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Protein

Diacylglycerol kinase 3

Gene

DGK3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress (By similarity).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Plant defense, Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G18730-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase 3 (EC:2.7.1.107)
Short name:
AtDGK3
Short name:
DAG kinase 3
Alternative name(s):
Diglyceride kinase 3
Short name:
DGK 3
Gene namesi
Name:DGK3
Ordered Locus Names:At2g18730
ORF Names:MSF3.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G18730.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Diacylglycerol kinase 3PRO_0000422111Add
BLAST

Proteomic databases

PaxDbiQ8VZG1.
PRIDEiQ8VZG1.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi1745. 7 interactions.
IntActiQ8VZG1. 7 interactions.
STRINGi3702.AT2G18730.1.

Structurei

3D structure databases

ProteinModelPortaliQ8VZG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 245159DAGKcPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG47311.
HOGENOMiHOG000239559.
InParanoidiQ8VZG1.
KOiK00901.
OMAiRARLRIM.
PhylomeDBiQ8VZG1.

Family and domain databases

InterProiIPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016961. Diacylglycerol_kinase_pln.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
PIRSFiPIRSF030829. Diacylglycerol_kinase_pln. 1 hit.
SMARTiSM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VZG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPVSKTDA SKEKFVASRP STADSKTMRG CGLANLAWVG VDKVELRQRL
60 70 80 90 100
MMPEYLRLAM RDCIKRKDSS AIPDHLLLPG GAVADMAPHA PMVVFINPNS
110 120 130 140 150
GGRHGPVLKE RLQQLMSEEQ VFDLTEVKPH EFVRYGLGCL EKVAAEGDEC
160 170 180 190 200
AKECRARLRI MVAGGDGTVG WVLGCLGELN KDGKSQIPPV GVIPLGTGND
210 220 230 240 250
LSRSFGWGGS FPFAWRSAVK RTLHRASMGP VARLDSWKIL VSMPSGEVVD
260 270 280 290 300
PPYSLKPAEE NELDQGLDAG IDAPPLAKAY EGVFYNYLSI GMDAQVAYGF
310 320 330 340 350
HHLRNTKPYL AQGPISNKII YSSFGCSQGW FCTPCVNDPG LRGLRNIMKI
360 370 380 390 400
HIKKVNCSQW EEIAVPKNVR SIVALNLHSY GSGSHPWGNL KPDYLEKRGF
410 420 430 440 450
VEAHCDDGLI EIFGFKQGWH ASFVMAELIS AKHIAQAAAV RFELRGGDWR
460 470 480
DAFLQMDGEP WKQPMSTEYS TFVEIKKVPY QSLMINNE
Length:488
Mass (Da):53,881
Last modified:March 1, 2002 - v1
Checksum:i126012C84473CA3F
GO

Sequence cautioni

The sequence AAD08942.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005724 Genomic DNA. Translation: AAD08942.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06799.1.
AY064982 mRNA. Translation: AAL57635.1.
AY141990 mRNA. Translation: AAM98254.1.
PIRiH84567.
RefSeqiNP_849980.1. NM_179649.3.
UniGeneiAt.27505.

Genome annotation databases

EnsemblPlantsiAT2G18730.1; AT2G18730.1; AT2G18730.
GeneIDi816388.
KEGGiath:AT2G18730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005724 Genomic DNA. Translation: AAD08942.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06799.1.
AY064982 mRNA. Translation: AAL57635.1.
AY141990 mRNA. Translation: AAM98254.1.
PIRiH84567.
RefSeqiNP_849980.1. NM_179649.3.
UniGeneiAt.27505.

3D structure databases

ProteinModelPortaliQ8VZG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1745. 7 interactions.
IntActiQ8VZG1. 7 interactions.
STRINGi3702.AT2G18730.1.

Proteomic databases

PaxDbiQ8VZG1.
PRIDEiQ8VZG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18730.1; AT2G18730.1; AT2G18730.
GeneIDi816388.
KEGGiath:AT2G18730.

Organism-specific databases

TAIRiAT2G18730.

Phylogenomic databases

eggNOGiNOG47311.
HOGENOMiHOG000239559.
InParanoidiQ8VZG1.
KOiK00901.
OMAiRARLRIM.
PhylomeDBiQ8VZG1.

Enzyme and pathway databases

BioCyciARA:AT2G18730-MONOMER.

Miscellaneous databases

PROiQ8VZG1.

Family and domain databases

InterProiIPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016961. Diacylglycerol_kinase_pln.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
PIRSFiPIRSF030829. Diacylglycerol_kinase_pln. 1 hit.
SMARTiSM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiDGK3_ARATH
AccessioniPrimary (citable) accession number: Q8VZG1
Secondary accession number(s): Q9ZV46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.