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Q8W4P1

- CDKC2_ARATH

UniProt

Q8W4P1 - CDKC2_ARATH

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Protein

Cyclin-dependent kinase C-2

Gene

CDKC-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATPPROSITE-ProRule annotation
Active sitei164 – 1641Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 409ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. kinase activity Source: TAIR
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. carpel development Source: TAIR
  2. flower development Source: TAIR
  3. leaf development Source: TAIR
  4. mRNA processing Source: TAIR
  5. regulation of viral process Source: TAIR
  6. response to virus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G64960-MONOMER.
ARA:GQT-2793-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase C-2 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKC;2
Gene namesi
Name:CDKC-2
Ordered Locus Names:At5g64960
ORF Names:MXK3.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G64960.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. nuclear body Source: TAIR
  3. nucleus Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Cyclin-dependent kinase C-2PRO_0000293118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371PhosphotyrosineBy similarity
Modified residuei198 – 1981PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8W4P1.
PRIDEiQ8W4P1.

Expressioni

Tissue specificityi

Highly expressed in flowers. Expressed in seedlings, roots, rosettes and stems.1 Publication

Gene expression databases

ExpressionAtlasiQ8W4P1. baseline and differential.
GenevestigatoriQ8W4P1.

Interactioni

Subunit structurei

Interacts with CYCT1-3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CYCT1-3Q8LBC02EBI-2025894,EBI-2025764

Protein-protein interaction databases

BioGridi21862. 10 interactions.
IntActiQ8W4P1. 12 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8W4P1.
SMRiQ8W4P1. Positions 17-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 325300Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 54Poly-Ala
Compositional biasi413 – 50391Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ8W4P1.
OMAiHHENVIH.
PhylomeDBiQ8W4P1.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q8W4P1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAFGQLN LEEPPPIWGS RSVDCFEKLE QIGEGTYGQV YMAKEIKTGE
60 70 80 90 100
IVALKKIRMD NEREGFPITA IREIKILKKL HHENVIHLKE IVTSPGRDRD
110 120 130 140 150
DQGKPDNNKY KGGIYMVFEY MDHDLTGLAD RPGLRFTVPQ IKCYMKQLLT
160 170 180 190 200
GLHYCHVNQV LHRDIKGSNL LIDNEGNLKL ADFGLARSYS HDHTGNLTNR
210 220 230 240 250
VITLWYRPPE LLLGATKYGP AIDMWSVGCI FAELLNGKPI LPGKTENEQL
260 270 280 290 300
NKIYELCGSP DESNWPGVSK MPWYNQMKSS RPLKRRVREI YRHFDRHALE
310 320 330 340 350
LLEKMLVLDP SQRICAKDAL DAEYFWTDPL PCDPKSLPTY ESSHEFQTKK
360 370 380 390 400
KRQQMRHNEE AAKKQKLQHP QQQHSRLPPQ QHGVGQSHAA PLWPAGPNHP
410 420 430 440 450
MNNNAPPPQI PAGGHYYGGK PRGGAPVPNR YPPSGNQTGG YNNQSRGGYS
460 470 480 490 500
SGAYPPQGRG APYGAGPRGP SGGYGVGPPN YSQGGGQYGG SGGSGRGQNP
510
MGGARNQQYG WQP
Length:513
Mass (Da):57,129
Last modified:July 10, 2007 - v2
Checksum:iF348F40377CA3756
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261F → Y in AAL32527. (PubMed:14593172)Curated
Sequence conflicti26 – 261F → Y in AAO00925. (PubMed:14593172)Curated
Sequence conflicti188 – 1881S → P in AAL32527. (PubMed:14593172)Curated
Sequence conflicti188 – 1881S → P in AAO00925. (PubMed:14593172)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019236 Genomic DNA. Translation: BAA97308.1.
CP002688 Genomic DNA. Translation: AED97975.1.
AF360134 mRNA. Translation: AAK25844.1.
AY039990 mRNA. Translation: AAK64067.1.
AY062449 mRNA. Translation: AAL32527.1.
BT002565 mRNA. Translation: AAO00925.1.
RefSeqiNP_201301.1. NM_125895.4. [Q8W4P1-1]
UniGeneiAt.72847.

Genome annotation databases

EnsemblPlantsiAT5G64960.1; AT5G64960.1; AT5G64960. [Q8W4P1-1]
GeneIDi836620.
KEGGiath:AT5G64960.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019236 Genomic DNA. Translation: BAA97308.1 .
CP002688 Genomic DNA. Translation: AED97975.1 .
AF360134 mRNA. Translation: AAK25844.1 .
AY039990 mRNA. Translation: AAK64067.1 .
AY062449 mRNA. Translation: AAL32527.1 .
BT002565 mRNA. Translation: AAO00925.1 .
RefSeqi NP_201301.1. NM_125895.4. [Q8W4P1-1 ]
UniGenei At.72847.

3D structure databases

ProteinModelPortali Q8W4P1.
SMRi Q8W4P1. Positions 17-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 21862. 10 interactions.
IntActi Q8W4P1. 12 interactions.

Proteomic databases

PaxDbi Q8W4P1.
PRIDEi Q8W4P1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G64960.1 ; AT5G64960.1 ; AT5G64960 . [Q8W4P1-1 ]
GeneIDi 836620.
KEGGi ath:AT5G64960.

Organism-specific databases

GeneFarmi 3284. 108.
TAIRi AT5G64960.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q8W4P1.
OMAi HHENVIH.
PhylomeDBi Q8W4P1.

Enzyme and pathway databases

BioCyci ARA:AT5G64960-MONOMER.
ARA:GQT-2793-MONOMER.

Miscellaneous databases

PROi Q8W4P1.

Gene expression databases

ExpressionAtlasi Q8W4P1. baseline and differential.
Genevestigatori Q8W4P1.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
    DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide analysis of core cell cycle genes in Arabidopsis."
    Vandepoele K., Raes J., de Veylder L., Rouze P., Rombauts S., Inze D.
    Plant Cell 14:903-916(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. "Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division."
    Barroco R.M., de Veylder L., Magyar Z., Engler G., Inze D., Mironov V.
    Cell. Mol. Life Sci. 60:401-412(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH CYCT1-3.
  6. "Cell cycle regulation in plant development."
    Inze D., de Veylder L.
    Annu. Rev. Genet. 40:77-105(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiCDKC2_ARATH
AccessioniPrimary (citable) accession number: Q8W4P1
Secondary accession number(s): Q9LV82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3