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Q8VX04

- MAM2_ARATH

UniProt

Q8VX04 - MAM2_ARATH

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Protein
Methylthioalkylmalate synthase 2, chloroplastic
Gene
MAM2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes only the first methionine chain elongation cycle.1 Publication

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. carboxylic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioalkylmalate synthase 2, chloroplastic (EC:2.3.3.-)
Gene namesi
Name:MAM2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Subcellular locationi

Plastidchloroplast Reviewed prediction

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949Chloroplast Reviewed prediction
Add
BLAST
Chaini50 – 506457Methylthioalkylmalate synthase 2, chloroplastic
PRO_5000064969Add
BLAST

Expressioni

Gene expression databases

ArrayExpressiQ8VX04.
GenevestigatoriQ8VX04.

Structurei

3D structure databases

ProteinModelPortaliQ8VX04.

Family & Domainsi

Domaini

The N-terminal part of the protein controls substrate specificity.

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR000891. PYR_CT.
[Graphical view]
PfamiPF00682. HMGL-like. 1 hit.
[Graphical view]
PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VX04-1 [UniParc]FASTAAdd to Basket

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MASSLLTSSG MIPTTGSTVV GRSVLPFQSS LHSLRLTHSY KNPALFISCC    50
SSVSKNAATS STDLKPAVER WPEYLPNKLP DENYVRVFDT TLRDGEQAPG 100
GSLTPPQKLE IARQLAKLRV DIMEVGFPGS SEEELETVKT IAKTVGNEVD 150
EETGYVPVIC AIARSKHRDI EAAWEAVKYA KRPRILIFTS TSDIHMKYKL 200
KKTQEEVIEM AVSSIRFAKS LGFNDIQLGC EDGGRSDKDF LCKILGEAIK 250
ADVTVVNVAD TVGINMPHEY AELVTYLKAN TPGIDDVVFS VHCHNDLGLA 300
TANSIAGIRA GARQVEVTIN GIGERSGNAS LEEVVMALKC RGAYVINGVY 350
TRIDTRQIMA TSKMVQEYTG LYVQAHKPIV GANCFVHESG IHQDGILKNR 400
STYEILSPED IGIVKSQNSG LVLGKLSGRH AVKDRLKELG YELDDEKLNA 450
VFSLFRDLTK NKKRITDADM KALVTSSDGI SLEKSNGANG LKSNGYIPVL 500
QVSSNV 506
Length:506
Mass (Da):55,130
Last modified:March 1, 2002 - v1
Checksum:iDB9C306055E8C82A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671A → V in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural varianti75 – 751L → I in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural varianti86 – 861R → H in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural varianti109 – 1091L → Q in strain: cv. Sorbo.
Natural varianti252 – 2521D → G in strain: cv. Bl-0, cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Sorbo, cv. Tsu-0 and cv. Wl-0.
Natural varianti450 – 4501A → V in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural varianti470 – 4701M → L in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural varianti479 – 4791G → E in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.
Natural varianti485 – 4851S → L in strain: cv. Ka-0, cv. Lip-0, cv. No-0, cv. Sei-0, cv. Tsu-0 and cv. Wl-0.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133892 mRNA. Translation: CAC80207.1.
AJ486889 mRNA. Translation: CAD31147.1.
AJ486890 mRNA. Translation: CAD31148.1.
AJ486891 mRNA. Translation: CAD31149.1.
AJ486892 mRNA. Translation: CAD31150.1.
AJ486893 mRNA. Translation: CAD31151.1.
AJ486894 mRNA. Translation: CAD31152.1.
AJ486895 mRNA. Translation: CAD31153.1.
AJ486896 mRNA. Translation: CAD31154.1.
AJ486897 mRNA. Translation: CAD31155.1.
AJ486898 mRNA. Translation: CAD31156.1.
AJ486899 mRNA. Translation: CAD31157.1.
AM180571 Genomic DNA. Translation: CAJ55503.1.
AM180569 Genomic DNA. Translation: CAJ55501.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133892 mRNA. Translation: CAC80207.1 .
AJ486889 mRNA. Translation: CAD31147.1 .
AJ486890 mRNA. Translation: CAD31148.1 .
AJ486891 mRNA. Translation: CAD31149.1 .
AJ486892 mRNA. Translation: CAD31150.1 .
AJ486893 mRNA. Translation: CAD31151.1 .
AJ486894 mRNA. Translation: CAD31152.1 .
AJ486895 mRNA. Translation: CAD31153.1 .
AJ486896 mRNA. Translation: CAD31154.1 .
AJ486897 mRNA. Translation: CAD31155.1 .
AJ486898 mRNA. Translation: CAD31156.1 .
AJ486899 mRNA. Translation: CAD31157.1 .
AM180571 Genomic DNA. Translation: CAJ55503.1 .
AM180569 Genomic DNA. Translation: CAJ55501.1 .

3D structure databases

ProteinModelPortali Q8VX04.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ArrayExpressi Q8VX04.
Genevestigatori Q8VX04.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR000891. PYR_CT.
[Graphical view ]
Pfami PF00682. HMGL-like. 1 hit.
[Graphical view ]
PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A MYB transcription factor and a gene similar to MYJ24.1 are encoded in the region between MRN17 and MYJ24."
    Kroymann J., Schnabelrauch D., Mitchell-Olds T.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Landsberg erecta.
  2. "Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus."
    Kroymann J., Donnerhacke S., Schnabelrauch D., Mitchell-Olds T.
    Proc. Natl. Acad. Sci. U.S.A. 100:14587-14592(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
    Strain: cv. Bl-0, cv. Di-G, cv. Ka-0, cv. Landsberg erecta, cv. Lip-0, cv. No-0, cv. Petergof, cv. Sei-0, cv. Sorbo, cv. Tsu-0 and cv. Wl-0.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS, FUNCTION.
    Strain: cv. Landsberg erecta and cv. Sorbo.
  4. "MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis."
    Textor S., de Kraker J.-W., Hause B., Gershenzon J., Tokuhisa J.G.
    Plant Physiol. 144:60-71(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMAM2_ARATH
AccessioniPrimary (citable) accession number: Q8VX04
Secondary accession number(s): Q70YW3, Q70YW8, Q70YX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The gene encoding this protein is not present in cv. Aa-0, cv. Ag-0, cv. Columbia, cv. Ema-1, cv. Gy-0, cv. Mt-0 and cv. Pla-0.

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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