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Protein

Cystatin-A

Gene

CSTA

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This is an intracellular thiol proteinase inhibitor.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei4 – 41Reactive siteBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-A
Alternative name(s):
Allergen: Fel d 3
Cleaved into the following chain:
Gene namesi
Name:CSTA
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3280. Fel d 3.0101.
347. Fel d 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Cystatin-APRO_0000207127Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 9897Cystatin-A, N-terminally processedPRO_0000421777Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000008082.

Structurei

3D structure databases

ProteinModelPortaliQ8WNR9.
SMRiQ8WNR9. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 505Secondary area of contact

Sequence similaritiesi

Belongs to the cystatin family.Curated

Phylogenomic databases

eggNOGiENOG410J1PC. Eukaryota.
ENOG41121QW. LUCA.
HOVERGENiHBG002292.
InParanoidiQ8WNR9.
KOiK13907.

Family and domain databases

InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WNR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGGLSEAK PATPEIQEIA NEVKPQLEEK TNETYQKFEA IEYKTQVVAG
60 70 80 90
INYYIKVQVD DNRYIHIKVF KGLPVQDSSL TLTGYQTGKS EDDELTGF
Length:98
Mass (Da):11,041
Last modified:March 1, 2002 - v1
Checksum:i77E25F5567E0624D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238996 mRNA. Translation: AAL49391.1.
RefSeqiNP_001009864.1. NM_001009864.1.

Genome annotation databases

GeneIDi493942.
KEGGifca:493942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238996 mRNA. Translation: AAL49391.1.
RefSeqiNP_001009864.1. NM_001009864.1.

3D structure databases

ProteinModelPortaliQ8WNR9.
SMRiQ8WNR9. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000008082.

Protein family/group databases

Allergomei3280. Fel d 3.0101.
347. Fel d 3.
MEROPSiI25.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493942.
KEGGifca:493942.

Organism-specific databases

CTDi1475.

Phylogenomic databases

eggNOGiENOG410J1PC. Eukaryota.
ENOG41121QW. LUCA.
HOVERGENiHBG002292.
InParanoidiQ8WNR9.
KOiK13907.

Family and domain databases

InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, expression and modelling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor."
    Ichikawa K., Vailes L.D., Pomes A., Chapman M.D.
    Clin. Exp. Allergy 31:1279-1286(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
    Tissue: Skin.

Entry informationi

Entry nameiCYTA_FELCA
AccessioniPrimary (citable) accession number: Q8WNR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: November 11, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.