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Protein

Alcohol dehydrogenase-like 4

Gene

At1g64710

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Binding sitei70SubstrateBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi180Zinc 1; catalyticBy similarity1
Binding sitei229NADBy similarity1
Binding sitei234NADBy similarity1
Binding sitei325NAD; via amide nitrogenBy similarity1
Binding sitei375NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 210NADBy similarity6
Nucleotide bindingi298 – 300NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-2161541. Abacavir metabolism.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 4 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At1g64710
ORF Names:F13O11.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002991862 – 380Alcohol dehydrogenase-like 4Add BLAST379

Proteomic databases

PaxDbiQ8VZ49.
PRIDEiQ8VZ49.

Expressioni

Gene expression databases

ExpressionAtlasiQ8VZ49. baseline and differential.
GenevisibleiQ8VZ49. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi28000. 1 interactor.
STRINGi3702.AT1G64710.1.

Structurei

3D structure databases

ProteinModelPortaliQ8VZ49.
SMRiQ8VZ49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
InParanoidiQ8VZ49.
KOiK00001.
OrthoDBiEOG09360EUW.
PhylomeDBiQ8VZ49.

Family and domain databases

Gene3Di3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8VZ49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METQGKVITC KAAVAWGAGE PLVMEDVKVD PPQRLEVRIR ILFTSICHTD
60 70 80 90 100
LSAWKGENEA QRAYPRILGH EAAGIVESVG EGVEEMMAGD HVLPIFTGEC
110 120 130 140 150
GDCRVCKRDG ANLCERFRVD PMKKVMVTDG KTRFFTSKDN KPIYHFLNTS
160 170 180 190 200
TFSEYTVIDS ACVLKVDPLF PLEKISLLSC GVSTGVGAAW NVADIQPAST
210 220 230 240 250
VAIFGLGAVG LAVAEGARAR GASKIIGIDI NPDKFQLGRE AGISEFINPK
260 270 280 290 300
ESDKAVHERV MEITEGGVEY SFECAGSIEA LREAFLSTNS GVGVTVMLGV
310 320 330 340 350
HASPQLLPIH PMELFQGRSI TASVFGGFKP KTQLPFFITQ CLQGLLNLDL
360 370 380
FISHQLPFHD INEAMQLLHQ GKALRCLLHL
Length:380
Mass (Da):41,316
Last modified:March 1, 2002 - v1
Checksum:i1B442E1677307419
GO

Sequence cautioni

The sequence AAD38247 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006193 Genomic DNA. Translation: AAD38247.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34276.2.
AY065250 mRNA. Translation: AAL38726.1.
BT006064 mRNA. Translation: AAP04049.1.
PIRiC96670.
RefSeqiNP_176652.3. NM_105146.6. [Q8VZ49-1]
UniGeneiAt.28546.

Genome annotation databases

EnsemblPlantsiAT1G64710.1; AT1G64710.1; AT1G64710. [Q8VZ49-1]
GeneIDi842779.
GrameneiAT1G64710.1; AT1G64710.1; AT1G64710.
KEGGiath:AT1G64710.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006193 Genomic DNA. Translation: AAD38247.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34276.2.
AY065250 mRNA. Translation: AAL38726.1.
BT006064 mRNA. Translation: AAP04049.1.
PIRiC96670.
RefSeqiNP_176652.3. NM_105146.6. [Q8VZ49-1]
UniGeneiAt.28546.

3D structure databases

ProteinModelPortaliQ8VZ49.
SMRiQ8VZ49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28000. 1 interactor.
STRINGi3702.AT1G64710.1.

Proteomic databases

PaxDbiQ8VZ49.
PRIDEiQ8VZ49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G64710.1; AT1G64710.1; AT1G64710. [Q8VZ49-1]
GeneIDi842779.
GrameneiAT1G64710.1; AT1G64710.1; AT1G64710.
KEGGiath:AT1G64710.

Organism-specific databases

AraportiAT1G64710.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
InParanoidiQ8VZ49.
KOiK00001.
OrthoDBiEOG09360EUW.
PhylomeDBiQ8VZ49.

Enzyme and pathway databases

ReactomeiR-ATH-2161541. Abacavir metabolism.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-71384. Ethanol oxidation.

Miscellaneous databases

PROiPR:Q8VZ49.

Gene expression databases

ExpressionAtlasiQ8VZ49. baseline and differential.
GenevisibleiQ8VZ49. AT.

Family and domain databases

Gene3Di3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADHL4_ARATH
AccessioniPrimary (citable) accession number: Q8VZ49
Secondary accession number(s): F4I880, Q9XIS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: April 12, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.