SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8VQN0

- Q8VQN0_PROFR

UniProt

Q8VQN0 - Q8VQN0_PROFR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Methylmalonyl CoA epimerase
Gene
N/A
Organism
Propionibacterium freudenreichii subsp. shermanii
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481Sulfate 1Imported
Binding sitei65 – 651Sulfate 1Imported
Binding sitei65 – 651Sulfate 2Imported
Binding sitei122 – 1221Sulfate 1Imported
Binding sitei122 – 1221Sulfate 2Imported
Binding sitei141 – 1411Sulfate 1Imported
Binding sitei141 – 1411Sulfate 2Imported

GO - Molecular functioni

  1. methylmalonyl-CoA epimerase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    IsomeraseImported

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-13075.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Methylmalonyl CoA epimeraseImported (EC:5.1.99.1Imported)
    Submitted name:
    Methylmalonyl-CoA epimeraseImported (EC:5.1.99.1Imported)
    OrganismiPropionibacterium freudenreichii subsp. shermaniiImported
    Taxonomic identifieri1752 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JC4X-ray2.00A/B/C/D1-148[»]
    1JC5X-ray2.20A/B/C/D/E/F1-148[»]

    Miscellaneous databases

    EvolutionaryTraceiQ8VQN0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 603Sulfate 3 bindingImported
    Regioni58 – 603Sulfate 4 bindingImported
    Regioni116 – 1172Sulfate 5 bindingImported

    Family and domain databases

    Gene3Di3.10.180.10. 1 hit.
    InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR017515. MeMalonyl-CoA_epimerase.
    [Graphical view]
    SUPFAMiSSF54593. SSF54593. 1 hit.
    TIGRFAMsiTIGR03081. metmalonyl_epim. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8VQN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNEDLFICI DHVAYACPDA DEASKYYQET FGWHELHREE NPEQGVVEIM    50
    MAPAAKLTEH MTQVQVMAPL NDESTVAKWL AKHNGRAGLH HMAWRVDDID 100
    AVSATLRERG VQLLYDEPKL GTGGNRINFM HPKSGKGVLI ELTQYPKN 148
    Length:148
    Mass (Da):16,717
    Last modified:March 1, 2002 - v1
    Checksum:i258F88915E03F598
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY046899 Genomic DNA. Translation: AAL02261.1.
    AF454511 Genomic DNA. Translation: AAL57846.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY046899 Genomic DNA. Translation: AAL02261.1 .
    AF454511 Genomic DNA. Translation: AAL57846.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JC4 X-ray 2.00 A/B/C/D 1-148 [» ]
    1JC5 X-ray 2.20 A/B/C/D/E/F 1-148 [» ]
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-13075.

    Miscellaneous databases

    EvolutionaryTracei Q8VQN0.

    Family and domain databases

    Gene3Di 3.10.180.10. 1 hit.
    InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR017515. MeMalonyl-CoA_epimerase.
    [Graphical view ]
    SUPFAMi SSF54593. SSF54593. 1 hit.
    TIGRFAMsi TIGR03081. metmalonyl_epim. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The structural genes for methylmalonyl CoA metabolism in Propionibacterium shermanii."
      Davis N.K.
      Thesis (1986), University of Cambridge
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NCIB 9885Imported.
    2. "Crystal structure of methylmalonyl-coenzyme A epimerase from P. shermanii: a novel enzymatic function on an ancient metal binding scaffold."
      McCarthy A.A., Baker H.M., Shewry S.C., Patchett M.L., Baker E.N.
      Structure 9:637-646(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NCIB 9885Imported.
    3. "Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli."
      Dayem L.C., Santi D.V., Pfeifer B.A., Khosla C., Kealey J.T.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Davis N.K., Leadlay P.F., Patchett M.L.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NCIB 9885Imported.

    Entry informationi

    Entry nameiQ8VQN0_PROFR
    AccessioniPrimary (citable) accession number: Q8VQN0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: June 11, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3

    Similar proteinsi