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Protein

Polyol transporter 5

Gene

PLT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plasma membrane broad-spectrum sugar-proton symporter. Mediates the uptake of linear polyols such as sorbitol, xylitol, erythritol or glycerol. Can transport the cyclic polyol myo-inositol and different hexoses, pentoses (including ribose), tetroses and sugar alcohols.2 Publications

Kineticsi

Determined at -60 mV (membrane potential) and an extracellular pH of 5.5.
  1. KM=0.5 mM for sorbitol2 Publications
  2. KM=1.5 mM for glucose2 Publications
  3. KM=3.5 mM for myo-inositol2 Publications
  4. KM=23.4 mM for glycerol2 Publications

    pH dependencei

    Optimum extracellular pH is 4.5 for sorbitol as substrate.2 Publications

    GO - Molecular functioni

    • carbohydrate:proton symporter activity Source: TAIR
    • D-ribose transmembrane transporter activity Source: TAIR
    • D-xylose transmembrane transporter activity Source: TAIR
    • galactose transmembrane transporter activity Source: TAIR
    • glucose transmembrane transporter activity Source: TAIR
    • glycerol transmembrane transporter activity Source: TAIR
    • mannitol transmembrane transporter activity Source: TAIR
    • monosaccharide transmembrane transporter activity Source: TAIR
    • myo-inositol transmembrane transporter activity Source: TAIR
    • sorbitol transmembrane transporter activity Source: TAIR

    GO - Biological processi

    • glucose import Source: GO_Central
    • lateral root formation Source: CACAO

    Keywordsi

    Biological processSugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.34 the major facilitator superfamily (mfs)

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyol transporter 5
    Alternative name(s):
    Protein POLYOL TRANSPORTER 5
    Short name:
    AtPLT5
    Sugar-proton symporter PLT5
    Gene namesi
    Name:PLT5
    Ordered Locus Names:At3g18830
    ORF Names:MVE11.10, MVE11.22
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 3

    Organism-specific databases

    AraportiAT3G18830
    TAIRilocus:2094034 AT3G18830

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
    Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
    Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
    Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
    Transmembranei196 – 216Helical; Name=6Sequence analysisAdd BLAST21
    Transmembranei296 – 316Helical; Name=7Sequence analysisAdd BLAST21
    Transmembranei333 – 353Helical; Name=8Sequence analysisAdd BLAST21
    Transmembranei364 – 384Helical; Name=9Sequence analysisAdd BLAST21
    Transmembranei391 – 411Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei433 – 453Helical; Name=11Sequence analysisAdd BLAST21
    Transmembranei463 – 483Helical; Name=12Sequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002598731 – 539Polyol transporter 5Add BLAST539

    Proteomic databases

    PaxDbiQ8VZ80
    PRIDEiQ8VZ80

    PTM databases

    iPTMnetiQ8VZ80

    Expressioni

    Tissue specificityi

    Highly expressed in roots. Expressed in vascular tissue of leaves, sepals and siliques.2 Publications

    Inductioni

    By wounding and insect feeding.1 Publication

    Gene expression databases

    ExpressionAtlasiQ8VZ80 baseline and differential
    GenevisibleiQ8VZ80 AT

    Interactioni

    Protein-protein interaction databases

    BioGridi6749, 1 interactor
    STRINGi3702.AT3G18830.1

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VZ80
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254 Eukaryota
    ENOG410XNQK LUCA
    HOGENOMiHOG000202868
    InParanoidiQ8VZ80
    OMAiCIPVYVS
    OrthoDBiEOG09360C4T
    PhylomeDBiQ8VZ80

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 1 hit
    PRINTSiPR00171 SUGRTRNSPORT
    SUPFAMiSSF103473 SSF103473, 2 hits
    TIGRFAMsiTIGR00879 SP, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 1 hit
    PS00217 SUGAR_TRANSPORT_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q8VZ80-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MTGATPENRT APSPPPVKHV PESVLPAKPP KRNNYAFACA ILASMTSILL
    60 70 80 90 100
    GYDIGVMSGA MIYIKRDLKI NDLQIGILAG SLNIYSLIGS CAAGRTSDWI
    110 120 130 140 150
    GRRYTIVLAG AIFFAGAILM GLSPNYAFLM FGRFIAGIGV GYALMIAPVY
    160 170 180 190 200
    TAEVSPASSR GFLNSFPEVF INAGIMLGYV SNLAFSNLPL KVGWRLMLGI
    210 220 230 240 250
    GAVPSVILAI GVLAMPESPR WLVMQGRLGD AKRVLDKTSD SPTEATLRLE
    260 270 280 290 300
    DIKHAAGIPA DCHDDVVQVS RRNSHGEGVW RELLIRPTPA VRRVMIAAIG
    310 320 330 340 350
    IHFFQQASGI DAVVLFSPRI FKTAGLKTDH QQLLATVAVG VVKTSFILVA
    360 370 380 390 400
    TFLLDRIGRR PLLLTSVGGM VLSLAALGTS LTIIDQSEKK VMWAVVVAIA
    410 420 430 440 450
    TVMTYVATFS IGAGPITWVY SSEIFPLRLR SQGSSMGVVV NRVTSGVISI
    460 470 480 490 500
    SFLPMSKAMT TGGAFYLFGG IATVAWVFFY TFLPETQGRM LEDMDELFSG
    510 520 530
    FRWRDSKSKP KGNPEKTVPN PEVEIGSNKQ WKEGDTQSS
    Length:539
    Mass (Da):58,103
    Last modified:November 28, 2006 - v2
    Checksum:i36B389284E5563A0
    GO

    Sequence cautioni

    The sequence AAL38359 differs from that shown. Reason: Frameshift at position 251.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti527S → L in AAL38359 (PubMed:14593172).Curated1
    Sequence conflicti527S → L in AAM10180 (PubMed:14593172).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB026654 Genomic DNA Translation: BAB01812.1
    CP002686 Genomic DNA Translation: AEE76153.1
    AY065183 mRNA Translation: AAL38359.1 Frameshift.
    AY081618 mRNA Translation: AAM10180.1
    RefSeqiNP_188513.1, NM_112769.3
    UniGeneiAt.6395

    Genome annotation databases

    EnsemblPlantsiAT3G18830.1; AT3G18830.1; AT3G18830
    GeneIDi821416
    GrameneiAT3G18830.1; AT3G18830.1; AT3G18830
    KEGGiath:AT3G18830

    Similar proteinsi

    Entry informationi

    Entry nameiPLT5_ARATH
    AccessioniPrimary (citable) accession number: Q8VZ80
    Secondary accession number(s): Q9LS92
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: April 25, 2018
    This is version 108 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

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