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Q8W3M6

- UBCP_ARATH

UniProt

Q8W3M6 - UBCP_ARATH

Protein

Ubiquitin-like domain-containing CTD phosphatase

Gene

At4g06599

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciARA:AT4G06599-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like domain-containing CTD phosphatase (EC:3.1.3.16)
    Alternative name(s):
    Nuclear proteasome inhibitor UBLCP1
    Gene namesi
    Ordered Locus Names:At4g06599
    ORF Names:T11G11
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G06599.

    Subcellular locationi

    Nucleus By similarity
    Note: Colocalizes with nuclear proteasomes.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Ubiquitin-like domain-containing CTD phosphatasePRO_0000305941Add
    BLAST

    Proteomic databases

    PaxDbiQ8W3M6.
    PRIDEiQ8W3M6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8W3M6.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT4G06599.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8W3M6.
    SMRiQ8W3M6. Positions 22-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 10178Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 312162FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni151 – 312162PhosphataseBy similarityAdd
    BLAST

    Domaini

    The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

    Sequence similaritiesi

    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG310886.
    HOGENOMiHOG000231279.
    InParanoidiQ8W3M6.
    KOiK17618.
    OMAiELNPPRE.
    PhylomeDBiQ8W3M6.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8W3M6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSSSSPTP SAAAAVSPLT EEELTLTVKW NGKEYTVRIC ADDSVAELKR    50
    RICLLTTVLP KRQKLLYPKI GNKLSDDSLL LSSISFKPSL KMTMIGTVED 100
    DIIVDQAESP EIVDDFELGK EEAVDVKDKE VNKQKLRRRI DQYKINLRTP 150
    CRQGKKLLVL DIDYTLFDHR STAENPLQLM RPYLHEFLTA AYAEYDIMIW 200
    SATSMKWVEL KMTELGVLNN PNYKVTALLD HLAMITVQSD TRGIFDCKPL 250
    GLIWALLPEF YNPGNTIMFD DLRRNFVMNP QNGLTIKPFR KAHANRDTDQ 300
    ELVKLTQYLL TIAELSDLSS LHHSRWESFS QDNVKRRRQE 340
    Length:340
    Mass (Da):38,956
    Last modified:March 1, 2002 - v1
    Checksum:i1B9D23EF3E424382
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073160 Genomic DNA. Translation: BAB83612.1.
    CP002687 Genomic DNA. Translation: AEE82552.1.
    RefSeqiNP_849320.1. NM_178989.3.
    UniGeneiAt.23843.
    At.44411.

    Genome annotation databases

    EnsemblPlantsiAT4G06599.1; AT4G06599.1; AT4G06599.
    GeneIDi826068.
    KEGGiath:AT4G06599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073160 Genomic DNA. Translation: BAB83612.1 .
    CP002687 Genomic DNA. Translation: AEE82552.1 .
    RefSeqi NP_849320.1. NM_178989.3.
    UniGenei At.23843.
    At.44411.

    3D structure databases

    ProteinModelPortali Q8W3M6.
    SMRi Q8W3M6. Positions 22-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT4G06599.1-P.

    Proteomic databases

    PaxDbi Q8W3M6.
    PRIDEi Q8W3M6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G06599.1 ; AT4G06599.1 ; AT4G06599 .
    GeneIDi 826068.
    KEGGi ath:AT4G06599.

    Organism-specific databases

    TAIRi AT4G06599.

    Phylogenomic databases

    eggNOGi NOG310886.
    HOGENOMi HOG000231279.
    InParanoidi Q8W3M6.
    KOi K17618.
    OMAi ELNPPRE.
    PhylomeDBi Q8W3M6.

    Enzyme and pathway databases

    BioCyci ARA:AT4G06599-MONOMER.

    Miscellaneous databases

    PROi Q8W3M6.

    Gene expression databases

    Genevestigatori Q8W3M6.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4."
      Kumekawa N., Hosouchi T., Tsuruoka H., Kotani H.
      DNA Res. 8:285-290(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiUBCP_ARATH
    AccessioniPrimary (citable) accession number: Q8W3M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3