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Q8W4P1 (CDKC2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase C-2

Short name=CDKC;2
EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:CDKC-2
Ordered Locus Names:At5g64960
ORF Names:MXK3.19
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subunit structure

Interacts with CYCT1-3. Ref.5

Tissue specificity

Highly expressed in flowers. Expressed in seedlings, roots, rosettes and stems. Ref.5

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CYCT1-3Q8LBC02EBI-2025894,EBI-2025764

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8W4P1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Cyclin-dependent kinase C-2
PRO_0000293118

Regions

Domain26 – 325300Protein kinase
Nucleotide binding32 – 409ATP By similarity
Compositional bias2 – 54Poly-Ala
Compositional bias413 – 50391Gly-rich

Sites

Active site1641Proton acceptor By similarity
Binding site551ATP By similarity

Amino acid modifications

Modified residue371Phosphotyrosine By similarity
Modified residue1981Phosphothreonine By similarity

Experimental info

Sequence conflict261F → Y in AAL32527. Ref.3
Sequence conflict261F → Y in AAO00925. Ref.3
Sequence conflict1881S → P in AAL32527. Ref.3
Sequence conflict1881S → P in AAO00925. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: F348F40377CA3756

FASTA51357,129
        10         20         30         40         50         60 
MAAAAFGQLN LEEPPPIWGS RSVDCFEKLE QIGEGTYGQV YMAKEIKTGE IVALKKIRMD 

        70         80         90        100        110        120 
NEREGFPITA IREIKILKKL HHENVIHLKE IVTSPGRDRD DQGKPDNNKY KGGIYMVFEY 

       130        140        150        160        170        180 
MDHDLTGLAD RPGLRFTVPQ IKCYMKQLLT GLHYCHVNQV LHRDIKGSNL LIDNEGNLKL 

       190        200        210        220        230        240 
ADFGLARSYS HDHTGNLTNR VITLWYRPPE LLLGATKYGP AIDMWSVGCI FAELLNGKPI 

       250        260        270        280        290        300 
LPGKTENEQL NKIYELCGSP DESNWPGVSK MPWYNQMKSS RPLKRRVREI YRHFDRHALE 

       310        320        330        340        350        360 
LLEKMLVLDP SQRICAKDAL DAEYFWTDPL PCDPKSLPTY ESSHEFQTKK KRQQMRHNEE 

       370        380        390        400        410        420 
AAKKQKLQHP QQQHSRLPPQ QHGVGQSHAA PLWPAGPNHP MNNNAPPPQI PAGGHYYGGK 

       430        440        450        460        470        480 
PRGGAPVPNR YPPSGNQTGG YNNQSRGGYS SGAYPPQGRG APYGAGPRGP SGGYGVGPPN 

       490        500        510 
YSQGGGQYGG SGGSGRGQNP MGGARNQQYG WQP 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Genome-wide analysis of core cell cycle genes in Arabidopsis."
Vandepoele K., Raes J., de Veylder L., Rouze P., Rombauts S., Inze D.
Plant Cell 14:903-916(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division."
Barroco R.M., de Veylder L., Magyar Z., Engler G., Inze D., Mironov V.
Cell. Mol. Life Sci. 60:401-412(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH CYCT1-3.
[6]"Cell cycle regulation in plant development."
Inze D., de Veylder L.
Annu. Rev. Genet. 40:77-105(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB019236 Genomic DNA. Translation: BAA97308.1.
CP002688 Genomic DNA. Translation: AED97975.1.
AF360134 mRNA. Translation: AAK25844.1.
AY039990 mRNA. Translation: AAK64067.1.
AY062449 mRNA. Translation: AAL32527.1.
BT002565 mRNA. Translation: AAO00925.1.
RefSeqNP_201301.1. NM_125895.4.
UniGeneAt.72847.

3D structure databases

ProteinModelPortalQ8W4P1.
SMRQ8W4P1. Positions 23-372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid21862. 8 interactions.
IntActQ8W4P1. 12 interactions.

Proteomic databases

PaxDbQ8W4P1.
PRIDEQ8W4P1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G64960.1; AT5G64960.1; AT5G64960. [Q8W4P1-1]
GeneID836620.
KEGGath:AT5G64960.

Organism-specific databases

GeneFarm3284. 108.
TAIRAT5G64960.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
InParanoidQ8W4P1.
OMAHHENVIH.
PhylomeDBQ8W4P1.
ProtClustDBCLSN2692317.

Enzyme and pathway databases

BioCycARA:AT5G64960-MONOMER.
ARA:GQT-2793-MONOMER.

Gene expression databases

GenevestigatorQ8W4P1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8W4P1.

Entry information

Entry nameCDKC2_ARATH
AccessionPrimary (citable) accession number: Q8W4P1
Secondary accession number(s): Q9LV82
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names