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Protein

Peptidyl-prolyl cis-trans isomerase CYP71

Gene

CYP71

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Histone remodeling factor involved in chromatin-based gene silencing. Reinforces H3K27 methylation. Involved in fundamental processes of chromatin assembly and histone modification by mediating the targeting of FAS1 and LHP1 on the chromatin. Required for the formation and development of leaves, for normal phyllotaxy and for the formation, maintenance and activity of root and shoot apical meristems.2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • chromatin binding Source: TAIR
  • histone binding Source: TAIR
  • peptide binding Source: UniProtKB-KW
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  • carpel development Source: TAIR
  • leaf formation Source: TAIR
  • leaf shaping Source: TAIR
  • leaf vascular tissue pattern formation Source: TAIR
  • meristem structural organization Source: TAIR
  • protein folding Source: InterPro
  • regulation of flower development Source: TAIR
  • regulation of histone methylation Source: TAIR
  • regulation of root meristem growth Source: TAIR
  • sepal formation Source: TAIR
  • stamen development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Enzyme and pathway databases

BioCyciARA:AT3G44600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP71 (EC:5.2.1.8)
Short name:
PPIase CYP71
Alternative name(s):
Cyclophilin of 71 kDa
Cyclophilin-71
Gene namesi
Name:CYP71
Ordered Locus Names:At3g44600
ORF Names:F14L2.150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G44600.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Bushy and stunted stature.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Peptidyl-prolyl cis-trans isomerase CYP71PRO_0000429943Add
BLAST

Proteomic databases

PaxDbiQ8W4D0.
PRIDEiQ8W4D0.

PTM databases

iPTMnetiQ8W4D0.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in the meristems.3 Publications

Inductioni

Down-regulated by auxin treatment.1 Publication

Gene expression databases

GenevisibleiQ8W4D0. AT.

Interactioni

Subunit structurei

Interacts with FAS1, LHP1 and (via WD repeat domain) with histone H3.2 Publications

GO - Molecular functioni

  • histone binding Source: TAIR

Protein-protein interaction databases

BioGridi8905. 3 interactions.
STRINGi3702.AT3G44600.1.

Structurei

3D structure databases

ProteinModelPortaliQ8W4D0.
SMRiQ8W4D0. Positions 69-297, 338-371, 476-628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati68 – 10639WD 1Add
BLAST
Repeati111 – 15040WD 2Add
BLAST
Repeati201 – 24040WD 3Add
BLAST
Repeati257 – 29741WD 4Add
BLAST
Domaini474 – 628155PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 304Poly-Glu
Compositional biasi403 – 4064Poly-Ala

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0882. Eukaryota.
ENOG410XQB4. LUCA.
HOGENOMiHOG000213214.
InParanoidiQ8W4D0.
KOiK12736.
OMAiPMPSEQS.
OrthoDBiEOG093604NO.
PhylomeDBiQ8W4D0.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8W4D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEESKNGGT TIPTEELAVV AVPPVVEEEE PMVGPGPAPR GKRKRPLQFE
60 70 80 90 100
QAYLDSLPSA NMYEKSYMHR DVVTHVAVSA AEFFISGSMD GHLKFWKKKG
110 120 130 140 150
VGIEFAKHFR SHLGPIEGLA VSIDGLLCCT ISNDHAVKIY DVVNYDMMAM
160 170 180 190 200
IRLPYIPGAV EWVYKQGDVK AKLAVSDRDS LFVHIYDPRS GSNEPIASKE
210 220 230 240 250
IHMNPIKVMK YNPVSDTMIS GDTKGIIEYW SATTLQFPED EVNFKLKSDT
260 270 280 290 300
NLFEIIKCKT TISAIEVSPD GKQFSITAPD RRIRVFWFRT GKLRRVYDES
310 320 330 340 350
LVVAQDLQRS DAPLYRLEAI DFGRRMAVEK ELEKTESAPQ PNAVFDESSN
360 370 380 390 400
FLIYATFLGI KVINLHTNTV ARILGKVESN ERYLRVALYQ GDQGGKKVRK
410 420 430 440 450
IPAAAANVNE SKEPLTDPTI LCCAFKKHRI YMFSRREPEE PEDASQGRDV
460 470 480 490 500
FNEKPAADEL MSVSDIGNSA TTSLPENVIM HTTLGDIHMK LYPEECPKTV
510 520 530 540 550
ENFTTHCRNG YYDNHLFHRV IRGFMIQTGD PLGDGTGGQS IWGREFEDEF
560 570 580 590 600
HKSLRHDRPF TLSMANAGPN TNGSQFFITT VATPWLDNKH TVFGRVVKGM
610 620 630
DVVQGIEKVK TDKNDRPYQD VKILNVTVPK S
Length:631
Mass (Da):70,984
Last modified:March 1, 2002 - v1
Checksum:i15CCAD94C2EA09D4
GO

Sequence cautioni

The sequence CAB88542 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353818 Genomic DNA. Translation: CAB88542.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE77920.1.
AY062653 mRNA. Translation: AAL32731.1.
BT008382 mRNA. Translation: AAP37741.1.
PIRiT48940.
RefSeqiNP_190046.2. NM_114328.3.
UniGeneiAt.27435.

Genome annotation databases

EnsemblPlantsiAT3G44600.1; AT3G44600.1; AT3G44600.
GeneIDi823585.
GrameneiAT3G44600.1; AT3G44600.1; AT3G44600.
KEGGiath:AT3G44600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353818 Genomic DNA. Translation: CAB88542.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE77920.1.
AY062653 mRNA. Translation: AAL32731.1.
BT008382 mRNA. Translation: AAP37741.1.
PIRiT48940.
RefSeqiNP_190046.2. NM_114328.3.
UniGeneiAt.27435.

3D structure databases

ProteinModelPortaliQ8W4D0.
SMRiQ8W4D0. Positions 69-297, 338-371, 476-628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi8905. 3 interactions.
STRINGi3702.AT3G44600.1.

PTM databases

iPTMnetiQ8W4D0.

Proteomic databases

PaxDbiQ8W4D0.
PRIDEiQ8W4D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G44600.1; AT3G44600.1; AT3G44600.
GeneIDi823585.
GrameneiAT3G44600.1; AT3G44600.1; AT3G44600.
KEGGiath:AT3G44600.

Organism-specific databases

TAIRiAT3G44600.

Phylogenomic databases

eggNOGiKOG0882. Eukaryota.
ENOG410XQB4. LUCA.
HOGENOMiHOG000213214.
InParanoidiQ8W4D0.
KOiK12736.
OMAiPMPSEQS.
OrthoDBiEOG093604NO.
PhylomeDBiQ8W4D0.

Enzyme and pathway databases

BioCyciARA:AT3G44600-MONOMER.

Miscellaneous databases

PROiQ8W4D0.

Gene expression databases

GenevisibleiQ8W4D0. AT.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPY71_ARATH
AccessioniPrimary (citable) accession number: Q8W4D0
Secondary accession number(s): Q9LXM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.