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Protein

60 kDa chaperonin

Gene

groL

Organism
Streptococcus gordonii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
OrganismiStreptococcus gordonii
Taxonomic identifieri1302 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000635521 – 54060 kDa chaperoninAdd BLAST540

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8VT58.
SMRiQ8VT58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VT58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDIKFSAD ARSAMVRGVD ILADTVKVTL GPKGRNVVLE KSFGSPLITN
60 70 80 90 100
DGVTIAKEIE LEDHFENMGA KLVSEVASKT NDIAGDGTTT ATVLTQAIVR
110 120 130 140 150
EGIKNVTAGA NPIGIRRGIE AAVATAVSAL KETAIPVSNK EAIAQVAAVS
160 170 180 190 200
SRSEKVGEYI SEAMEKVGND GVITIEESKG METELDVVEG MQFDRGYLSQ
210 220 230 240 250
YMVTDSEKMV ADLDNPYILI TDKKISNIQE ILPLLESILK TNRPLLIIAD
260 270 280 290 300
DVDGEALPTL VLNKIRGTFN VVAVKAPGFG DRRKAMLEDI AILTGGTVIT
310 320 330 340 350
EDLGLDLKDA TIEALGQASK VTVDKDSTVI VEGSGNPEAI ANRVAVIKSQ
360 370 380 390 400
IESATSEFDK EKLQERLAKL SGGVAVIKVG AATETELKEM KLRIEDALNA
410 420 430 440 450
TRAAVEEGIV SGGGTAFVSV LDAVAGLELT GDEATGRNIV LRALEEPVRQ
460 470 480 490 500
IALNAGFEGS IVIDRLKNSE AGTGFNAATG EWVNMIEAGI IDPVKVTRSA
510 520 530 540
LQNAASVASL ILTTEAVVAN QPEPASPAPA MDPSMMGGMM
Length:540
Mass (Da):56,770
Last modified:March 1, 2002 - v1
Checksum:iEA4A7712767CEF39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338228 Genomic DNA. Translation: AAL73234.1.
RefSeqiWP_060553822.1. NZ_LQWV01000001.1.

Similar proteinsi

Entry informationi

Entry nameiCH60_STRGN
AccessioniPrimary (citable) accession number: Q8VT58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families