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Protein

Peptidyl-prolyl cis-trans isomerase CYP71

Gene

CYP71

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Histone remodeling factor involved in chromatin-based gene silencing. Reinforces H3K27 methylation. Involved in fundamental processes of chromatin assembly and histone modification by mediating the targeting of FAS1 and LHP1 on the chromatin. Required for the formation and development of leaves, for normal phyllotaxy and for the formation, maintenance and activity of root and shoot apical meristems.2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • chromatin binding Source: TAIR
  • histone binding Source: TAIR
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  • carpel development Source: TAIR
  • leaf formation Source: TAIR
  • leaf shaping Source: TAIR
  • leaf vascular tissue pattern formation Source: TAIR
  • meristem structural organization Source: TAIR
  • regulation of flower development Source: TAIR
  • regulation of histone methylation Source: TAIR
  • regulation of root meristem growth Source: TAIR
  • sepal formation Source: TAIR
  • stamen development Source: TAIR

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-ATH-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP71 (EC:5.2.1.8)
Short name:
PPIase CYP71
Alternative name(s):
Cyclophilin of 71 kDa
Cyclophilin-71
Gene namesi
Name:CYP71
Ordered Locus Names:At3g44600
ORF Names:F14L2.150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G44600
TAIRilocus:2076003 AT3G44600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Bushy and stunted stature.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004299431 – 631Peptidyl-prolyl cis-trans isomerase CYP71Add BLAST631

Proteomic databases

PaxDbiQ8W4D0

PTM databases

iPTMnetiQ8W4D0

Expressioni

Tissue specificityi

Ubiquitous. Expressed in the meristems.3 Publications

Inductioni

Down-regulated by auxin treatment.1 Publication

Gene expression databases

ExpressionAtlasiQ8W4D0 baseline and differential
GenevisibleiQ8W4D0 AT

Interactioni

Subunit structurei

Interacts with FAS1, LHP1 and (via WD repeat domain) with histone H3.2 Publications

GO - Molecular functioni

  • histone binding Source: TAIR

Protein-protein interaction databases

BioGridi8905, 3 interactors
STRINGi3702.AT3G44600.1

Structurei

3D structure databases

ProteinModelPortaliQ8W4D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 106WD 1Add BLAST39
Repeati111 – 150WD 2Add BLAST40
Repeati201 – 240WD 3Add BLAST40
Repeati257 – 297WD 4Add BLAST41
Domaini474 – 628PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 30Poly-Glu4
Compositional biasi403 – 406Poly-Ala4

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0882 Eukaryota
ENOG410XQB4 LUCA
HOGENOMiHOG000213214
InParanoidiQ8W4D0
KOiK12736
OMAiRFYMFTN
OrthoDBiEOG093604NO
PhylomeDBiQ8W4D0

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00400 WD40, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50891 SSF50891, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q8W4D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEESKNGGT TIPTEELAVV AVPPVVEEEE PMVGPGPAPR GKRKRPLQFE
60 70 80 90 100
QAYLDSLPSA NMYEKSYMHR DVVTHVAVSA AEFFISGSMD GHLKFWKKKG
110 120 130 140 150
VGIEFAKHFR SHLGPIEGLA VSIDGLLCCT ISNDHAVKIY DVVNYDMMAM
160 170 180 190 200
IRLPYIPGAV EWVYKQGDVK AKLAVSDRDS LFVHIYDPRS GSNEPIASKE
210 220 230 240 250
IHMNPIKVMK YNPVSDTMIS GDTKGIIEYW SATTLQFPED EVNFKLKSDT
260 270 280 290 300
NLFEIIKCKT TISAIEVSPD GKQFSITAPD RRIRVFWFRT GKLRRVYDES
310 320 330 340 350
LVVAQDLQRS DAPLYRLEAI DFGRRMAVEK ELEKTESAPQ PNAVFDESSN
360 370 380 390 400
FLIYATFLGI KVINLHTNTV ARILGKVESN ERYLRVALYQ GDQGGKKVRK
410 420 430 440 450
IPAAAANVNE SKEPLTDPTI LCCAFKKHRI YMFSRREPEE PEDASQGRDV
460 470 480 490 500
FNEKPAADEL MSVSDIGNSA TTSLPENVIM HTTLGDIHMK LYPEECPKTV
510 520 530 540 550
ENFTTHCRNG YYDNHLFHRV IRGFMIQTGD PLGDGTGGQS IWGREFEDEF
560 570 580 590 600
HKSLRHDRPF TLSMANAGPN TNGSQFFITT VATPWLDNKH TVFGRVVKGM
610 620 630
DVVQGIEKVK TDKNDRPYQD VKILNVTVPK S
Length:631
Mass (Da):70,984
Last modified:March 1, 2002 - v1
Checksum:i15CCAD94C2EA09D4
GO

Sequence cautioni

The sequence CAB88542 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353818 Genomic DNA Translation: CAB88542.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE77920.1
AY062653 mRNA Translation: AAL32731.1
BT008382 mRNA Translation: AAP37741.1
PIRiT48940
RefSeqiNP_190046.2, NM_114328.4
UniGeneiAt.27435

Genome annotation databases

EnsemblPlantsiAT3G44600.1; AT3G44600.1; AT3G44600
GeneIDi823585
GrameneiAT3G44600.1; AT3G44600.1; AT3G44600
KEGGiath:AT3G44600

Similar proteinsi

Entry informationi

Entry nameiCPY71_ARATH
AccessioniPrimary (citable) accession number: Q8W4D0
Secondary accession number(s): Q9LXM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health