Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WN98

- MIOX_PIG

UniProt

Q8WN98 - MIOX_PIG

Protein

Inositol oxygenase

Gene

MIOX

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Myo-inositol + O2 = D-glucuronate + H2O.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Temperature dependencei

    Thermolabile.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei26 – 261SubstrateBy similarity
    Metal bindingi95 – 951Iron 1By similarity
    Metal bindingi120 – 1201Iron 1By similarity
    Metal bindingi121 – 1211Iron 1By similarity
    Metal bindingi121 – 1211Iron 2By similarity
    Binding sitei124 – 1241SubstrateBy similarity
    Metal bindingi191 – 1911Iron 2By similarity
    Metal bindingi217 – 2171Iron 2By similarity
    Metal bindingi250 – 2501Iron 1By similarity

    GO - Molecular functioni

    1. ferric iron binding Source: UniProtKB
    2. inositol oxygenase activity Source: UniProtKB
    3. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Source: UniProtKB

    GO - Biological processi

    1. cellular water homeostasis Source: UniProtKB
    2. inositol catabolic process Source: UniProtKB
    3. inositol phosphate-mediated signaling Source: UniProtKB
    4. membrane organization Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKQ8WN98.
    UniPathwayiUPA00111; UER00527.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol oxygenase (EC:1.13.99.1)
    Alternative name(s):
    Aldehyde reductase-like 6
    Myo-inositol oxygenase
    Short name:
    MI oxygenase
    Gene namesi
    Name:MIOX
    Synonyms:ALDRL6
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. inclusion body Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Inositol oxygenasePRO_0000079150Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Proteomic databases

    PaxDbiQ8WN98.

    Expressioni

    Tissue specificityi

    Kidney specific.

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000001029.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WN98.
    SMRiQ8WN98. Positions 25-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 843Substrate bindingBy similarity
    Regioni138 – 1392Substrate bindingBy similarity
    Regioni217 – 2182Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the myo-inositol oxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG135479.
    HOGENOMiHOG000163182.
    HOVERGENiHBG039556.
    KOiK00469.

    Family and domain databases

    InterProiIPR007828. Inositol_oxygenase.
    [Graphical view]
    PANTHERiPTHR12588. PTHR12588. 1 hit.
    PfamiPF05153. DUF706. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WN98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDPDPSQVY RPDMDPEAAK DKGSFRNYTS GPLLDRVFRT YKLMHTWQTV    50
    DFVRKKHAQF GGFSYKRMTV LEAVDMLDGL VDESDPDVDF PNSFHAFQTA 100
    EGIRKAHPDK DWFHLVGLLH DLGKVLVLAG EPQWAVVGDT FPVGCRPQAS 150
    VVFCDSTFQD NPDLQDPVYS TELGMYQPHC GLENALMSWG HDEYMYQMMK 200
    FNKFSLPGEA FYIIRFHSFY PWHTGGDYRQ LCNEQDLAML PWVQEFNKFD 250
    LYTKGSDMPD VDELRPYYQG LIDKYCPGVL CW 282
    Length:282
    Mass (Da):32,653
    Last modified:March 1, 2002 - v1
    Checksum:i0B9D4D54A3AE5DE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF401311 mRNA. Translation: AAL39076.1.
    RefSeqiNP_999267.1. NM_214102.2.
    UniGeneiSsc.15816.

    Genome annotation databases

    GeneIDi397189.
    KEGGissc:397189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF401311 mRNA. Translation: AAL39076.1 .
    RefSeqi NP_999267.1. NM_214102.2.
    UniGenei Ssc.15816.

    3D structure databases

    ProteinModelPortali Q8WN98.
    SMRi Q8WN98. Positions 25-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000001029.

    Proteomic databases

    PaxDbi Q8WN98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397189.
    KEGGi ssc:397189.

    Organism-specific databases

    CTDi 55586.

    Phylogenomic databases

    eggNOGi NOG135479.
    HOGENOMi HOG000163182.
    HOVERGENi HBG039556.
    KOi K00469.

    Enzyme and pathway databases

    UniPathwayi UPA00111 ; UER00527 .
    SABIO-RK Q8WN98.

    Family and domain databases

    InterProi IPR007828. Inositol_oxygenase.
    [Graphical view ]
    PANTHERi PTHR12588. PTHR12588. 1 hit.
    Pfami PF05153. DUF706. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Myo-inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and d-chiro-inositol."
      Arner R.J., Prabhu K.S., Thompson J.T., Hildenbrandt G.R., Liken A.D., Reddy C.C.
      Biochem. J. 360:313-320(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Kidney.

    Entry informationi

    Entry nameiMIOX_PIG
    AccessioniPrimary (citable) accession number: Q8WN98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3