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Protein

5,6-dihydroxyindole-2-carboxylic acid oxidase

Gene

TYRP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.By similarity

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi192Copper ABy similarity1
Metal bindingi215Copper ABy similarity1
Metal bindingi224Copper ABy similarity1
Metal bindingi377Copper BBy similarity1
Metal bindingi381Copper BBy similarity1
Metal bindingi404Copper BBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
5,6-dihydroxyindole-2-carboxylic acid oxidase (EC:1.14.18.-)
Short name:
DHICA oxidase
Alternative name(s):
Tyrosinase-related protein 1
Short name:
TRP-1
Short name:
TRP1
Gene namesi
Name:TYRP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Melanosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Melanosome By similarity

  • Note: Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 477Lumenal, melanosomeSequence analysisAdd BLAST453
Transmembranei478 – 501HelicalSequence analysisAdd BLAST24
Topological domaini502 – 537CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Albinism

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000003588825 – 5375,6-dihydroxyindole-2-carboxylic acid oxidaseAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Glycosylationi304N-linked (GlcNAc...)Sequence analysis1
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WN57.
PRIDEiQ8WN57.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027945.

Structurei

3D structure databases

ProteinModelPortaliQ8WN57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEEB. Eukaryota.
ENOG410XSJD. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiQ8WN57.
KOiK00506.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR015559. DiOHindole_carboxylic_A_Oxase.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11474:SF3. PTHR11474:SF3. 2 hits.
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 2 hits.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WN57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSPTLLSLG YMFLVLLFFQ QAWAQFPREC ATIEALRNGV CCPDLSPLSG
60 70 80 90 100
PGSDRCGLSS GRGRCEVVIA DSRPHSHHYP HDGRDDREGW PTRSFNRTCH
110 120 130 140 150
CNGNFSGHNC GTCRPGWGGA ACDQRVLTVR RNLLDLSTEE KNRFVRALDM
160 170 180 190 200
AKRTTHPQFV IATRRSEEIL GPDGNTPQFE NISIYNYFVW THYYSVKKTF
210 220 230 240 250
LGAGQESFGE VDFSHEGPAF LTWHRYHLLQ LERDMQEMLQ DPSFSLPYWN
260 270 280 290 300
FATGKNTCDI CTDDLMGSRS NFDSTLISPN SVFSQWRVVC ESLEDYDTLG
310 320 330 340 350
TLCNSTEGGP IKRNPAGNVA RPMVQRLPKP QDVAQCLEVG SYDTPPFYSN
360 370 380 390 400
STNSFRNTVE GYSHPTGRYD PAVRSLHNLA HLFLNGTGGQ THLSPNDPIF
410 420 430 440 450
VLLHTFTDAV FDEWLRRYNA DISTYPLENA PIGHNRQYNM VPFWPPVTNI
460 470 480 490 500
EMFVTAPDNL GYTYEVQWPS RSFSISEIVT IAVVAALSLV AVIFAGASCL
510 520 530
IRARSNMDEA NQPLLTDQYQ HYIEEYEKIH NPNQSVV
Length:537
Mass (Da):60,617
Last modified:June 1, 2003 - v2
Checksum:i2FAB599AE3FA217B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF445638 mRNA. Translation: AAL38167.2.
RefSeqiNP_776905.2. NM_174480.3.
UniGeneiBt.221.

Genome annotation databases

GeneIDi282105.
KEGGibta:282105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF445638 mRNA. Translation: AAL38167.2.
RefSeqiNP_776905.2. NM_174480.3.
UniGeneiBt.221.

3D structure databases

ProteinModelPortaliQ8WN57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027945.

Proteomic databases

PaxDbiQ8WN57.
PRIDEiQ8WN57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282105.
KEGGibta:282105.

Organism-specific databases

CTDi7306.

Phylogenomic databases

eggNOGiENOG410IEEB. Eukaryota.
ENOG410XSJD. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiQ8WN57.
KOiK00506.

Enzyme and pathway databases

UniPathwayiUPA00785.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR015559. DiOHindole_carboxylic_A_Oxase.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11474:SF3. PTHR11474:SF3. 2 hits.
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 2 hits.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYRP1_BOVIN
AccessioniPrimary (citable) accession number: Q8WN57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2003
Last modified: October 5, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.