Reviewed, UniProtKB/Swiss-Prot Q8WN97 (UDB30_MACFA)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B30
      Short name=UDPGT 2B30
    EC=2.4.1.17

Gene names

Name:

UGT2B30

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on testosterone, dihydrotestosterone, 5-alpha-androstane-3-alpha,17-beta-diol, androsterone, oestradiol, tetrahydroaldosterone and tetrahydrocortisone. This enzyme is essential to inactivation of several steroids.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in several tissues, including prostate, testis, mammary gland, kidney, adrenals and intestine. Ref.1
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 528	505	UDP-glucuronosyltransferase 2B30		PRO_0000036047
Regions
	Transmembrane	493 – 513	21	Potential
Amino acid modifications
	Glycosylation	315	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8WN97-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 361349D4717C68D5	FASTA	528	60,366
	10 20 30 40 50 60 MSMKWTSALL LIQLSCYLSS GNCGKVLVWP TEFSHWMNIK TILDELVQRG HEVTVLAYSP 70 80 90 100 110 120 SILPGPNNPS ALKFEICPTS LTETEFEDSV TQLVKRWSDI PKDTFWPHFL QVQEMMWTYG 130 140 150 160 170 180 DMIRKFCKDV VSNKKLMKKL QESRFDVVLA DAISPCGELL AELLKIPFVY SLRFSPGYAI 190 200 210 220 230 240 EKHGGGFLFP PSYVPVVMSE FSDQMTFMER VKNMIYMVYF DFWFQAWDTK KWDQFYSEVL 250 260 270 280 290 300 GRPTTLFETM AKAEIWLIRN YWDFQFPHPL LPHVELVGGL HCKPAKPLPK EMEGFVQSSG 310 320 330 340 350 360 DNGVVVFSLG SMVSNMSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN TQLYKWLPQN 370 380 390 400 410 420 DLLGHPKTRA FITHGGANAI YEAIYHGIPM VGVPLFADQL DNIAHMKAKG ARVSLDFNTM 430 440 450 460 470 480 SSTDLLHALK TVINDPFYKE NAMKLSSIHH DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA 490 500 510 520 YDLTWFQYHS LDVIGFLLAC VATVIFIITK CLFCVLKFVR TGKKGKRD

References

[1]

"Isolation and characterization of the monkey UGT2B30 gene that encodes a uridine diphosphate-glucuronosyltransferase enzyme active on mineralocorticoid, glucocorticoid, androgen and oestrogen hormones." Girard C., Barbier O., Turgeon D., Belanger A. Biochem. J. 365:213-222(2002) [PubMed: 12071853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY. Tissue: Prostate.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF401657 mRNA. Translation: AAL60145.1.
3D structure databases
SMR	Q8WN97. Positions 285-446.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Phylogenomic databases
HOVERGEN	Q8WN97.
Enzyme and pathway databases
BRENDA	2.4.1.17. 3438.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDB30_MACFA

Accession

Primary (citable) accession number: Q8WN97

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	March 1, 2002
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)