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Protein

Rhodopsin kinase

Gene

GRK7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).By similarity

Catalytic activityi

ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.By similarity

Enzyme regulationi

Inhibited by phosphorylation of Ser-36.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220ATPPROSITE-ProRule annotation1
Active sitei316Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 205ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rhodopsin kinase (EC:2.7.11.14By similarity)
Alternative name(s):
G protein-coupled receptor kinase 7
G protein-coupled receptor kinase GRK7
Gene namesi
Name:GRK7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002741931 – 549Rhodopsin kinaseAdd BLAST549
PropeptideiPRO_0000274194550 – 552Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36Phosphoserine; by PKABy similarity1
Modified residuei549Cysteine methyl esterSequence analysis1
Lipidationi549S-geranylgeranyl cysteineSequence analysis1

Post-translational modificationi

Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ8WMV0.
PRIDEiQ8WMV0.

PTM databases

iPTMnetiQ8WMV0.

Interactioni

Subunit structurei

Interacts (when prenylated) with PDE6D; this promotes release from membranes.1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029175.

Structurei

3D structure databases

ProteinModelPortaliQ8WMV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 176RGSPROSITE-ProRule annotationAdd BLAST121
Domaini191 – 454Protein kinasePROSITE-ProRule annotationAdd BLAST264
Domaini455 – 520AGC-kinase C-terminalAdd BLAST66

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
HOGENOMiHOG000006742.
HOVERGENiHBG004532.
InParanoidiQ8WMV0.
KOiK00909.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WMV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDMGGLDNL IANTAYLQAR KSSDADSKEL QRRRRSLMLP GPQSCEQLRQ
60 70 80 90 100
ALATDFHSLC EQQPIGRRLF RDFLATVPAY QEARGFLEEV QSWELAEEGP
110 120 130 140 150
AKGSALQGLV TTCAAAPVPG RPHPFFSPAL VTKCQAATTD DDRASLVELA
160 170 180 190 200
KAEVMAFLQD QPFREFLASP FYDKFLQWKV FEMQPVSDKY FEEFRVLGKG
210 220 230 240 250
GFGEVCAVQV KNTGKMYACK KLDKKRLKKK NGEKMALLEK EILERVSSPF
260 270 280 290 300
IVSLAYAFES KSHLCLVMSL MNGGDLKFHI YSVGEPGLDM SRVIFYSAQI
310 320 330 340 350
TCGVLHLHSL GIVYRDMKPE NVLLDDLGNC RLSDLGLAVQ IQDGKPITQR
360 370 380 390 400
AGTNGYMAPE ILMEKASYSY PVDWFAMGCS IYEMVAGRTP FRDYKEKVSK
410 420 430 440 450
EDLKQRTLKE EVRFQHSNFT EEAKDICRLF LAKTPEQRLG SREKSDDPRK
460 470 480 490 500
HHFFKTINFP RLEAGLVEPP FVPDPSVVYA KDINEIDDFS EVRGVEFDDN
510 520 530 540 550
DKQFFQRFAT GAVPIAWQEE IIETGPFAEL NDPNRPAGCG EGSSRSGVCL

LL
Length:552
Mass (Da):62,125
Last modified:March 1, 2002 - v1
Checksum:i6112CB3B9EB0376D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049726 mRNA. Translation: AAL06241.1.
RefSeqiNP_776757.1. NM_174332.3.
UniGeneiBt.9422.

Genome annotation databases

GeneIDi281802.
KEGGibta:281802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049726 mRNA. Translation: AAL06241.1.
RefSeqiNP_776757.1. NM_174332.3.
UniGeneiBt.9422.

3D structure databases

ProteinModelPortaliQ8WMV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029175.

PTM databases

iPTMnetiQ8WMV0.

Proteomic databases

PaxDbiQ8WMV0.
PRIDEiQ8WMV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281802.
KEGGibta:281802.

Organism-specific databases

CTDi131890.

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
HOGENOMiHOG000006742.
HOVERGENiHBG004532.
InParanoidiQ8WMV0.
KOiK00909.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRK7_BOVIN
AccessioniPrimary (citable) accession number: Q8WMV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.