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Protein

ATP-dependent zinc metalloprotease FTSH 10, mitochondrial

Gene

FTSH10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi592 – 5921Zinc; catalyticBy similarity
Active sitei593 – 5931By similarity
Metal bindingi596 – 5961Zinc; catalyticBy similarity
Metal bindingi668 – 6681Zinc; catalyticBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi367 – 3748ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B20. 399.

Protein family/group databases

MEROPSiM41.023.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FTSH 10, mitochondrial (EC:3.4.24.-)
Short name:
AtFTSH10
Gene namesi
Name:FTSH10
Ordered Locus Names:At1g07510
ORF Names:F22G5.10, F22G5_9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G07510.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei139 – 15719HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • chloroplast thylakoid membrane Source: TAIR
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: GO_Central
  • mitochondrion Source: TAIR
  • plastid Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8686MitochondrionSequence analysisAdd
BLAST
Chaini87 – 813727ATP-dependent zinc metalloprotease FTSH 10, mitochondrialPRO_0000341335Add
BLAST

Proteomic databases

PaxDbiQ8VZI8.
PRIDEiQ8VZI8.

Expressioni

Inductioni

By high light.1 Publication

Gene expression databases

GenevisibleiQ8VZI8. AT.

Interactioni

Protein-protein interaction databases

BioGridi22506. 6 interactions.
STRINGi3702.AT1G07510.1.

Structurei

3D structure databases

ProteinModelPortaliQ8VZI8.
SMRiQ8VZI8. Positions 158-261, 323-770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0731. Eukaryota.
COG0465. LUCA.
HOGENOMiHOG000217277.
InParanoidiQ8VZI8.
KOiK08956.
OMAiTKMDKNA.
OrthoDBiEOG093603BD.
PhylomeDBiQ8VZI8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VZI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFSKLGSSL ARSSRSKGFV YGGGVRSAVF NQGRLRAPQN LEAAVNQVDG
60 70 80 90 100
GLGFLRRHFA SFAARKGLEA GDLSRAFANP RLRRFFSSQT PKKKNYENYY
110 120 130 140 150
PKDSKKAPKN EQKSESRDGS KKNENENAGD AFSNEYQNML IPLMAIALIL
160 170 180 190 200
STFSLGSREQ QQISFQEFKN KLLEAGLVDH IDVSNKEVAK VYVRSSPKSQ
210 220 230 240 250
TTEEVVQGPG NGVPAKGRGG QYKYYFNIGS VESFEEKLEE AQEAIGVNSH
260 270 280 290 300
DFVPVTYVSE TIWYQELLRF APTLLLVATL IFGARRMQGG LGGLGGPGGK
310 320 330 340 350
AGRGIFNIGK AQITRADKNS KNKIYFKDVA GCEEAKQEIM EFVHFLQNPK
360 370 380 390 400
KYEDLGAKIP KGALLVGPPG TGKTLLAKAT AGESAVPFLS ISGSDFMEMF
410 420 430 440 450
VGVGPSRVRN LFQEARQCAP SIIFIDEIDA IGRARGRGGF SGGNDEREST
460 470 480 490 500
LNQLLVEMDG FGTTAGVVVL AGTNRPDILD KALLRPGRFD RQITIDKPDI
510 520 530 540 550
KGRDQIFQIY LKKIKLDHEP SYYSQRLAAL TPGFAGADIA NVCNEAALIA
560 570 580 590 600
ARHEGATVTM AHFDSAIDRV IGGLEKKNRV ISKLERRTVA YHESGHAVAG
610 620 630 640 650
WFLEHAEPLL KVTIVPRGTA ALGFAQYVPN ENLLMTKEQL FDMTCMTLGG
660 670 680 690 700
RAAEQVLIGR ISTGAQNDLE KVTKMTYAQV AVYGFSDKIG LLSFPQREDE
710 720 730 740 750
FSKPYSNRTG AMIDEEVREW VGKAYKRTVE LIEEHKEQVA QIAELLLEKE
760 770 780 790 800
VLHQDDLTKV LGERPFKSGE TTNYDRFKSG FEESEKESQK ESVPVKPVED
810
DGIPPLEPQV VPT
Length:813
Mass (Da):89,555
Last modified:March 1, 2002 - v1
Checksum:i149D65CC4DC4C7EC
GO

Sequence cautioni

The sequence AAF79577 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti642 – 6421D → N in BAF01982 (Ref. 4) Curated
Sequence conflicti675 – 6751M → L in BAF01982 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022464 Genomic DNA. Translation: AAF79577.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28137.1.
AY064138 mRNA. Translation: AAL36045.1.
AY124808 mRNA. Translation: AAM70517.1.
AK230173 mRNA. Translation: BAF01982.1.
PIRiH86209.
RefSeqiNP_172231.2. NM_100625.3.
UniGeneiAt.23339.

Genome annotation databases

EnsemblPlantsiAT1G07510.1; AT1G07510.1; AT1G07510.
GeneIDi837265.
GrameneiAT1G07510.1; AT1G07510.1; AT1G07510.
KEGGiath:AT1G07510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022464 Genomic DNA. Translation: AAF79577.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28137.1.
AY064138 mRNA. Translation: AAL36045.1.
AY124808 mRNA. Translation: AAM70517.1.
AK230173 mRNA. Translation: BAF01982.1.
PIRiH86209.
RefSeqiNP_172231.2. NM_100625.3.
UniGeneiAt.23339.

3D structure databases

ProteinModelPortaliQ8VZI8.
SMRiQ8VZI8. Positions 158-261, 323-770.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22506. 6 interactions.
STRINGi3702.AT1G07510.1.

Protein family/group databases

MEROPSiM41.023.

Proteomic databases

PaxDbiQ8VZI8.
PRIDEiQ8VZI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G07510.1; AT1G07510.1; AT1G07510.
GeneIDi837265.
GrameneiAT1G07510.1; AT1G07510.1; AT1G07510.
KEGGiath:AT1G07510.

Organism-specific databases

TAIRiAT1G07510.

Phylogenomic databases

eggNOGiKOG0731. Eukaryota.
COG0465. LUCA.
HOGENOMiHOG000217277.
InParanoidiQ8VZI8.
KOiK08956.
OMAiTKMDKNA.
OrthoDBiEOG093603BD.
PhylomeDBiQ8VZI8.

Enzyme and pathway databases

BRENDAi3.4.24.B20. 399.

Miscellaneous databases

PROiQ8VZI8.

Gene expression databases

GenevisibleiQ8VZI8. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSHA_ARATH
AccessioniPrimary (citable) accession number: Q8VZI8
Secondary accession number(s): Q0WLM5, Q9LNX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.