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Protein

Farnesyl pyrophosphate synthase

Gene

FDPS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).By similarity

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Enzyme regulationi

Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell (By similarity).By similarity

Pathwayi: farnesyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (FDPS), Geranylgeranyl pyrophosphate synthase (GGPS1)
This subpathway is part of the pathway farnesyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, the pathway farnesyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (FDPS), Geranylgeranyl pyrophosphate synthase (GGPS1)
This subpathway is part of the pathway geranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate, the pathway geranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571Isopentenyl diphosphateBy similarity
Binding sitei60 – 601Isopentenyl diphosphateBy similarity
Binding sitei96 – 961Isopentenyl diphosphateBy similarity
Sitei98 – 981Important for determining product chain lengthBy similarity
Sitei99 – 991Important for determining product chain lengthBy similarity
Metal bindingi103 – 1031Magnesium 1By similarity
Metal bindingi103 – 1031Magnesium 2By similarity
Metal bindingi107 – 1071Magnesium 1By similarity
Metal bindingi107 – 1071Magnesium 2By similarity
Binding sitei112 – 1121Dimethylallyl diphosphateBy similarity
Binding sitei113 – 1131Isopentenyl diphosphateBy similarity
Binding sitei200 – 2001Dimethylallyl diphosphateBy similarity
Binding sitei201 – 2011Dimethylallyl diphosphateBy similarity
Binding sitei240 – 2401Dimethylallyl diphosphateBy similarity
Metal bindingi243 – 2431Magnesium 3By similarity
Binding sitei257 – 2571Dimethylallyl diphosphateBy similarity
Binding sitei266 – 2661Dimethylallyl diphosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Host-virus interaction, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00259; UER00368.
UPA00260; UER00369.

Names & Taxonomyi

Protein namesi
Recommended name:
Farnesyl pyrophosphate synthase (EC:2.5.1.10)
Short name:
FPP synthase
Short name:
FPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Geranyltranstransferase
Gene namesi
Name:FDPS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Farnesyl pyrophosphate synthasePRO_0000237610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PeptideAtlasiQ8WMY2.
PRIDEiQ8WMY2.

Interactioni

Subunit structurei

Homodimer. Interacts with RSAD2 (By similarity). Interacts with bovine leukemia virus (BLV) protein G4.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8WMY2.
SMRiQ8WMY2. Positions 8-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

HOVERGENiHBG005741.
InParanoidiQ8WMY2.
KOiK00787.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WMY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGDQKLDAY AQERQDFIQH FSQIVKVLTE EDIGHPEIGD AITRLKEVLE
60 70 80 90 100
YNAIGGKYNR GLTVVITFRE LVEPGKQDPD SLQRALTVGW CVELLQAFFL
110 120 130 140 150
VSDDIMDSSL TRRGQTCWYQ KPGIGLDAIN DAFLLESSIY RLLKLYCREQ
160 170 180 190 200
PYYLDLIELF LQSSYQTEIG QTLDLITAPQ GNVDLGRFTE KRYKSIVKYK
210 220 230 240 250
TAFYSFYLPV AAAMYMAGID GEKEHAHAKK ILLEMGEFFQ IQDDYLDLFG
260 270 280 290 300
DPSMTGKIGT DIQDNKCSWL VVQCLQRASP EQRQILQENY GQKEAEKVAR
310 320 330 340 350
VKALYEEMNL SAVYMQYEED SYNHIMGLIE QYAAPLPPAI FLGLAQKIYK

RKK
Length:353
Mass (Da):40,510
Last modified:March 1, 2002 - v1
Checksum:i6FCAA8526E0826BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461050 mRNA. Translation: AAL58886.1.
BC149572 mRNA. Translation: AAI49573.1.
RefSeqiNP_803463.1. NM_177497.2.
XP_005203665.1. XM_005203608.2.
UniGeneiBt.23182.

Genome annotation databases

GeneIDi281156.
KEGGibta:281156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461050 mRNA. Translation: AAL58886.1.
BC149572 mRNA. Translation: AAI49573.1.
RefSeqiNP_803463.1. NM_177497.2.
XP_005203665.1. XM_005203608.2.
UniGeneiBt.23182.

3D structure databases

ProteinModelPortaliQ8WMY2.
SMRiQ8WMY2. Positions 8-353.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ8WMY2.
PRIDEiQ8WMY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281156.
KEGGibta:281156.

Organism-specific databases

CTDi2224.

Phylogenomic databases

HOVERGENiHBG005741.
InParanoidiQ8WMY2.
KOiK00787.

Enzyme and pathway databases

UniPathwayiUPA00259; UER00368.
UPA00260; UER00369.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase."
    Lefebvre L., Vanderplasschen A., Ciminale V., Heremans H., Dangoisse O., Jauniaux J.-C., Toussaint J.-F., Zelnik V., Burny A., Kettmann R., Willems L.
    J. Virol. 76:1400-1414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH BLV G4.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiFPPS_BOVIN
AccessioniPrimary (citable) accession number: Q8WMY2
Secondary accession number(s): A6QPZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.