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Protein

Alcohol dehydrogenase-like 4

Gene

At1g64710

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Binding sitei70SubstrateBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi180Zinc 1; catalyticBy similarity1
Binding sitei229NADBy similarity1
Binding sitei234NADBy similarity1
Binding sitei325NAD; via amide nitrogenBy similarity1
Binding sitei375NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 210NADBy similarity6
Nucleotide bindingi298 – 300NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G64710-MONOMER
ReactomeiR-ATH-2161541 Abacavir metabolism
R-ATH-5365859 RA biosynthesis pathway
R-ATH-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 4 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At1g64710
ORF Names:F13O11.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G64710

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991861 – 380Alcohol dehydrogenase-like 4Add BLAST380

Proteomic databases

PaxDbiQ8VZ49
PRIDEiQ8VZ49

Expressioni

Gene expression databases

ExpressionAtlasiQ8VZ49 baseline and differential
GenevisibleiQ8VZ49 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi28000, 1 interactor
STRINGi3702.AT1G64710.1

Structurei

3D structure databases

ProteinModelPortaliQ8VZ49
SMRiQ8VZ49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
InParanoidiQ8VZ49
KOiK00001
OrthoDBiEOG09360EUW
PhylomeDBiQ8VZ49

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8VZ49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METQGKVITC KAAVAWGAGE PLVMEDVKVD PPQRLEVRIR ILFTSICHTD
60 70 80 90 100
LSAWKGENEA QRAYPRILGH EAAGIVESVG EGVEEMMAGD HVLPIFTGEC
110 120 130 140 150
GDCRVCKRDG ANLCERFRVD PMKKVMVTDG KTRFFTSKDN KPIYHFLNTS
160 170 180 190 200
TFSEYTVIDS ACVLKVDPLF PLEKISLLSC GVSTGVGAAW NVADIQPAST
210 220 230 240 250
VAIFGLGAVG LAVAEGARAR GASKIIGIDI NPDKFQLGRE AGISEFINPK
260 270 280 290 300
ESDKAVHERV MEITEGGVEY SFECAGSIEA LREAFLSTNS GVGVTVMLGV
310 320 330 340 350
HASPQLLPIH PMELFQGRSI TASVFGGFKP KTQLPFFITQ CLQGLLNLDL
360 370 380
FISHQLPFHD INEAMQLLHQ GKALRCLLHL
Length:380
Mass (Da):41,316
Last modified:March 1, 2002 - v1
Checksum:i1B442E1677307419
GO

Sequence cautioni

The sequence AAD38247 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006193 Genomic DNA Translation: AAD38247.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE34276.2
AY065250 mRNA Translation: AAL38726.1
BT006064 mRNA Translation: AAP04049.1
PIRiC96670
RefSeqiNP_176652.3, NM_105146.6 [Q8VZ49-1]
UniGeneiAt.28546

Genome annotation databases

EnsemblPlantsiAT1G64710.1; AT1G64710.1; AT1G64710 [Q8VZ49-1]
GeneIDi842779
GrameneiAT1G64710.1; AT1G64710.1; AT1G64710 [Q8VZ49-1]
KEGGiath:AT1G64710

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiADHL4_ARATH
AccessioniPrimary (citable) accession number: Q8VZ49
Secondary accession number(s): F4I880, Q9XIS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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