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Reviewed, UniProtKB/Swiss-Prot Q8VZZ4 (AB6C_ARATH)

Last modified February 9, 2010. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ABC transporter C family member 6
      Short name=ABC transporter ABCC.6
      Short name=AtABCC6
    EC=3.6.3.44
Alternative name(s):
    Multidrug resistance-associated protein 8
    Glutathione S-conjugate-transporting ATPase 8
    ATP-energized glutathione S-conjugate pump 8
Gene names
Name: ABCC6
Synonyms: MRP6, MRP8
Ordered Locus Names: At3g13090
ORF Names: MJG19.4
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length1466 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Pump for glutathione S-conjugates By similarity.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.5

Induction

By salicylic acid (SA). Ref.5

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence caution

The sequence BAB01400.1 differs from that shown. Reason: Erroneous gene model prediction.

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Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay. Source: TAIR

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14661466ABC transporter C family member 6
PRO_0000226079

Regions

Transmembrane16 – 3621 Potential
Transmembrane63 – 8321 Potential
Transmembrane91 – 11121 Potential
Transmembrane128 – 14821 Potential
Transmembrane158 – 17821 Potential
Transmembrane286 – 30621 Potential
Transmembrane322 – 33918 Potential
Transmembrane400 – 42021 Potential
Transmembrane425 – 44521 Potential
Transmembrane512 – 53221 Potential
Transmembrane890 – 91021 Potential
Transmembrane937 – 95721 Potential
Transmembrane1026 – 104621 Potential
Domain286 – 567282ABC transmembrane type-1 1
Domain601 – 824224ABC transporter 1
Domain900 – 1182283ABC transmembrane type-1 2
Domain1219 – 1453235ABC transporter 2
Nucleotide binding636 – 6438ATP 1 Potential
Nucleotide binding1253 – 12608ATP 2 Potential

Experimental info

Sequence conflict2431L → V in AAL14776. Ref.1
Sequence conflict6121D → E in AAL14776. Ref.1
Sequence conflict8091H → N in AAL14776. Ref.1
Sequence conflict8531L → I in AAL14776. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q8VZZ4-1 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: 4DF808FB31E57532

FASTA1,466164,401
        10         20         30         40         50         60 
MENPIDSLLL QPIYLSVLSF FLNLVLLLIL FGSWLFKKRV ACEDTDAIMN EEFKHISFSY 

        70         80         90        100        110        120 
NKLVLICCVS LSVFYSVLSL LSCLHWHTNG WPFLDLLLAA LTWGSISVYL FGRYTNSCEQ 

       130        140        150        160        170        180 
KVLFLLRVWW VFFFVVSCYH LVVDFVLYKK QEMVSVHFVI SDLVGVCAGL FLCCSCLWKK 

       190        200        210        220        230        240 
GEGERIDLLK EPLLSSAESS DNEEVTAPFS KAGILSRMSF SWMSPLITLG NEKIIDIKDV 

       250        260        270        280        290        300 
PQLDRSDTTE SLFWIFRSKL EWDDGERRIT TFKLIKALFL SVWRDIVLSA LLAFVYTVSC 

       310        320        330        340        350        360 
YVAPYLMDNF VQYLNGNRQY KNQGYVLVTT FFVAKLVECQ TQRQWFFRGQ KAGLGMRSVL 

       370        380        390        400        410        420 
VSMIYEKGLT LPCHSKQGHT SGEIINLMAV DADRISAFSW FMHDPWILVL QVSLALWILY 

       430        440        450        460        470        480 
KSLGLGSIAA FPATILVMLA NYPFAKLEEK FQSSLMKSKD NRMKKTSEVL LNMKILKLQG 

       490        500        510        520        530        540 
WEMKFLSKIL ELRHIEAGWL KKFVYNSSAI NSVLWAAPSF ISATAFGACL LLKIPLESGK 

       550        560        570        580        590        600 
ILAALATFRI LQGPIYKLPE TISMIVQTKV SLNRIASFLC LDDLQQDVVG RLPSGSSEMA 

       610        620        630        640        650        660 
VEISNGTFSW DDSSPIPTLR DMNFKVSQGM NVAICGTVGS GKSSLLSSIL GEVPKISGNL 

       670        680        690        700        710        720 
KVCGRKAYIA QSPWIQSGKV EENILFGKPM EREWYDRVLE ACSLNKDLEI LPFHDQTVIG 

       730        740        750        760        770        780 
ERGINLSGGQ KQRIQIARAL YQDADIYLFD DPFSAVDAHT GSHLFKEVLL GLLRHKTVIY 

       790        800        810        820        830        840 
VTHQVEFLPE ADLILVMKDG KITQAGKYHE ILDSGTDFME LVGAHTEALA TIDSCETGYA 

       850        860        870        880        890        900 
SEKSTTDKEN EVLHHKEKQE NGSDNKPSGQ LVQEEEREKG KVGFTVYKKY MALAYGGAVI 

       910        920        930        940        950        960 
PLILVVQVLF QLLSIGSNYW MTWVTPVSKD VEPPVSGFTL ILVYVLLAVA SSFCILIRAL 

       970        980        990       1000       1010       1020 
LVAMTGFKMA TELFTQMHLR IFRASMSFFD ATPMGRILNR ASTDQSVADL RLPGQFAYVA 

      1030       1040       1050       1060       1070       1080 
IAAINILGII GVIVQVAWQV LIVFIPVVAA CAWYRQYYIS AARELARLAG ISRSPVVHHF 

      1090       1100       1110       1120       1130       1140 
SETLSGITTI RSFDQEPRFR GDIMRLSDCY SRLKFHSTGA MEWLCFRLEL LSTFAFASSL 

      1150       1160       1170       1180       1190       1200 
VILVSAPEGV INPSLAGLAI TYALNLNTLQ ATLIWTLCDL ENKMISVERM LQYTNIPSEP 

      1210       1220       1230       1240       1250       1260 
PLVIETTRPE KSWPSRGEIT ICNLQVRYGP HLPMVLHGLT CTFPGGLKTG IVGRTGCGKS 

      1270       1280       1290       1300       1310       1320 
TLIQTLFRIV EPAAGEIRID GINILSIGLH DLRSRLSIIP QDPTMFEGTI RSNLDPLEEY 

      1330       1340       1350       1360       1370       1380 
TDDQIWEALD NCQLGDEVRK KELKLDSPVS ENGQNWSVGQ RQLVCLGRVL LKRSKLLVLD 

      1390       1400       1410       1420       1430       1440 
EATASIDTAT DNLIQETLRH HFADCTVITI AHRISSVIDS DMVLLLDQGL IKEHDSPARL 

      1450       1460 
LEDRSSLFSK FVAEYTTSSE SKSKRS

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References

« Hide 'large scale' references
[1]"AtMRP6, a full size ABC transporter from the multidrug resistance protein subfamily."
Forestier C.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
DNA Res. 7:217-221(2000) [PubMed: 10907853] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-1441.
Strain: cv. Columbia.
[3]"The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[4]"Multifunctionality of plant ABC transporters -- more than just detoxifiers."
Martinoia E., Klein M., Geisler M., Bovet L., Forestier C., Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.
Planta 214:345-355(2002) [PubMed: 11855639] [Abstract]
Cited for: GENE FAMILY.
[5]"Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana."
Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M., Wanke D., Martinoia E., Schulz B.
Planta 216:107-119(2002) [PubMed: 12430019] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION.
[6]"Plant ABC proteins - a unified nomenclature and updated inventory."
Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.
Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY052368 mRNA. Translation: AAL14776.1.
AP000375 Genomic DNA. Translation: BAB01400.1. Sequence problems.
IPIIPI00535534.

3D structure databases

SMRQ8VZZ4. Positions 281-823, 942-1451.
ModBaseSearch...

Proteomic databases

PRIDEQ8VZZ4.

Genome annotation databases

GenomeReviewsGene locus AT3G13090 in contig BA000014_GR.

Organism-specific databases

TAIRAt3g13090.

Phylogenomic databases

eggNOGKOG0054.
HOGENOMHBG758042.
InParanoidQ8VZZ4.
PhylomeDBQ8VZZ4.

Enzyme and pathway databases

BRENDA3.6.3.44. 302.

Gene expression databases

GenevestigatorQ8VZZ4.
GermOnlineAT3G13090. Arabidopsis thaliana.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAB6C_ARATH
AccessionPrimary (citable) accession number: Q8VZZ4
Secondary accession number(s): Q9LK63
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: February 9, 2010
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents