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Protein

Bowman-Birk type proteinase inhibitor

Gene
N/A
Organism
Lens culinaris (Lentil) (Cicer lens)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of trypsin and of chymotrypsin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei58 – 59Reactive bond for trypsinBy similarity2
Sitei84 – 85Reactive bond for chymotrypsinBy similarity2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI12.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Bowman-Birk type proteinase inhibitor
Alternative name(s):
LCTI
Trypsin/chymotrypsin inhibitor
OrganismiLens culinaris (Lentil) (Cicer lens)
Taxonomic identifieri3864 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaeLens

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000000326829 – 42Sequence analysis2 PublicationsAdd BLAST14
ChainiPRO_000000326943 – 110Bowman-Birk type proteinase inhibitor2 PublicationsAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 1031 Publication
Disulfide bondi51 ↔ 661 Publication
Disulfide bondi54 ↔ 991 Publication
Disulfide bondi56 ↔ 641 Publication
Disulfide bondi73 ↔ 801 Publication
Disulfide bondi77 ↔ 921 Publication
Disulfide bondi82 ↔ 901 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi54 – 56Combined sources3
Beta strandi58 – 61Combined sources4
Beta strandi64 – 66Combined sources3
Beta strandi80 – 83Combined sources4
Beta strandi89 – 92Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AIHNMR-A43-109[»]
ProteinModelPortaliQ8W4Y8.
SMRiQ8W4Y8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8W4Y8.

Family & Domainsi

Sequence similaritiesi

Belongs to the Bowman-Birk serine protease inhibitor family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

CDDicd00023. BBI. 1 hit.
Gene3Di2.10.69.10. 1 hit.
InterProiIPR000877. Prot_inh_BBI.
[Graphical view]
PfamiPF00228. Bowman-Birk_leg. 1 hit.
[Graphical view]
SMARTiSM00269. BowB. 1 hit.
[Graphical view]
SUPFAMiSSF57247. SSF57247. 1 hit.
PROSITEiPS00281. BOWMAN_BIRK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8W4Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMNKKAIM KLALMLFLLG FTANVVDARF DSTSFITQVL SNGDDVKSAC
60 70 80 90 100
CDTCLCTRSQ PPTCRCVDVR ESCHSACDKC VCAYSNPPQC QCYDTHKFCY
110
KACHNSEIEE
Length:110
Mass (Da):12,266
Last modified:June 21, 2005 - v2
Checksum:i0FB31C642323D764
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27D → N in CAD12252 (PubMed:15655663).Curated1
Sequence conflicti97K → N in CAD12253 (PubMed:15655663).Curated1
Sequence conflicti97K → N in CAD12252 (PubMed:15655663).Curated1
Sequence conflicti102A → T in CAD12253 (PubMed:15655663).Curated1
Sequence conflicti110Missing AA sequence (PubMed:16889634).Curated1

Mass spectrometryi

Molecular mass is 7446.63 Da from positions 43 - 109. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ420110 Genomic DNA. Translation: CAD12253.1.
AJ420109 Genomic DNA. Translation: CAD12252.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ420110 Genomic DNA. Translation: CAD12253.1.
AJ420109 Genomic DNA. Translation: CAD12252.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AIHNMR-A43-109[»]
ProteinModelPortaliQ8W4Y8.
SMRiQ8W4Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI12.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ8W4Y8.

Family and domain databases

CDDicd00023. BBI. 1 hit.
Gene3Di2.10.69.10. 1 hit.
InterProiIPR000877. Prot_inh_BBI.
[Graphical view]
PfamiPF00228. Bowman-Birk_leg. 1 hit.
[Graphical view]
SMARTiSM00269. BowB. 1 hit.
[Graphical view]
SUPFAMiSSF57247. SSF57247. 1 hit.
PROSITEiPS00281. BOWMAN_BIRK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBB_LENCU
AccessioniPrimary (citable) accession number: Q8W4Y8
Secondary accession number(s): Q8W4Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 2, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.