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Q8VX04

- MAM2_ARATH

UniProt

Q8VX04 - MAM2_ARATH

Protein

Methylthioalkylmalate synthase 2, chloroplastic

Gene

MAM2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes only the first methionine chain elongation cycle.1 Publication

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

    GO - Biological processi

    1. carboxylic acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylthioalkylmalate synthase 2, chloroplastic (EC:2.3.3.-)
    Gene namesi
    Name:MAM2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

    Subcellular locationi

    Plastidchloroplast Curated

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4949ChloroplastSequence AnalysisAdd
    BLAST
    Chaini50 – 506457Methylthioalkylmalate synthase 2, chloroplasticPRO_5000064969Add
    BLAST

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VX04.
    GenevestigatoriQ8VX04.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VX04.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The N-terminal part of the protein controls substrate specificity.

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR000891. PYR_CT.
    [Graphical view]
    PfamiPF00682. HMGL-like. 1 hit.
    [Graphical view]
    PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VX04-1 [UniParc]FASTAAdd to Basket

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    MASSLLTSSG MIPTTGSTVV GRSVLPFQSS LHSLRLTHSY KNPALFISCC    50
    SSVSKNAATS STDLKPAVER WPEYLPNKLP DENYVRVFDT TLRDGEQAPG 100
    GSLTPPQKLE IARQLAKLRV DIMEVGFPGS SEEELETVKT IAKTVGNEVD 150
    EETGYVPVIC AIARSKHRDI EAAWEAVKYA KRPRILIFTS TSDIHMKYKL 200
    KKTQEEVIEM AVSSIRFAKS LGFNDIQLGC EDGGRSDKDF LCKILGEAIK 250
    ADVTVVNVAD TVGINMPHEY AELVTYLKAN TPGIDDVVFS VHCHNDLGLA 300
    TANSIAGIRA GARQVEVTIN GIGERSGNAS LEEVVMALKC RGAYVINGVY 350
    TRIDTRQIMA TSKMVQEYTG LYVQAHKPIV GANCFVHESG IHQDGILKNR 400
    STYEILSPED IGIVKSQNSG LVLGKLSGRH AVKDRLKELG YELDDEKLNA 450
    VFSLFRDLTK NKKRITDADM KALVTSSDGI SLEKSNGANG LKSNGYIPVL 500
    QVSSNV 506
    Length:506
    Mass (Da):55,130
    Last modified:March 1, 2002 - v1
    Checksum:iDB9C306055E8C82A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671A → V in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
    Natural varianti75 – 751L → I in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
    Natural varianti86 – 861R → H in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
    Natural varianti109 – 1091L → Q in strain: cv. Sorbo.
    Natural varianti252 – 2521D → G in strain: cv. Bl-0, cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Sorbo, cv. Tsu-0 and cv. Wl-0.
    Natural varianti450 – 4501A → V in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
    Natural varianti470 – 4701M → L in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
    Natural varianti479 – 4791G → E in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
    Natural varianti485 – 4851S → L in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133892 mRNA. Translation: CAC80207.1.
    AJ486889 mRNA. Translation: CAD31147.1.
    AJ486890 mRNA. Translation: CAD31148.1.
    AJ486891 mRNA. Translation: CAD31149.1.
    AJ486892 mRNA. Translation: CAD31150.1.
    AJ486893 mRNA. Translation: CAD31151.1.
    AJ486894 mRNA. Translation: CAD31152.1.
    AJ486895 mRNA. Translation: CAD31153.1.
    AJ486896 mRNA. Translation: CAD31154.1.
    AJ486897 mRNA. Translation: CAD31155.1.
    AJ486898 mRNA. Translation: CAD31156.1.
    AJ486899 mRNA. Translation: CAD31157.1.
    AM180571 Genomic DNA. Translation: CAJ55503.1.
    AM180569 Genomic DNA. Translation: CAJ55501.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133892 mRNA. Translation: CAC80207.1 .
    AJ486889 mRNA. Translation: CAD31147.1 .
    AJ486890 mRNA. Translation: CAD31148.1 .
    AJ486891 mRNA. Translation: CAD31149.1 .
    AJ486892 mRNA. Translation: CAD31150.1 .
    AJ486893 mRNA. Translation: CAD31151.1 .
    AJ486894 mRNA. Translation: CAD31152.1 .
    AJ486895 mRNA. Translation: CAD31153.1 .
    AJ486896 mRNA. Translation: CAD31154.1 .
    AJ486897 mRNA. Translation: CAD31155.1 .
    AJ486898 mRNA. Translation: CAD31156.1 .
    AJ486899 mRNA. Translation: CAD31157.1 .
    AM180571 Genomic DNA. Translation: CAJ55503.1 .
    AM180569 Genomic DNA. Translation: CAJ55501.1 .

    3D structure databases

    ProteinModelPortali Q8VX04.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q8VX04.
    Genevestigatori Q8VX04.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR000891. PYR_CT.
    [Graphical view ]
    Pfami PF00682. HMGL-like. 1 hit.
    [Graphical view ]
    PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A MYB transcription factor and a gene similar to MYJ24.1 are encoded in the region between MRN17 and MYJ24."
      Kroymann J., Schnabelrauch D., Mitchell-Olds T.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Landsberg erecta.
    2. "Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus."
      Kroymann J., Donnerhacke S., Schnabelrauch D., Mitchell-Olds T.
      Proc. Natl. Acad. Sci. U.S.A. 100:14587-14592(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
      Strain: cv. Bl-0, cv. Di-G, cv. Ka-0, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tsu-0 and cv. Wl-0.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS, FUNCTION.
      Strain: cv. Landsberg erecta and cv. Sorbo.
    4. "MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis."
      Textor S., de Kraker J.-W., Hause B., Gershenzon J., Tokuhisa J.G.
      Plant Physiol. 144:60-71(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMAM2_ARATH
    AccessioniPrimary (citable) accession number: Q8VX04
    Secondary accession number(s): Q70YW3, Q70YW8, Q70YX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The gene encoding this protein is not present in cv. Aa-0, cv. Ag-0, cv. Columbia, cv. Ema-1, cv. Gy-0, cv. Mt-0 and cv. Pla-0.

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3