HLA-DRB1

Functionⁱ

GO - Biological processⁱ

antigen processing and presentation Source: InterPro
immune response Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: MHC class II antigenImported
Gene namesⁱ	Name:HLA-DRB1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q8WMA1.
PRIDEⁱ	Q8WMA1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WMA1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 78	MHC_II_betaInterPro annotationAdd BLAST		71

Phylogenomic databases

eggNOGⁱ	ENOG410IWG3. Eukaryota. ENOG410YI0S. LUCA.

eggNOGⁱ

ENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.

Family and domain databases

Gene3Dⁱ	3.10.320.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00969. MHC_II_beta. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000328. MHC_II_b_N. 1 hit.
SMARTⁱ	View protein in SMART SM00921. MHC_II_beta. 1 hit.
SUPFAMⁱ	SSF54452. SSF54452. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q8WMA1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
RFLWQPKREC HFFNGTERVR FLDRYFYNQE ESVRFDSDVG EFRAVTELGR 
        60         70 
PDAEYWNSQD ILEQARAAVD TYCRHNYG

Length:78

Mass (Da):9,503

Last modified:March 1, 2002 - v1

Checksum:ⁱCB38BF59BD2BE946

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1
Non-terminal residueⁱ	78	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF439712 Genomic DNA. Translation: AAL35224.1.
UniGeneⁱ	Hs.534322. Hs.696211. Hs.736560.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WMA1	Q9MYD9	Homo sapiens (Human)	88	UniRef100_Q9MYD9	Cluster: MHC class II antigen (Fragment)	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WMA1	Q9BCS7 Q30130 A0A2H4G4B9 A0A0E3DCJ0 U6EFL1 A0A2H4FZS3 A0A2I4PZU1 A0A2H4FZS0 A0A2H4G491 A0A2H4FZT6 +310	Homo sapiens (Human) Macaca silenus (Lion-tailed macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque)	89	UniRef90_Q9BCS7	Cluster: MHC class II antigen (Fragment)	321

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WMA1	C9K6J0 E2RWT6 E7FLM5 J9UD80 A0A291R900 O77843 Q30273 Q30298 Q9TTM3 Q5I6W7 +2816	Bos taurus (Bovine) Bos indicus x Bos taurus (Hybrid cattle) Bos javanicus (Wild banteng) Canis lupus familiaris (Dog) (Canis familiaris) Canis lupus (Gray wolf) Spheniscus humboldti (Humboldt penguin) Brachyramphus marmoratus (Marbled murrelet) Neophron percnopterus (Egyptian vulture) Desmodus rotundus (Vampire bat) Geothlypis trichas (Common yellowthroat) And more	89	UniRef50_C9K6J0	Cluster: MHC class II antigen (Fragment)	2,827

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF439712 Genomic DNA. Translation: AAL35224.1.
UniGeneⁱ	Hs.534322. Hs.696211. Hs.736560.

3D structure databases

ProteinModelPortalⁱ	Q8WMA1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q8WMA1.
PRIDEⁱ	Q8WMA1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWG3. Eukaryota. ENOG410YI0S. LUCA.

eggNOGⁱ

ENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.

Miscellaneous databases

ChiTaRSⁱ	HLA-DRB1. human.

ChiTaRSⁱ

HLA-DRB1. human.

Family and domain databases

Gene3Dⁱ	3.10.320.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00969. MHC_II_beta. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000328. MHC_II_b_N. 1 hit.
SMARTⁱ	View protein in SMART SM00921. MHC_II_beta. 1 hit.
SUPFAMⁱ	SSF54452. SSF54452. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8WMA1_HUMAN
Accessionⁱ	Q8WMA1Primary (citable) accession number: Q8WMA1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 1, 2002
	Last sequence update:	March 1, 2002
	Last modified:	January 31, 2018
	This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q8WMA1 (Q8WMA1_HUMAN)

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MHC class II antigen

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Plasma Membrane

PTM / Processingⁱ

Proteomic databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WMA1 (Q8WMA1_HUMAN)

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MHC class II antigen

HLA-DRB1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ