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Protein

Telomere repeat-binding factor 1

Gene

TRB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds preferentially double-stranded telomeric repeats.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 57H-T-H motifPROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

  • activating transcription factor binding Source: TAIR
  • DNA binding transcription factor activity Source: TAIR
  • double-stranded telomeric DNA binding Source: TAIR
  • promoter-specific chromatin binding Source: TAIR
  • protein homodimerization activity Source: TAIR
  • repressing transcription factor binding Source: TAIR
  • sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • nucleosome assembly Source: InterPro
  • regulation of transcription by RNA polymerase II Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to auxin Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to ethylene Source: TAIR
  • response to gibberellin Source: TAIR
  • response to jasmonic acid Source: TAIR
  • response to salicylic acid Source: TAIR
  • response to salt stress Source: TAIR
  • telomeric loop formation Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Telomere repeat-binding factor 1
Short name:
AtTRB1
Alternative name(s):
MYB transcription factor
Gene namesi
Name:TRB1
Ordered Locus Names:At1g49950
ORF Names:F2J10.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G49950
TAIRilocus:2031095 AT1G49950

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004170101 – 300Telomere repeat-binding factor 1Add BLAST300

Proteomic databases

PaxDbiQ8VWK4

PTM databases

iPTMnetiQ8VWK4

Expressioni

Gene expression databases

ExpressionAtlasiQ8VWK4 baseline and differential
GenevisibleiQ8VWK4 AT

Interactioni

Subunit structurei

Forms a homodimer and heterodimers with TRB2 or TRB3. Interacts with POT1b, TRB2 and TRB3 through its H15 domain.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • activating transcription factor binding Source: TAIR
  • protein homodimerization activity Source: TAIR
  • repressing transcription factor binding Source: TAIR

Protein-protein interaction databases

BioGridi26643, 5 interactors
IntActiQ8VWK4, 4 interactors
MINTiQ8VWK4
STRINGi3702.AT1G49950.1

Structurei

3D structure databases

ProteinModelPortaliQ8VWK4
SMRiQ8VWK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH myb-typePROSITE-ProRule annotationAdd BLAST58
Domaini117 – 185H15PROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili241 – 290Sequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 284Ala-richAdd BLAST43

Domaini

HTH myb-type domain confers double-stranded telomeric DNA-binding while the H15 domain is involved in non-specific DNA-protein interaction and multimerization.1 Publication

Sequence similaritiesi

Belongs to the histone H1/H5 family. SMH subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHMF Eukaryota
ENOG4111SQS LUCA
HOGENOMiHOG000238013
InParanoidiQ8VWK4
KOiK09422
OMAiCKMMIRA
OrthoDBiEOG09360JWA
PhylomeDBiQ8VWK4

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00526 H15, 1 hit
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
PS51294 HTH_MYB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VWK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPKQKWTQ EEESALKSGV IKHGPGKWRT ILKDPEFSGV LYLRSNVDLK
60 70 80 90 100
DKWRNMSVMA NGWGSREKSR LAVKRTFSLP KQEENSLALT NSLQSDEENV
110 120 130 140 150
DATSGLQVSS NPPPRRPNVR LDSLIMEAIA TLKEPGGCNK TTIGAYIEDQ
160 170 180 190 200
YHAPPDFKRL LSTKLKYLTS CGKLVKVKRK YRIPNSTPLS SHRRKGLGVF
210 220 230 240 250
GGKQRTSSLP SPKTDIDEVN FQTRSQIDTE IARMKSMNVH EAAAVAAQAV
260 270 280 290 300
AEAEAAMAEA EEAAKEAEAA EAEAEAAQAF AEEASKTLKG RNICKMMIRA
Length:300
Mass (Da):33,017
Last modified:March 1, 2002 - v1
Checksum:i3B4A383E129F537B
GO

Sequence cautioni

The sequence AAF76448 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188P → S in AAM65540 (Ref. 6) Curated1
Sequence conflicti276A → V in AAL73438 (Ref. 1) Curated1
Sequence conflicti276A → V in AAM65540 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83623 Genomic DNA Translation: AAL73123.1
U83624 mRNA Translation: AAL73438.1
AY519539 mRNA Translation: AAS10009.1
AC015445 Genomic DNA Translation: AAF76448.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32497.1
CP002684 Genomic DNA Translation: AEE32498.1
CP002684 Genomic DNA Translation: AEE32499.1
AY062736 mRNA Translation: AAL32814.1
BT009677 mRNA Translation: AAP80178.1
AY087994 mRNA Translation: AAM65540.1
RefSeqiNP_564559.1, NM_103882.4
NP_849789.1, NM_179458.3
NP_973998.1, NM_202269.2
UniGeneiAt.27250

Genome annotation databases

EnsemblPlantsiAT1G49950.1; AT1G49950.1; AT1G49950
AT1G49950.2; AT1G49950.2; AT1G49950
AT1G49950.3; AT1G49950.3; AT1G49950
GeneIDi841418
GrameneiAT1G49950.1; AT1G49950.1; AT1G49950
AT1G49950.2; AT1G49950.2; AT1G49950
AT1G49950.3; AT1G49950.3; AT1G49950
KEGGiath:AT1G49950

Similar proteinsi

Entry informationi

Entry nameiTRB1_ARATH
AccessioniPrimary (citable) accession number: Q8VWK4
Secondary accession number(s): Q8LA70, Q8VX39, Q9LPL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health