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Protein

Cyclin-dependent kinase C-2

Gene

CDKC-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • carpel development Source: TAIR
  • flower development Source: TAIR
  • leaf development Source: TAIR
  • mRNA processing Source: TAIR
  • regulation of viral process Source: TAIR
  • response to virus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 399.
ReactomeiR-ATH-674695. RNA Polymerase II Pre-transcription Events.
R-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase C-2 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKC;2
Gene namesi
Name:CDKC-2
Ordered Locus Names:At5g64960
ORF Names:MXK3.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G64960.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • nuclear body Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931181 – 513Cyclin-dependent kinase C-2Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphotyrosineBy similarity1
Modified residuei198PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8W4P1.
PRIDEiQ8W4P1.

PTM databases

iPTMnetiQ8W4P1.

Expressioni

Tissue specificityi

Highly expressed in flowers. Expressed in seedlings, roots, rosettes and stems.1 Publication

Gene expression databases

ExpressionAtlasiQ8W4P1. baseline and differential.
GenevisibleiQ8W4P1. AT.

Interactioni

Subunit structurei

Interacts with CYCT1-3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CYCT1-3Q8LBC02EBI-2025894,EBI-2025764

Protein-protein interaction databases

BioGridi21862. 14 interactors.
IntActiQ8W4P1. 12 interactors.
STRINGi3702.AT5G64960.1.

Structurei

3D structure databases

ProteinModelPortaliQ8W4P1.
SMRiQ8W4P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 325Protein kinasePROSITE-ProRule annotationAdd BLAST300

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 5Poly-Ala4
Compositional biasi413 – 503Gly-richAdd BLAST91

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
HOGENOMiHOG000233024.
InParanoidiQ8W4P1.
OMAiHHENVIH.
OrthoDBiEOG093607V4.
PhylomeDBiQ8W4P1.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8W4P1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAFGQLN LEEPPPIWGS RSVDCFEKLE QIGEGTYGQV YMAKEIKTGE
60 70 80 90 100
IVALKKIRMD NEREGFPITA IREIKILKKL HHENVIHLKE IVTSPGRDRD
110 120 130 140 150
DQGKPDNNKY KGGIYMVFEY MDHDLTGLAD RPGLRFTVPQ IKCYMKQLLT
160 170 180 190 200
GLHYCHVNQV LHRDIKGSNL LIDNEGNLKL ADFGLARSYS HDHTGNLTNR
210 220 230 240 250
VITLWYRPPE LLLGATKYGP AIDMWSVGCI FAELLNGKPI LPGKTENEQL
260 270 280 290 300
NKIYELCGSP DESNWPGVSK MPWYNQMKSS RPLKRRVREI YRHFDRHALE
310 320 330 340 350
LLEKMLVLDP SQRICAKDAL DAEYFWTDPL PCDPKSLPTY ESSHEFQTKK
360 370 380 390 400
KRQQMRHNEE AAKKQKLQHP QQQHSRLPPQ QHGVGQSHAA PLWPAGPNHP
410 420 430 440 450
MNNNAPPPQI PAGGHYYGGK PRGGAPVPNR YPPSGNQTGG YNNQSRGGYS
460 470 480 490 500
SGAYPPQGRG APYGAGPRGP SGGYGVGPPN YSQGGGQYGG SGGSGRGQNP
510
MGGARNQQYG WQP
Length:513
Mass (Da):57,129
Last modified:July 10, 2007 - v2
Checksum:iF348F40377CA3756
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26F → Y in AAL32527 (PubMed:14593172).Curated1
Sequence conflicti26F → Y in AAO00925 (PubMed:14593172).Curated1
Sequence conflicti188S → P in AAL32527 (PubMed:14593172).Curated1
Sequence conflicti188S → P in AAO00925 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019236 Genomic DNA. Translation: BAA97308.1.
CP002688 Genomic DNA. Translation: AED97975.1.
AF360134 mRNA. Translation: AAK25844.1.
AY039990 mRNA. Translation: AAK64067.1.
AY062449 mRNA. Translation: AAL32527.1.
BT002565 mRNA. Translation: AAO00925.1.
RefSeqiNP_201301.1. NM_125895.5. [Q8W4P1-1]
UniGeneiAt.72847.

Genome annotation databases

EnsemblPlantsiAT5G64960.1; AT5G64960.1; AT5G64960. [Q8W4P1-1]
GeneIDi836620.
GrameneiAT5G64960.1; AT5G64960.1; AT5G64960.
KEGGiath:AT5G64960.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019236 Genomic DNA. Translation: BAA97308.1.
CP002688 Genomic DNA. Translation: AED97975.1.
AF360134 mRNA. Translation: AAK25844.1.
AY039990 mRNA. Translation: AAK64067.1.
AY062449 mRNA. Translation: AAL32527.1.
BT002565 mRNA. Translation: AAO00925.1.
RefSeqiNP_201301.1. NM_125895.5. [Q8W4P1-1]
UniGeneiAt.72847.

3D structure databases

ProteinModelPortaliQ8W4P1.
SMRiQ8W4P1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi21862. 14 interactors.
IntActiQ8W4P1. 12 interactors.
STRINGi3702.AT5G64960.1.

PTM databases

iPTMnetiQ8W4P1.

Proteomic databases

PaxDbiQ8W4P1.
PRIDEiQ8W4P1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G64960.1; AT5G64960.1; AT5G64960. [Q8W4P1-1]
GeneIDi836620.
GrameneiAT5G64960.1; AT5G64960.1; AT5G64960.
KEGGiath:AT5G64960.

Organism-specific databases

TAIRiAT5G64960.

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
HOGENOMiHOG000233024.
InParanoidiQ8W4P1.
OMAiHHENVIH.
OrthoDBiEOG093607V4.
PhylomeDBiQ8W4P1.

Enzyme and pathway databases

BRENDAi2.7.11.22. 399.
ReactomeiR-ATH-674695. RNA Polymerase II Pre-transcription Events.
R-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.

Miscellaneous databases

PROiQ8W4P1.

Gene expression databases

ExpressionAtlasiQ8W4P1. baseline and differential.
GenevisibleiQ8W4P1. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKC2_ARATH
AccessioniPrimary (citable) accession number: Q8W4P1
Secondary accession number(s): Q9LV82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.