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Q8VX04 (MAM2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methylthioalkylmalate synthase 2, chloroplastic

EC=2.3.3.-
Gene names
Name:MAM2
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes only the first methionine chain elongation cycle. Ref.3

Subcellular location

Plastidchloroplast Potential.

Domain

The N-terminal part of the protein controls substrate specificity.

Miscellaneous

The gene encoding this protein is not present in cv. Aa-0, cv. Ag-0, cv. Columbia, cv. Ema-1, cv. Gy-0, cv. Mt-0 and cv. Pla-0.

Sequence similarities

Belongs to the alpha-IPM synthase/homocitrate synthase family.

Ontologies

Keywords
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processcarboxylic acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4949Chloroplast Potential
Chain50 – 506457Methylthioalkylmalate synthase 2, chloroplastic
PRO_5000064969

Natural variations

Natural variant671A → V in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural variant751L → I in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural variant861R → H in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural variant1091L → Q in strain: cv. Sorbo.
Natural variant2521D → G in strain: cv. Bl-0, cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Sorbo, cv. Tsu-0 and cv. Wl-0.
Natural variant4501A → V in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural variant4701M → L in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural variant4791G → E in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural variant4851S → L in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.

Sequences

Sequence LengthMass (Da)Tools
Q8VX04 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: DB9C306055E8C82A

FASTA50655,130
        10         20         30         40         50         60 
MASSLLTSSG MIPTTGSTVV GRSVLPFQSS LHSLRLTHSY KNPALFISCC SSVSKNAATS 

        70         80         90        100        110        120 
STDLKPAVER WPEYLPNKLP DENYVRVFDT TLRDGEQAPG GSLTPPQKLE IARQLAKLRV 

       130        140        150        160        170        180 
DIMEVGFPGS SEEELETVKT IAKTVGNEVD EETGYVPVIC AIARSKHRDI EAAWEAVKYA 

       190        200        210        220        230        240 
KRPRILIFTS TSDIHMKYKL KKTQEEVIEM AVSSIRFAKS LGFNDIQLGC EDGGRSDKDF 

       250        260        270        280        290        300 
LCKILGEAIK ADVTVVNVAD TVGINMPHEY AELVTYLKAN TPGIDDVVFS VHCHNDLGLA 

       310        320        330        340        350        360 
TANSIAGIRA GARQVEVTIN GIGERSGNAS LEEVVMALKC RGAYVINGVY TRIDTRQIMA 

       370        380        390        400        410        420 
TSKMVQEYTG LYVQAHKPIV GANCFVHESG IHQDGILKNR STYEILSPED IGIVKSQNSG 

       430        440        450        460        470        480 
LVLGKLSGRH AVKDRLKELG YELDDEKLNA VFSLFRDLTK NKKRITDADM KALVTSSDGI 

       490        500 
SLEKSNGANG LKSNGYIPVL QVSSNV 

« Hide

References

[1]"A MYB transcription factor and a gene similar to MYJ24.1 are encoded in the region between MRN17 and MYJ24."
Kroymann J., Schnabelrauch D., Mitchell-Olds T.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Landsberg erecta.
[2]"Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus."
Kroymann J., Donnerhacke S., Schnabelrauch D., Mitchell-Olds T.
Proc. Natl. Acad. Sci. U.S.A. 100:14587-14592(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
Strain: cv. Bl-0, cv. Di-G, cv. Ka-0, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tsu-0 and cv. Wl-0.
[3]"Positive selection driving diversification in plant secondary metabolism."
Benderoth M., Textor S., Windsor A.J., Mitchell-Olds T., Gershenzon J., Kroymann J.
Proc. Natl. Acad. Sci. U.S.A. 103:9118-9123(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS, FUNCTION.
Strain: cv. Landsberg erecta and cv. Sorbo.
[4]"MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis."
Textor S., de Kraker J.-W., Hause B., Gershenzon J., Tokuhisa J.G.
Plant Physiol. 144:60-71(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ133892 mRNA. Translation: CAC80207.1.
AJ486889 mRNA. Translation: CAD31147.1.
AJ486890 mRNA. Translation: CAD31148.1.
AJ486891 mRNA. Translation: CAD31149.1.
AJ486892 mRNA. Translation: CAD31150.1.
AJ486893 mRNA. Translation: CAD31151.1.
AJ486894 mRNA. Translation: CAD31152.1.
AJ486895 mRNA. Translation: CAD31153.1.
AJ486896 mRNA. Translation: CAD31154.1.
AJ486897 mRNA. Translation: CAD31155.1.
AJ486898 mRNA. Translation: CAD31156.1.
AJ486899 mRNA. Translation: CAD31157.1.
AM180571 Genomic DNA. Translation: CAJ55503.1.
AM180569 Genomic DNA. Translation: CAJ55501.1.

3D structure databases

ProteinModelPortalQ8VX04.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Gene expression databases

ArrayExpressQ8VX04.
GenevestigatorQ8VX04.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR000891. PYR_CT.
[Graphical view]
PfamPF00682. HMGL-like. 1 hit.
[Graphical view]
PROSITEPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMAM2_ARATH
AccessionPrimary (citable) accession number: Q8VX04
Secondary accession number(s): Q70YW3, Q70YW8, Q70YX0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names