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Q8WEW4 (COX1_DORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismDoryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)
Taxonomic identifier1051067 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeDoryteuthis

Protein attributes

Sequence length223 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›223›223Cytochrome c oxidase subunit 1
PRO_0000183356

Regions

Topological domain‹1 – 4›4Mitochondrial matrix Potential
Transmembrane5 – 2723Helical; Name=1; Potential
Topological domain28 – 4619Mitochondrial intermembrane Potential
Transmembrane47 – 6923Helical; Name=2; Potential
Topological domain70 – 8819Mitochondrial matrix Potential
Transmembrane89 – 11123Helical; Name=3; Potential
Topological domain112 – 13019Mitochondrial intermembrane Potential
Transmembrane131 – 15323Helical; Name=4; Potential
Topological domain154 – 17320Mitochondrial matrix Potential
Transmembrane174 – 19623Helical; Name=5; Potential

Sites

Metal binding471Iron (heme A axial ligand) Probable

Experimental info

Non-terminal residue11
Non-terminal residue2231

Sequences

Sequence LengthMass (Da)Tools
Q8WEW4 [UniParc].

Last modified July 19, 2003. Version 2.
Checksum: 440EF0D5B4514979

FASTA22324,373
        10         20         30         40         50         60 
IGTLYFMFGI WAGLVGTSLS LMIRTELGKP GSLLNDDQLY NVVVTAHGFI MIFFMVMPIM 

        70         80         90        100        110        120 
IGGFGNWLVP LMLGAPDMAF PRMNNMSFWL LPPSLTLLLA SSAVESGAGT GWTVYPPLSS 

       130        140        150        160        170        180 
NLSHAGPSVD LAIFSLHLAG ISSILGAINF ITTIMNMRWE GLLMERLSLF VWSVFITAIL 

       190        200        210        220 
LLLSLPVLAG AITMLLTDRN FNTTFFDPSG GGDPILYQHL FWF 

« Hide

References

[1]"On bivalve phylogeny: a high-level phylogeny of the mollusk class Bivalvia based on a combined analysis of morphology and DNA sequence data."
Giribet G., Wheeler W.C.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Phylogenetic analysis of cytochrome c oxidase I sequences to determine higher-level relationships within the coleoid cephalopods."
Carlini D.B., Graves J.E.
Bull. Mar. Sci. 64:57-76(1999)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.
[3]"Phylogeography of two Loligo squid (Cephalopoda: Myopsida) in the Gulf of Mexico and the northwestern Atlantic Ocean."
Herke S.W., Foltz D.W.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.
Strain: Isolate A-A128, Isolate A-R1, Isolate B-A25, Isolate B-B233, Isolate B-C13, Isolate B-R11, Isolate B-R59, Isolate C-A52, Isolate D-R2, Isolate E-A55, Isolate F-C70, Isolate G-B35, Isolate G-R46, Isolate H-A123, Isolate H-A80, Isolate H-S26, Isolate I-C7, Isolate J-C39, Isolate K-A92, Isolate L-A63 and Isolate M-C50.
[4]"Phylogeography of two squid (Loligo pealei and L. plei) in the Gulf of Mexico and Northwestern Atlantic Ocean."
Herke S.W., Foltz D.W.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.
Strain: Isolate B-B233, Isolate B-C13 and Isolate B-R59.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF120629 Genomic DNA. Translation: AAL55479.1.
AF000052 Genomic DNA. Translation: AAC95097.1.
AF207923 Genomic DNA. Translation: AAF20964.1.
AF207909 Genomic DNA. Translation: AAF20950.1.
AF207910 Genomic DNA. Translation: AAF20951.1.
AF207911 Genomic DNA. Translation: AAF20952.1.
AF207912 Genomic DNA. Translation: AAF20953.1.
AF207913 Genomic DNA. Translation: AAF20954.1.
AF207914 Genomic DNA. Translation: AAF20955.1.
AF207915 Genomic DNA. Translation: AAF20956.1.
AF207916 Genomic DNA. Translation: AAF20957.1.
AF207917 Genomic DNA. Translation: AAF20958.1.
AF207918 Genomic DNA. Translation: AAF20959.1.
AF207919 Genomic DNA. Translation: AAF20960.1.
AF207920 Genomic DNA. Translation: AAF20961.1.
AF207921 Genomic DNA. Translation: AAF20962.1.
AF207922 Genomic DNA. Translation: AAF20963.1.
AF207924 Genomic DNA. Translation: AAF20965.1.
AF207925 Genomic DNA. Translation: AAF20966.1.
AF207926 Genomic DNA. Translation: AAF20967.1.
AY039621 Genomic DNA. Translation: AAK73250.1.
AY039622 Genomic DNA. Translation: AAK73251.1.
AY039623 Genomic DNA. Translation: AAK73252.1.

3D structure databases

ProteinModelPortalQ8WEW4.
SMRQ8WEW4. Positions 1-223.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_DORPE
AccessionPrimary (citable) accession number: Q8WEW4
Secondary accession number(s): Q9ZYZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: April 16, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways