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Q8WMV0 (GRK7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G protein-coupled receptor kinase 7

EC=2.7.11.14
EC=2.7.11.16
Alternative name(s):
G protein-coupled receptor kinase GRK7
Gene names
Name:GRK7
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO) By similarity.

Catalytic activity

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.

Enzyme regulation

Inhibited by phosphorylation of Ser-36 By similarity.

Subcellular location

Membrane; Lipid-anchor By similarity.

Post-translational modification

Autophosphorylated in vitro at Ser-490 By similarity. Phosphorylation at Ser-36 is regulated by light and activated by cAMP By similarity.

Miscellaneous

Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549G protein-coupled receptor kinase 7
PRO_0000274193
Propeptide550 – 5523Removed in mature form By similarity
PRO_0000274194

Regions

Domain56 – 176121RGS
Domain191 – 454264Protein kinase
Domain455 – 52066AGC-kinase C-terminal
Nucleotide binding197 – 2059ATP By similarity

Sites

Active site3161Proton acceptor By similarity
Binding site2201ATP By similarity

Amino acid modifications

Modified residue361Phosphoserine; by PKA By similarity
Modified residue5491Cysteine methyl ester Potential
Lipidation5491S-geranylgeranyl cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
Q8WMV0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6112CB3B9EB0376D

FASTA55262,125
        10         20         30         40         50         60 
MVDMGGLDNL IANTAYLQAR KSSDADSKEL QRRRRSLMLP GPQSCEQLRQ ALATDFHSLC 

        70         80         90        100        110        120 
EQQPIGRRLF RDFLATVPAY QEARGFLEEV QSWELAEEGP AKGSALQGLV TTCAAAPVPG 

       130        140        150        160        170        180 
RPHPFFSPAL VTKCQAATTD DDRASLVELA KAEVMAFLQD QPFREFLASP FYDKFLQWKV 

       190        200        210        220        230        240 
FEMQPVSDKY FEEFRVLGKG GFGEVCAVQV KNTGKMYACK KLDKKRLKKK NGEKMALLEK 

       250        260        270        280        290        300 
EILERVSSPF IVSLAYAFES KSHLCLVMSL MNGGDLKFHI YSVGEPGLDM SRVIFYSAQI 

       310        320        330        340        350        360 
TCGVLHLHSL GIVYRDMKPE NVLLDDLGNC RLSDLGLAVQ IQDGKPITQR AGTNGYMAPE 

       370        380        390        400        410        420 
ILMEKASYSY PVDWFAMGCS IYEMVAGRTP FRDYKEKVSK EDLKQRTLKE EVRFQHSNFT 

       430        440        450        460        470        480 
EEAKDICRLF LAKTPEQRLG SREKSDDPRK HHFFKTINFP RLEAGLVEPP FVPDPSVVYA 

       490        500        510        520        530        540 
KDINEIDDFS EVRGVEFDDN DKQFFQRFAT GAVPIAWQEE IIETGPFAEL NDPNRPAGCG 

       550 
EGSSRSGVCL LL 

« Hide

References

[1]Zhang K., Chen J.K.C., Baehr W.
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY049726 mRNA. Translation: AAL06241.1.
RefSeqNP_776757.1. NM_174332.3.
UniGeneBt.9422.

3D structure databases

ProteinModelPortalQ8WMV0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000029175.

Proteomic databases

PRIDEQ8WMV0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281802.
KEGGbta:281802.

Organism-specific databases

CTD131890.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000006742.
HOVERGENHBG004532.
InParanoidQ8WMV0.
KOK00909.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR00717. GPCRKINASE.
SMARTSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805715.

Entry information

Entry nameGRK7_BOVIN
AccessionPrimary (citable) accession number: Q8WMV0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2002
Last modified: January 22, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families