Q8VQN0 (Q8VQN0_PROFR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Methylmalonyl CoA epimerase EMBL AAL57846.1 EC=5.1.99.1 EMBL AAL57846.1 Submitted name: Methylmalonyl-CoA epimerase EMBL AAL02261.1 EC=5.1.99.1 EMBL AAL02261.1
Organism	Propionibacterium freudenreichii subsp. shermanii EMBL AAL57846.1
Taxonomic identifier	1752 [NCBI]
Taxonomic lineage	cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium › Propionibacterium freudenreichii

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Isomerase EMBL AAL57846.1
Technical term	3D-structure PDB 1JC4 PDB 1JC5
Gene Ontology (GO)
Molecular_function	methylmalonyl-CoA epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8VQN0 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 258F88915E03F598	FASTA	148	16,717
	10 20 30 40 50 60 MSNEDLFICI DHVAYACPDA DEASKYYQET FGWHELHREE NPEQGVVEIM MAPAAKLTEH 70 80 90 100 110 120 MTQVQVMAPL NDESTVAKWL AKHNGRAGLH HMAWRVDDID AVSATLRERG VQLLYDEPKL 130 140 GTGGNRINFM HPKSGKGVLI ELTQYPKN

References

[1]	"The structural genes for methylmalonyl CoA metabolism in Propionibacterium shermanii." Davis N.K. Thesis (1986), University of Cambridge Cited for: NUCLEOTIDE SEQUENCE. Strain: NCIB 9885 EMBL AAL57846.1.
[2]	"Crystal structure of methylmalonyl-coenzyme A epimerase from P. shermanii: a novel enzymatic function on an ancient metal binding scaffold." McCarthy A.A., Baker H.M., Shewry S.C., Patchett M.L., Baker E.N. Structure 9:637-646(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NCIB 9885 EMBL AAL57846.1.
[3]	"Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli." Dayem L.C., Santi D.V., Pfeifer B.A., Khosla C., Kealey J.T. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Davis N.K., Leadlay P.F., Patchett M.L. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NCIB 9885 EMBL AAL57846.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY046899 Genomic DNA. Translation: AAL02261.1.
AF454511 Genomic DNA. Translation: AAL57846.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JC4	X-ray	2.00	A/B/C/D	1-148	[»]
1JC5	X-ray	2.20	A/B/C/D/E/F	1-148	[»]

SMR

Q8VQN0. Positions 1-147.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Enzyme and pathway databases

BioCyc

MetaCyc:MONOMER-13075.

Family and domain databases

InterPro

IPR017515. MeMalonyl-CoA_epimerase.
[Graphical view]

TIGRFAMs

TIGR03081. metmalonyl_epim. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q8VQN0.

Entry information

Entry name

Q8VQN0_PROFR

Accession

Primary (citable) accession number: Q8VQN0

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)