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Q8VVB7

- G6PI_STRT2

UniProt

Q8VVB7 - G6PI_STRT2

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei291 – 2911Proton donorBy similarity
    Active sitei312 – 3121By similarity
    Active sitei426 – 4261By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciSTHE264199:GI6K-245-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    Ordered Locus Names:stu0194
    OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
    Taxonomic identifieri264199 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001170: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Glucose-6-phosphate isomerasePRO_0000180745Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264199.stu0194.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VVB7.
    SMRiQ8VVB7. Positions 4-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VVB7-1 [UniParc]FASTAAdd to Basket

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    MAHIKFDYSK VLDKFVAPHE VDNLQAQVTV ADEMIRKGTG PGADFLGWRD    50
    LPENYDREEF DRILKAAEKI KEESDVLVVI GIGGSYLGAK AAIDFLSNHF 100
    ANLQTKEERK APQIVYAGNS ISSTYLADLL EYVEGKDFSV NVISKSGTTT 150
    EPAIAFRLFK ELLVKKYGQE EANKRIYATT DRQKGAVKVE ADANGWETFV 200
    VPDDIGGRFS VLTAVGLLPI AVSGADIKAL MEGANAARKE YSSSKISENE 250
    AYQYAAIRNI LYRKGYTTEI LANYEPSLQY FAEWWKQLAG ESEGKDQRGI 300
    YPTSANFSTD LHSLGQFIQE GTRNLFETVV RVDKPRKNVV IPELAEDLDG 350
    LGYLQGKDVD FVNKKATDGV LLAHTDGDVP NMFITIPEQD AFTLGYIIYF 400
    FELAIALSGY LNAVNPFNQP GVEAYKKNMF ALLGKPGFEE LGAELNARL 449
    Length:449
    Mass (Da):49,789
    Last modified:March 1, 2005 - v2
    Checksum:i996EE8CA53C08A8A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1922AD → PN in AAL35379. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF442553 Genomic DNA. Translation: AAL35379.1.
    CP000023 Genomic DNA. Translation: AAV59919.1.
    RefSeqiYP_138734.1. NC_006448.1.

    Genome annotation databases

    EnsemblBacteriaiAAV59919; AAV59919; stu0194.
    GeneIDi3164355.
    KEGGistl:stu0194.
    PATRICi19801958. VBIStrThe97850_0201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF442553 Genomic DNA. Translation: AAL35379.1 .
    CP000023 Genomic DNA. Translation: AAV59919.1 .
    RefSeqi YP_138734.1. NC_006448.1.

    3D structure databases

    ProteinModelPortali Q8VVB7.
    SMRi Q8VVB7. Positions 4-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264199.stu0194.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV59919 ; AAV59919 ; stu0194 .
    GeneIDi 3164355.
    KEGGi stl:stu0194.
    PATRICi 19801958. VBIStrThe97850_0201.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci STHE264199:GI6K-245-MONOMER.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Modulation of glycolysis by lactose availability in Streptococcus thermophilus."
      van den Bogaard P.T.C., Kleerebezem M., Hols P., Crispie F., Kuipers O.P., de Vos W.M.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-250 / LMG 18311.

    Entry informationi

    Entry nameiG6PI_STRT2
    AccessioniPrimary (citable) accession number: Q8VVB7
    Secondary accession number(s): Q5M680
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3