB regulation of secondary heart field cardioblast proliferation Inferred from electronic annotation. Source: Compara regulation of smooth muscle cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB renal inner medulla development Inferred from electronic annotation. Source: Compara renal outer medulla development Inferred from electronic annotation. Source: Compara renal vesicle formation Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from sequence or structural similarity. Source: UniProtKB skin development Inferred from electronic annotation. Source: Compara smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara synapse organization Inferred from electronic annotation. Source: Compara synaptic vesicle transport Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara trachea formation Inferred from electronic annotation. Source: Compara
Cellular_component	Scrib-APC-beta-catenin complex Inferred from electronic annotation. Source: Compara Z disc Inferred from electronic annotation. Source: Compara apical junction complex Inferred from electronic annotation. Source: Compara apical part of cell Inferred from electronic annotation. Source: Compara basolateral plasma membrane Inferred from electronic annotation. Source: Compara beta-catenin destruction complex Inferred from sequence or structural similarity. Source: UniProtKB beta-catenin-TCF7L2 complex Inferred from sequence or structural similarity. Source: UniProtKB catenin complex Inferred from sequence or structural similarity. Source: UniProtKB cell cortex Inferred from sequence or structural similarity. Source: UniProtKB cell-cell adherens junction Inferred from sequence or structural similarity. Source: UniProtKB cell-substrate adherens junction Inferred from sequence or structural similarity. Source: UniProtKB centrosome Inferred from sequence or structural similarity. Source: UniProtKB cytosol Inferred from sequence or structural similarity. Source: UniProtKB fascia adherens Inferred from electronic annotation. Source: Compara lamellipodium Inferred from electronic annotation. Source: Compara lateral plasma membrane Inferred from electronic annotation. Source: Compara microvillus membrane Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB protein-DNA complex Inferred from sequence or structural similarity. Source: UniProtKB transcription factor complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	chromatin binding Inferred from electronic annotation. Source: Compara double-stranded DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara transcription coactivator activity Inferred from sequence or structural similarity. Source: UniProtKB transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8WNW4 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 6148652F953F0723	FASTA	781	85,511
	10 20 30 40 50 60 MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTT 70 80 90 100 110 120 QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT 130 140 150 160 170 180 NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 190 200 210 220 230 240 KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 250 260 270 280 290 300 VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 310 320 330 340 350 360 LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA 370 380 390 400 410 420 GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 430 440 450 460 470 480 AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 490 500 510 520 530 540 AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 550 560 570 580 590 600 VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 610 620 630 640 650 660 QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 670 680 690 700 710 720 RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEPLGYR QDDPSYRSFH 730 740 750 760 770 780 SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells." Hirano M., Niiro N., Hirano K., Nishimura J., Hartshorne D.J., Kanaide H. Biochem. Biophys. Res. Commun. 254:490-496(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Transcriptional upregulation of p27Kip1 during contact-induced growth arrest in endotehlial cells." Hirano M., Hirano K., Nishimura J., Kanaide H. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Tumour necrosis factor-alpha inhibits differentiation of porcine preadipocytes via Wnt/beta-catenin signaling pathway." Luo X., Li H.X., Wu Z.S., Yang G.S. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Porcine genome sequencing project Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Ensembl Submitted (JUN-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU861524 Genomic DNA. No translation available. EU431333 mRNA. Translation: ACA03158.1. AB046171 mRNA. Translation: BAB82984.1.
RefSeq	NP_999532.1. NM_214367.1.
UniGene	Ssc.25839.
3D structure databases
SMR	Q8WNW4. Positions 19-44, 142-691.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000012019.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000012342; ENSSSCP00000012019; ENSSSCG00000011274.
GeneID	397657.
KEGG	ssc:397657.
Organism-specific databases
CTD	1499.
Phylogenomic databases
eggNOG	NOG297695.
GeneTree	ENSGT00680000099702.
HOGENOM	HOG000230958.
HOVERGEN	HBG000919.
KO	K02105.
OMA	QLSQTRS.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR013284. Beta-catenin. [Graphical view]
Pfam	PF00514. Arm. 4 hits. [Graphical view]
PRINTS	PR01869. BCATNINFAMLY.
SMART	SM00185. ARM. 12 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 9 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8WNW4_PIG

Accession

Primary (citable) accession number: Q8WNW4

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	May 29, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)