SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8WEW4

- COX1_DORPE

UniProt

Q8WEW4 - COX1_DORPE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiDoryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)
Taxonomic identifieri1051067 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeDoryteuthis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 4›4Mitochondrial matrix Reviewed prediction
Transmembranei5 – 2723Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini28 – 4619Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei47 – 6923Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini70 – 8819Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei89 – 11123Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini112 – 13019Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei131 – 15323Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini154 – 17320Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei174 – 19623Helical; Name=5; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›223›223Cytochrome c oxidase subunit 1
PRO_0000183356Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8WEW4.
SMRiQ8WEW4. Positions 1-223.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WEW4-1 [UniParc]FASTAAdd to Basket

« Hide

IGTLYFMFGI WAGLVGTSLS LMIRTELGKP GSLLNDDQLY NVVVTAHGFI    50
MIFFMVMPIM IGGFGNWLVP LMLGAPDMAF PRMNNMSFWL LPPSLTLLLA 100
SSAVESGAGT GWTVYPPLSS NLSHAGPSVD LAIFSLHLAG ISSILGAINF 150
ITTIMNMRWE GLLMERLSLF VWSVFITAIL LLLSLPVLAG AITMLLTDRN 200
FNTTFFDPSG GGDPILYQHL FWF 223
Length:223
Mass (Da):24,373
Last modified:July 19, 2003 - v2
Checksum:i440EF0D5B4514979
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei223 – 2231

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF120629 Genomic DNA. Translation: AAL55479.1.
AF000052 Genomic DNA. Translation: AAC95097.1.
AF207923 Genomic DNA. Translation: AAF20964.1.
AF207909 Genomic DNA. Translation: AAF20950.1.
AF207910 Genomic DNA. Translation: AAF20951.1.
AF207911 Genomic DNA. Translation: AAF20952.1.
AF207912 Genomic DNA. Translation: AAF20953.1.
AF207913 Genomic DNA. Translation: AAF20954.1.
AF207914 Genomic DNA. Translation: AAF20955.1.
AF207915 Genomic DNA. Translation: AAF20956.1.
AF207916 Genomic DNA. Translation: AAF20957.1.
AF207917 Genomic DNA. Translation: AAF20958.1.
AF207918 Genomic DNA. Translation: AAF20959.1.
AF207919 Genomic DNA. Translation: AAF20960.1.
AF207920 Genomic DNA. Translation: AAF20961.1.
AF207921 Genomic DNA. Translation: AAF20962.1.
AF207922 Genomic DNA. Translation: AAF20963.1.
AF207924 Genomic DNA. Translation: AAF20965.1.
AF207925 Genomic DNA. Translation: AAF20966.1.
AF207926 Genomic DNA. Translation: AAF20967.1.
AY039621 Genomic DNA. Translation: AAK73250.1.
AY039622 Genomic DNA. Translation: AAK73251.1.
AY039623 Genomic DNA. Translation: AAK73252.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF120629 Genomic DNA. Translation: AAL55479.1 .
AF000052 Genomic DNA. Translation: AAC95097.1 .
AF207923 Genomic DNA. Translation: AAF20964.1 .
AF207909 Genomic DNA. Translation: AAF20950.1 .
AF207910 Genomic DNA. Translation: AAF20951.1 .
AF207911 Genomic DNA. Translation: AAF20952.1 .
AF207912 Genomic DNA. Translation: AAF20953.1 .
AF207913 Genomic DNA. Translation: AAF20954.1 .
AF207914 Genomic DNA. Translation: AAF20955.1 .
AF207915 Genomic DNA. Translation: AAF20956.1 .
AF207916 Genomic DNA. Translation: AAF20957.1 .
AF207917 Genomic DNA. Translation: AAF20958.1 .
AF207918 Genomic DNA. Translation: AAF20959.1 .
AF207919 Genomic DNA. Translation: AAF20960.1 .
AF207920 Genomic DNA. Translation: AAF20961.1 .
AF207921 Genomic DNA. Translation: AAF20962.1 .
AF207922 Genomic DNA. Translation: AAF20963.1 .
AF207924 Genomic DNA. Translation: AAF20965.1 .
AF207925 Genomic DNA. Translation: AAF20966.1 .
AF207926 Genomic DNA. Translation: AAF20967.1 .
AY039621 Genomic DNA. Translation: AAK73250.1 .
AY039622 Genomic DNA. Translation: AAK73251.1 .
AY039623 Genomic DNA. Translation: AAK73252.1 .

3D structure databases

ProteinModelPortali Q8WEW4.
SMRi Q8WEW4. Positions 1-223.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "On bivalve phylogeny: a high-level phylogeny of the mollusk class Bivalvia based on a combined analysis of morphology and DNA sequence data."
    Giribet G., Wheeler W.C.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Phylogenetic analysis of cytochrome c oxidase I sequences to determine higher-level relationships within the coleoid cephalopods."
    Carlini D.B., Graves J.E.
    Bull. Mar. Sci. 64:57-76(1999)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.
  3. "Phylogeography of two Loligo squid (Cephalopoda: Myopsida) in the Gulf of Mexico and the northwestern Atlantic Ocean."
    Herke S.W., Foltz D.W.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.
    Strain: Isolate A-A128, Isolate A-R1, Isolate B-A25, Isolate B-B233, Isolate B-C13, Isolate B-R11, Isolate B-R59, Isolate C-A52, Isolate D-R2, Isolate E-A55, Isolate F-C70, Isolate G-B35, Isolate G-R46, Isolate H-A123, Isolate H-A80, Isolate H-S26, Isolate I-C7, Isolate J-C39, Isolate K-A92, Isolate L-A63 and Isolate M-C50.
  4. "Phylogeography of two squid (Loligo pealei and L. plei) in the Gulf of Mexico and Northwestern Atlantic Ocean."
    Herke S.W., Foltz D.W.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.
    Strain: Isolate B-B233, Isolate B-C13 and Isolate B-R59.

Entry informationi

Entry nameiCOX1_DORPE
AccessioniPrimary (citable) accession number: Q8WEW4
Secondary accession number(s): Q9ZYZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: September 3, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi