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Protein

Beta-amyrin synthase

Gene

OSCBPY

Organism
Betula platyphylla (Asian white birch)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase converting oxidosqualene into beta-amyrin, generating five rings and eight asymmetric centers in a single transformation.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.1 Publication

GO - Molecular functioni

  • beta-amyrin synthase activity Source: UniProtKB

GO - Biological processi

  • pentacyclic triterpenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BRENDAi5.4.99.39. 9789.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-amyrin synthase (EC:5.4.99.39)
Gene namesi
Name:OSCBPY
OrganismiBetula platyphylla (Asian white birch)
Taxonomic identifieri78630 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Beta-amyrin synthasePRO_0000413997Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8W3Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18942PFTB 1Add
BLAST
Repeati514 – 55643PFTB 2Add
BLAST
Repeati640 – 68142PFTB 3Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 3 PFTB repeats.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8W3Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLKIADGG SDPYIYSTNN FVGRQTWEFD PQAGSPQERA EVEEARRNFY
60 70 80 90 100
DNRYQVKPSG DLLWRMQFLK EKNFKQTIPP VKVEDGEEIT YEKSTAALRR
110 120 130 140 150
AVHFYSALQA SDGHWPAENA GPLFFLPPLV MCMYITGHLN TVFPAEHQKE
160 170 180 190 200
ILRYIYYHQN EDGGWGLHIE GHSTMFCTAL SYICMRILGE GPDGGQDNAC
210 220 230 240 250
ARARKWILDH GGVTHMPSWG KTWLSILGIF EWIGSNPMPP EFWILPSFLP
260 270 280 290 300
MHPAKMWCYC RMVYMPMSYL YGKRFVGPIT PLILQLREEL YTQPYHQVNW
310 320 330 340 350
KKVRHLCAKE DIYYPHPLIQ DLLWDSLYIF TEPLLTRWPF NKLVREKALQ
360 370 380 390 400
VTMKHIHYED ENSRYITIGC VEKVLCMLAC WVEDPNGDYF KKHIARIPDY
410 420 430 440 450
IWVAEDGIKM QSFGSQEWDT GFAIQALLAS NLTDEIGPTL ARGHDFIKKS
460 470 480 490 500
QVKDNPSGDF ESMHRHISKG SWTFSDQDHG WQVSDCTAEG LKCCLLFSIM
510 520 530 540 550
PPEIVGEKME PEQLYDSVNV LLSLQSKNGG LAAWEPAGAQ EWLELLNSTE
560 570 580 590 600
FFADIVIEHE YIECTASAMQ TLVLFKKLYP GHRKKEIENF IKNAAQFLQV
610 620 630 640 650
IQMPDGSWYG NWGVCFTYGT WFALGGLAAV GKTYNNCLAV RRAVDFLLRA
660 670 680 690 700
QRDNGGWGES YLSCPKKEYV PLEGNKSNLV HTAWAMMGLI HAGQAERDPT
710 720 730 740 750
PLHRAAKLII NSQLEDGDFP QQEITGVFMK NCMLHYAAYK NIYPLWALAE
760 770
YRKHVPLPLG KNLNQVVNCI GQSLYKKYK
Length:779
Mass (Da):89,558
Last modified:March 1, 2002 - v1
Checksum:i2719195638B22B58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055512 mRNA. Translation: BAB83088.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055512 mRNA. Translation: BAB83088.1.

3D structure databases

ProteinModelPortaliQ8W3Z1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi5.4.99.39. 9789.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants."
    Zhang H., Shibuya M., Yokota S., Ebizuka Y.
    Biol. Pharm. Bull. 26:642-650(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiBAMS_BETPL
AccessioniPrimary (citable) accession number: Q8W3Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: March 1, 2002
Last modified: January 20, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.