Cytochrome c oxidase subunit 1 - Doryteuthis pealeii (Longfin inshore squid)

Contribute

Send feedback

Read comments (?) or add your own

Q8WEW4 (COX1_DORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 55. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide I

Gene names

Name:

COI

Encoded on

Mitochondrion

Organism

Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)

Taxonomic identifier

1051067 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Cephalopoda › Coleoidea › Neocoleoidea › Decapodiformes › Teuthida › Myopsina › Loliginidae › Doryteuthis

Protein attributes

Sequence length	223 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW oxidative phosphorylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – ›223

›223

Cytochrome c oxidase subunit 1

PRO_0000183356

Regions

Topological domain

‹1 – 4

›4

Mitochondrial matrix Potential

Transmembrane

5 – 27

Helical; Name=1; Potential

Topological domain

28 – 46

Mitochondrial intermembrane Potential

Transmembrane

47 – 69

Helical; Name=2; Potential

Topological domain

70 – 88

Mitochondrial matrix Potential

Transmembrane

89 – 111

Helical; Name=3; Potential

Topological domain

112 – 130

Mitochondrial intermembrane Potential

Transmembrane

131 – 153

Helical; Name=4; Potential

Topological domain

154 – 173

Mitochondrial matrix Potential

Transmembrane

174 – 196

Helical; Name=5; Potential

Sites

Metal binding

Iron (heme A axial ligand) Probable

Experimental info

Non-terminal residue

223

Sequences

Sequence

Length

Mass (Da)

Tools

Q8WEW4 [UniParc].

Last modified July 19, 2003. Version 2.
Checksum: 440EF0D5B4514979
Show »

FASTA

223

24,373

        10         20         30         40         50         60 
IGTLYFMFGI WAGLVGTSLS LMIRTELGKP GSLLNDDQLY NVVVTAHGFI MIFFMVMPIM 

        70         80         90        100        110        120 
IGGFGNWLVP LMLGAPDMAF PRMNNMSFWL LPPSLTLLLA SSAVESGAGT GWTVYPPLSS 

       130        140        150        160        170        180 
NLSHAGPSVD LAIFSLHLAG ISSILGAINF ITTIMNMRWE GLLMERLSLF VWSVFITAIL 

       190        200        210        220 
LLLSLPVLAG AITMLLTDRN FNTTFFDPSG GGDPILYQHL FWF

« Hide

References

[1]	"On bivalve phylogeny: a high-level phylogeny of the mollusk class Bivalvia based on a combined analysis of morphology and DNA sequence data." Giribet G., Wheeler W.C. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Phylogenetic analysis of cytochrome c oxidase I sequences to determine higher-level relationships within the coleoid cephalopods." Carlini D.B., Graves J.E. Bull. Mar. Sci. 64:57-76(1999) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.
[3]	"Phylogeography of two Loligo squid (Cephalopoda: Myopsida) in the Gulf of Mexico and the northwestern Atlantic Ocean." Herke S.W., Foltz D.W. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221. Strain: Isolate A-A128, Isolate A-R1, Isolate B-A25, Isolate B-B233, Isolate B-C13, Isolate B-R11, Isolate B-R59, Isolate C-A52, Isolate D-R2, Isolate E-A55, Isolate F-C70, Isolate G-B35, Isolate G-R46, Isolate H-A123, Isolate H-A80, Isolate H-S26, Isolate I-C7, Isolate J-C39, Isolate K-A92, Isolate L-A63 and Isolate M-C50.
[4]	"Phylogeography of two squid (Loligo pealei and L. plei) in the Gulf of Mexico and Northwestern Atlantic Ocean." Herke S.W., Foltz D.W. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221. Strain: Isolate B-B233, Isolate B-C13 and Isolate B-R59.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF120629 Genomic DNA. Translation: AAL55479.1. AF000052 Genomic DNA. Translation: AAC95097.1. AF207923 Genomic DNA. Translation: AAF20964.1. AF207909 Genomic DNA. Translation: AAF20950.1. AF207910 Genomic DNA. Translation: AAF20951.1. AF207911 Genomic DNA. Translation: AAF20952.1. AF207912 Genomic DNA. Translation: AAF20953.1. AF207913 Genomic DNA. Translation: AAF20954.1. AF207914 Genomic DNA. Translation: AAF20955.1. AF207915 Genomic DNA. Translation: AAF20956.1. AF207916 Genomic DNA. Translation: AAF20957.1. AF207917 Genomic DNA. Translation: AAF20958.1. AF207918 Genomic DNA. Translation: AAF20959.1. AF207919 Genomic DNA. Translation: AAF20960.1. AF207920 Genomic DNA. Translation: AAF20961.1. AF207921 Genomic DNA. Translation: AAF20962.1. AF207922 Genomic DNA. Translation: AAF20963.1. AF207924 Genomic DNA. Translation: AAF20965.1. AF207925 Genomic DNA. Translation: AAF20966.1. AF207926 Genomic DNA. Translation: AAF20967.1. AY039621 Genomic DNA. Translation: AAK73250.1. AY039622 Genomic DNA. Translation: AAK73251.1. AY039623 Genomic DNA. Translation: AAK73252.1.
3D structure databases
ProteinModelPortal	Q8WEW4.
SMR	Q8WEW4. Positions 1-223.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00705.
Family and domain databases
Gene3D	1.20.210.10. 1 hit.
InterPro	IPR000883. Cyt_c_Oxase_su1. IPR023616. Cyt_c_Oxase_su1_dom. [Graphical view]
PANTHER	PTHR10422. PTHR10422. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
SUPFAM	SSF81442. COX1. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_DORPE

Accession

Primary (citable) accession number: Q8WEW4
Secondary accession number(s): Q9ZYZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	July 19, 2003
Last modified:	March 6, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents