Q8W3M6 (UBCP_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like domain-containing CTD phosphatase
EC=3.1.3.16

Alternative name(s):
Nuclear proteasome inhibitor UBLCP1

Gene names

Ordered Locus Names:	At4g06599
ORF Names:	T11G11

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.
Domain	The Ubiquitin-like domain mediates interaction with proteasomes By similarity.
Sequence similarities	Contains 1 FCP1 homology domain. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Ubiquitin-like domain-containing CTD phosphatase		PRO_0000305941
Regions
	Domain	24 – 101	78	Ubiquitin-like
	Domain	151 – 312	162	FCP1 homology
	Region	151 – 312	162	Phosphatase By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8W3M6 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 1B9D23EF3E424382	FASTA	340	38,956
	10 20 30 40 50 60 MASSSSSPTP SAAAAVSPLT EEELTLTVKW NGKEYTVRIC ADDSVAELKR RICLLTTVLP 70 80 90 100 110 120 KRQKLLYPKI GNKLSDDSLL LSSISFKPSL KMTMIGTVED DIIVDQAESP EIVDDFELGK 130 140 150 160 170 180 EEAVDVKDKE VNKQKLRRRI DQYKINLRTP CRQGKKLLVL DIDYTLFDHR STAENPLQLM 190 200 210 220 230 240 RPYLHEFLTA AYAEYDIMIW SATSMKWVEL KMTELGVLNN PNYKVTALLD HLAMITVQSD 250 260 270 280 290 300 TRGIFDCKPL GLIWALLPEF YNPGNTIMFD DLRRNFVMNP QNGLTIKPFR KAHANRDTDQ 310 320 330 340 ELVKLTQYLL TIAELSDLSS LHHSRWESFS QDNVKRRRQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4." Kumekawa N., Hosouchi T., Tsuruoka H., Kotani H. DNA Res. 8:285-290(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB073160 Genomic DNA. Translation: BAB83612.1. CP002687 Genomic DNA. Translation: AEE82552.1.
IPI	IPI00540176.
RefSeq	NP_849320.1. NM_178989.3.
UniGene	At.23843. At.44411.
3D structure databases
ProteinModelPortal	Q8W3M6.
SMR	Q8W3M6. Positions 22-329.
ModBase	Search...
Proteomic databases
PaxDb	Q8W3M6.
PRIDE	Q8W3M6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT4G06599.1; AT4G06599.1; AT4G06599.
GeneID	826068.
KEGG	ath:AT4G06599.
Organism-specific databases
TAIR	At4g06599.
Phylogenomic databases
eggNOG	NOG310886.
HOGENOM	HOG000231279.
InParanoid	Q8W3M6.
KO	K01090.
OMA	KWIDAKM.
PhylomeDB	Q8W3M6.
ProtClustDB	CLSN2690761.
Gene expression databases
Genevestigator	Q8W3M6.
Family and domain databases
Gene3D	3.40.50.1000. 1 hit.
InterPro	IPR023214. HAD-like_dom. IPR011943. HAD-SF_hydro_IIID. IPR004274. NIF. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. [Graphical view]
Pfam	PF03031. NIF. 1 hit. PF00240. ubiquitin. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. SM00213. UBQ. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR02245. HAD_IIID1. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBCP_ARATH

Accession

Primary (citable) accession number: Q8W3M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program