Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8VXQ2

- ALDH_CRAPL

UniProt

Q8VXQ2 - ALDH_CRAPL

Protein

Aldehyde dehydrogenase

Gene

ALDH

Organism
Craterostigma plantagineum (Blue gem) (Torenia plantagineum)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Oxidizes nonanal, propionaldehyde and acetaldehyde in vitro, in the following decreasing order of reactivity: nonanal, propionaldehyde, acetaldehyde.1 Publication

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Kineticsi

    Measured at pH 9.5 for all experiments.

    1. KM=2.2 µM for nonanal1 Publication
    2. KM=267 µM for propionaldehyde1 Publication
    3. KM=32.3 mM for acetaldehyde1 Publication

    Vmax=0.03 µmol/sec/mg enzyme with nonanal as substrate1 Publication

    Vmax=0.196 µmol/sec/mg enzyme with propionaldehyde as substrate1 Publication

    Vmax=0.102 µmol/sec/mg enzyme with acetaldehyde as substrate1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei117 – 1171Transition state stabilizerBy similarity
    Active sitei212 – 2121Proton acceptorBy similarity
    Active sitei247 – 2471NucleophileBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi190 – 1956NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Alternative name(s):
    Cp-ALDH
    Gene namesi
    Name:ALDH
    OrganismiCraterostigma plantagineum (Blue gem) (Torenia plantagineum)
    Taxonomic identifieri4153 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesLinderniaceaeCraterostigma

    Subcellular locationi

    Plastidamyloplast 1 Publication. Plastidchloroplast 1 Publication

    GO - Cellular componenti

    1. amyloplast Source: UniProtKB-SubCell
    2. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Amyloplast, Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Aldehyde dehydrogenasePRO_0000256068Add
    BLAST

    Expressioni

    Inductioni

    By abscisic acid (ABA) and dehydration.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VXQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8VXQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQVDAEGVV DGLRRTYISG KTKSYEWRVS QLKALLKITT HHDKEVVEAL    50
    RADLKKPEHE AYVHEIFMVS NACKSALKEL HQWMKPQKVK TSLATYPSSA 100
    EIVSEPLGVV LVITAWNYPF LLALDPMIGA IAAGNCVVLK PSEIAPATSA 150
    LLAKLLNQYV DTSAIRVVEG AVPEMQALLD QRWDKIFYTG SSKVGQIVLS 200
    SAAKHLTPVV LELGGKCPTV VDANIDLKVA ARRIISWKWS GNSGQTCISP 250
    DYIITTEENA PKLVDAIKCE LESFYGKDPL KSQDMSSIIN ERQFERMTGL 300
    LDDKKVSDKI VYGGQSDKSN LKIAPTILLD VSEDSSVMSE EIFGPLLPII 350
    TVGKIEECYK IIASKPKPLA AYLFTNDKKR TEEFVSNVSA GGITINDIAL 400
    HFLEPRLPFG GVGESGMGSY HGKFSFDAFS HKKSVLKRSF GGEVAARYPP 450
    YAPWKLHFME AILQGDIFGL LKAWLGWSS 479
    Length:479
    Mass (Da):52,741
    Last modified:March 1, 2002 - v1
    Checksum:i47F266AE6CF77FCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ306960 mRNA. Translation: CAC84900.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ306960 mRNA. Translation: CAC84900.1 .

    3D structure databases

    ProteinModelPortali Q8VXQ2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel ABA- and dehydration-inducible aldehyde dehydrogenase genes isolated from the resurrection plant Craterostigma plantagineum and Arabidopsis thaliana."
      Kirch H.-H., Nair A., Bartels D.
      Plant J. 28:555-567(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, INDUCTION.

    Entry informationi

    Entry nameiALDH_CRAPL
    AccessioniPrimary (citable) accession number: Q8VXQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3