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Q8VQN0

- Q8VQN0_PROFR

UniProt

Q8VQN0 - Q8VQN0_PROFR

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Protein
Submitted name:

Methylmalonyl CoA epimerase

Gene
N/A
Organism
Propionibacterium freudenreichii subsp. shermanii
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481Sulfate 1Imported
Binding sitei65 – 651Sulfate 1Imported
Binding sitei65 – 651Sulfate 2Imported
Binding sitei122 – 1221Sulfate 1Imported
Binding sitei122 – 1221Sulfate 2Imported
Binding sitei141 – 1411Sulfate 1Imported
Binding sitei141 – 1411Sulfate 2Imported

GO - Molecular functioni

  1. methylmalonyl-CoA epimerase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13075.

Names & Taxonomyi

Protein namesi
Submitted name:
Methylmalonyl CoA epimeraseImported (EC:5.1.99.1Imported)
Submitted name:
Methylmalonyl-CoA epimeraseImported (EC:5.1.99.1Imported)
OrganismiPropionibacterium freudenreichii subsp. shermaniiImported
Taxonomic identifieri1752 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JC4X-ray2.00A/B/C/D1-148[»]
1JC5X-ray2.20A/B/C/D/E/F1-148[»]

Miscellaneous databases

EvolutionaryTraceiQ8VQN0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 603Sulfate 3 bindingImported
Regioni58 – 603Sulfate 4 bindingImported
Regioni116 – 1172Sulfate 5 bindingImported

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR017515. MeMalonyl-CoA_epimerase.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR03081. metmalonyl_epim. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VQN0-1 [UniParc]FASTAAdd to Basket

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MSNEDLFICI DHVAYACPDA DEASKYYQET FGWHELHREE NPEQGVVEIM    50
MAPAAKLTEH MTQVQVMAPL NDESTVAKWL AKHNGRAGLH HMAWRVDDID 100
AVSATLRERG VQLLYDEPKL GTGGNRINFM HPKSGKGVLI ELTQYPKN 148
Length:148
Mass (Da):16,717
Last modified:March 1, 2002 - v1
Checksum:i258F88915E03F598
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY046899 Genomic DNA. Translation: AAL02261.1.
AF454511 Genomic DNA. Translation: AAL57846.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY046899 Genomic DNA. Translation: AAL02261.1 .
AF454511 Genomic DNA. Translation: AAL57846.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JC4 X-ray 2.00 A/B/C/D 1-148 [» ]
1JC5 X-ray 2.20 A/B/C/D/E/F 1-148 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-13075.

Miscellaneous databases

EvolutionaryTracei Q8VQN0.

Family and domain databases

Gene3Di 3.10.180.10. 1 hit.
InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR017515. MeMalonyl-CoA_epimerase.
[Graphical view ]
SUPFAMi SSF54593. SSF54593. 1 hit.
TIGRFAMsi TIGR03081. metmalonyl_epim. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The structural genes for methylmalonyl CoA metabolism in Propionibacterium shermanii."
    Davis N.K.
    Thesis (1986), University of Cambridge
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCIB 9885Imported.
  2. "Crystal structure of methylmalonyl-coenzyme A epimerase from P. shermanii: a novel enzymatic function on an ancient metal binding scaffold."
    McCarthy A.A., Baker H.M., Shewry S.C., Patchett M.L., Baker E.N.
    Structure 9:637-646(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCIB 9885Imported.
  3. "Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli."
    Dayem L.C., Santi D.V., Pfeifer B.A., Khosla C., Kealey J.T.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Davis N.K., Leadlay P.F., Patchett M.L.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCIB 9885Imported.

Entry informationi

Entry nameiQ8VQN0_PROFR
AccessioniPrimary (citable) accession number: Q8VQN0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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