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Protein

Cyclin-dependent kinase C-2

Gene

CDKC-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • carpel development Source: TAIR
  • flower development Source: TAIR
  • leaf development Source: TAIR
  • mRNA processing Source: TAIR
  • protein phosphorylation Source: GO_Central
  • regulation of viral process Source: TAIR
  • response to virus Source: TAIR

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 399.
ReactomeiR-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-ATH-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase C-2 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKC;2
Gene namesi
Name:CDKC-2
Ordered Locus Names:At5g64960
ORF Names:MXK3.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G64960.
TAIRilocus:2177744. AT5G64960.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • nuclear body Source: TAIR
  • nucleus Source: TAIR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931181 – 513Cyclin-dependent kinase C-2Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphotyrosineBy similarity1
Modified residuei198PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8W4P1.
PRIDEiQ8W4P1.

PTM databases

iPTMnetiQ8W4P1.

Expressioni

Tissue specificityi

Highly expressed in flowers. Expressed in seedlings, roots, rosettes and stems.1 Publication

Gene expression databases

ExpressionAtlasiQ8W4P1. baseline and differential.
GenevisibleiQ8W4P1. AT.

Interactioni

Subunit structurei

Interacts with CYCT1-3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CYCT1-3Q8LBC02EBI-2025894,EBI-2025764

Protein-protein interaction databases

BioGridi21862. 14 interactors.
IntActiQ8W4P1. 12 interactors.
STRINGi3702.AT5G64960.1.

Structurei

3D structure databases

ProteinModelPortaliQ8W4P1.
SMRiQ8W4P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 325Protein kinasePROSITE-ProRule annotationAdd BLAST300

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 5Poly-Ala4
Compositional biasi413 – 503Gly-richAdd BLAST91

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
HOGENOMiHOG000233024.
InParanoidiQ8W4P1.
OMAiIWDLMGS.
OrthoDBiEOG093607V4.
PhylomeDBiQ8W4P1.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8W4P1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAFGQLN LEEPPPIWGS RSVDCFEKLE QIGEGTYGQV YMAKEIKTGE
60 70 80 90 100
IVALKKIRMD NEREGFPITA IREIKILKKL HHENVIHLKE IVTSPGRDRD
110 120 130 140 150
DQGKPDNNKY KGGIYMVFEY MDHDLTGLAD RPGLRFTVPQ IKCYMKQLLT
160 170 180 190 200
GLHYCHVNQV LHRDIKGSNL LIDNEGNLKL ADFGLARSYS HDHTGNLTNR
210 220 230 240 250
VITLWYRPPE LLLGATKYGP AIDMWSVGCI FAELLNGKPI LPGKTENEQL
260 270 280 290 300
NKIYELCGSP DESNWPGVSK MPWYNQMKSS RPLKRRVREI YRHFDRHALE
310 320 330 340 350
LLEKMLVLDP SQRICAKDAL DAEYFWTDPL PCDPKSLPTY ESSHEFQTKK
360 370 380 390 400
KRQQMRHNEE AAKKQKLQHP QQQHSRLPPQ QHGVGQSHAA PLWPAGPNHP
410 420 430 440 450
MNNNAPPPQI PAGGHYYGGK PRGGAPVPNR YPPSGNQTGG YNNQSRGGYS
460 470 480 490 500
SGAYPPQGRG APYGAGPRGP SGGYGVGPPN YSQGGGQYGG SGGSGRGQNP
510
MGGARNQQYG WQP
Length:513
Mass (Da):57,129
Last modified:July 10, 2007 - v2
Checksum:iF348F40377CA3756
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26F → Y in AAL32527 (PubMed:14593172).Curated1
Sequence conflicti26F → Y in AAO00925 (PubMed:14593172).Curated1
Sequence conflicti188S → P in AAL32527 (PubMed:14593172).Curated1
Sequence conflicti188S → P in AAO00925 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019236 Genomic DNA. Translation: BAA97308.1.
CP002688 Genomic DNA. Translation: AED97975.1.
AF360134 mRNA. Translation: AAK25844.1.
AY039990 mRNA. Translation: AAK64067.1.
AY062449 mRNA. Translation: AAL32527.1.
BT002565 mRNA. Translation: AAO00925.1.
RefSeqiNP_201301.1. NM_125895.5. [Q8W4P1-1]
UniGeneiAt.72847.

Genome annotation databases

EnsemblPlantsiAT5G64960.1; AT5G64960.1; AT5G64960. [Q8W4P1-1]
GeneIDi836620.
GrameneiAT5G64960.1; AT5G64960.1; AT5G64960.
KEGGiath:AT5G64960.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCDKC2_ARATH
AccessioniPrimary (citable) accession number: Q8W4P1
Secondary accession number(s): Q9LV82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: August 30, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families