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Q8WNN6

- SODC_CANFA

UniProt

Q8WNN6 - SODC_CANFA

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Protein
Superoxide dismutase [Cu-Zn]
Gene
SOD1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 copper ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461Copper; catalytic By similarity
Metal bindingi48 – 481Copper; catalytic By similarity
Metal bindingi63 – 631Copper; catalytic By similarity
Metal bindingi63 – 631Zinc; structural By similarity
Metal bindingi71 – 711Zinc; structural By similarity
Metal bindingi80 – 801Zinc; structural By similarity
Metal bindingi83 – 831Zinc; structural By similarity
Metal bindingi120 – 1201Copper; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB

GO - Biological processi

  1. reactive oxygen species metabolic process Source: UniProtKB
  2. removal of superoxide radicals Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:SOD1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 153152Superoxide dismutase [Cu-Zn]
PRO_0000164051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41N6-succinyllysine By similarity
Lipidationi7 – 71S-palmitoyl cysteine By similarity
Modified residuei10 – 101N6-succinyllysine By similarity
Disulfide bondi57 ↔ 146 By similarity
Modified residuei91 – 911N6-succinyllysine By similarity
Modified residuei98 – 981Phosphoserine By similarity
Modified residuei122 – 1221N6-acetyllysine; alternate By similarity
Modified residuei122 – 1221N6-succinyllysine; alternate By similarity

Post-translational modificationi

Palmitoylation helps nuclear targeting and decreases catalytic activity By similarity.
Succinylation, adjacent to copper catalytic site probably inhibit activity. Desuccinylated by SIRT5, enhancing activity By similarity.

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000062.
KOiK04565.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WNN6-1 [UniParc]FASTAAdd to Basket

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MEMKAVCVLK GQGPVEGTIH FVQKGSGPVV VSGTITGLTE GEHGFHVHQF    50
EDXTQGCTSA GPHFNPLSKK HGGPKDQERH VGDLGNVTAG KDGVAIVSIE 100
DSLIALSGDY SIIGRTMVVH EKRDDLGKGD NEESTQTGNA GSRLACGVIG 150
IAQ 153
Length:153
Mass (Da):15,913
Last modified:March 1, 2002 - v1
Checksum:i0D7900E59C57E6B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF346417 mRNA. Translation: AAL61608.1.
RefSeqiNP_001003035.1. NM_001003035.1.
UniGeneiCfa.6360.

Genome annotation databases

GeneIDi403559.
KEGGicfa:403559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF346417 mRNA. Translation: AAL61608.1 .
RefSeqi NP_001003035.1. NM_001003035.1.
UniGenei Cfa.6360.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403559.
KEGGi cfa:403559.

Organism-specific databases

CTDi 6647.

Phylogenomic databases

HOVERGENi HBG000062.
KOi K04565.

Miscellaneous databases

NextBioi 20817068.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure, chromosomal location, and analysis of the canine Cu/Zn superoxide dismutase (SOD1) gene."
    Green S.L., Tolwani R.J., Varma S., Quignon P., Galibert F., Cork L.C.
    J. Hered. 93:119-124(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSODC_CANFA
AccessioniPrimary (citable) accession number: Q8WNN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi