Q8WNR9 (CYTA_FELCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cystatin-A

Alternative name(s):
Allergen=Fel d 3

Cleaved into the following chain:

1. Cystatin-A, N-terminally processed

Gene names

Name:

CSTA

Organism

Felis catus (Cat) (Felis silvestris catus) [Complete proteome]

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is an intracellular thiol proteinase inhibitor By similarity.
Subcellular location	Cytoplasm By similarity.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE. Ref.1
Sequence similarities	Belongs to the cystatin family.

Ontologies

Keywords
Cellular component	Cytoplasm
Disease	Allergen
Molecular function	Protease inhibitor Thiol protease inhibitor
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell-cell adhesion Inferred from electronic annotation. Source: Compara keratinocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of endopeptidase activity Inferred from electronic annotation. Source: GOC peptide cross-linking Inferred from electronic annotation. Source: Compara
Cellular_component	cornified envelope Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	cysteine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW structural molecule activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	Cystatin-A		PRO_0000207127
	Initiator methionine	1	1	Removed; alternate By similarity
	Chain	2 – 98	97	Cystatin-A, N-terminally processed		PRO_0000421777
Regions
	Motif	46 – 50	5	Secondary area of contact
Sites
	Site	4	1	Reactive site By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8WNR9 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 77E25F5567E0624D	FASTA	98	11,041
	10 20 30 40 50 60 MIPGGLSEAK PATPEIQEIA NEVKPQLEEK TNETYQKFEA IEYKTQVVAG INYYIKVQVD 70 80 90 DNRYIHIKVF KGLPVQDSSL TLTGYQTGKS EDDELTGF

References

[1]	"Molecular cloning, expression and modelling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor." Ichikawa K., Vailes L.D., Pomes A., Chapman M.D. Clin. Exp. Allergy 31:1279-1286(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN. Tissue: Skin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF238996 mRNA. Translation: AAL49391.1.
RefSeq	NP_001009864.1. NM_001009864.1.
3D structure databases
ProteinModelPortal	Q8WNR9.
SMR	Q8WNR9. Positions 1-98.
ModBase	Search...
Protein family/group databases
Allergome	3280. Fel d 3.0101. 347. Fel d 3.
MEROPS	I25.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSFCAT00000008720; ENSFCAP00000008082; ENSFCAG00000008718.
GeneID	493942.
KEGG	fca:493942.
Organism-specific databases
CTD	1475.
Phylogenomic databases
eggNOG	NOG119299.
GeneTree	ENSGT00390000015607.
HOVERGEN	HBG002292.
KO	K13907.
OrthoDB	EOG42Z4RQ.
Family and domain databases
InterPro	IPR000010. Prot_inh_cystat. IPR018073. Prot_inh_cystat_CS. IPR001713. Prot_inh_stefinA. [Graphical view]
Pfam	PF00031. Cystatin. 1 hit. [Graphical view]
PRINTS	PR00295. STEFINA.
SMART	SM00043. CY. 1 hit. [Graphical view]
PROSITE	PS00287. CYSTATIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYTA_FELCA

Accession

Primary (citable) accession number: Q8WNR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program