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Q8W491

- U73B3_ARATH

UniProt

Q8W491 - U73B3_ARATH

Protein

UDP-glycosyltransferase 73B3

Gene

UGT73B3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Possesses quercetin 3-O-glucosyltransferase activity in vitro. Also active in vitro on benzoates and benzoate derivatives. Involved in stress or defense responses.3 Publications

    Catalytic activityi

    UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei297 – 2971UDP-glucoseBy similarity

    GO - Molecular functioni

    1. flavonol 3-O-glucosyltransferase activity Source: UniProtKB-EC
    2. quercetin 3-O-glucosyltransferase activity Source: TAIR
    3. UDP-glucosyltransferase activity Source: TAIR

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. response to other organism Source: TAIR

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Plant defense

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glycosyltransferase 73B3 (EC:2.4.1.-)
    Alternative name(s):
    Flavonol 3-O-glucosyltransferase UGT73B3 (EC:2.4.1.91)
    Gene namesi
    Name:UGT73B3
    Ordered Locus Names:At4g34131
    ORF Names:F28A23.120
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G34131.

    Pathology & Biotechi

    Disruption phenotypei

    Decreased resistance to avirulent strains of P.syringae.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481UDP-glycosyltransferase 73B3PRO_0000403936Add
    BLAST

    Proteomic databases

    PaxDbiQ8W491.
    PRIDEiQ8W491.

    Expressioni

    Tissue specificityi

    Expressed in roots and flowers.1 Publication

    Inductioni

    Induced by pathogen infection, by H2O2 and by salicylic acid.1 Publication

    Gene expression databases

    GenevestigatoriQ8W491.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT4G34131.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8W491.
    SMRiQ8W491. Positions 9-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni355 – 3573UDP-glucose bindingBy similarity
    Regioni372 – 3809UDP-glucose bindingBy similarity
    Regioni394 – 3974UDP-glucose bindingBy similarity

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Phylogenomic databases

    eggNOGiNOG263906.
    HOGENOMiHOG000237565.
    InParanoidiQ8W491.
    OMAiETSGANF.
    PhylomeDBiQ8W491.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8W491-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDPHRKLH VVFFPFMAYG HMIPTLDMAK LFSSRGAKST ILTTPLNSKI    50
    FQKPIERFKN LNPSFEIDIQ IFDFPCVDLG LPEGCENVDF FTSNNNDDRQ 100
    YLTLKFFKST RFFKDQLEKL LETTRPDCLI ADMFFPWATE AAEKFNVPRL 150
    VFHGTGYFSL CSEYCIRVHN PQNIVASRYE PFVIPDLPGN IVITQEQIAD 200
    RDEESEMGKF MIEVKESDVK SSGVIVNSFY ELEPDYADFY KSVVLKRAWH 250
    IGPLSVYNRG FEEKAERGKK ASINEVECLK WLDSKKPDSV IYISFGSVAC 300
    FKNEQLFEIA AGLETSGANF IWVVRKNIGI EKEEWLPEGF EERVKGKGMI 350
    IRGWAPQVLI LDHQATCGFV THCGWNSLLE GVAAGLPMVT WPVAAEQFYN 400
    EKLVTQVLRT GVSVGAKKNV RTTGDFISRE KVVKAVREVL VGEEADERRE 450
    RAKKLAEMAK AAVEGGSSFN DLNSFIEEFT S 481
    Length:481
    Mass (Da):54,591
    Last modified:March 1, 2002 - v1
    Checksum:iFAE0484361DD072A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL161584 Genomic DNA. No translation available.
    CP002687 Genomic DNA. Translation: AEE86327.1.
    AY062753 mRNA. Translation: AAL32831.1.
    AY114680 mRNA. Translation: AAM47999.1.
    RefSeqiNP_567953.1. NM_119574.3.
    UniGeneiAt.27243.
    At.68482.

    Genome annotation databases

    EnsemblPlantsiAT4G34131.1; AT4G34131.1; AT4G34131.
    GeneIDi829559.
    KEGGiath:AT4G34131.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL161584 Genomic DNA. No translation available.
    CP002687 Genomic DNA. Translation: AEE86327.1 .
    AY062753 mRNA. Translation: AAL32831.1 .
    AY114680 mRNA. Translation: AAM47999.1 .
    RefSeqi NP_567953.1. NM_119574.3.
    UniGenei At.27243.
    At.68482.

    3D structure databases

    ProteinModelPortali Q8W491.
    SMRi Q8W491. Positions 9-481.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT4G34131.1-P.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi Q8W491.
    PRIDEi Q8W491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G34131.1 ; AT4G34131.1 ; AT4G34131 .
    GeneIDi 829559.
    KEGGi ath:AT4G34131.

    Organism-specific databases

    TAIRi AT4G34131.

    Phylogenomic databases

    eggNOGi NOG263906.
    HOGENOMi HOG000237565.
    InParanoidi Q8W491.
    OMAi ETSGANF.
    PhylomeDBi Q8W491.

    Gene expression databases

    Genevestigatori Q8W491.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of Arabidopsis thaliana."
      Li Y., Baldauf S., Lim E.K., Bowles D.J.
      J. Biol. Chem. 276:4338-4343(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.
    5. "The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates."
      Lim E.K., Doucet C.J., Li Y., Elias L., Worrall D., Spencer S.P., Ross J., Bowles D.J.
      J. Biol. Chem. 277:586-592(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides."
      Lim E.K., Ashford D.A., Hou B., Jackson R.G., Bowles D.J.
      Biotechnol. Bioeng. 87:623-631(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Pathogen-responsive expression of glycosyltransferase genes UGT73B3 and UGT73B5 is necessary for resistance to Pseudomonas syringae pv tomato in Arabidopsis."
      Langlois-Meurinne M., Gachon C.M., Saindrenan P.
      Plant Physiol. 139:1890-1901(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, INDUCTION BY PATHOGEN AND SALICYLIC ACID.

    Entry informationi

    Entry nameiU73B3_ARATH
    AccessioniPrimary (citable) accession number: Q8W491
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3