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Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00477

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
Short name:
UDP-N-acetylglucosamine acyltransferaseUniRule annotation
Gene namesi
Name:lpxAUniRule annotation
Ordered Locus Names:BH06310
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003025621 – 274Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseAdd BLAST274

Proteomic databases

PaxDbiQ8VQ21
PRIDEiQ8VQ21

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH06310

Structurei

3D structure databases

ProteinModelPortaliQ8VQ21
SMRiQ8VQ21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DAF Bacteria
COG1043 LUCA
HOGENOMiHOG000294326
KOiK00677
OMAiLGRMSMI
OrthoDBiPOG091H022E

Family and domain databases

CDDicd03351 LbH_UDP-GlcNAc_AT, 1 hit
Gene3Di1.20.1180.10, 1 hit
HAMAPiMF_00387 LpxA, 1 hit
InterProiView protein in InterPro
IPR029098 Acetyltransf_C
IPR037157 Acetyltransf_C_sf
IPR001451 Hexapep
IPR010137 Lipid_A_LpxA
IPR011004 Trimer_LpxA-like_sf
PANTHERiPTHR43480 PTHR43480, 1 hit
PfamiView protein in Pfam
PF13720 Acetyltransf_11, 1 hit
PF00132 Hexapep, 3 hits
PIRSFiPIRSF000456 UDP-GlcNAc_acltr, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01852 lipid_A_lpxA, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VQ21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTKIHPTA LVEKGAQLGE NVFVGPFCHI SSEAVIGDGC SLMSHVVIMG
60 70 80 90 100
KTTLGADSKV FSHAILGAEP QDNKHKGGYT TLSIGKNCTI REGVTMHRGS
110 120 130 140 150
DSSVGMTIVG DNCQFFCYAH IAHDCRVGNN VTFANNVMIA GHVTVGDYVI
160 170 180 190 200
IGGGAAVHQF VRVGHHAFIG GVSALVGDLI PYGTAVGVQA KLAGLNIIGM
210 220 230 240 250
KRAGLERKDI HALRHAVAML FDHSKPFKER VSDVASFYPA SQSVVDVVNF
260 270
IKEKGKRFYC TPKFEGDRIK ENKD
Length:274
Mass (Da):29,269
Last modified:March 1, 2002 - v1
Checksum:iA89C996B040CB893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461795 Genomic DNA Translation: AAL66377.1
BX897699 Genomic DNA Translation: CAF27435.1
RefSeqiWP_011180555.1, NZ_LRIJ02000001.1

Genome annotation databases

EnsemblBacteriaiCAF27435; CAF27435; BH06310
GeneIDi29620929
KEGGibhe:BH06310

Entry informationi

Entry nameiLPXA_BARHE
AccessioniPrimary (citable) accession number: Q8VQ21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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