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Q8WML3

- KAT6B_MACFA

UniProt

Q8WML3 - KAT6B_MACFA

Protein

Histone acetyltransferase KAT6B

Gene

KAT6B

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei523 – 5231By similarity
    Active sitei565 – 5651NucleophileBy similarity
    Binding sitei603 – 6031Acetyl-CoABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri213 – 27260PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri269 – 32052PHD-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri457 – 47923C2HC-typeAdd
    BLAST

    GO - Molecular functioni

    1. acetyltransferase activity Source: UniProtKB
    2. DNA binding Source: InterPro
    3. histone acetyltransferase activity Source: UniProtKB
    4. transcription factor binding Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone acetylation Source: UniProtKB
    2. histone H3 acetylation Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. nucleosome assembly Source: InterPro
    5. positive regulation of transcription, DNA-templated Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase KAT6B (EC:2.3.1.48)
    Alternative name(s):
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
    Short name:
    MYST-4
    Gene namesi
    Name:KAT6B
    Synonyms:MYST4
    ORF Names:QflA-12408
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. MOZ/MORF histone acetyltransferase complex Source: UniProtKB
    2. nucleosome Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17841784Histone acetyltransferase KAT6BPRO_0000051576Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei523 – 5231N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei746 – 7461N6-acetyllysineBy similarity
    Modified residuei750 – 7501N6-acetyllysineBy similarity
    Modified residuei752 – 7521N6-acetyllysineBy similarity

    Post-translational modificationi

    Autoacetylated.By similarity
    Autoacetylation at Lys-523 is required for proper function.By similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WML3.
    SMRiQ8WML3. Positions 426-698.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini103 – 17674H15PROSITE-ProRule annotationAdd
    BLAST
    Domaini423 – 697275MYST-type HATAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni361 – 42565Negatively regulates HAT activityBy similarityAdd
    BLAST
    Regioni426 – 716291CatalyticBy similarityAdd
    BLAST
    Regioni460 – 716257Interaction with BRPF1By similarityAdd
    BLAST
    Regioni564 – 5685Acetyl-CoA bindingBy similarity
    Regioni573 – 5797Acetyl-CoA bindingBy similarity
    Regioni1271 – 1784514Interaction with RUNX1 and RUNX2By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi778 – 81841Poly-GluAdd
    BLAST
    Compositional biasi918 – 9214Poly-Glu
    Compositional biasi1065 – 108521Poly-GluAdd
    BLAST
    Compositional biasi1120 – 11289Poly-Glu
    Compositional biasi1305 – 1474170Ser-richAdd
    BLAST
    Compositional biasi1672 – 1772101Met-richAdd
    BLAST

    Domaini

    The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.By similarity

    Sequence similaritiesi

    Belongs to the MYST (SAS/MOZ) family.Curated
    Contains 1 C2HC-type zinc finger.Curated
    Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation
    Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri213 – 27260PHD-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri269 – 32052PHD-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri457 – 47923C2HC-typeAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG052563.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.40.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR016024. ARM-type_fold.
    IPR005818. Histone_H1/H5_H15.
    IPR002717. MOZ_SAS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00538. Linker_histone. 1 hit.
    PF01853. MOZ_SAS. 1 hit.
    PF00628. PHD. 1 hit.
    [Graphical view]
    SMARTiSM00526. H15. 1 hit.
    SM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF55729. SSF55729. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51504. H15. 1 hit.
    PS51726. MYST_HAT. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WML3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKLANPLYT EWILEAIQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ     50
    LELSVQDGSV LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK STKESRGSCN 100
    DLRNVDWNKL LRRAIEGLEE PNGSSLKNIE KYLRSQSDLT STTNNPAFQQ 150
    RLRLGAKRAV NNGRLLKDGP QYRVNYGSLD GKGAPQYPSA FPSSLPPVSL 200
    LPHEKDQPRA DPIPICSFCL GTKESNREKK PEELLSCADC GSSGHPSCLK 250
    FCPELTTNVK ALRWQCIECK TCSACRVQGR NADNMLFCDS CDRGFHMECC 300
    DPPLSRMPKG MWICQVCRPK KKGRKLLHEK AAQIKRRYAK PIGRPKNKLK 350
    QRLLSVTSDE GSMNAFTGRG SPDTEIKINI KQESADVNVI GNKDVVTEED 400
    LDVFKQAQEL SWEKIECESG VEDCGRYPSV IEFGKYEIQT WYSSPYPQEY 450
    ARLPKLYLCE FCLKYMKSKN ILLRHSKKCG WFHPPANEIY RRKDLSVFEV 500
    DGNMSKIYCQ NLCLLAKLFL DHKTLYYDVE PFLFYVLTKN DEKGCHLVGY 550
    FSKEKLCQQK YNVSCIMIMP QHQRQGFGRF LIDFSYLLSR REGQAGSPEK 600
    PLSDLGRLSY LAYWKSVILE YLYHHHERHI SIKAISRATG MCPHDIATTL 650
    QHLHMIDKRD GGFVIIRREK LILSHMEKLK TCSRANELDP DSLRWTPILI 700
    SNAAVSEEER EAEKEAERLM EQASCWEKEE QEVLSTRANS RQSPAKVQSK 750
    NKYLHSPESR PVTGERGQLL ELSKESSEEE EEEEEDEEEE DEEEEEEEEE 800
    DEEEEEEEEE EEEEEEEENI QSSPPRLTKP QSVAIKRKRP FVLKKKRGRK 850
    RRRINSSVTT ETISETTEVL NEPFDNSDEE RPMPQLEPTC EIEVEEDGRK 900
    PVLRKAFQHQ PGKKRQTEEE EGKDNHCFKN ADPCRNNMND DSRNLKEGSK 950
    DNPEPLKCKQ AWPKGTKRGL SKWRQNKERK TGFKLNLYTP PETPLEPDEQ 1000
    VTVEEQKETS EGKTSPTPIS IEEEAKEAGE ALLPQEENRR QETCAPVSPN 1050
    TSPGEKPEDD LIKPEEEEEE EEEEEEEEGE EEEEEGGNVE KDPDGAKSQE 1100
    KEEPEISPEK EDSARLDDHE EEEEEDEEPS HNEDHDADDE DDSHMESAEV 1150
    EKEELPRESF KEVLENEEAF LDLNVQPSHS NPEVLMDCGV DLTASCNSEP 1200
    KELAGDPEAV PESDEEPPPG EQAQKQDQKN SKEVDTEFKE GNPATMEIDS 1250
    ETVQAVQSLT QESSEQDDTF QDCAETQEAC RSLQNYTRAD QSPQIATTLD 1300
    DCQQSDHSSP VSSVHSHPGQ SVRSVNSPSV PALENSYAQI SPDQSAISVP 1350
    SLQNMETSPM MDVPSVSDHS QQVVDSGFSD LGSIESTTEN YENPSSYDST 1400
    MGGSICGNGS SQNSCSYSNL TSSSLTQSSC AVTQQMSNIS GSCSMLQQTS 1450
    ISSPPTCSVK SPQGCVVERP PSSSQQLAQC SMAANFTPPM QLAEIPETGN 1500
    ANIGLYERMG QSDFGAGHYP QPSATFSLAK LQQLTNTLID HSLPYSHSAA 1550
    VTSYANSASL STPLSNTGLV QLSQSPHSVP GGPQAQATMT PPPNLTPPPM 1600
    NLPPPLLQRN MAASNIGISH SQRLQTQIAS KGHVSMRTKS ASLSPAAATH 1650
    QSQIYGRSQT VAMQGPARTL TMQRGMNMSV NLMPAPAYNV NSVNMNMNTL 1700
    NAMNGYSMSQ PMMNSGYHSN HGYMNQTPQY PMQMQMGMMG TQPYAQQPMQ 1750
    TPPHGNMMYT APGHHGYMNT GMSKQSLNGS YMRR 1784
    Length:1,784
    Mass (Da):200,154
    Last modified:March 1, 2002 - v1
    Checksum:iF5A93EB283D3AE17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB061870 mRNA. Translation: BAB72094.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB061870 mRNA. Translation: BAB72094.1 .

    3D structure databases

    ProteinModelPortali Q8WML3.
    SMRi Q8WML3. Positions 426-698.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG052563.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.40.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR016024. ARM-type_fold.
    IPR005818. Histone_H1/H5_H15.
    IPR002717. MOZ_SAS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00538. Linker_histone. 1 hit.
    PF01853. MOZ_SAS. 1 hit.
    PF00628. PHD. 1 hit.
    [Graphical view ]
    SMARTi SM00526. H15. 1 hit.
    SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF55729. SSF55729. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51504. H15. 1 hit.
    PS51726. MYST_HAT. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of full-length cDNA clones from macaque brain cDNA libraries."
      Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Terao K., Hirai M., Sugano S., Hashimoto K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Frontal cortex.

    Entry informationi

    Entry nameiKAT6B_MACFA
    AccessioniPrimary (citable) accession number: Q8WML3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3