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Q8WEW3

- COX1_SEPOF

UniProt

Q8WEW3 - COX1_SEPOF

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Sepia officinalis (Common cuttlefish)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (19 Jul 2003)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiSepia officinalis (Common cuttlefish)
    Taxonomic identifieri6610 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesSepiidaSepiinaSepiidaeSepia

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›223›223Cytochrome c oxidase subunit 1PRO_0000183416Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WEW3.
    SMRiQ8WEW3. Positions 1-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini‹1 – 4›4Mitochondrial matrixSequence Analysis
    Topological domaini28 – 4619Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8819Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini112 – 13019Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini154 – 17320Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini197 – 22327Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2723Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei47 – 6923Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 11123Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15323Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei174 – 19623Helical; Name=5Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8WEW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    IGTLYFIFGI WSGLLGTSLS LMIRTELGKP GSLLNDDQLY NVVVTAHGFV    50
    MIFFLVMPIM IGGFGNWLVP LMLGAPDMAF PRMNNMSFWL LPPSLTLLLA 100
    SSAVESGAGT GWTVYPPLSS NISHAGPSVD LAIFSLHLAG VSSILGAINF 150
    ITTIMNMRWE GLQMERLPLF VWSVFITAIL LLLSLPVLAG AITMLLTDRN 200
    FNTTFFDPSG GGDPILYQHL FWF 223
    Length:223
    Mass (Da):24,364
    Last modified:July 19, 2003 - v2
    Checksum:i2C48081196B6CDF4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Sequence conflicti25 – 251T → S in AAC95107. 1 PublicationCurated
    Sequence conflicti32 – 321S → T in AAC95107. 1 PublicationCurated
    Sequence conflicti50 – 501V → I in AAC95107. 1 PublicationCurated
    Sequence conflicti100 – 1001A → S in AAC95107. 1 PublicationCurated
    Sequence conflicti122 – 1221I → L in AAC95107. 1 PublicationCurated
    Sequence conflicti155 – 1551M → L in AAC95107. 1 PublicationCurated
    Sequence conflicti171 – 1711V → A in AAC95107. 1 PublicationCurated
    Non-terminal residuei223 – 2231

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120630 Genomic DNA. Translation: AAL55480.1.
    AF000062 Genomic DNA. Translation: AAC95107.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120630 Genomic DNA. Translation: AAL55480.1 .
    AF000062 Genomic DNA. Translation: AAC95107.1 .

    3D structure databases

    ProteinModelPortali Q8WEW3.
    SMRi Q8WEW3. Positions 1-223.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "On bivalve phylogeny: a high-level phylogeny of the mollusk class Bivalvia based on a combined analysis of morphology and DNA sequence data."
      Giribet G., Wheeler W.C.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Phylogenetic analysis of cytochrome c oxidase I sequences to determine higher-level relationships within the coleoid cephalopods."
      Carlini D.B., Graves J.E.
      Bull. Mar. Sci. 64:57-76(1999)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-221.

    Entry informationi

    Entry nameiCOX1_SEPOF
    AccessioniPrimary (citable) accession number: Q8WEW3
    Secondary accession number(s): Q9ZYY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: July 19, 2003
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3