Q8WNN6 (SODC_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1

Gene names

Name:

SOD1

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Acetylation Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 153	152	Superoxide dismutase [Cu-Zn]		PRO_0000164051
Sites
	Metal binding	46	1	Copper; catalytic By similarity
	Metal binding	48	1	Copper; catalytic By similarity
	Metal binding	63	1	Copper; catalytic By similarity
	Metal binding	63	1	Zinc; structural By similarity
	Metal binding	71	1	Zinc; structural By similarity
	Metal binding	80	1	Zinc; structural By similarity
	Metal binding	83	1	Zinc; structural By similarity
	Metal binding	120	1	Copper; catalytic By similarity
Amino acid modifications
	Modified residue	70	1	N6-acetyllysine By similarity
	Modified residue	98	1	Phosphoserine By similarity
	Modified residue	122	1	N6-acetyllysine By similarity
	Disulfide bond	57 ↔ 146		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8WNN6 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 0D7900E59C57E6B0	FASTA	153	15,913
	10 20 30 40 50 60 MEMKAVCVLK GQGPVEGTIH FVQKGSGPVV VSGTITGLTE GEHGFHVHQF EDXTQGCTSA 70 80 90 100 110 120 GPHFNPLSKK HGGPKDQERH VGDLGNVTAG KDGVAIVSIE DSLIALSGDY SIIGRTMVVH 130 140 150 EKRDDLGKGD NEESTQTGNA GSRLACGVIG IAQ

References

[1]	"Structure, chromosomal location, and analysis of the canine Cu/Zn superoxide dismutase (SOD1) gene." Green S.L., Tolwani R.J., Varma S., Quignon P., Galibert F., Cork L.C. J. Hered. 93:119-124(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF346417 mRNA. Translation: AAL61608.1.
RefSeq	NP_001003035.1. NM_001003035.1.
UniGene	Cfa.6360.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403559.
KEGG	cfa:403559.
Organism-specific databases
CTD	6647.
Phylogenomic databases
HOVERGEN	HBG000062.
KO	K04565.
Family and domain databases
Gene3D	2.60.40.200. 1 hit.
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
PANTHER	PTHR10003. PTHR10003. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20817068.

Entry information

Entry name

SODC_CANFA

Accession

Primary (citable) accession number: Q8WNN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program