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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei291 – 2911Proton donorBy similarity
Active sitei312 – 3121By similarity
Active sitei426 – 4261By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSTHE264199:GI6K-245-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:stu0194
OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Taxonomic identifieri264199 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001170 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Glucose-6-phosphate isomerasePRO_0000180745Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264199.stu0194.

Structurei

3D structure databases

ProteinModelPortaliQ8VVB7.
SMRiQ8VVB7. Positions 4-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VVB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHIKFDYSK VLDKFVAPHE VDNLQAQVTV ADEMIRKGTG PGADFLGWRD
60 70 80 90 100
LPENYDREEF DRILKAAEKI KEESDVLVVI GIGGSYLGAK AAIDFLSNHF
110 120 130 140 150
ANLQTKEERK APQIVYAGNS ISSTYLADLL EYVEGKDFSV NVISKSGTTT
160 170 180 190 200
EPAIAFRLFK ELLVKKYGQE EANKRIYATT DRQKGAVKVE ADANGWETFV
210 220 230 240 250
VPDDIGGRFS VLTAVGLLPI AVSGADIKAL MEGANAARKE YSSSKISENE
260 270 280 290 300
AYQYAAIRNI LYRKGYTTEI LANYEPSLQY FAEWWKQLAG ESEGKDQRGI
310 320 330 340 350
YPTSANFSTD LHSLGQFIQE GTRNLFETVV RVDKPRKNVV IPELAEDLDG
360 370 380 390 400
LGYLQGKDVD FVNKKATDGV LLAHTDGDVP NMFITIPEQD AFTLGYIIYF
410 420 430 440
FELAIALSGY LNAVNPFNQP GVEAYKKNMF ALLGKPGFEE LGAELNARL
Length:449
Mass (Da):49,789
Last modified:March 1, 2005 - v2
Checksum:i996EE8CA53C08A8A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1922AD → PN in AAL35379 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442553 Genomic DNA. Translation: AAL35379.1.
CP000023 Genomic DNA. Translation: AAV59919.1.
RefSeqiYP_138734.1. NC_006448.1.

Genome annotation databases

EnsemblBacteriaiAAV59919; AAV59919; stu0194.
KEGGistl:stu0194.
PATRICi19801958. VBIStrThe97850_0201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442553 Genomic DNA. Translation: AAL35379.1.
CP000023 Genomic DNA. Translation: AAV59919.1.
RefSeqiYP_138734.1. NC_006448.1.

3D structure databases

ProteinModelPortaliQ8VVB7.
SMRiQ8VVB7. Positions 4-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264199.stu0194.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV59919; AAV59919; stu0194.
KEGGistl:stu0194.
PATRICi19801958. VBIStrThe97850_0201.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciSTHE264199:GI6K-245-MONOMER.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Modulation of glycolysis by lactose availability in Streptococcus thermophilus."
    van den Bogaard P.T.C., Kleerebezem M., Hols P., Crispie F., Kuipers O.P., de Vos W.M.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-250 / LMG 18311.

Entry informationi

Entry nameiG6PI_STRT2
AccessioniPrimary (citable) accession number: Q8VVB7
Secondary accession number(s): Q5M680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2005
Last modified: April 1, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.