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Q8WNE1 (CP2F5_GORGO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2F5

Short name=CYP4502F5
EC=1.14.14.1
Alternative name(s):
CYPIIF5
Gene names
Name:CYP2F5
OrganismGorilla gorilla gorilla (Lowland gorilla) [Reference proteome]
Taxonomic identifier9595 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2F5
PRO_0000051763

Sites

Metal binding4361Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8WNE1 [UniParc].

Last modified October 1, 2003. Version 2.
Checksum: 60B220260A9FEF07

FASTA49155,702
        10         20         30         40         50         60 
MDSVSTAILL LLLALICLLL TLSSRDKGKL PPGPRPLPLL GNLLLLRSQD MLTSLTKLSK 

        70         80         90        100        110        120 
EYGSMYTVHL GPRRVVVLSG YQAVKEALVD QGEEFSGRRD FPAFFNFTKG NGIAFSNGDR 

       130        140        150        160        170        180 
WKVLRRFSIQ ILRNFGMGKR SIEERILEEG SFLLAELRKT EGEPFDPTFV LSRSVSNIIC 

       190        200        210        220        230        240 
SVLFGSRFDY DDERLLTIIR HINDNFQIMS SPWGELYDIF PSLLDWVPGP HQRIFQNFKC 

       250        260        270        280        290        300 
LRDLIAHSVH DHQASLDPRS PRDFIDCFLT KMAEENEDPL SHFHMDTLLM TTHNLLFGGT 

       310        320        330        340        350        360 
ETVGTTLRYA FLALMKYPKV QARVQEEIDL VVGRARLPAL KDRAAMPYTD AVIHEVQRFA 

       370        380        390        400        410        420 
DIIPMSLPHR VTRDTAFRGF LIPKGTDIIT LLNTVHYDPS QFLTPQEFNP EHFLDANQSF 

       430        440        450        460        470        480 
KKSPAFMPFS AGRRLCLGES LARMELFLYL TAILQSFSLQ PLGAPKDIDL TPLSSGLGNL 

       490 
PRPFQLCLRP R 

« Hide

References

[1]"Identification and cross-species comparisons of CYP2F subfamily genes in mammals."
Chen N., Whitehead S.E., Caillat A.W., Gavit K., Isphording D.R., Kovacevic D., McCreary M.B., Hoffman S.M.G.
Mutat. Res. 499:155-161(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF372494 expand/collapse EMBL AC list , AF372488, AF372489, AF372490, AF372492 Genomic DNA. Translation: AAL72278.2.

3D structure databases

ProteinModelPortalQ8WNE1.
SMRQ8WNE1. Positions 27-491.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2F5_GORGO
AccessionPrimary (citable) accession number: Q8WNE1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2003
Last modified: December 11, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families