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Protein

Transcription factor HY5-like

Gene

HYH

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that promotes photomorphogenesis in light. Acts downstream of the light receptor network and directly affects transcription of light-induced genes. Specifically involved in the blue light specific pathway, suggesting that it participates in transmission of cryptochromes (CRY1 and CRY2) signals to downstream responses. In darkness, its degradation prevents the activation of light-induced genes.1 Publication

GO - Molecular functioni

GO - Biological processi

  • red, far-red light phototransduction Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: GO_Central
  • response to karrikin Source: TAIR
  • response to UV-B Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processPhytochrome signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HY5-like
Alternative name(s):
HY5 homolog
bZIP transcription factor 641 Publication
Short name:
AtbZIP641 Publication
Gene namesi
Name:HYH
Synonyms:BZIP641 Publication
Ordered Locus Names:At3g17609
ORF Names:MKP6.27
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRilocus:1005716533. AT3G17609.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31 – 32VP → AA: Abolishes interaction with COP1. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765621 – 149Transcription factor HY5-likeAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by COP1. Ubiquitination takes place in darkness and leads to its subsequent degradation, thereby preventing the activation of photomorphogenesis signals.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8W191.

Expressioni

Gene expression databases

ExpressionAtlasiQ8W191. baseline and differential.
GenevisibleiQ8W191. AT.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with HY5 via the leucine-zipper domains. Interacts with COP1 WD40 domain (PubMed:12023303). Interacts with BBX24/STO and BBX25/STH (PubMed:23733077).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COP1P432543EBI-11463635,EBI-301649

Protein-protein interaction databases

BioGridi6360. 5 interactors.
IntActiQ8W191. 3 interactors.
MINTiMINT-238318.
STRINGi3702.AT3G17609.2.

Structurei

3D structure databases

ProteinModelPortaliQ8W191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 141bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 36Interaction with COP11 PublicationAdd BLAST14
Regioni80 – 100Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni106 – 134Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000272717.
OMAiLTNENTM.
OrthoDBiEOG09360WFY.
PhylomeDBiQ8W191.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8W191-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLQRPNGNS SSSSSHKKHK TEESDEELLM VPDMEAAGST CVLSSSADDG
60 70 80 90 100
VNNPELDQTQ NGVSTAKRRR GRNPVDKEYR SLKRLLRNRV SAQQARERKK
110 120 130 140
VYVSDLESRA NELQNNNDQL EEKISTLTNE NTMLRKMLIN TRPKTDDNH
Length:149
Mass (Da):16,899
Last modified:March 1, 2002 - v1
Checksum:iFCAA23AFBED351B6
GO
Isoform 2 (identifier: Q8W191-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-35: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):15,251
Checksum:iAEB732EE32A88386
GO

Sequence cautioni

The sequence BAB02051 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At3g17610 has been split into 2 genes: At3g17609 and At3g17611.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01201122 – 35Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453477 mRNA. Translation: AAL57834.1.
AB022219 Genomic DNA. Translation: BAB02051.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75974.1.
CP002686 Genomic DNA. Translation: AEE75975.1.
AY087436 mRNA. Translation: AAM64982.1.
AK175440 mRNA. Translation: BAD43203.1.
AK175523 mRNA. Translation: BAD43286.1.
RefSeqiNP_850604.1. NM_180273.2. [Q8W191-2]
NP_850605.1. NM_180274.3. [Q8W191-1]
UniGeneiAt.28302.

Genome annotation databases

EnsemblPlantsiAT3G17609.2; AT3G17609.2; AT3G17609. [Q8W191-1]
GeneIDi821027.
GrameneiAT3G17609.2; AT3G17609.2; AT3G17609.
KEGGiath:AT3G17609.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453477 mRNA. Translation: AAL57834.1.
AB022219 Genomic DNA. Translation: BAB02051.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75974.1.
CP002686 Genomic DNA. Translation: AEE75975.1.
AY087436 mRNA. Translation: AAM64982.1.
AK175440 mRNA. Translation: BAD43203.1.
AK175523 mRNA. Translation: BAD43286.1.
RefSeqiNP_850604.1. NM_180273.2. [Q8W191-2]
NP_850605.1. NM_180274.3. [Q8W191-1]
UniGeneiAt.28302.

3D structure databases

ProteinModelPortaliQ8W191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi6360. 5 interactors.
IntActiQ8W191. 3 interactors.
MINTiMINT-238318.
STRINGi3702.AT3G17609.2.

Proteomic databases

PaxDbiQ8W191.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G17609.2; AT3G17609.2; AT3G17609. [Q8W191-1]
GeneIDi821027.
GrameneiAT3G17609.2; AT3G17609.2; AT3G17609.
KEGGiath:AT3G17609.

Organism-specific databases

AraportiAT3G17609.
TAIRilocus:1005716533. AT3G17609.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000272717.
OMAiLTNENTM.
OrthoDBiEOG09360WFY.
PhylomeDBiQ8W191.

Miscellaneous databases

PROiPR:Q8W191.

Gene expression databases

ExpressionAtlasiQ8W191. baseline and differential.
GenevisibleiQ8W191. AT.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHYH_ARATH
AccessioniPrimary (citable) accession number: Q8W191
Secondary accession number(s): Q8LB41, Q9LUN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.