Q8WNE1 (CP2F5_GORGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 2F5
Short name=CYP4502F5
EC=1.14.14.1

Alternative name(s):
CYPIIF5

Gene names

Name:

CYP2F5

Organism

Gorilla gorilla gorilla (Lowland gorilla) [Reference proteome]

Taxonomic identifier

9595 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Gorilla › Gorilla gorilla

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Cytochrome P450 2F5		PRO_0000051763
Sites
	Metal binding	436	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8WNE1 [UniParc]. Last modified October 1, 2003. Version 2. Checksum: 60B220260A9FEF07	FASTA	491	55,702
	10 20 30 40 50 60 MDSVSTAILL LLLALICLLL TLSSRDKGKL PPGPRPLPLL GNLLLLRSQD MLTSLTKLSK 70 80 90 100 110 120 EYGSMYTVHL GPRRVVVLSG YQAVKEALVD QGEEFSGRRD FPAFFNFTKG NGIAFSNGDR 130 140 150 160 170 180 WKVLRRFSIQ ILRNFGMGKR SIEERILEEG SFLLAELRKT EGEPFDPTFV LSRSVSNIIC 190 200 210 220 230 240 SVLFGSRFDY DDERLLTIIR HINDNFQIMS SPWGELYDIF PSLLDWVPGP HQRIFQNFKC 250 260 270 280 290 300 LRDLIAHSVH DHQASLDPRS PRDFIDCFLT KMAEENEDPL SHFHMDTLLM TTHNLLFGGT 310 320 330 340 350 360 ETVGTTLRYA FLALMKYPKV QARVQEEIDL VVGRARLPAL KDRAAMPYTD AVIHEVQRFA 370 380 390 400 410 420 DIIPMSLPHR VTRDTAFRGF LIPKGTDIIT LLNTVHYDPS QFLTPQEFNP EHFLDANQSF 430 440 450 460 470 480 KKSPAFMPFS AGRRLCLGES LARMELFLYL TAILQSFSLQ PLGAPKDIDL TPLSSGLGNL 490 PRPFQLCLRP R

References

[1]

"Identification and cross-species comparisons of CYP2F subfamily genes in mammals." Chen N., Whitehead S.E., Caillat A.W., Gavit K., Isphording D.R., Kovacevic D., McCreary M.B., Hoffman S.M.G. Mutat. Res. 499:155-161(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF372494 , AF372488, AF372489, AF372490, AF372492 Genomic DNA. Translation: AAL72278.2.
3D structure databases
ProteinModelPortal	Q8WNE1.
SMR	Q8WNE1. Positions 27-491.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG015789.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR020469. Cyt_P450_CYP2_fam. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01957. EP450ICYP2F. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP2F5_GORGO

Accession

Primary (citable) accession number: Q8WNE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program