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Q8WNR9

- CYTA_FELCA

UniProt

Q8WNR9 - CYTA_FELCA

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Protein

Cystatin-A

Gene
CSTA
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This is an intracellular thiol proteinase inhibitor By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei4 – 41Reactive site By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-A
Alternative name(s):
Allergen: Fel d 3
Cleaved into the following chain:
Gene namesi
Name:CSTA
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3280. Fel d 3.0101.
347. Fel d 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Cystatin-APRO_0000207127Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 9897Cystatin-A, N-terminally processedPRO_0000421777Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000008082.

Structurei

3D structure databases

ProteinModelPortaliQ8WNR9.
SMRiQ8WNR9. Positions 1-98.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 505Secondary area of contact

Sequence similaritiesi

Belongs to the cystatin family.

Phylogenomic databases

eggNOGiNOG119299.
HOVERGENiHBG002292.
KOiK13907.

Family and domain databases

InterProiIPR000010. Prot_inh_cystat.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WNR9-1 [UniParc]FASTAAdd to Basket

« Hide

MIPGGLSEAK PATPEIQEIA NEVKPQLEEK TNETYQKFEA IEYKTQVVAG   50
INYYIKVQVD DNRYIHIKVF KGLPVQDSSL TLTGYQTGKS EDDELTGF 98
Length:98
Mass (Da):11,041
Last modified:March 1, 2002 - v1
Checksum:i77E25F5567E0624D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF238996 mRNA. Translation: AAL49391.1.
RefSeqiNP_001009864.1. NM_001009864.1.

Genome annotation databases

GeneIDi493942.
KEGGifca:493942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF238996 mRNA. Translation: AAL49391.1 .
RefSeqi NP_001009864.1. NM_001009864.1.

3D structure databases

ProteinModelPortali Q8WNR9.
SMRi Q8WNR9. Positions 1-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000008082.

Protein family/group databases

Allergomei 3280. Fel d 3.0101.
347. Fel d 3.
MEROPSi I25.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493942.
KEGGi fca:493942.

Organism-specific databases

CTDi 1475.

Phylogenomic databases

eggNOGi NOG119299.
HOVERGENi HBG002292.
KOi K13907.

Family and domain databases

InterProi IPR000010. Prot_inh_cystat.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view ]
Pfami PF00031. Cystatin. 1 hit.
[Graphical view ]
PRINTSi PR00295. STEFINA.
SMARTi SM00043. CY. 1 hit.
[Graphical view ]
PROSITEi PS00287. CYSTATIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, expression and modelling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor."
    Ichikawa K., Vailes L.D., Pomes A., Chapman M.D.
    Clin. Exp. Allergy 31:1279-1286(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
    Tissue: Skin.

Entry informationi

Entry nameiCYTA_FELCA
AccessioniPrimary (citable) accession number: Q8WNR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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