SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8WEW3

- COX1_SEPOF

UniProt

Q8WEW3 - COX1_SEPOF

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 1

Gene
COI
Organism
Sepia officinalis (Common cuttlefish)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiSepia officinalis (Common cuttlefish)
Taxonomic identifieri6610 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesSepiidaSepiinaSepiidaeSepia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 4›4Mitochondrial matrix Reviewed prediction
Transmembranei5 – 2723Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini28 – 4619Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei47 – 6923Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini70 – 8819Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei89 – 11123Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini112 – 13019Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei131 – 15323Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini154 – 17320Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei174 – 19623Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini197 – 22327Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›223›223Cytochrome c oxidase subunit 1PRO_0000183416Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8WEW3.
SMRiQ8WEW3. Positions 1-223.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WEW3-1 [UniParc]FASTAAdd to Basket

« Hide

IGTLYFIFGI WSGLLGTSLS LMIRTELGKP GSLLNDDQLY NVVVTAHGFV    50
MIFFLVMPIM IGGFGNWLVP LMLGAPDMAF PRMNNMSFWL LPPSLTLLLA 100
SSAVESGAGT GWTVYPPLSS NISHAGPSVD LAIFSLHLAG VSSILGAINF 150
ITTIMNMRWE GLQMERLPLF VWSVFITAIL LLLSLPVLAG AITMLLTDRN 200
FNTTFFDPSG GGDPILYQHL FWF 223
Length:223
Mass (Da):24,364
Last modified:July 19, 2003 - v2
Checksum:i2C48081196B6CDF4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251T → S in AAC95107. 1 Publication
Sequence conflicti32 – 321S → T in AAC95107. 1 Publication
Sequence conflicti50 – 501V → I in AAC95107. 1 Publication
Sequence conflicti100 – 1001A → S in AAC95107. 1 Publication
Sequence conflicti122 – 1221I → L in AAC95107. 1 Publication
Sequence conflicti155 – 1551M → L in AAC95107. 1 Publication
Sequence conflicti171 – 1711V → A in AAC95107. 1 Publication

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei223 – 2231

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF120630 Genomic DNA. Translation: AAL55480.1.
AF000062 Genomic DNA. Translation: AAC95107.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF120630 Genomic DNA. Translation: AAL55480.1 .
AF000062 Genomic DNA. Translation: AAC95107.1 .

3D structure databases

ProteinModelPortali Q8WEW3.
SMRi Q8WEW3. Positions 1-223.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "On bivalve phylogeny: a high-level phylogeny of the mollusk class Bivalvia based on a combined analysis of morphology and DNA sequence data."
    Giribet G., Wheeler W.C.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Phylogenetic analysis of cytochrome c oxidase I sequences to determine higher-level relationships within the coleoid cephalopods."
    Carlini D.B., Graves J.E.
    Bull. Mar. Sci. 64:57-76(1999)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.

Entry informationi

Entry nameiCOX1_SEPOF
AccessioniPrimary (citable) accession number: Q8WEW3
Secondary accession number(s): Q9ZYY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: September 3, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi