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Q8WMV0

- GRK7_BOVIN

UniProt

Q8WMV0 - GRK7_BOVIN

Protein

G protein-coupled receptor kinase 7

Gene

GRK7

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).By similarity

    Catalytic activityi

    ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
    ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.

    Enzyme regulationi

    Inhibited by phosphorylation of Ser-36.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei220 – 2201ATPPROSITE-ProRule annotation
    Active sitei316 – 3161Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi197 – 2059ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
    3. rhodopsin kinase activity Source: UniProtKB

    GO - Biological processi

    1. signal transduction Source: InterPro
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro
    3. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G protein-coupled receptor kinase 7 (EC:2.7.11.14, EC:2.7.11.16)
    Alternative name(s):
    G protein-coupled receptor kinase GRK7
    Gene namesi
    Name:GRK7
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549G protein-coupled receptor kinase 7PRO_0000274193Add
    BLAST
    Propeptidei550 – 5523Removed in mature formBy similarityPRO_0000274194

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei36 – 361Phosphoserine; by PKABy similarity
    Modified residuei549 – 5491Cysteine methyl esterSequence Analysis
    Lipidationi549 – 5491S-geranylgeranyl cysteineSequence Analysis

    Post-translational modificationi

    Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.By similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PRIDEiQ8WMV0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000029175.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WMV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 176121RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 454264Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini455 – 52066AGC-kinase C-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000006742.
    HOVERGENiHBG004532.
    InParanoidiQ8WMV0.
    KOiK00909.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR00717. GPCRKINASE.
    SMARTiSM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WMV0-1 [UniParc]FASTAAdd to Basket

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    MVDMGGLDNL IANTAYLQAR KSSDADSKEL QRRRRSLMLP GPQSCEQLRQ    50
    ALATDFHSLC EQQPIGRRLF RDFLATVPAY QEARGFLEEV QSWELAEEGP 100
    AKGSALQGLV TTCAAAPVPG RPHPFFSPAL VTKCQAATTD DDRASLVELA 150
    KAEVMAFLQD QPFREFLASP FYDKFLQWKV FEMQPVSDKY FEEFRVLGKG 200
    GFGEVCAVQV KNTGKMYACK KLDKKRLKKK NGEKMALLEK EILERVSSPF 250
    IVSLAYAFES KSHLCLVMSL MNGGDLKFHI YSVGEPGLDM SRVIFYSAQI 300
    TCGVLHLHSL GIVYRDMKPE NVLLDDLGNC RLSDLGLAVQ IQDGKPITQR 350
    AGTNGYMAPE ILMEKASYSY PVDWFAMGCS IYEMVAGRTP FRDYKEKVSK 400
    EDLKQRTLKE EVRFQHSNFT EEAKDICRLF LAKTPEQRLG SREKSDDPRK 450
    HHFFKTINFP RLEAGLVEPP FVPDPSVVYA KDINEIDDFS EVRGVEFDDN 500
    DKQFFQRFAT GAVPIAWQEE IIETGPFAEL NDPNRPAGCG EGSSRSGVCL 550
    LL 552
    Length:552
    Mass (Da):62,125
    Last modified:March 1, 2002 - v1
    Checksum:i6112CB3B9EB0376D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049726 mRNA. Translation: AAL06241.1.
    RefSeqiNP_776757.1. NM_174332.3.
    UniGeneiBt.9422.

    Genome annotation databases

    GeneIDi281802.
    KEGGibta:281802.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049726 mRNA. Translation: AAL06241.1 .
    RefSeqi NP_776757.1. NM_174332.3.
    UniGenei Bt.9422.

    3D structure databases

    ProteinModelPortali Q8WMV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000029175.

    Proteomic databases

    PRIDEi Q8WMV0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281802.
    KEGGi bta:281802.

    Organism-specific databases

    CTDi 131890.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000006742.
    HOVERGENi HBG004532.
    InParanoidi Q8WMV0.
    KOi K00909.

    Miscellaneous databases

    NextBioi 20805715.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00717. GPCRKINASE.
    SMARTi SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Zhang K., Chen J.K.C., Baehr W.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGRK7_BOVIN
    AccessioniPrimary (citable) accession number: Q8WMV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3