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Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104Proton acceptorUniRule annotation1
Metal bindingi160ZincUniRule annotation1
Metal bindingi163ZincUniRule annotation1
Metal bindingi198ZincUniRule annotation1
Metal bindingi201ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 32ATPUniRule annotation8
Nucleotide bindingi103 – 106ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:MSC_0149
OrganismiMycoplasma mycoides subsp. mycoides SC (strain PG1)
Taxonomic identifieri272632 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001016 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749971 – 209Thymidine kinaseAdd BLAST209

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272632.MSC_0149.

Structurei

3D structure databases

ProteinModelPortaliQ8VVL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VVL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELDINEIE AYNSNKMGWI ELITGCMFAG KTEEFIRRLR VLSYAKKRVL
60 70 80 90 100
AFKPSIDNRY SVENIISHSG SKLDSYLVHS SDEIKQIIEK ENQIQQVDVI
110 120 130 140 150
GIDEVQFFDE QVVELIEQLA NQGIIVIVNG LDKDFRCLPF KNVDKLLVTA
160 170 180 190 200
EFVTKLRARC HLCGNFANRS QKIVNGQPAL WDSPLILVDG KESYEARCRN

CFIVPKKEV
Length:209
Mass (Da):23,943
Last modified:March 1, 2002 - v1
Checksum:i081C94637451C2E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313087 Genomic DNA. Translation: CAC85214.1.
BX293980 Genomic DNA. Translation: CAE76794.1.
RefSeqiNP_975152.1. NC_005364.2.
WP_011166351.1. NC_005364.2.

Genome annotation databases

EnsemblBacteriaiCAE76794; CAE76794; MSC_0149.
GeneIDi2744372.
KEGGimmy:MSC_0149.
PATRICi20017004. VBIMycMyc4973_0158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313087 Genomic DNA. Translation: CAC85214.1.
BX293980 Genomic DNA. Translation: CAE76794.1.
RefSeqiNP_975152.1. NC_005364.2.
WP_011166351.1. NC_005364.2.

3D structure databases

ProteinModelPortaliQ8VVL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272632.MSC_0149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE76794; CAE76794; MSC_0149.
GeneIDi2744372.
KEGGimmy:MSC_0149.
PATRICi20017004. VBIMycMyc4973_0158.

Phylogenomic databases

eggNOGiENOG4107T8J. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_MYCMS
AccessioniPrimary (citable) accession number: Q8VVL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.