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Protein

Polyol transporter 5

Gene

PLT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plasma membrane broad-spectrum sugar-proton symporter. Mediates the uptake of linear polyols such as sorbitol, xylitol, erythritol or glycerol. Can transport the cyclic polyol myo-inositol and different hexoses, pentoses (including ribose), tetroses and sugar alcohols.2 Publications

Kineticsi

Determined at -60 mV (membrane potential) and an extracellular pH of 5.5.

  1. KM=0.5 mM for sorbitol2 Publications
  2. KM=1.5 mM for glucose2 Publications
  3. KM=3.5 mM for myo-inositol2 Publications
  4. KM=23.4 mM for glycerol2 Publications

    pH dependencei

    Optimum extracellular pH is 4.5 for sorbitol as substrate.2 Publications

    GO - Molecular functioni

    • D-ribose transmembrane transporter activity Source: TAIR
    • D-xylose transmembrane transporter activity Source: TAIR
    • galactose transmembrane transporter activity Source: TAIR
    • glucose transmembrane transporter activity Source: TAIR
    • glycerol transmembrane transporter activity Source: TAIR
    • mannitol transmembrane transporter activity Source: TAIR
    • monosaccharide transmembrane transporter activity Source: TAIR
    • myo-inositol transmembrane transporter activity Source: TAIR
    • sorbitol transmembrane transporter activity Source: TAIR
    • sugar:proton symporter activity Source: TAIR

    GO - Biological processi

    • glucose import Source: GO_Central
    • lateral root formation Source: CACAO
    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.34. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyol transporter 5
    Alternative name(s):
    Protein POLYOL TRANSPORTER 5
    Short name:
    AtPLT5
    Sugar-proton symporter PLT5
    Gene namesi
    Name:PLT5
    Ordered Locus Names:At3g18830
    ORF Names:MVE11.10, MVE11.22
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 3

    Organism-specific databases

    TAIRiAT3G18830.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
    Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
    Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
    Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
    Transmembranei196 – 216Helical; Name=6Sequence analysisAdd BLAST21
    Transmembranei296 – 316Helical; Name=7Sequence analysisAdd BLAST21
    Transmembranei333 – 353Helical; Name=8Sequence analysisAdd BLAST21
    Transmembranei364 – 384Helical; Name=9Sequence analysisAdd BLAST21
    Transmembranei391 – 411Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei433 – 453Helical; Name=11Sequence analysisAdd BLAST21
    Transmembranei463 – 483Helical; Name=12Sequence analysisAdd BLAST21

    GO - Cellular componenti

    • integral component of plasma membrane Source: GO_Central
    • plasma membrane Source: TAIR
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002598731 – 539Polyol transporter 5Add BLAST539

    Proteomic databases

    PaxDbiQ8VZ80.
    PRIDEiQ8VZ80.

    PTM databases

    iPTMnetiQ8VZ80.

    Expressioni

    Tissue specificityi

    Highly expressed in roots. Expressed in vascular tissue of leaves, sepals and siliques.2 Publications

    Inductioni

    By wounding and insect feeding.1 Publication

    Gene expression databases

    GenevisibleiQ8VZ80. AT.

    Interactioni

    Protein-protein interaction databases

    BioGridi6749. 1 interactor.
    STRINGi3702.AT3G18830.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VZ80.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202868.
    InParanoidiQ8VZ80.
    OMAiNSHGEGV.
    OrthoDBiEOG09360C4T.
    PhylomeDBiQ8VZ80.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VZ80-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MTGATPENRT APSPPPVKHV PESVLPAKPP KRNNYAFACA ILASMTSILL
    60 70 80 90 100
    GYDIGVMSGA MIYIKRDLKI NDLQIGILAG SLNIYSLIGS CAAGRTSDWI
    110 120 130 140 150
    GRRYTIVLAG AIFFAGAILM GLSPNYAFLM FGRFIAGIGV GYALMIAPVY
    160 170 180 190 200
    TAEVSPASSR GFLNSFPEVF INAGIMLGYV SNLAFSNLPL KVGWRLMLGI
    210 220 230 240 250
    GAVPSVILAI GVLAMPESPR WLVMQGRLGD AKRVLDKTSD SPTEATLRLE
    260 270 280 290 300
    DIKHAAGIPA DCHDDVVQVS RRNSHGEGVW RELLIRPTPA VRRVMIAAIG
    310 320 330 340 350
    IHFFQQASGI DAVVLFSPRI FKTAGLKTDH QQLLATVAVG VVKTSFILVA
    360 370 380 390 400
    TFLLDRIGRR PLLLTSVGGM VLSLAALGTS LTIIDQSEKK VMWAVVVAIA
    410 420 430 440 450
    TVMTYVATFS IGAGPITWVY SSEIFPLRLR SQGSSMGVVV NRVTSGVISI
    460 470 480 490 500
    SFLPMSKAMT TGGAFYLFGG IATVAWVFFY TFLPETQGRM LEDMDELFSG
    510 520 530
    FRWRDSKSKP KGNPEKTVPN PEVEIGSNKQ WKEGDTQSS
    Length:539
    Mass (Da):58,103
    Last modified:November 28, 2006 - v2
    Checksum:i36B389284E5563A0
    GO

    Sequence cautioni

    The sequence AAL38359 differs from that shown. Reason: Frameshift at position 251.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti527S → L in AAL38359 (PubMed:14593172).Curated1
    Sequence conflicti527S → L in AAM10180 (PubMed:14593172).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB026654 Genomic DNA. Translation: BAB01812.1.
    CP002686 Genomic DNA. Translation: AEE76153.1.
    AY065183 mRNA. Translation: AAL38359.1. Frameshift.
    AY081618 mRNA. Translation: AAM10180.1.
    RefSeqiNP_188513.1. NM_112769.3.
    UniGeneiAt.6395.

    Genome annotation databases

    EnsemblPlantsiAT3G18830.1; AT3G18830.1; AT3G18830.
    GeneIDi821416.
    GrameneiAT3G18830.1; AT3G18830.1; AT3G18830.
    KEGGiath:AT3G18830.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB026654 Genomic DNA. Translation: BAB01812.1.
    CP002686 Genomic DNA. Translation: AEE76153.1.
    AY065183 mRNA. Translation: AAL38359.1. Frameshift.
    AY081618 mRNA. Translation: AAM10180.1.
    RefSeqiNP_188513.1. NM_112769.3.
    UniGeneiAt.6395.

    3D structure databases

    ProteinModelPortaliQ8VZ80.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi6749. 1 interactor.
    STRINGi3702.AT3G18830.1.

    Protein family/group databases

    TCDBi2.A.1.1.34. the major facilitator superfamily (mfs).

    PTM databases

    iPTMnetiQ8VZ80.

    Proteomic databases

    PaxDbiQ8VZ80.
    PRIDEiQ8VZ80.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT3G18830.1; AT3G18830.1; AT3G18830.
    GeneIDi821416.
    GrameneiAT3G18830.1; AT3G18830.1; AT3G18830.
    KEGGiath:AT3G18830.

    Organism-specific databases

    TAIRiAT3G18830.

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202868.
    InParanoidiQ8VZ80.
    OMAiNSHGEGV.
    OrthoDBiEOG09360C4T.
    PhylomeDBiQ8VZ80.

    Miscellaneous databases

    PROiQ8VZ80.

    Gene expression databases

    GenevisibleiQ8VZ80. AT.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiPLT5_ARATH
    AccessioniPrimary (citable) accession number: Q8VZ80
    Secondary accession number(s): Q9LS92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: November 30, 2016
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.