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Protein

Elongator complex protein 1

Gene

IKBKAP

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).By similarity
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 1
Short name:
ELP1
Alternative name(s):
IkappaB kinase complex-associated protein
Short name:
IKK complex-associated protein
Gene namesi
Name:IKBKAP
Synonyms:ELP1, IKAP
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13331333Elongator complex protein 1PRO_0000283996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei805 – 8051PhosphoserineBy similarity
Modified residuei868 – 8681PhosphoserineBy similarity
Modified residuei1172 – 11721PhosphoserineBy similarity
Modified residuei1175 – 11751PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023479.

Structurei

3D structure databases

ProteinModelPortaliQ8WND5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP1/IKA1 family.Curated

Phylogenomic databases

eggNOGiKOG1920. Eukaryota.
COG5290. LUCA.
HOGENOMiHOG000007712.
HOVERGENiHBG019038.
InParanoidiQ8WND5.
KOiK11373.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR006849. Iki3.
[Graphical view]
PANTHERiPTHR12747. PTHR12747. 1 hit.
PfamiPF04762. IKI3. 1 hit.
[Graphical view]
PIRSFiPIRSF017233. IKAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WND5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNLKLLQTL EFKDIQAPGK PQCFSLRTEP GTVLIGSEHG LIEVDPVTRE
60 70 80 90 100
VKNEIPLVAE GFLPEDKSGC IVGIQDLLDQ ESVCIATASG DVILCNLSTH
110 120 130 140 150
QLECVGSVAS GISVMSWSPD QELVLLATGQ QTLIMMTKDF EPIMEQQIHQ
160 170 180 190 200
DDFGESKFIT VGWGKKETQF HGSEGRQAAF QIQTHESALP WDDHRPRVTW
210 220 230 240 250
RGDGQFFAVS VVCPETGARK VRVWNREFAL QSTSEPVPGL GPALAWKPSG
260 270 280 290 300
SLIASTQNKP NQQDVVFFEK NGLLHGQFTL PFLKDEVKVN DLLWNADSSV
310 320 330 340 350
LAVWLEDLQR EEDSVLKTYV QLWTVGNYHW YLNECLPFST YGKSKIVSLM
360 370 380 390 400
WDPVIPYRLH VLCQGWHYLC YDWRWTTDRS SGDNESDLAN VAVIDGNRIL
410 420 430 440 450
VTVFQQTVVP PPMCTYRLLL PHPVNQVTFC ALPKKSNDLA VLDASNQISV
460 470 480 490 500
YKCGDSPSMD PTVKLGAVGG NGFKVSLRTP HLEKRYKIQF ESNEDQETNP
510 520 530 540 550
LKLSLLSWIE EDIFLAICHS QCSPQQSVIH RLTVVPCEVD EEQGQLSVSS
560 570 580 590 600
SISVDGIIIS MCCNSKTKSV ALQLADGQIL KYIWESPSLA VEPWKNPGGF
610 620 630 640 650
PIQFPYPCIQ TELAMIGGEE CVLGLTDRCR FFINDTEVAS NITSFAVYDE
660 670 680 690 700
FLLLTTHSHT CQCYCLKDAS IKTLQAGLSS SHVSNGEILR KVERGSRIVT
710 720 730 740 750
VVPQDTKLIL QMPRGNLEVV HHRALVLAQI RKWLDKIMFK EAFECMRKLR
760 770 780 790 800
INLNLIHDHN PEVFLQNVET FIRQIDCVNH INLFFTELKE EDVTKTMYPP
810 820 830 840 850
PVPSSVQQSR DPGGTKLDLI CDALRVAMEN INPHKYCLPI LTSHVKKTTP
860 870 880 890 900
ELEIVLQKVH ELQGNAPSDP DAVSAEEALK YLLLLVDVNE LYDHSLGTYD
910 920 930 940 950
FDLVLMVAEK SQKDPKEYLP FLNTLKKMET NYQRFTIDKY LKRYEKAIGH
960 970 980 990 1000
LSKCGPEYFS ECLNLIKDKN LYNEALKLYP PTSQEYKDIS IAYGEHLMEE
1010 1020 1030 1040 1050
HQYEPAGLVF ARCGAHEKAL SAFLTCGSWQ QTLCMAAQLN MTEEQLAGLG
1060 1070 1080 1090 1100
RTLAGKLAEQ RKHSDAAIVL EQYTQDYEEA VLLLLEGAAW EEALRLVYKY
1110 1120 1130 1140 1150
NRLDIIETNI KPSILEAYKN YMAFLESQSA TFSRHKERLL EVRELKERAQ
1160 1170 1180 1190 1200
QVDLDDEMPH GQEADLFSET SSIVSGSEMS SKYSHSNSRI SARSSKNRRK
1210 1220 1230 1240 1250
AERKKHSLKE GSPLEDLALL EALNEVVQSL DKLKDEVYRI LKVLFLFEFD
1260 1270 1280 1290 1300
EQGRELQKTF QDTLQLVERS LPEIWTLTYQ QNSAMPVLGP SSTANSIMAS
1310 1320 1330
YQQQKTSVPV LDAELFVPPK INRKTQWKLS LLE
Length:1,333
Mass (Da):150,794
Last modified:March 1, 2002 - v1
Checksum:i00FA2FEE7046CC5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388202 mRNA. Translation: AAL40927.1.
RefSeqiNP_001076124.1. NM_001082655.1.
UniGeneiOcu.4098.

Genome annotation databases

GeneIDi100009360.
KEGGiocu:100009360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388202 mRNA. Translation: AAL40927.1.
RefSeqiNP_001076124.1. NM_001082655.1.
UniGeneiOcu.4098.

3D structure databases

ProteinModelPortaliQ8WND5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023479.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009360.
KEGGiocu:100009360.

Organism-specific databases

CTDi8518.

Phylogenomic databases

eggNOGiKOG1920. Eukaryota.
COG5290. LUCA.
HOGENOMiHOG000007712.
HOVERGENiHBG019038.
InParanoidiQ8WND5.
KOiK11373.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR006849. Iki3.
[Graphical view]
PANTHERiPTHR12747. PTHR12747. 1 hit.
PfamiPF04762. IKI3. 1 hit.
[Graphical view]
PIRSFiPIRSF017233. IKAP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiELP1_RABIT
AccessioniPrimary (citable) accession number: Q8WND5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.