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Q8WN98

- MIOX_PIG

UniProt

Q8WN98 - MIOX_PIG

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Protein

Inositol oxygenase

Gene
MIOX, ALDRL6
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Binds 2 iron ions per subunit By similarity.

Temperature dependencei

Thermolabile.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261Substrate By similarity
Metal bindingi95 – 951Iron 1 By similarity
Metal bindingi120 – 1201Iron 1 By similarity
Metal bindingi121 – 1211Iron 1 By similarity
Metal bindingi121 – 1211Iron 2 By similarity
Binding sitei124 – 1241Substrate By similarity
Metal bindingi191 – 1911Iron 2 By similarity
Metal bindingi217 – 2171Iron 2 By similarity
Metal bindingi250 – 2501Iron 1 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: UniProtKB
  2. inositol oxygenase activity Source: UniProtKB
  3. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Source: UniProtKB

GO - Biological processi

  1. cellular water homeostasis Source: UniProtKB
  2. inositol catabolic process Source: UniProtKB
  3. inositol phosphate-mediated signaling Source: UniProtKB
  4. membrane organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKQ8WN98.
UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Aldehyde reductase-like 6
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:MIOX
Synonyms:ALDRL6
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. inclusion body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Inositol oxygenasePRO_0000079150Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiQ8WN98.

Expressioni

Tissue specificityi

Kidney specific.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001029.

Structurei

3D structure databases

ProteinModelPortaliQ8WN98.
SMRiQ8WN98. Positions 25-282.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Substrate binding By similarity
Regioni138 – 1392Substrate binding By similarity
Regioni217 – 2182Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG135479.
HOGENOMiHOG000163182.
HOVERGENiHBG039556.
KOiK00469.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WN98-1 [UniParc]FASTAAdd to Basket

« Hide

MKDPDPSQVY RPDMDPEAAK DKGSFRNYTS GPLLDRVFRT YKLMHTWQTV    50
DFVRKKHAQF GGFSYKRMTV LEAVDMLDGL VDESDPDVDF PNSFHAFQTA 100
EGIRKAHPDK DWFHLVGLLH DLGKVLVLAG EPQWAVVGDT FPVGCRPQAS 150
VVFCDSTFQD NPDLQDPVYS TELGMYQPHC GLENALMSWG HDEYMYQMMK 200
FNKFSLPGEA FYIIRFHSFY PWHTGGDYRQ LCNEQDLAML PWVQEFNKFD 250
LYTKGSDMPD VDELRPYYQG LIDKYCPGVL CW 282
Length:282
Mass (Da):32,653
Last modified:March 1, 2002 - v1
Checksum:i0B9D4D54A3AE5DE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF401311 mRNA. Translation: AAL39076.1.
RefSeqiNP_999267.1. NM_214102.2.
UniGeneiSsc.15816.

Genome annotation databases

GeneIDi397189.
KEGGissc:397189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF401311 mRNA. Translation: AAL39076.1 .
RefSeqi NP_999267.1. NM_214102.2.
UniGenei Ssc.15816.

3D structure databases

ProteinModelPortali Q8WN98.
SMRi Q8WN98. Positions 25-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000001029.

Proteomic databases

PaxDbi Q8WN98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397189.
KEGGi ssc:397189.

Organism-specific databases

CTDi 55586.

Phylogenomic databases

eggNOGi NOG135479.
HOGENOMi HOG000163182.
HOVERGENi HBG039556.
KOi K00469.

Enzyme and pathway databases

UniPathwayi UPA00111 ; UER00527 .
SABIO-RK Q8WN98.

Family and domain databases

InterProi IPR007828. Inositol_oxygenase.
[Graphical view ]
PANTHERi PTHR12588. PTHR12588. 1 hit.
Pfami PF05153. DUF706. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Myo-inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and d-chiro-inositol."
    Arner R.J., Prabhu K.S., Thompson J.T., Hildenbrandt G.R., Liken A.D., Reddy C.C.
    Biochem. J. 360:313-320(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Kidney.

Entry informationi

Entry nameiMIOX_PIG
AccessioniPrimary (citable) accession number: Q8WN98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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