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Protein

ATP-dependent zinc metalloprotease FTSH 10, mitochondrial

Gene

FTSH10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi592Zinc; catalyticBy similarity1
Active sitei593By similarity1
Metal bindingi596Zinc; catalyticBy similarity1
Metal bindingi668Zinc; catalyticBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi367 – 374ATPSequence analysis8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B20 399

Protein family/group databases

MEROPSiM41.023

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FTSH 10, mitochondrial (EC:3.4.24.-)
Short name:
AtFTSH10
Gene namesi
Name:FTSH10
Ordered Locus Names:At1g07510
ORF Names:F22G5.10, F22G5_9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G07510
TAIRilocus:2025052 AT1G07510

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei139 – 157HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 86MitochondrionSequence analysisAdd BLAST86
ChainiPRO_000034133587 – 813ATP-dependent zinc metalloprotease FTSH 10, mitochondrialAdd BLAST727

Proteomic databases

PaxDbiQ8VZI8
PRIDEiQ8VZI8

Expressioni

Inductioni

By high light.1 Publication

Gene expression databases

ExpressionAtlasiQ8VZI8 baseline and differential
GenevisibleiQ8VZI8 AT

Interactioni

Protein-protein interaction databases

BioGridi22506, 6 interactors
STRINGi3702.AT1G07510.1

Structurei

3D structure databases

ProteinModelPortaliQ8VZI8
SMRiQ8VZI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0731 Eukaryota
COG0465 LUCA
HOGENOMiHOG000217277
InParanoidiQ8VZI8
KOiK08956
OMAiESAQVTM
OrthoDBiEOG093603BD
PhylomeDBiQ8VZI8

Family and domain databases

HAMAPiMF_01458 FtsH, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR005936 FtsH
IPR027417 P-loop_NTPase
IPR011546 Pept_M41_FtsH_extracell
IPR000642 Peptidase_M41
IPR037219 Peptidase_M41-like
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF06480 FtsH_ext, 1 hit
PF01434 Peptidase_M41, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF140990 SSF140990, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01241 FtsH_fam, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VZI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFSKLGSSL ARSSRSKGFV YGGGVRSAVF NQGRLRAPQN LEAAVNQVDG
60 70 80 90 100
GLGFLRRHFA SFAARKGLEA GDLSRAFANP RLRRFFSSQT PKKKNYENYY
110 120 130 140 150
PKDSKKAPKN EQKSESRDGS KKNENENAGD AFSNEYQNML IPLMAIALIL
160 170 180 190 200
STFSLGSREQ QQISFQEFKN KLLEAGLVDH IDVSNKEVAK VYVRSSPKSQ
210 220 230 240 250
TTEEVVQGPG NGVPAKGRGG QYKYYFNIGS VESFEEKLEE AQEAIGVNSH
260 270 280 290 300
DFVPVTYVSE TIWYQELLRF APTLLLVATL IFGARRMQGG LGGLGGPGGK
310 320 330 340 350
AGRGIFNIGK AQITRADKNS KNKIYFKDVA GCEEAKQEIM EFVHFLQNPK
360 370 380 390 400
KYEDLGAKIP KGALLVGPPG TGKTLLAKAT AGESAVPFLS ISGSDFMEMF
410 420 430 440 450
VGVGPSRVRN LFQEARQCAP SIIFIDEIDA IGRARGRGGF SGGNDEREST
460 470 480 490 500
LNQLLVEMDG FGTTAGVVVL AGTNRPDILD KALLRPGRFD RQITIDKPDI
510 520 530 540 550
KGRDQIFQIY LKKIKLDHEP SYYSQRLAAL TPGFAGADIA NVCNEAALIA
560 570 580 590 600
ARHEGATVTM AHFDSAIDRV IGGLEKKNRV ISKLERRTVA YHESGHAVAG
610 620 630 640 650
WFLEHAEPLL KVTIVPRGTA ALGFAQYVPN ENLLMTKEQL FDMTCMTLGG
660 670 680 690 700
RAAEQVLIGR ISTGAQNDLE KVTKMTYAQV AVYGFSDKIG LLSFPQREDE
710 720 730 740 750
FSKPYSNRTG AMIDEEVREW VGKAYKRTVE LIEEHKEQVA QIAELLLEKE
760 770 780 790 800
VLHQDDLTKV LGERPFKSGE TTNYDRFKSG FEESEKESQK ESVPVKPVED
810
DGIPPLEPQV VPT
Length:813
Mass (Da):89,555
Last modified:March 1, 2002 - v1
Checksum:i149D65CC4DC4C7EC
GO

Sequence cautioni

The sequence AAF79577 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti642D → N in BAF01982 (Ref. 4) Curated1
Sequence conflicti675M → L in BAF01982 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022464 Genomic DNA Translation: AAF79577.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28137.1
AY064138 mRNA Translation: AAL36045.1
AY124808 mRNA Translation: AAM70517.1
AK230173 mRNA Translation: BAF01982.1
PIRiH86209
RefSeqiNP_172231.2, NM_100625.4
UniGeneiAt.23339

Genome annotation databases

EnsemblPlantsiAT1G07510.1; AT1G07510.1; AT1G07510
GeneIDi837265
GrameneiAT1G07510.1; AT1G07510.1; AT1G07510
KEGGiath:AT1G07510

Similar proteinsi

Entry informationi

Entry nameiFTSHA_ARATH
AccessioniPrimary (citable) accession number: Q8VZI8
Secondary accession number(s): Q0WLM5, Q9LNX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health