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Q8WNN6 (SODC_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Cu-Zn]

EC=1.15.1.1
Gene names
Name:SOD1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 copper ion per subunit By similarity.

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Post-translational modification

Palmitoylation helps nuclear targeting and decreases catalytic activity By similarity.

Succinylation, adjacent to copper catalytic site probably inhibit activity. Desuccinylated by SIRT5, enhancing activity By similarity.

Sequence similarities

Belongs to the Cu-Zn superoxide dismutase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 153152Superoxide dismutase [Cu-Zn]
PRO_0000164051

Sites

Metal binding461Copper; catalytic By similarity
Metal binding481Copper; catalytic By similarity
Metal binding631Copper; catalytic By similarity
Metal binding631Zinc; structural By similarity
Metal binding711Zinc; structural By similarity
Metal binding801Zinc; structural By similarity
Metal binding831Zinc; structural By similarity
Metal binding1201Copper; catalytic By similarity

Amino acid modifications

Modified residue41N6-succinyllysine By similarity
Modified residue101N6-succinyllysine By similarity
Modified residue911N6-succinyllysine By similarity
Modified residue981Phosphoserine By similarity
Modified residue1221N6-acetyllysine; alternate By similarity
Modified residue1221N6-succinyllysine; alternate By similarity
Lipidation71S-palmitoyl cysteine By similarity
Disulfide bond57 ↔ 146 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8WNN6 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 0D7900E59C57E6B0

FASTA15315,913
        10         20         30         40         50         60 
MEMKAVCVLK GQGPVEGTIH FVQKGSGPVV VSGTITGLTE GEHGFHVHQF EDXTQGCTSA 

        70         80         90        100        110        120 
GPHFNPLSKK HGGPKDQERH VGDLGNVTAG KDGVAIVSIE DSLIALSGDY SIIGRTMVVH 

       130        140        150 
EKRDDLGKGD NEESTQTGNA GSRLACGVIG IAQ 

« Hide

References

[1]"Structure, chromosomal location, and analysis of the canine Cu/Zn superoxide dismutase (SOD1) gene."
Green S.L., Tolwani R.J., Varma S., Quignon P., Galibert F., Cork L.C.
J. Hered. 93:119-124(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF346417 mRNA. Translation: AAL61608.1.
RefSeqNP_001003035.1. NM_001003035.1.
UniGeneCfa.6360.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403559.
KEGGcfa:403559.

Organism-specific databases

CTD6647.

Phylogenomic databases

HOVERGENHBG000062.
KOK04565.

Family and domain databases

Gene3D2.60.40.200. 1 hit.
InterProIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSPR00068. CUZNDISMTASE.
SUPFAMSSF49329. SSF49329. 1 hit.
PROSITEPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817068.

Entry information

Entry nameSODC_CANFA
AccessionPrimary (citable) accession number: Q8WNN6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families