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Protein

Xylan alpha-1,2-glucuronidase

Gene

aguA

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->2)-alpha-D-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei150GlucuronateCombined sources1
Binding sitei201GlucuronateCombined sources1
Binding sitei281GlucuronateCombined sources1
Binding sitei285GlucuronateCombined sources1
Binding sitei359GlucuronateCombined sources1
Binding sitei364GlucuronateCombined sources1
Binding sitei392GlucuronateCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradationUniRule annotation

Protein family/group databases

CAZyiGH67. Glycoside Hydrolase Family 67.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylan alpha-1,2-glucuronidaseUniRule annotation (EC:3.2.1.131UniRule annotation)
Gene namesi
Name:aguAImported
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)Imported
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

DrugBankiDB04303. 4-O-methyl-alpha-D-glucuronic acid.
DB02722. 4-O-methyl-beta-D-glucuronic acid.
DB03156. D-Glucuronic Acid.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K9DX-ray1.70A1-679[»]
1L8NX-ray1.50A1-679[»]
1MQQX-ray1.65A1-679[»]
ProteinModelPortaliQ8VVD2.
SMRiQ8VVD2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VVD2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 121Glyco_hydro_67NInterPro annotationAdd BLAST114
Domaini125 – 452Glyco_hydro_67MInterPro annotationAdd BLAST328
Domaini453 – 675Glyco_hydro_67CInterPro annotationAdd BLAST223

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni158 – 159Glucuronate bindingCombined sources2
Regioni318 – 320Glucuronate bindingCombined sources3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 67 family.UniRule annotation

Family and domain databases

Gene3Di3.90.1330.10. 1 hit.
InterProiView protein in InterPro
IPR029018. Chitobiase/Hex_dom_2-like.
IPR011395. Glyco_hydro_67_aGlcAse.
IPR005154. Glyco_hydro_67_aGlcAse_N.
IPR011099. Glyco_hydro_67_C.
IPR011100. Glyco_hydro_67_cat.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF07477. Glyco_hydro_67C. 1 hit.
PF07488. Glyco_hydro_67M. 1 hit.
PF03648. Glyco_hydro_67N. 1 hit.
PIRSFiPIRSF029900. Alpha-glucuronds. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VVD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAGYEPCWL RYERKDQYSR LRFEEIVAKR TSPIFQAAVE ELQKGLRSMM
60 70 80 90 100
EIEPQVVQEV NETANSIWLG TLEDEEFERP LEGTLVHPEG YVIRSDVDDG
110 120 130 140 150
PFRIYIIGKT DAGVLYGVFH FLRLLQMGEN IAQLSIIEQP KNRLRMINHW
160 170 180 190 200
DNMDGSIERG YAGRSIFFVD DQFVKQNQRI KDYARLLASV GINAISINNV
210 220 230 240 250
NVHKTETKLI TDHFLPDVAE VADIFRTYGI KTFLSINYAS PIEIGGLPTA
260 270 280 290 300
DPLDPEVRWW WKETAKRIYQ YIPDFGGFVV KADSEFRPGP FTYGRDHAEG
310 320 330 340 350
ANMLAEALAP FGGLVIWRCF VYNCQQDWRD RTTDRAKAAY DHFKPLDGQF
360 370 380 390 400
RENVILQIKN GPMDFQVREP VSPLFGAMPK TNQMMEVQIT QEYTGQQKHL
410 420 430 440 450
CFLIPQWKEV LDFDTYAKGK GSEVKKVIDG SLFDYRYSGI AGVSNIGSDP
460 470 480 490 500
NWTGHTLAQA NLYGFGRLAW NPDLSAEEIA NEWVVQTFGD DSQVVETISW
510 520 530 540 550
MLLSSWRIYE NYTSPLGVGW MVNPGHHYGP NVDGYEYSHW GTYHYADRDG
560 570 580 590 600
IGVDRTVATG TGYTAQYFPE NAAMYESLDT CPDELLLFFH HVPYTHRLHS
610 620 630 640 650
GETVIQHIYN THFEGVEQAK QLRKRWEQLK GKIDEKRYHD VLERLTIQVE
660 670
HAKEWRDVIN TYFYRKSGID DQYGRKIYR
Length:679
Mass (Da):78,486
Last modified:March 1, 2002 - v1
Checksum:iED9C389089FEEF3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441188 Genomic DNA. Translation: AAL32057.1.

Similar proteinsi

Entry informationi

Entry nameiQ8VVD2_GEOSE
AccessioniPrimary (citable) accession number: Q8VVD2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: September 27, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources