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Protein

Cystatin-A

Gene

CSTA

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This is an intracellular thiol proteinase inhibitor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4Reactive siteBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-A
Alternative name(s):
Allergen: Fel d 3
Gene namesi
Name:CSTA
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3280. Fel d 3.0101.
347. Fel d 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071271 – 98Cystatin-AAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000008082.

Structurei

3D structure databases

ProteinModelPortaliQ8WNR9.
SMRiQ8WNR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 50Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Phylogenomic databases

eggNOGiENOG410J1PC. Eukaryota.
ENOG41121QW. LUCA.
HOVERGENiHBG002292.
InParanoidiQ8WNR9.
KOiK13907.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
PRINTSiPR00295. STEFINA.
SMARTiView protein in SMART
SM00043. CY. 1 hit.
PROSITEiView protein in PROSITE
PS00287. CYSTATIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WNR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGGLSEAK PATPEIQEIA NEVKPQLEEK TNETYQKFEA IEYKTQVVAG
60 70 80 90
INYYIKVQVD DNRYIHIKVF KGLPVQDSSL TLTGYQTGKS EDDELTGF
Length:98
Mass (Da):11,041
Last modified:March 1, 2002 - v1
Checksum:i77E25F5567E0624D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238996 mRNA. Translation: AAL49391.1.
RefSeqiNP_001009864.1. NM_001009864.1.

Genome annotation databases

GeneIDi493942.
KEGGifca:493942.

Similar proteinsi

Entry informationi

Entry nameiCYTA_FELCA
AccessioniPrimary (citable) accession number: Q8WNR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: August 30, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families