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Q8WNR9

- CYTA_FELCA

UniProt

Q8WNR9 - CYTA_FELCA

Protein

Cystatin-A

Gene

CSTA

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is an intracellular thiol proteinase inhibitor.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei4 – 41Reactive siteBy similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Protein family/group databases

    MEROPSiI25.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cystatin-A
    Alternative name(s):
    Allergen: Fel d 3
    Cleaved into the following chain:
    Gene namesi
    Name:CSTA
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3280. Fel d 3.0101.
    347. Fel d 3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9898Cystatin-APRO_0000207127Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 9897Cystatin-A, N-terminally processedPRO_0000421777Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000008082.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WNR9.
    SMRiQ8WNR9. Positions 1-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 505Secondary area of contact

    Sequence similaritiesi

    Belongs to the cystatin family.Curated

    Phylogenomic databases

    eggNOGiNOG119299.
    HOVERGENiHBG002292.
    KOiK13907.

    Family and domain databases

    InterProiIPR000010. Prot_inh_cystat.
    IPR018073. Prot_inh_cystat_CS.
    IPR001713. Prot_inh_stefinA.
    [Graphical view]
    PfamiPF00031. Cystatin. 1 hit.
    [Graphical view]
    PRINTSiPR00295. STEFINA.
    SMARTiSM00043. CY. 1 hit.
    [Graphical view]
    PROSITEiPS00287. CYSTATIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WNR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPGGLSEAK PATPEIQEIA NEVKPQLEEK TNETYQKFEA IEYKTQVVAG   50
    INYYIKVQVD DNRYIHIKVF KGLPVQDSSL TLTGYQTGKS EDDELTGF 98
    Length:98
    Mass (Da):11,041
    Last modified:March 1, 2002 - v1
    Checksum:i77E25F5567E0624D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF238996 mRNA. Translation: AAL49391.1.
    RefSeqiNP_001009864.1. NM_001009864.1.

    Genome annotation databases

    GeneIDi493942.
    KEGGifca:493942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF238996 mRNA. Translation: AAL49391.1 .
    RefSeqi NP_001009864.1. NM_001009864.1.

    3D structure databases

    ProteinModelPortali Q8WNR9.
    SMRi Q8WNR9. Positions 1-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000008082.

    Protein family/group databases

    Allergomei 3280. Fel d 3.0101.
    347. Fel d 3.
    MEROPSi I25.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493942.
    KEGGi fca:493942.

    Organism-specific databases

    CTDi 1475.

    Phylogenomic databases

    eggNOGi NOG119299.
    HOVERGENi HBG002292.
    KOi K13907.

    Family and domain databases

    InterProi IPR000010. Prot_inh_cystat.
    IPR018073. Prot_inh_cystat_CS.
    IPR001713. Prot_inh_stefinA.
    [Graphical view ]
    Pfami PF00031. Cystatin. 1 hit.
    [Graphical view ]
    PRINTSi PR00295. STEFINA.
    SMARTi SM00043. CY. 1 hit.
    [Graphical view ]
    PROSITEi PS00287. CYSTATIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression and modelling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor."
      Ichikawa K., Vailes L.D., Pomes A., Chapman M.D.
      Clin. Exp. Allergy 31:1279-1286(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
      Tissue: Skin.

    Entry informationi

    Entry nameiCYTA_FELCA
    AccessioniPrimary (citable) accession number: Q8WNR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3