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Protein

Peroxisomal adenine nucleotide carrier 2

Gene

PNC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Peroxisomal adenine nucleotide transporter catalyzing the counterexchange of ATP with AMP. ATP is needed by reactions that generate acyl-CoA for peroxisomal fatty acid beta-oxidation during postgerminative growth. Required for the beta-oxidation reactions involved in auxin biosynthesis and for the conversion of seed-reserved triacylglycerols into sucrose that is necessary for growth before the onset of photosynthesis.2 Publications

Kineticsi

  1. KM=150 µM for ATP1 Publication

    GO - Molecular functioni

    • ADP transmembrane transporter activity Source: TAIR
    • antiporter activity Source: UniProtKB-KW
    • ATP transmembrane transporter activity Source: TAIR

    GO - Biological processi

    • ADP transport Source: TAIR
    • ATP transport Source: TAIR
    • fatty acid beta-oxidation Source: TAIR
    • indolebutyric acid metabolic process Source: TAIR
    • mitochondrial transport Source: GO_Central

    Keywordsi

    Biological processAntiport, Transport

    Enzyme and pathway databases

    ReactomeiR-ATH-389599 Alpha-oxidation of phytanate

    Protein family/group databases

    TCDBi2.A.29.20.2 the mitochondrial carrier (mc) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal adenine nucleotide carrier 2
    Gene namesi
    Name:PNC2
    Ordered Locus Names:At5g27520
    ORF Names:F15A18, F21A20.230
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 5

    Organism-specific databases

    AraportiAT5G27520
    TAIRilocus:2146355 AT5G27520

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei106 – 126Helical; Name=2Sequence analysisAdd BLAST21
    Transmembranei160 – 180Helical; Name=3Sequence analysisAdd BLAST21
    Transmembranei203 – 223Helical; Name=4Sequence analysisAdd BLAST21
    Transmembranei256 – 276Helical; Name=5Sequence analysisAdd BLAST21
    Transmembranei288 – 308Helical; Name=6Sequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00004206931 – 321Peroxisomal adenine nucleotide carrier 2Add BLAST321

    Proteomic databases

    PaxDbiQ8VZS0
    PRIDEiQ8VZS0

    Expressioni

    Tissue specificityi

    Expressed in stamens, pollen grains, seeds, leaves, cotyledons, roots, stems, flowers, hypocotyls and siliques.1 Publication

    Developmental stagei

    Expressed in the early seedling stage of post-germinative growth.1 Publication

    Gene expression databases

    ExpressionAtlasiQ8VZS0 baseline and differential
    GenevisibleiQ8VZS0 AT

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G27520.1

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VZS0
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Repeati7 – 96Solcar 1Add BLAST90
    Repeati106 – 186Solcar 2Add BLAST81
    Repeati204 – 300Solcar 3Add BLAST97

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi115 – 120Poly-Ala6

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0769 Eukaryota
    ENOG410ZNC0 LUCA
    HOGENOMiHOG000212132
    InParanoidiQ8VZS0
    OMAiYGFFRQR
    OrthoDBiEOG09360J8D
    PhylomeDBiQ8VZS0

    Family and domain databases

    Gene3Di1.50.40.10, 2 hits
    InterProiView protein in InterPro
    IPR018108 Mitochondrial_sb/sol_carrier
    IPR023395 Mt_carrier_dom_sf
    PfamiView protein in Pfam
    PF00153 Mito_carr, 3 hits
    SUPFAMiSSF103506 SSF103506, 1 hit
    PROSITEiView protein in PROSITE
    PS50920 SOLCAR, 3 hits

    Sequencei

    Sequence statusi: Complete.

    Q8VZS0-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MGVDLDLESI SEATSGAIGS LLSTTILYPL DTCKSKFQAE IRVRGQQKYR
    60 70 80 90 100
    YLSDVFWEAI SSGNVLSLYQ GLGTKNLQSF ISSFIYFYSY SYFKRLHSQR
    110 120 130 140 150
    IGSKSIGTKA NLLIAAAAGA CTSVLTQPLD TASSRMQTSE FGKSKGLWKT
    160 170 180 190 200
    LTDGSWGNAF DGLGISLLLT SNPAIQYTVF DQLKQNLLEK GKAKSNKDSS
    210 220 230 240 250
    PVVLSAFMAF VLGAVSKSAA TVITYPAIRC KVMIQAADDS KENEAKKPRK
    260 270 280 290 300
    RIRKTIPGVV YAIWKKEGIL GFFKGLQAQI LKTVLSSALL LMIKEKITAT
    310 320
    TWILILAIRT LFVTKARLKS P
    Length:321
    Mass (Da):35,159
    Last modified:March 1, 2002 - v1
    Checksum:iD8E8E94745E49079
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC007123 Genomic DNA No translation available.
    AC007478 Genomic DNA No translation available.
    CP002688 Genomic DNA Translation: AED93696.1
    AY063892 mRNA Translation: AAL36248.1
    AY122919 mRNA Translation: AAM67452.1
    RefSeqiNP_198104.1, NM_122634.4
    UniGeneiAt.19841

    Genome annotation databases

    EnsemblPlantsiAT5G27520.1; AT5G27520.1; AT5G27520
    GeneIDi832812
    GrameneiAT5G27520.1; AT5G27520.1; AT5G27520
    KEGGiath:AT5G27520

    Similar proteinsi

    Entry informationi

    Entry nameiPNC2_ARATH
    AccessioniPrimary (citable) accession number: Q8VZS0
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
    Last sequence update: March 1, 2002
    Last modified: May 23, 2018
    This is version 110 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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