Reviewed, UniProtKB/Swiss-Prot Q8VQ21 (LPXA_BARHE)

Names and origin

Protein names

Recommended name:
    Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
      Short name=UDP-N-acetylglucosamine acyltransferase
    EC=2.3.1.129

Gene names

Name:	lpxA
Ordered Locus Names:	BH06310

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387		PRO_0000302562

Sequences

	Sequence		Length	Mass (Da)
	Q8VQ21-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: A89C996B040CB893	FASTA	274	29,269
	10 20 30 40 50 60 MSGTKIHPTA LVEKGAQLGE NVFVGPFCHI SSEAVIGDGC SLMSHVVIMG KTTLGADSKV 70 80 90 100 110 120 FSHAILGAEP QDNKHKGGYT TLSIGKNCTI REGVTMHRGS DSSVGMTIVG DNCQFFCYAH 130 140 150 160 170 180 IAHDCRVGNN VTFANNVMIA GHVTVGDYVI IGGGAAVHQF VRVGHHAFIG GVSALVGDLI 190 200 210 220 230 240 PYGTAVGVQA KLAGLNIIGM KRAGLERKDI HALRHAVAML FDHSKPFKER VSDVASFYPA 250 260 270 SQSVVDVVNF IKEKGKRFYC TPKFEGDRIK ENKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, nucleotide sequencing, and expression of a hemin-binding protein of Bartonella henselae." Zimmermann R., Augustin K., Schaal K., Sander A. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF461795 Genomic DNA. Translation: AAL66377.1. BX897699 Genomic DNA. Translation: CAF27435.1.
RefSeq	YP_033460.1.
3D structure databases
HSSP	HSSP built from PDB template 1LXA based on UniProtKB P0A722.
SMR	Q8VQ21. Positions 2-260.
ModBase	Search...
Genome annotation databases
GeneID	2865598.
GenomeReviews	Gene locus BH06310 in contig BX897699_GR.
KEGG	bhe:BH06310.
NMPDR	fig|283166.1.peg.588.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG659295.
OMA	TSAHIAH.
PhylomeDB	Q8VQ21.
Enzyme and pathway databases
BioCyc	BHEN283166:BH06310-MONOMER.
BRENDA	2.3.1.129. 277357.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
TIGRFAMs	TIGR01852. lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXA_BARHE

Accession

Primary (citable) accession number: Q8VQ21

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)