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Protein

Ubiquitin-like domain-containing CTD phosphatase

Gene

At4g06599

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Ordered Locus Names:At4g06599
ORF Names:T11G11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G06599.
TAIRilocus:1005716300. AT4G06599.

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalizes with nuclear proteasomes.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059411 – 340Ubiquitin-like domain-containing CTD phosphataseAdd BLAST340

Proteomic databases

PaxDbiQ8W3M6.
PRIDEiQ8W3M6.

Expressioni

Gene expression databases

ExpressionAtlasiQ8W3M6. baseline.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G06599.1.

Structurei

3D structure databases

ProteinModelPortaliQ8W3M6.
SMRiQ8W3M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 101Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78
Domaini151 – 312FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 312PhosphataseBy similarityAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
COG5190. LUCA.
HOGENOMiHOG000231279.
InParanoidiQ8W3M6.
KOiK17618.
OMAiFKLMMVG.
OrthoDBiEOG09360FVA.
PhylomeDBiQ8W3M6.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiView protein in PROSITE
PS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8W3M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSSPTP SAAAAVSPLT EEELTLTVKW NGKEYTVRIC ADDSVAELKR
60 70 80 90 100
RICLLTTVLP KRQKLLYPKI GNKLSDDSLL LSSISFKPSL KMTMIGTVED
110 120 130 140 150
DIIVDQAESP EIVDDFELGK EEAVDVKDKE VNKQKLRRRI DQYKINLRTP
160 170 180 190 200
CRQGKKLLVL DIDYTLFDHR STAENPLQLM RPYLHEFLTA AYAEYDIMIW
210 220 230 240 250
SATSMKWVEL KMTELGVLNN PNYKVTALLD HLAMITVQSD TRGIFDCKPL
260 270 280 290 300
GLIWALLPEF YNPGNTIMFD DLRRNFVMNP QNGLTIKPFR KAHANRDTDQ
310 320 330 340
ELVKLTQYLL TIAELSDLSS LHHSRWESFS QDNVKRRRQE
Length:340
Mass (Da):38,956
Last modified:March 1, 2002 - v1
Checksum:i1B9D23EF3E424382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073160 Genomic DNA. Translation: BAB83612.1.
CP002687 Genomic DNA. Translation: AEE82552.1.
RefSeqiNP_849320.1. NM_178989.3.
UniGeneiAt.23843.
At.44411.

Genome annotation databases

EnsemblPlantsiAT4G06599.1; AT4G06599.1; AT4G06599.
GeneIDi826068.
GrameneiAT4G06599.1; AT4G06599.1; AT4G06599.
KEGGiath:AT4G06599.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBCP_ARATH
AccessioniPrimary (citable) accession number: Q8W3M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names