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Q8VVB7

- G6PI_STRT2

UniProt

Q8VVB7 - G6PI_STRT2

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei291 – 2911Proton donorBy similarity
Active sitei312 – 3121By similarity
Active sitei426 – 4261By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSTHE264199:GI6K-245-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:stu0194
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001170: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Glucose-6-phosphate isomerasePRO_0000180745Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264199.stu0194.

Structurei

3D structure databases

ProteinModelPortaliQ8VVB7.
SMRiQ8VVB7. Positions 4-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VVB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHIKFDYSK VLDKFVAPHE VDNLQAQVTV ADEMIRKGTG PGADFLGWRD
60 70 80 90 100
LPENYDREEF DRILKAAEKI KEESDVLVVI GIGGSYLGAK AAIDFLSNHF
110 120 130 140 150
ANLQTKEERK APQIVYAGNS ISSTYLADLL EYVEGKDFSV NVISKSGTTT
160 170 180 190 200
EPAIAFRLFK ELLVKKYGQE EANKRIYATT DRQKGAVKVE ADANGWETFV
210 220 230 240 250
VPDDIGGRFS VLTAVGLLPI AVSGADIKAL MEGANAARKE YSSSKISENE
260 270 280 290 300
AYQYAAIRNI LYRKGYTTEI LANYEPSLQY FAEWWKQLAG ESEGKDQRGI
310 320 330 340 350
YPTSANFSTD LHSLGQFIQE GTRNLFETVV RVDKPRKNVV IPELAEDLDG
360 370 380 390 400
LGYLQGKDVD FVNKKATDGV LLAHTDGDVP NMFITIPEQD AFTLGYIIYF
410 420 430 440
FELAIALSGY LNAVNPFNQP GVEAYKKNMF ALLGKPGFEE LGAELNARL
Length:449
Mass (Da):49,789
Last modified:March 1, 2005 - v2
Checksum:i996EE8CA53C08A8A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1922AD → PN in AAL35379. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442553 Genomic DNA. Translation: AAL35379.1.
CP000023 Genomic DNA. Translation: AAV59919.1.
RefSeqiYP_138734.1. NC_006448.1.

Genome annotation databases

EnsemblBacteriaiAAV59919; AAV59919; stu0194.
GeneIDi3164355.
KEGGistl:stu0194.
PATRICi19801958. VBIStrThe97850_0201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442553 Genomic DNA. Translation: AAL35379.1 .
CP000023 Genomic DNA. Translation: AAV59919.1 .
RefSeqi YP_138734.1. NC_006448.1.

3D structure databases

ProteinModelPortali Q8VVB7.
SMRi Q8VVB7. Positions 4-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264199.stu0194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV59919 ; AAV59919 ; stu0194 .
GeneIDi 3164355.
KEGGi stl:stu0194.
PATRICi 19801958. VBIStrThe97850_0201.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000100403.
KOi K01810.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci STHE264199:GI6K-245-MONOMER.

Family and domain databases

HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Modulation of glycolysis by lactose availability in Streptococcus thermophilus."
    van den Bogaard P.T.C., Kleerebezem M., Hols P., Crispie F., Kuipers O.P., de Vos W.M.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-250 / LMG 18311.

Entry informationi

Entry nameiG6PI_STRT2
AccessioniPrimary (citable) accession number: Q8VVB7
Secondary accession number(s): Q5M680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3