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Q8WNN6

- SODC_CANFA

UniProt

Q8WNN6 - SODC_CANFA

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Protein

Superoxide dismutase [Cu-Zn]

Gene

SOD1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461Copper; catalyticBy similarity
Metal bindingi48 – 481Copper; catalyticBy similarity
Metal bindingi63 – 631Copper; catalyticBy similarity
Metal bindingi63 – 631Zinc; structuralBy similarity
Metal bindingi71 – 711Zinc; structuralBy similarity
Metal bindingi80 – 801Zinc; structuralBy similarity
Metal bindingi83 – 831Zinc; structuralBy similarity
Metal bindingi120 – 1201Copper; catalyticBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB

GO - Biological processi

  1. reactive oxygen species metabolic process Source: UniProtKB
  2. removal of superoxide radicals Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:SOD1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 153152Superoxide dismutase [Cu-Zn]PRO_0000164051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41N6-succinyllysineBy similarity
Lipidationi7 – 71S-palmitoyl cysteineBy similarity
Modified residuei10 – 101N6-succinyllysineBy similarity
Disulfide bondi57 ↔ 146By similarity
Modified residuei91 – 911N6-succinyllysineBy similarity
Modified residuei98 – 981PhosphoserineBy similarity
Modified residuei122 – 1221N6-acetyllysine; alternateBy similarity
Modified residuei122 – 1221N6-succinyllysine; alternateBy similarity

Post-translational modificationi

Palmitoylation helps nuclear targeting and decreases catalytic activity.By similarity
Succinylation, adjacent to copper catalytic site probably inhibit activity. Desuccinylated by SIRT5, enhancing activity (By similarity).By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

HOVERGENiHBG000062.
InParanoidiQ8WNN6.
KOiK04565.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WNN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEMKAVCVLK GQGPVEGTIH FVQKGSGPVV VSGTITGLTE GEHGFHVHQF
60 70 80 90 100
EDXTQGCTSA GPHFNPLSKK HGGPKDQERH VGDLGNVTAG KDGVAIVSIE
110 120 130 140 150
DSLIALSGDY SIIGRTMVVH EKRDDLGKGD NEESTQTGNA GSRLACGVIG

IAQ
Length:153
Mass (Da):15,913
Last modified:March 1, 2002 - v1
Checksum:i0D7900E59C57E6B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346417 mRNA. Translation: AAL61608.1.
RefSeqiNP_001003035.1. NM_001003035.1.
UniGeneiCfa.6360.

Genome annotation databases

GeneIDi403559.
KEGGicfa:403559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346417 mRNA. Translation: AAL61608.1 .
RefSeqi NP_001003035.1. NM_001003035.1.
UniGenei Cfa.6360.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403559.
KEGGi cfa:403559.

Organism-specific databases

CTDi 6647.

Phylogenomic databases

HOVERGENi HBG000062.
InParanoidi Q8WNN6.
KOi K04565.

Miscellaneous databases

NextBioi 20817068.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure, chromosomal location, and analysis of the canine Cu/Zn superoxide dismutase (SOD1) gene."
    Green S.L., Tolwani R.J., Varma S., Quignon P., Galibert F., Cork L.C.
    J. Hered. 93:119-124(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSODC_CANFA
AccessioniPrimary (citable) accession number: Q8WNN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3