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Protein

Cytochrome P450 2F5

Gene

CYP2F5

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. oxygen binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2F5 (EC:1.14.14.1)
Short name:
CYP4502F5
Alternative name(s):
CYPIIF5
Gene namesi
Name:CYP2F5
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
ProteomesiUP000001519 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2F5PRO_0000051763Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8WNE1.
SMRiQ8WNE1. Positions 27-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.
InParanoidiQ8WNE1.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WNE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVSTAILL LLLALICLLL TLSSRDKGKL PPGPRPLPLL GNLLLLRSQD
60 70 80 90 100
MLTSLTKLSK EYGSMYTVHL GPRRVVVLSG YQAVKEALVD QGEEFSGRRD
110 120 130 140 150
FPAFFNFTKG NGIAFSNGDR WKVLRRFSIQ ILRNFGMGKR SIEERILEEG
160 170 180 190 200
SFLLAELRKT EGEPFDPTFV LSRSVSNIIC SVLFGSRFDY DDERLLTIIR
210 220 230 240 250
HINDNFQIMS SPWGELYDIF PSLLDWVPGP HQRIFQNFKC LRDLIAHSVH
260 270 280 290 300
DHQASLDPRS PRDFIDCFLT KMAEENEDPL SHFHMDTLLM TTHNLLFGGT
310 320 330 340 350
ETVGTTLRYA FLALMKYPKV QARVQEEIDL VVGRARLPAL KDRAAMPYTD
360 370 380 390 400
AVIHEVQRFA DIIPMSLPHR VTRDTAFRGF LIPKGTDIIT LLNTVHYDPS
410 420 430 440 450
QFLTPQEFNP EHFLDANQSF KKSPAFMPFS AGRRLCLGES LARMELFLYL
460 470 480 490
TAILQSFSLQ PLGAPKDIDL TPLSSGLGNL PRPFQLCLRP R
Length:491
Mass (Da):55,702
Last modified:October 1, 2003 - v2
Checksum:i60B220260A9FEF07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF372494
, AF372488, AF372489, AF372490, AF372492 Genomic DNA. Translation: AAL72278.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF372494
, AF372488, AF372489, AF372490, AF372492 Genomic DNA. Translation: AAL72278.2.

3D structure databases

ProteinModelPortaliQ8WNE1.
SMRiQ8WNE1. Positions 27-491.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG015789.
InParanoidiQ8WNE1.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and cross-species comparisons of CYP2F subfamily genes in mammals."
    Chen N., Whitehead S.E., Caillat A.W., Gavit K., Isphording D.R., Kovacevic D., McCreary M.B., Hoffman S.M.G.
    Mutat. Res. 499:155-161(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCP2F5_GORGO
AccessioniPrimary (citable) accession number: Q8WNE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2003
Last modified: February 4, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.