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Protein

Cyclin-H1-1

Gene

CYCH1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with CDK-2 and CDK-3 and activates the CDK kinases.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • positive regulation of phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
  • positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • protein phosphorylation Source: GOC
  • reactive oxygen species metabolic process Source: TAIR
  • regulation of response to water deprivation Source: TAIR
  • regulation of stomatal movement Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • response to blue light Source: CACAO
  • response to water deprivation Source: CACAO
  • stomatal opening Source: TAIR
  • transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-ATH-113418. Formation of the Early Elongation Complex.
R-ATH-5696395. Formation of Incision Complex in GG-NER.
R-ATH-674695. RNA Polymerase II Pre-transcription Events.
R-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-ATH-69273. Cyclin A/B1 associated events during G2/M transition.
R-ATH-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-ATH-72086. mRNA Capping.
R-ATH-73776. RNA Polymerase II Promoter Escape.
R-ATH-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-ATH-75953. RNA Polymerase II Transcription Initiation.
R-ATH-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-ATH-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-H1-1
Short name:
CycH1;1
Gene namesi
Name:CYCH1-1
Synonyms:CYCH1
Ordered Locus Names:At5g27620
ORF Names:F15A18.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G27620.

Subcellular locationi

GO - Cellular componenti

  • cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
  • cytoplasm Source: TAIR
  • nucleus Source: TAIR
  • TFIIK complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 336335Cyclin-H1-1PRO_0000287049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8W5S1.
PRIDEiQ8W5S1.

Expressioni

Gene expression databases

GenevisibleiQ8W5S1. AT.

Interactioni

Subunit structurei

Interacts with CDKA-1, CDKD-2 and CDKD-3, but not CDKD-1 and CDKF-1.2 Publications

Protein-protein interaction databases

BioGridi18098. 40 interactions.
IntActiQ8W5S1. 23 interactions.
STRINGi3702.AT5G27620.1.

Structurei

3D structure databases

ProteinModelPortaliQ8W5S1.
SMRiQ8W5S1. Positions 47-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG2496. Eukaryota.
COG5333. LUCA.
HOGENOMiHOG000030045.
InParanoidiQ8W5S1.
KOiK06634.
OMAiQRAKWIF.
PhylomeDBiQ8W5S1.

Family and domain databases

Gene3Di1.10.472.10. 3 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PANTHERiPTHR10026:SF8. PTHR10026:SF8. 2 hits.
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8W5S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFQTSTQR AKWIFTPQKL AERYKAANQR AVQMLEKCGT TQVEVDASGS
60 70 80 90 100
LTYPKDKVGS GDQADKKLKP LSADEERFMR AFYEAKVQEV CSAFAFPHKI
110 120 130 140 150
QATALQYFKR FYLQWSVMQH HPKEIMLTCV YAACKIEENH VSAEEIGKGI
160 170 180 190 200
NQDHRIILKY EMAVLQSLEF DLIVYAPYRA IEGFVNNMEE FLQARDDEIQ
210 220 230 240 250
KLESLLKGAT AEADKVMLTD APLLFPPGQL ALASLRIANG VLGVIDFDRY
260 270 280 290 300
LENIVSQPNS EHTTSELTKL LDNIEYLVKN YKCPSEKDMK HINRKLKSCL
310 320 330
GHSSSHDESK KREKRSKHKS HRSSNDTPNG APPPIG
Length:336
Mass (Da):38,131
Last modified:March 1, 2002 - v1
Checksum:i488BCDA2B9B58C1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051072 mRNA. Translation: BAB72144.1.
AC007478 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93707.1.
AK118707 mRNA. Translation: BAC43301.1.
RefSeqiNP_198114.2. NM_122644.4.
UniGeneiAt.27359.

Genome annotation databases

EnsemblPlantsiAT5G27620.1; AT5G27620.1; AT5G27620.
GeneIDi832824.
GrameneiAT5G27620.1; AT5G27620.1; AT5G27620.
KEGGiath:AT5G27620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051072 mRNA. Translation: BAB72144.1.
AC007478 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93707.1.
AK118707 mRNA. Translation: BAC43301.1.
RefSeqiNP_198114.2. NM_122644.4.
UniGeneiAt.27359.

3D structure databases

ProteinModelPortaliQ8W5S1.
SMRiQ8W5S1. Positions 47-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi18098. 40 interactions.
IntActiQ8W5S1. 23 interactions.
STRINGi3702.AT5G27620.1.

Proteomic databases

PaxDbiQ8W5S1.
PRIDEiQ8W5S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G27620.1; AT5G27620.1; AT5G27620.
GeneIDi832824.
GrameneiAT5G27620.1; AT5G27620.1; AT5G27620.
KEGGiath:AT5G27620.

Organism-specific databases

TAIRiAT5G27620.

Phylogenomic databases

eggNOGiKOG2496. Eukaryota.
COG5333. LUCA.
HOGENOMiHOG000030045.
InParanoidiQ8W5S1.
KOiK06634.
OMAiQRAKWIF.
PhylomeDBiQ8W5S1.

Enzyme and pathway databases

ReactomeiR-ATH-113418. Formation of the Early Elongation Complex.
R-ATH-5696395. Formation of Incision Complex in GG-NER.
R-ATH-674695. RNA Polymerase II Pre-transcription Events.
R-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-ATH-69273. Cyclin A/B1 associated events during G2/M transition.
R-ATH-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-ATH-72086. mRNA Capping.
R-ATH-73776. RNA Polymerase II Promoter Escape.
R-ATH-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-ATH-75953. RNA Polymerase II Transcription Initiation.
R-ATH-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-ATH-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

PROiQ8W5S1.

Gene expression databases

GenevisibleiQ8W5S1. AT.

Family and domain databases

Gene3Di1.10.472.10. 3 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PANTHERiPTHR10026:SF8. PTHR10026:SF8. 2 hits.
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis."
    Shimotohno A., Umeda-Hara C., Bisova K., Uchimiya H., Umeda M.
    Plant Cell 16:2954-2966(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CDKA-1; CDKD-2 AND CDKD-3.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Genome-wide analysis of the cyclin family in Arabidopsis and comparative phylogenetic analysis of plant cyclin-like proteins."
    Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W., Ma H.
    Plant Physiol. 135:1084-1099(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. "Diverse phosphoregulatory mechanisms controlling cyclin-dependent kinase-activating kinases in Arabidopsis."
    Shimotohno A., Ohno R., Bisova K., Sakaguchi N., Huang J., Koncz C., Uchimiya H., Umeda M.
    Plant J. 47:701-710(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CDKD-2 AND CDKD-3.
    Strain: cv. Columbia.
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCH11_ARATH
AccessioniPrimary (citable) accession number: Q8W5S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.