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Q8WN98 (MIOX_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol oxygenase

EC=1.13.99.1
Alternative name(s):
Aldehyde reductase-like 6
Myo-inositol oxygenase
Short name=MI oxygenase
Gene names
Name:MIOX
Synonyms:ALDRL6
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Subcellular location

Cytoplasm.

Tissue specificity

Kidney specific.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the myo-inositol oxygenase family.

Biophysicochemical properties

Temperature dependence:

Thermolabile.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Inositol oxygenase
PRO_0000079150

Regions

Region82 – 843Substrate binding By similarity
Region138 – 1392Substrate binding By similarity
Region217 – 2182Substrate binding By similarity

Sites

Metal binding951Iron 1 By similarity
Metal binding1201Iron 1 By similarity
Metal binding1211Iron 1 By similarity
Metal binding1211Iron 2 By similarity
Metal binding1911Iron 2 By similarity
Metal binding2171Iron 2 By similarity
Metal binding2501Iron 1 By similarity
Binding site261Substrate By similarity
Binding site1241Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8WN98 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 0B9D4D54A3AE5DE0

FASTA28232,653
        10         20         30         40         50         60 
MKDPDPSQVY RPDMDPEAAK DKGSFRNYTS GPLLDRVFRT YKLMHTWQTV DFVRKKHAQF 

        70         80         90        100        110        120 
GGFSYKRMTV LEAVDMLDGL VDESDPDVDF PNSFHAFQTA EGIRKAHPDK DWFHLVGLLH 

       130        140        150        160        170        180 
DLGKVLVLAG EPQWAVVGDT FPVGCRPQAS VVFCDSTFQD NPDLQDPVYS TELGMYQPHC 

       190        200        210        220        230        240 
GLENALMSWG HDEYMYQMMK FNKFSLPGEA FYIIRFHSFY PWHTGGDYRQ LCNEQDLAML 

       250        260        270        280 
PWVQEFNKFD LYTKGSDMPD VDELRPYYQG LIDKYCPGVL CW 

« Hide

References

[1]"Myo-inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and d-chiro-inositol."
Arner R.J., Prabhu K.S., Thompson J.T., Hildenbrandt G.R., Liken A.D., Reddy C.C.
Biochem. J. 360:313-320(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF401311 mRNA. Translation: AAL39076.1.
RefSeqNP_999267.1. NM_214102.2.
UniGeneSsc.15816.

3D structure databases

ProteinModelPortalQ8WN98.
SMRQ8WN98. Positions 25-282.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000001029.

Proteomic databases

PaxDbQ8WN98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397189.
KEGGssc:397189.

Organism-specific databases

CTD55586.

Phylogenomic databases

eggNOGNOG135479.
HOGENOMHOG000163182.
HOVERGENHBG039556.
KOK00469.

Enzyme and pathway databases

SABIO-RKQ8WN98.
UniPathwayUPA00111; UER00527.

Family and domain databases

InterProIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERPTHR12588. PTHR12588. 1 hit.
PfamPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMIOX_PIG
AccessionPrimary (citable) accession number: Q8WN98
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways