HLA-DRB1

Functionⁱ

GO - Biological processⁱ

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
immune response Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: MHC class II antigenImported Automatic assertion inferred from database entriesⁱ EMBL:AAL35224.1
Gene namesⁱ	Name:HLA-DRB1Imported Automatic assertion inferred from database entriesⁱ EMBL:AAL35224.1
Organismⁱ	Homo sapiens (Human)Imported Automatic assertion inferred from database entriesⁱ EMBL:AAL35224.1
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
MHC class II protein complex Source: UniProtKB-KW

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q8WMA1.
PeptideAtlasⁱ	Q8WMA1.
PRIDEⁱ	Q8WMA1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196126.

Bgeeⁱ

ENSG00000196126.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000353099.

STRINGⁱ

9606.ENSP00000353099.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WMA1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	8 – 78	71	MHC_II_betaInterPro annotation Automatic assertion inferred from signature matchⁱ SMART:SM00921			Add BLAST

Phylogenomic databases

eggNOGⁱ	ENOG410IWG3. Eukaryota. ENOG410YI0S. LUCA.

eggNOGⁱ

ENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.

Family and domain databases

Gene3Dⁱ	3.10.320.10. 1 hit.
InterProⁱ	IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. [Graphical view]
Pfamⁱ	PF00969. MHC_II_beta. 1 hit. [Graphical view]
ProDomⁱ	PD000328. MHC_II_b_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMARTⁱ	SM00921. MHC_II_beta. 1 hit. [Graphical view]
SUPFAMⁱ	SSF54452. SSF54452. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q8WMA1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
RFLWQPKREC HFFNGTERVR FLDRYFYNQE ESVRFDSDVG EFRAVTELGR 
        60         70 
PDAEYWNSQD ILEQARAAVD TYCRHNYG

Length:78

Mass (Da):9,503

Last modified:March 1, 2002 - v1

Checksum:ⁱCB38BF59BD2BE946

GO

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Non-terminal residueⁱ	1 – 1	1	Imported Automatic assertion inferred from database entriesⁱ EMBL:AAL35224.1
Non-terminal residueⁱ	78 – 78	1	Imported Automatic assertion inferred from database entriesⁱ EMBL:AAL35224.1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF439712 Genomic DNA. Translation: AAL35224.1.
UniGeneⁱ	Hs.534322. Hs.696211. Hs.736560.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF439712 Genomic DNA. Translation: AAL35224.1.
UniGeneⁱ	Hs.534322. Hs.696211. Hs.736560.

3D structure databases

ProteinModelPortalⁱ	Q8WMA1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000353099.

STRINGⁱ

9606.ENSP00000353099.

Proteomic databases

PaxDbⁱ	Q8WMA1.
PeptideAtlasⁱ	Q8WMA1.
PRIDEⁱ	Q8WMA1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWG3. Eukaryota. ENOG410YI0S. LUCA.

eggNOGⁱ

ENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.

Miscellaneous databases

ChiTaRSⁱ	HLA-DRB1. human.

ChiTaRSⁱ

HLA-DRB1. human.

Gene expression databases

Bgeeⁱ	ENSG00000196126.

Bgeeⁱ

ENSG00000196126.

Family and domain databases

Gene3Dⁱ	3.10.320.10. 1 hit.
InterProⁱ	IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. [Graphical view]
Pfamⁱ	PF00969. MHC_II_beta. 1 hit. [Graphical view]
ProDomⁱ	PD000328. MHC_II_b_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMARTⁱ	SM00921. MHC_II_beta. 1 hit. [Graphical view]
SUPFAMⁱ	SSF54452. SSF54452. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

Q8WMA1_HUMAN

Accessionⁱ

Primary (citable) accession number: Q8WMA1

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB - Q8WMA1 (Q8WMA1_HUMAN)

UniProt

Q8WMA1 - Q8WMA1_HUMAN

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MHC class II antigen

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Similar proteinsⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WMA1 (Q8WMA1_HUMAN)

UniProt

Q8WMA1 - Q8WMA1_HUMAN

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MHC class II antigen

HLA-DRB1

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ