Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Laccase-11

Gene

LAC11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Copper 1; type 2By similarity1
Metal bindingi83Copper 2; type 3By similarity1
Metal bindingi126Copper 2; type 3By similarity1
Metal bindingi128Copper 3; type 3By similarity1
Metal bindingi458Copper 4; type 1By similarity1
Metal bindingi461Copper 1; type 2By similarity1
Metal bindingi463Copper 3; type 3By similarity1
Metal bindingi520Copper 3; type 3By similarity1
Metal bindingi521Copper 4; type 1By similarity1
Metal bindingi522Copper 2; type 3By similarity1
Metal bindingi526Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G03260-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-11 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 11
Diphenol oxidase 11
Urishiol oxidase 11
Gene namesi
Name:LAC11
Ordered Locus Names:At5g03260
ORF Names:F15A17_290, MOK16.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G03260
TAIRilocus:2143563 AT5G03260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000028363924 – 557Laccase-11Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VZA1

Expressioni

Tissue specificityi

Ubiquitous and constitutive.2 Publications

Gene expression databases

ExpressionAtlasiQ8VZA1 baseline and differential
GenevisibleiQ8VZA1 AT

Interactioni

Protein-protein interaction databases

BioGridi171633 interactors.
STRINGi3702.AT5G03260.1

Structurei

3D structure databases

ProteinModelPortaliQ8VZA1
SMRiQ8VZA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 147Plastocyanin-like 1Add BLAST117
Domaini158 – 308Plastocyanin-like 2Add BLAST151
Domaini406 – 541Plastocyanin-like 3Add BLAST136

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ8VZA1
KOiK05909
OMAiFPTDYNV
OrthoDBiEOG09360579
PhylomeDBiQ8VZA1

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.4203 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VZA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMGFLFLFC YLLAFLGYSP VDAAVKKYQF DVQVKNISRI CNAKPIVTVN
60 70 80 90 100
GMFPGPTVYA REGDRVIINV TNHVQYNMSI HWHGLKQYRN GWADGPAYIT
110 120 130 140 150
QCPIQTGQSY LYDFNVTGQR GTLWWHAHIL WLRATVYGAI VILPAPGKPY
160 170 180 190 200
PFPQPYQESN IILGEWWNKD VETAVNQANQ LGAPPPMSDA HTINGKPGPL
210 220 230 240 250
FPCSEKHTFV IEAEAGKTYL LRIINAALND ELFFGIAGHN MTVVEIDAVY
260 270 280 290 300
TKPFTTKAIL LGPGQTTNVL VKTDRSPNRY FMAASPFMDA PVSVDNKTVT
310 320 330 340 350
AILQYKGVPN TVLPILPKLP LPNDTSFALD YNGKLKSLNT PNFPALVPLK
360 370 380 390 400
VDRRLFYTIG LGINACPTCV NGTNLAASIN NITFIMPKTA LLKAHYSNIS
410 420 430 440 450
GVFRTDFPDR PPKAFNYTGV PLTANLGTST GTRLSRVKFN TTIELVLQDT
460 470 480 490 500
NLLTVESHPF HLHGYNFFVV GTGVGNFDPK KDPAKFNLVD PPERNTVGVP
510 520 530 540 550
TGGWAAIRFR ADNPGVWFMH CHLEVHTMWG LKMAFVVENG ETPELSVLPP

PKDYPSC
Length:557
Mass (Da):61,748
Last modified:March 1, 2002 - v1
Checksum:iF84A86C1E44B1E91
GO

Sequence cautioni

The sequence BAB08386 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB86093 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005240 Genomic DNA Translation: BAB08386.1 Different initiation.
AL163002 Genomic DNA Translation: CAB86093.1 Different initiation.
CP002688 Genomic DNA Translation: AED90578.1
AY065128 mRNA Translation: AAL38304.1
AY081592 mRNA Translation: AAM10154.1
AK229950 mRNA Translation: BAF01776.1
PIRiT48347
RefSeqiNP_195946.2, NM_120404.3
UniGeneiAt.23614
At.54702

Genome annotation databases

EnsemblPlantsiAT5G03260.1; AT5G03260.1; AT5G03260
GeneIDi831887
GrameneiAT5G03260.1; AT5G03260.1; AT5G03260
KEGGiath:AT5G03260

Similar proteinsi

Entry informationi

Entry nameiLAC11_ARATH
AccessioniPrimary (citable) accession number: Q8VZA1
Secondary accession number(s): Q0WM80, Q9LYV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome