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Q8W4P1

- CDKC2_ARATH

UniProt

Q8W4P1 - CDKC2_ARATH

Protein

Cyclin-dependent kinase C-2

Gene

CDKC-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei55 – 551ATPPROSITE-ProRule annotation
    Active sitei164 – 1641Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi32 – 409ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. kinase activity Source: TAIR
    4. protein binding Source: IntAct
    5. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carpel development Source: TAIR
    2. flower development Source: TAIR
    3. leaf development Source: TAIR
    4. mRNA processing Source: TAIR
    5. regulation of viral process Source: TAIR
    6. response to virus Source: TAIR

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G64960-MONOMER.
    ARA:GQT-2793-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase C-2 (EC:2.7.11.22, EC:2.7.11.23)
    Short name:
    CDKC;2
    Gene namesi
    Name:CDKC-2
    Ordered Locus Names:At5g64960
    ORF Names:MXK3.19
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G64960.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: TAIR
    2. nuclear body Source: TAIR
    3. nucleus Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Cyclin-dependent kinase C-2PRO_0000293118Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371PhosphotyrosineBy similarity
    Modified residuei198 – 1981PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8W4P1.
    PRIDEiQ8W4P1.

    Expressioni

    Tissue specificityi

    Highly expressed in flowers. Expressed in seedlings, roots, rosettes and stems.1 Publication

    Gene expression databases

    GenevestigatoriQ8W4P1.

    Interactioni

    Subunit structurei

    Interacts with CYCT1-3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CYCT1-3Q8LBC02EBI-2025894,EBI-2025764

    Protein-protein interaction databases

    BioGridi21862. 10 interactions.
    IntActiQ8W4P1. 12 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8W4P1.
    SMRiQ8W4P1. Positions 18-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 325300Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 54Poly-Ala
    Compositional biasi413 – 50391Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    InParanoidiQ8W4P1.
    OMAiHHENVIH.
    PhylomeDBiQ8W4P1.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q8W4P1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAFGQLN LEEPPPIWGS RSVDCFEKLE QIGEGTYGQV YMAKEIKTGE    50
    IVALKKIRMD NEREGFPITA IREIKILKKL HHENVIHLKE IVTSPGRDRD 100
    DQGKPDNNKY KGGIYMVFEY MDHDLTGLAD RPGLRFTVPQ IKCYMKQLLT 150
    GLHYCHVNQV LHRDIKGSNL LIDNEGNLKL ADFGLARSYS HDHTGNLTNR 200
    VITLWYRPPE LLLGATKYGP AIDMWSVGCI FAELLNGKPI LPGKTENEQL 250
    NKIYELCGSP DESNWPGVSK MPWYNQMKSS RPLKRRVREI YRHFDRHALE 300
    LLEKMLVLDP SQRICAKDAL DAEYFWTDPL PCDPKSLPTY ESSHEFQTKK 350
    KRQQMRHNEE AAKKQKLQHP QQQHSRLPPQ QHGVGQSHAA PLWPAGPNHP 400
    MNNNAPPPQI PAGGHYYGGK PRGGAPVPNR YPPSGNQTGG YNNQSRGGYS 450
    SGAYPPQGRG APYGAGPRGP SGGYGVGPPN YSQGGGQYGG SGGSGRGQNP 500
    MGGARNQQYG WQP 513
    Length:513
    Mass (Da):57,129
    Last modified:July 10, 2007 - v2
    Checksum:iF348F40377CA3756
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261F → Y in AAL32527. (PubMed:14593172)Curated
    Sequence conflicti26 – 261F → Y in AAO00925. (PubMed:14593172)Curated
    Sequence conflicti188 – 1881S → P in AAL32527. (PubMed:14593172)Curated
    Sequence conflicti188 – 1881S → P in AAO00925. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019236 Genomic DNA. Translation: BAA97308.1.
    CP002688 Genomic DNA. Translation: AED97975.1.
    AF360134 mRNA. Translation: AAK25844.1.
    AY039990 mRNA. Translation: AAK64067.1.
    AY062449 mRNA. Translation: AAL32527.1.
    BT002565 mRNA. Translation: AAO00925.1.
    RefSeqiNP_201301.1. NM_125895.4. [Q8W4P1-1]
    UniGeneiAt.72847.

    Genome annotation databases

    EnsemblPlantsiAT5G64960.1; AT5G64960.1; AT5G64960. [Q8W4P1-1]
    GeneIDi836620.
    KEGGiath:AT5G64960.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019236 Genomic DNA. Translation: BAA97308.1 .
    CP002688 Genomic DNA. Translation: AED97975.1 .
    AF360134 mRNA. Translation: AAK25844.1 .
    AY039990 mRNA. Translation: AAK64067.1 .
    AY062449 mRNA. Translation: AAL32527.1 .
    BT002565 mRNA. Translation: AAO00925.1 .
    RefSeqi NP_201301.1. NM_125895.4. [Q8W4P1-1 ]
    UniGenei At.72847.

    3D structure databases

    ProteinModelPortali Q8W4P1.
    SMRi Q8W4P1. Positions 18-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 21862. 10 interactions.
    IntActi Q8W4P1. 12 interactions.

    Proteomic databases

    PaxDbi Q8W4P1.
    PRIDEi Q8W4P1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G64960.1 ; AT5G64960.1 ; AT5G64960 . [Q8W4P1-1 ]
    GeneIDi 836620.
    KEGGi ath:AT5G64960.

    Organism-specific databases

    GeneFarmi 3284. 108.
    TAIRi AT5G64960.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    InParanoidi Q8W4P1.
    OMAi HHENVIH.
    PhylomeDBi Q8W4P1.

    Enzyme and pathway databases

    BioCyci ARA:AT5G64960-MONOMER.
    ARA:GQT-2793-MONOMER.

    Miscellaneous databases

    PROi Q8W4P1.

    Gene expression databases

    Genevestigatori Q8W4P1.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
      DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Genome-wide analysis of core cell cycle genes in Arabidopsis."
      Vandepoele K., Raes J., de Veylder L., Rouze P., Rombauts S., Inze D.
      Plant Cell 14:903-916(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    5. "Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division."
      Barroco R.M., de Veylder L., Magyar Z., Engler G., Inze D., Mironov V.
      Cell. Mol. Life Sci. 60:401-412(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH CYCT1-3.
    6. "Cell cycle regulation in plant development."
      Inze D., de Veylder L.
      Annu. Rev. Genet. 40:77-105(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiCDKC2_ARATH
    AccessioniPrimary (citable) accession number: Q8W4P1
    Secondary accession number(s): Q9LV82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3