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Q8WNR9 (CYTA_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cystatin-A
Alternative name(s):
Allergen=Fel d 3

Cleaved into the following chain:

  1. Cystatin-A, N-terminally processed
Gene names
Name:CSTA
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is an intracellular thiol proteinase inhibitor By similarity.

Subcellular location

Cytoplasm By similarity.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE. Ref.1

Sequence similarities

Belongs to the cystatin family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DiseaseAllergen
   Molecular functionProtease inhibitor
Thiol protease inhibitor
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9898Cystatin-A
PRO_0000207127
Initiator methionine11Removed; alternate By similarity
Chain2 – 9897Cystatin-A, N-terminally processed
PRO_0000421777

Regions

Motif46 – 505Secondary area of contact

Sites

Site41Reactive site By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8WNR9 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 77E25F5567E0624D

FASTA9811,041
        10         20         30         40         50         60 
MIPGGLSEAK PATPEIQEIA NEVKPQLEEK TNETYQKFEA IEYKTQVVAG INYYIKVQVD 

        70         80         90 
DNRYIHIKVF KGLPVQDSSL TLTGYQTGKS EDDELTGF 

« Hide

References

[1]"Molecular cloning, expression and modelling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor."
Ichikawa K., Vailes L.D., Pomes A., Chapman M.D.
Clin. Exp. Allergy 31:1279-1286(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
Tissue: Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF238996 mRNA. Translation: AAL49391.1.
RefSeqNP_001009864.1. NM_001009864.1.

3D structure databases

ProteinModelPortalQ8WNR9.
SMRQ8WNR9. Positions 1-98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000008082.

Protein family/group databases

Allergome3280. Fel d 3.0101.
347. Fel d 3.
MEROPSI25.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493942.
KEGGfca:493942.

Organism-specific databases

CTD1475.

Phylogenomic databases

eggNOGNOG119299.
HOVERGENHBG002292.
KOK13907.

Family and domain databases

InterProIPR000010. Prot_inh_cystat.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSPR00295. STEFINA.
SMARTSM00043. CY. 1 hit.
[Graphical view]
PROSITEPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYTA_FELCA
AccessionPrimary (citable) accession number: Q8WNR9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries