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Protein

Aquaporin NIP2-1

Gene

NIP2-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Low water transport activity in yeast cells.1 Publication

GO - Molecular functioni

  • lactate transmembrane transporter activity Source: TAIR
  • water channel activity Source: GO_Central

GO - Biological processi

  • lactate transport Source: TAIR
  • response to hypoxia Source: TAIR

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi1.A.8.12.4. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin NIP2-1
Alternative name(s):
NOD26-like intrinsic protein 2-1
Short name:
AtNIP2;1
Nodulin-26-like major intrinsic protein 4
Short name:
NodLikeMip4
Short name:
Protein NLM4
Gene namesi
Name:NIP2-1
Synonyms:NLM4
Ordered Locus Names:At2g34390
ORF Names:T31E10.27
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G34390.
TAIRilocus:2040904. AT2G34390.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640641 – 288Aquaporin NIP2-1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei278PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8W037.

Expressioni

Tissue specificityi

Specifically expressed in roots with high expression in root elongation zone and root stele.1 Publication

Gene expression databases

ExpressionAtlasiQ8W037. baseline and differential.
GenevisibleiQ8W037. AT.

Interactioni

Protein-protein interaction databases

BioGridi3349. 24 interactors.
STRINGi3702.AT2G34390.1.

Structurei

3D structure databases

ProteinModelPortaliQ8W037.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi106 – 108NPA 13
Motifi225 – 227NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288286.
InParanoidiQ8W037.
KOiK09874.
OMAiNAEPEFS.
OrthoDBiEOG09360N7X.
PhylomeDBiQ8W037.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8W037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDISVSKSN HGNVVVLNIK ASSLADTSLP SNKHESSSPP LLSVHFLQKL
60 70 80 90 100
LAELVGTYYL IFAGCAAIAV NAQHNHVVTL VGIAVVWGIV IMVLVYCLGH
110 120 130 140 150
LSAHFNPAVT LALASSQRFP LNQVPAYITV QVIGSTLASA TLRLLFDLNN
160 170 180 190 200
DVCSKKHDVF LGSSPSGSDL QAFVMEFIIT GFLMLVVCAV TTTKRTTEEL
210 220 230 240 250
EGLIIGATVT LNVIFAGEVS GASMNPARSI GPALVWGCYK GIWIYLLAPT
260 270 280
LGAVSGALIH KMLPSIQNAE PEFSKTGSSH KRVTDLPL
Length:288
Mass (Da):30,581
Last modified:June 27, 2003 - v2
Checksum:i909D0990C3CFE785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276475 mRNA. Translation: CAC81707.2.
AC004077 Genomic DNA. Translation: AAC26712.1.
AC004481 Genomic DNA. Translation: AAM14952.1.
CP002685 Genomic DNA. Translation: AEC08967.1.
BT025726 mRNA. Translation: ABF82629.1.
PIRiT02327.
RefSeqiNP_180986.1. NM_128991.5.
UniGeneiAt.38427.

Genome annotation databases

EnsemblPlantsiAT2G34390.1; AT2G34390.1; AT2G34390.
GeneIDi818002.
GrameneiAT2G34390.1; AT2G34390.1; AT2G34390.
KEGGiath:AT2G34390.

Similar proteinsi

Entry informationi

Entry nameiNIP21_ARATH
AccessioniPrimary (citable) accession number: Q8W037
Secondary accession number(s): O64706, Q1ECK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 27, 2003
Last modified: August 30, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families