ID   CYTA_FELCA              Reviewed;          98 AA.
AC   Q8WNR9;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=Cystatin-A;
DE   AltName: Allergen=Fel d 3;
GN   Name=CSTA;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   TISSUE=Skin;
RX   PubMed=11529899; DOI=10.1046/j.1365-2222.2001.01169.x;
RA   Ichikawa K., Vailes L.D., Pomes A., Chapman M.D.;
RT   "Molecular cloning, expression and modelling of cat allergen, cystatin (Fel
RT   d 3), a cysteine protease inhibitor.";
RL   Clin. Exp. Allergy 31:1279-1286(2001).
CC   -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:11529899}.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   EMBL; AF238996; AAL49391.1; -; mRNA.
DR   RefSeq; NP_001009864.1; NM_001009864.1.
DR   AlphaFoldDB; Q8WNR9; -.
DR   SMR; Q8WNR9; -.
DR   STRING; 9685.ENSFCAP00000008082; -.
DR   Allergome; 3280; Fel d 3.0101.
DR   Allergome; 347; Fel d 3.
DR   MEROPS; I25.001; -.
DR   PaxDb; 9685-ENSFCAP00000008082; -.
DR   GeneID; 493942; -.
DR   KEGG; fca:493942; -.
DR   eggNOG; ENOG502SF2X; Eukaryota.
DR   InParanoid; Q8WNR9; -.
DR   OrthoDB; 179019at2759; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd00042; CY; 1.
DR   Gene3D; 3.10.450.10; -; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; CYSTATIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR11414:SF20; CYSTATIN-A; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; Cystatin/monellin; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Allergen; Cytoplasm; Protease inhibitor; Reference proteome;
KW   Thiol protease inhibitor.
FT   CHAIN           1..98
FT                   /note="Cystatin-A"
FT                   /id="PRO_0000207127"
FT   MOTIF           46..50
FT                   /note="Secondary area of contact"
FT   SITE            4
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P01039"
SQ   SEQUENCE   98 AA;  11041 MW;  77E25F5567E0624D CRC64;
     MIPGGLSEAK PATPEIQEIA NEVKPQLEEK TNETYQKFEA IEYKTQVVAG INYYIKVQVD
     DNRYIHIKVF KGLPVQDSSL TLTGYQTGKS EDDELTGF
//