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Q8WEW3 (COX1_SEPOF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismSepia officinalis (Common cuttlefish)
Taxonomic identifier6610 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesSepiidaSepiinaSepiidaeSepia

Protein attributes

Sequence length223 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›223›223Cytochrome c oxidase subunit 1
PRO_0000183416

Regions

Topological domain‹1 – 4›4Mitochondrial matrix Potential
Transmembrane5 – 2723Helical; Name=1; Potential
Topological domain28 – 4619Mitochondrial intermembrane Potential
Transmembrane47 – 6923Helical; Name=2; Potential
Topological domain70 – 8819Mitochondrial matrix Potential
Transmembrane89 – 11123Helical; Name=3; Potential
Topological domain112 – 13019Mitochondrial intermembrane Potential
Transmembrane131 – 15323Helical; Name=4; Potential
Topological domain154 – 17320Mitochondrial matrix Potential
Transmembrane174 – 19623Helical; Name=5; Potential
Topological domain197 – 22327Mitochondrial intermembrane Potential

Sites

Metal binding471Iron (heme A axial ligand) Probable

Experimental info

Sequence conflict251T → S in AAC95107. Ref.2
Sequence conflict321S → T in AAC95107. Ref.2
Sequence conflict501V → I in AAC95107. Ref.2
Sequence conflict1001A → S in AAC95107. Ref.2
Sequence conflict1221I → L in AAC95107. Ref.2
Sequence conflict1551M → L in AAC95107. Ref.2
Sequence conflict1711V → A in AAC95107. Ref.2
Non-terminal residue11
Non-terminal residue2231

Sequences

Sequence LengthMass (Da)Tools
Q8WEW3 [UniParc].

Last modified July 19, 2003. Version 2.
Checksum: 2C48081196B6CDF4

FASTA22324,364
        10         20         30         40         50         60 
IGTLYFIFGI WSGLLGTSLS LMIRTELGKP GSLLNDDQLY NVVVTAHGFV MIFFLVMPIM 

        70         80         90        100        110        120 
IGGFGNWLVP LMLGAPDMAF PRMNNMSFWL LPPSLTLLLA SSAVESGAGT GWTVYPPLSS 

       130        140        150        160        170        180 
NISHAGPSVD LAIFSLHLAG VSSILGAINF ITTIMNMRWE GLQMERLPLF VWSVFITAIL 

       190        200        210        220 
LLLSLPVLAG AITMLLTDRN FNTTFFDPSG GGDPILYQHL FWF 

« Hide

References

[1]"On bivalve phylogeny: a high-level phylogeny of the mollusk class Bivalvia based on a combined analysis of morphology and DNA sequence data."
Giribet G., Wheeler W.C.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Phylogenetic analysis of cytochrome c oxidase I sequences to determine higher-level relationships within the coleoid cephalopods."
Carlini D.B., Graves J.E.
Bull. Mar. Sci. 64:57-76(1999)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF120630 Genomic DNA. Translation: AAL55480.1.
AF000062 Genomic DNA. Translation: AAC95107.1.

3D structure databases

ProteinModelPortalQ8WEW3.
SMRQ8WEW3. Positions 1-223.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_SEPOF
AccessionPrimary (citable) accession number: Q8WEW3
Secondary accession number(s): Q9ZYY9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: May 14, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways