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Protein

Laccase-11

Gene

LAC11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Copper 1; type 2By similarity1
Metal bindingi83Copper 2; type 3By similarity1
Metal bindingi126Copper 2; type 3By similarity1
Metal bindingi128Copper 3; type 3By similarity1
Metal bindingi458Copper 4; type 1By similarity1
Metal bindingi461Copper 1; type 2By similarity1
Metal bindingi463Copper 3; type 3By similarity1
Metal bindingi520Copper 3; type 3By similarity1
Metal bindingi521Copper 4; type 1By similarity1
Metal bindingi522Copper 2; type 3By similarity1
Metal bindingi526Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G03260-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-11 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 11
Diphenol oxidase 11
Urishiol oxidase 11
Gene namesi
Name:LAC11
Ordered Locus Names:At5g03260
ORF Names:F15A17_290, MOK16.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G03260.
TAIRilocus:2143563. AT5G03260.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000028363924 – 557Laccase-11Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VZA1.

Expressioni

Tissue specificityi

Ubiquitous and constitutive.2 Publications

Gene expression databases

GenevisibleiQ8VZA1. AT.

Interactioni

Protein-protein interaction databases

BioGridi17163. 3 interactors.
STRINGi3702.AT5G03260.1.

Structurei

3D structure databases

ProteinModelPortaliQ8VZA1.
SMRiQ8VZA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 147Plastocyanin-like 1Add BLAST117
Domaini158 – 308Plastocyanin-like 2Add BLAST151
Domaini406 – 541Plastocyanin-like 3Add BLAST136

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ8VZA1.
KOiK05909.
OMAiFLSCDRP.
OrthoDBiEOG09360579.
PhylomeDBiQ8VZA1.

Family and domain databases

CDDicd13849. CuRO_1_LCC_plant. 1 hit.
cd13875. CuRO_2_LCC_plant. 1 hit.
cd13897. CuRO_3_LCC_plant. 1 hit.
Gene3Di2.60.40.420. 3 hits.
InterProiView protein in InterPro
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR034288. CuRO_1_LCC.
IPR034285. CuRO_2_LCC.
IPR034289. CuRO_3_LCC.
IPR017761. Laccase.
PfamiView protein in Pfam
PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiView protein in PROSITE
PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VZA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMGFLFLFC YLLAFLGYSP VDAAVKKYQF DVQVKNISRI CNAKPIVTVN
60 70 80 90 100
GMFPGPTVYA REGDRVIINV TNHVQYNMSI HWHGLKQYRN GWADGPAYIT
110 120 130 140 150
QCPIQTGQSY LYDFNVTGQR GTLWWHAHIL WLRATVYGAI VILPAPGKPY
160 170 180 190 200
PFPQPYQESN IILGEWWNKD VETAVNQANQ LGAPPPMSDA HTINGKPGPL
210 220 230 240 250
FPCSEKHTFV IEAEAGKTYL LRIINAALND ELFFGIAGHN MTVVEIDAVY
260 270 280 290 300
TKPFTTKAIL LGPGQTTNVL VKTDRSPNRY FMAASPFMDA PVSVDNKTVT
310 320 330 340 350
AILQYKGVPN TVLPILPKLP LPNDTSFALD YNGKLKSLNT PNFPALVPLK
360 370 380 390 400
VDRRLFYTIG LGINACPTCV NGTNLAASIN NITFIMPKTA LLKAHYSNIS
410 420 430 440 450
GVFRTDFPDR PPKAFNYTGV PLTANLGTST GTRLSRVKFN TTIELVLQDT
460 470 480 490 500
NLLTVESHPF HLHGYNFFVV GTGVGNFDPK KDPAKFNLVD PPERNTVGVP
510 520 530 540 550
TGGWAAIRFR ADNPGVWFMH CHLEVHTMWG LKMAFVVENG ETPELSVLPP

PKDYPSC
Length:557
Mass (Da):61,748
Last modified:March 1, 2002 - v1
Checksum:iF84A86C1E44B1E91
GO

Sequence cautioni

The sequence BAB08386 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB86093 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005240 Genomic DNA. Translation: BAB08386.1. Different initiation.
AL163002 Genomic DNA. Translation: CAB86093.1. Different initiation.
CP002688 Genomic DNA. Translation: AED90578.1.
AY065128 mRNA. Translation: AAL38304.1.
AY081592 mRNA. Translation: AAM10154.1.
AK229950 mRNA. Translation: BAF01776.1.
PIRiT48347.
RefSeqiNP_195946.2. NM_120404.3.
UniGeneiAt.23614.
At.54702.

Genome annotation databases

EnsemblPlantsiAT5G03260.1; AT5G03260.1; AT5G03260.
GeneIDi831887.
GrameneiAT5G03260.1; AT5G03260.1; AT5G03260.
KEGGiath:AT5G03260.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLAC11_ARATH
AccessioniPrimary (citable) accession number: Q8VZA1
Secondary accession number(s): Q0WM80, Q9LYV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families