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Protein

Aquaporin NIP1-1

Gene

NIP1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Water channel probably required to promote glycerol permeability and water transport across cell membranes.1 Publication

GO - Molecular functioni

  • arsenite transmembrane transporter activity Source: TAIR
  • glycerol channel activity Source: GO_Central
  • water channel activity Source: TAIR

GO - Biological processi

  • arsenite transport Source: TAIR
  • cellular water homeostasis Source: GO_Central
  • regulation of defense response Source: TAIR
  • response to arsenic-containing substance Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi1.A.8.12.8. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin NIP1-1
Alternative name(s):
NOD26-like intrinsic protein 1-1
Short name:
AtNIP1;1
Nodulin-26-like major intrinsic protein 1
Short name:
NodLikeMip1
Short name:
Protein NLM1
Cleaved into the following chain:
Gene namesi
Name:NIP1-1
Synonyms:NLM1
Ordered Locus Names:At4g19030
ORF Names:F13C5.200
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G19030.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7721Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei84 – 10421Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei249 – 26921Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Aquaporin NIP1-1PRO_0000064062Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 296295Aquaporin NIP1-1, N-terminally processedPRO_0000425774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei286 – 2861PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8VZW1.
PRIDEiQ8VZW1.

Expressioni

Tissue specificityi

Expressed in roots.1 Publication

Gene expression databases

GenevisibleiQ8VZW1. AT.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
At1g44800Q9LPF12EBI-4424378,EBI-4466346
At1g80170Q94AJ52EBI-4424378,EBI-4457426
DWF5Q9LDU62EBI-4424378,EBI-4439540
F3H9.10Q9FZ983EBI-4424378,EBI-4425682
PSBRP272022EBI-4424378,EBI-4461393
SYP31Q9FFK12EBI-4424378,EBI-4434817

Protein-protein interaction databases

BioGridi12934. 184 interactions.
IntActiQ8VZW1. 181 interactions.
STRINGi3702.AT4G19030.1.

Structurei

3D structure databases

ProteinModelPortaliQ8VZW1.
SMRiQ8VZW1. Positions 50-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 1163NPA 1
Motifi233 – 2353NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala/Gly (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288286.
InParanoidiQ8VZW1.
KOiK09874.
OMAiGYGNARE.
OrthoDBiEOG09360N7X.
PhylomeDBiQ8VZW1.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VZW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADISGNGYG NAREEVVMVN LKDEVEHQQE MEDIHNPRPL KKQDSLLSVS
60 70 80 90 100
VPFLQKLIAE FLGTYFLVFT GCASVVVNMQ NDNVVTLPGI AIVWGLTIMV
110 120 130 140 150
LIYSLGHISG AHINPAVTIA FASCGRFPLK QVPAYVISQV IGSTLAAATL
160 170 180 190 200
RLLFGLDHDV CSGKHDVFIG SSPVGSDLQA FTMEFIVTFY LMFIISGVAT
210 220 230 240 250
DNRAIGELAG LAIGSTVLLN VLIAAPVSSA SMNPGRSLGP ALVYGCYKGI
260 270 280 290
WIYLVAPTLG AIAGAWVYNT VRYTDKPLRE ITKSGSFLKT VRIGST
Length:296
Mass (Da):31,715
Last modified:March 1, 2002 - v1
Checksum:i4D66695D9E879C68
GO

Sequence cautioni

The sequence CAA16760 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAA68906 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB78905 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07625 mRNA. Translation: CAA68906.1. Different initiation.
AL021711 Genomic DNA. Translation: CAA16760.2. Sequence problems.
AL161550 Genomic DNA. Translation: CAB78905.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE84127.1.
AY063796 mRNA. Translation: AAL36152.1.
AY117197 mRNA. Translation: AAM51272.1.
AY084497 mRNA. Translation: AAM61066.1.
PIRiH85214.
T05040.
RefSeqiNP_567572.1. NM_118021.3.
UniGeneiAt.5405.

Genome annotation databases

EnsemblPlantsiAT4G19030.1; AT4G19030.1; AT4G19030.
GeneIDi827641.
GrameneiAT4G19030.1; AT4G19030.1; AT4G19030.
KEGGiath:AT4G19030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07625 mRNA. Translation: CAA68906.1. Different initiation.
AL021711 Genomic DNA. Translation: CAA16760.2. Sequence problems.
AL161550 Genomic DNA. Translation: CAB78905.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE84127.1.
AY063796 mRNA. Translation: AAL36152.1.
AY117197 mRNA. Translation: AAM51272.1.
AY084497 mRNA. Translation: AAM61066.1.
PIRiH85214.
T05040.
RefSeqiNP_567572.1. NM_118021.3.
UniGeneiAt.5405.

3D structure databases

ProteinModelPortaliQ8VZW1.
SMRiQ8VZW1. Positions 50-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12934. 184 interactions.
IntActiQ8VZW1. 181 interactions.
STRINGi3702.AT4G19030.1.

Protein family/group databases

TCDBi1.A.8.12.8. the major intrinsic protein (mip) family.

Proteomic databases

PaxDbiQ8VZW1.
PRIDEiQ8VZW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G19030.1; AT4G19030.1; AT4G19030.
GeneIDi827641.
GrameneiAT4G19030.1; AT4G19030.1; AT4G19030.
KEGGiath:AT4G19030.

Organism-specific databases

TAIRiAT4G19030.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288286.
InParanoidiQ8VZW1.
KOiK09874.
OMAiGYGNARE.
OrthoDBiEOG09360N7X.
PhylomeDBiQ8VZW1.

Miscellaneous databases

PROiQ8VZW1.

Gene expression databases

GenevisibleiQ8VZW1. AT.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIP11_ARATH
AccessioniPrimary (citable) accession number: Q8VZW1
Secondary accession number(s): O48595, O49416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.