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Q8WN97

- UDB30_MACFA

UniProt

Q8WN97 - UDB30_MACFA

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Protein

UDP-glucuronosyltransferase 2B30

Gene

UGT2B30

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on testosterone, dihydrotestosterone, 5-alpha-androstane-3-alpha,17-beta-diol, androsterone, oestradiol, tetrahydroaldosterone and tetrahydrocortisone. This enzyme is essential to inactivation of several steroids.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

SABIO-RKQ8WN97.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B30 (EC:2.4.1.17)
Short name:
UDPGT 2B30
Gene namesi
Name:UGT2B30
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 51321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 528505UDP-glucuronosyltransferase 2B30PRO_0000036047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in several tissues, including prostate, testis, mammary gland, kidney, adrenals and intestine.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8WN97.
SMRiQ8WN97. Positions 285-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WN97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMKWTSALL LIQLSCYLSS GNCGKVLVWP TEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLAYSP SILPGPNNPS ALKFEICPTS LTETEFEDSV TQLVKRWSDI
110 120 130 140 150
PKDTFWPHFL QVQEMMWTYG DMIRKFCKDV VSNKKLMKKL QESRFDVVLA
160 170 180 190 200
DAISPCGELL AELLKIPFVY SLRFSPGYAI EKHGGGFLFP PSYVPVVMSE
210 220 230 240 250
FSDQMTFMER VKNMIYMVYF DFWFQAWDTK KWDQFYSEVL GRPTTLFETM
260 270 280 290 300
AKAEIWLIRN YWDFQFPHPL LPHVELVGGL HCKPAKPLPK EMEGFVQSSG
310 320 330 340 350
DNGVVVFSLG SMVSNMSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN
360 370 380 390 400
TQLYKWLPQN DLLGHPKTRA FITHGGANAI YEAIYHGIPM VGVPLFADQL
410 420 430 440 450
DNIAHMKAKG ARVSLDFNTM SSTDLLHALK TVINDPFYKE NAMKLSSIHH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA YDLTWFQYHS LDVIGFLLAC
510 520
VATVIFIITK CLFCVLKFVR TGKKGKRD
Length:528
Mass (Da):60,366
Last modified:March 1, 2002 - v1
Checksum:i361349D4717C68D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401657 mRNA. Translation: AAL60145.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401657 mRNA. Translation: AAL60145.1 .

3D structure databases

ProteinModelPortali Q8WN97.
SMRi Q8WN97. Positions 285-446.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004033.

Enzyme and pathway databases

SABIO-RK Q8WN97.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the monkey UGT2B30 gene that encodes a uridine diphosphate-glucuronosyltransferase enzyme active on mineralocorticoid, glucocorticoid, androgen and oestrogen hormones."
    Girard C., Barbier O., Turgeon D., Belanger A.
    Biochem. J. 365:213-222(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Prostate.

Entry informationi

Entry nameiUDB30_MACFA
AccessioniPrimary (citable) accession number: Q8WN97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3