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Protein

Polypyrimidine tract-binding protein 1

Gene

PTBP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-6803529. FGFR2 alternative splicing.
R-BTA-72163. mRNA Splicing - Major Pathway.
R-BTA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Polypyrimidine tract-binding protein 1
Short name:
PTB
Gene namesi
Name:PTBP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329311 – 531Polypyrimidine tract-binding protein 1Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei127PhosphotyrosineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Modified residuei433PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8WN55.
PeptideAtlasiQ8WN55.
PRIDEiQ8WN55.

Expressioni

Gene expression databases

BgeeiENSBTAG00000045828.
ExpressionAtlasiQ8WN55. differential.

Interactioni

Subunit structurei

Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with RAVER1 and SFPQ (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054889.

Structurei

3D structure databases

ProteinModelPortaliQ8WN55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 143RRM 1PROSITE-ProRule annotationAdd BLAST85
Domaini184 – 260RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini337 – 411RRM 3PROSITE-ProRule annotationAdd BLAST75
Domaini454 – 529RRM 4PROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi316 – 323Poly-Ala8

Sequence similaritiesi

Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1190. Eukaryota.
ENOG410XPMZ. LUCA.
GeneTreeiENSGT00550000074508.
HOVERGENiHBG069548.
InParanoidiQ8WN55.
KOiK13218.
OMAiELFSCVT.
OrthoDBiEOG091G0Z5R.
TreeFamiTF319824.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR006536. HnRNP-L/PTB.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 4 hits.
TIGRFAMsiTIGR01649. hnRNP-L_PTB. 1 hit.
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WN55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGIVPDIAV GTKRGSDELF SACVTNGPFI MSGTSASTAN GNDSKKFKGD
60 70 80 90 100
SRSAGVPSRV IHIRKLPGDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE
110 120 130 140 150
MHTEEAANTM VNYYTSVTPV LRGQPIYIQF SNHKELKTDS SPNQARAQAA
160 170 180 190 200
LQAVNSVQSG NLALAASAAA VDAGMAMAGQ SPVLRIIVEN LFYPVTLDVL
210 220 230 240 250
HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS LDGQNIYNAC
260 270 280 290 300
CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFGLS
310 320 330 340 350
VPNVHGALAP LAIPSAAAAA AAAGRIAIPG LAGAGNSVLL VSNLNPERVT
360 370 380 390 400
PQSLFILFGV YGDVQRVKVL FNKKENALVQ MADGSQAQLA MSHLNGHKLH
410 420 430 440 450
GKPVRITLSK HQSVQLPREG QEDQGLTKDY GNSPLHRFKK PGSKNFQNIF
460 470 480 490 500
PPSATLHLSN IPPSISEDDL KILFSSNGGI VKGFKFFQKD RKMALIQMGS
510 520 530
VEEAIQALID LHNHDLGENH HLRVSFSKST I
Length:531
Mass (Da):57,105
Last modified:March 1, 2002 - v1
Checksum:i99CF43EDA6238133
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF445640 mRNA. Translation: AAL38169.1.
RefSeqiNP_776867.1. NM_174442.3.
UniGeneiBt.9031.

Genome annotation databases

EnsembliENSBTAT00000066209; ENSBTAP00000054889; ENSBTAG00000045828.
GeneIDi282018.
KEGGibta:282018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF445640 mRNA. Translation: AAL38169.1.
RefSeqiNP_776867.1. NM_174442.3.
UniGeneiBt.9031.

3D structure databases

ProteinModelPortaliQ8WN55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054889.

Proteomic databases

PaxDbiQ8WN55.
PeptideAtlasiQ8WN55.
PRIDEiQ8WN55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000066209; ENSBTAP00000054889; ENSBTAG00000045828.
GeneIDi282018.
KEGGibta:282018.

Organism-specific databases

CTDi5725.

Phylogenomic databases

eggNOGiKOG1190. Eukaryota.
ENOG410XPMZ. LUCA.
GeneTreeiENSGT00550000074508.
HOVERGENiHBG069548.
InParanoidiQ8WN55.
KOiK13218.
OMAiELFSCVT.
OrthoDBiEOG091G0Z5R.
TreeFamiTF319824.

Enzyme and pathway databases

ReactomeiR-BTA-6803529. FGFR2 alternative splicing.
R-BTA-72163. mRNA Splicing - Major Pathway.
R-BTA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Gene expression databases

BgeeiENSBTAG00000045828.
ExpressionAtlasiQ8WN55. differential.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR006536. HnRNP-L/PTB.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 4 hits.
TIGRFAMsiTIGR01649. hnRNP-L_PTB. 1 hit.
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTBP1_BOVIN
AccessioniPrimary (citable) accession number: Q8WN55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.