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Q8VYU7

- PPA4_ARATH

UniProt

Q8VYU7 - PPA4_ARATH

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Protein

Purple acid phosphatase 4

Gene

PAP4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531IronBy similarity
Metal bindingi86 – 861IronBy similarity
Metal bindingi86 – 861ZincBy similarity
Metal bindingi89 – 891IronBy similarity
Metal bindingi124 – 1241ZincBy similarity
Metal bindingi218 – 2181ZincBy similarity
Active sitei227 – 2271Proton donorBy similarity
Metal bindingi253 – 2531ZincBy similarity
Metal bindingi255 – 2551IronBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G25230-MONOMER.
ReactomeiREACT_244898. Vitamin B2 (riboflavin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Purple acid phosphatase 4 (EC:3.1.3.2)
Gene namesi
Name:PAP4
Ordered Locus Names:At1g25230
ORF Names:F4F7.38
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G25230.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 339308Purple acid phosphatase 4PRO_0000372809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VYU7.
PRIDEiQ8VYU7.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ8VYU7. baseline and differential.
GenevestigatoriQ8VYU7.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G25230.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8VYU7.
SMRiQ8VYU7. Positions 45-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni253 – 2553Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000239892.
InParanoidiQ8VYU7.
OMAiGEEMDIN.
PhylomeDBiQ8VYU7.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VYU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKFDIGSL SIVMTLLICF LLLSLAPKLE AELATVQHAP NPDGSISFLV
60 70 80 90 100
IGDWGRHGLY NQSQVALQMG RIGEEMDINF VVSTGDNIYD NGMKSIDDPA
110 120 130 140 150
FQLSFSNIYT SPSLQKPWYL VLGNHDYRGD VEAQLSPILR SMDSRWICMR
160 170 180 190 200
SFIVDAEIAE LFFVDTTPFV DAYFLSPQDQ TYDWSGVSPR KSYLQTILTE
210 220 230 240 250
LEMGLRESSA KWKIVVGHHA IKSASIHGNT KELESLLLPI LEANKVDLYM
260 270 280 290 300
NGHDHCLQHI STSQSPIQFL TSGGGSKAWR GYYNWTTPED MKFFYDGQGF
310 320 330
MSVKITRSEL SVVFYDVSGN SLHKWDTSKM LDSDFYFPL
Length:339
Mass (Da):38,241
Last modified:March 1, 2002 - v1
Checksum:iA801B23B57C92609
GO

Sequence cautioni

The sequence AAG28815.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY842021 mRNA. Translation: AAW29946.1.
AC079374 Genomic DNA. Translation: AAG28815.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30591.1.
AY069908 mRNA. Translation: AAL47459.1.
AY141997 mRNA. Translation: AAM98261.1.
PIRiH86381.
RefSeqiNP_173894.2. NM_102332.3.
UniGeneiAt.19616.

Genome annotation databases

EnsemblPlantsiAT1G25230.1; AT1G25230.1; AT1G25230.
GeneIDi839105.
KEGGiath:AT1G25230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY842021 mRNA. Translation: AAW29946.1 .
AC079374 Genomic DNA. Translation: AAG28815.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE30591.1 .
AY069908 mRNA. Translation: AAL47459.1 .
AY141997 mRNA. Translation: AAM98261.1 .
PIRi H86381.
RefSeqi NP_173894.2. NM_102332.3.
UniGenei At.19616.

3D structure databases

ProteinModelPortali Q8VYU7.
SMRi Q8VYU7. Positions 45-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G25230.1-P.

Proteomic databases

PaxDbi Q8VYU7.
PRIDEi Q8VYU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G25230.1 ; AT1G25230.1 ; AT1G25230 .
GeneIDi 839105.
KEGGi ath:AT1G25230.

Organism-specific databases

TAIRi AT1G25230.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000239892.
InParanoidi Q8VYU7.
OMAi GEEMDIN.
PhylomeDBi Q8VYU7.

Enzyme and pathway databases

BioCyci ARA:AT1G25230-MONOMER.
Reactomei REACT_244898. Vitamin B2 (riboflavin) metabolism.

Gene expression databases

ExpressionAtlasi Q8VYU7. baseline and differential.
Genevestigatori Q8VYU7.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower."
    Zhu H., Qian W., Lu X., Li D., Liu X., Liu K., Wang D.
    Plant Mol. Biol. 59:581-594(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivation."
    Li D., Zhu H., Liu K., Liu X., Leggewie G., Udvardi M., Wang D.
    J. Biol. Chem. 277:27772-27781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPPA4_ARATH
AccessioniPrimary (citable) accession number: Q8VYU7
Secondary accession number(s): Q9FRH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3