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Protein
Submitted name:

CylR2

Gene

cylR2

Organism
Enterococcus faecalis (Streptococcus faecalis)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CylR2Imported
Submitted name:
Putative transcription regulatorImported
Gene namesi
Name:cylR2Imported
Encoded oniPlasmid pAD1Imported
OrganismiEnterococcus faecalis (Streptococcus faecalis)Imported
Taxonomic identifieri1351 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Interactioni

Protein-protein interaction databases

DIPiDIP-61746N.
STRINGi226185.EF0524.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UTXX-ray1.90A/B1-66[»]
2GZUNMR-A/B1-66[»]
2LYJNMR-A/B1-66[»]
2LYKNMR-A/B1-66[»]
2LYLNMR-A/B1-66[»]
2LYPNMR-A1-66[»]
2LYQNMR-A1-66[»]
2LYRNMR-A1-66[»]
2LYSNMR-A1-66[»]
2XI8X-ray1.21A/B1-66[»]
2XIUX-ray1.50A/B1-66[»]
2XJ3X-ray1.23A/B1-66[»]
SMRiQ8VL32. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6055HTH cro/C1-type DNA-bindingInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105VZ8. Bacteria.
COG1476. LUCA.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VL32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIINNLKLIR EKKKISQSEL AALLEVSRQT INGIEKNKYN PSLQLALKIA
60
YYLNTPLEDI FQWQPE
Length:66
Mass (Da):7,716
Last modified:March 1, 2002 - v1
Checksum:iF2BCB28D87D46842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343837 Genomic DNA. Translation: AAL59476.1.
AF394225 Genomic DNA. Translation: AAL60140.1.
RefSeqiWP_002358483.1. NZ_JWAR01000007.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343837 Genomic DNA. Translation: AAL59476.1.
AF394225 Genomic DNA. Translation: AAL60140.1.
RefSeqiWP_002358483.1. NZ_JWAR01000007.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UTXX-ray1.90A/B1-66[»]
2GZUNMR-A/B1-66[»]
2LYJNMR-A/B1-66[»]
2LYKNMR-A/B1-66[»]
2LYLNMR-A/B1-66[»]
2LYPNMR-A1-66[»]
2LYQNMR-A1-66[»]
2LYRNMR-A1-66[»]
2LYSNMR-A1-66[»]
2XI8X-ray1.21A/B1-66[»]
2XIUX-ray1.50A/B1-66[»]
2XJ3X-ray1.23A/B1-66[»]
SMRiQ8VL32. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61746N.
STRINGi226185.EF0524.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105VZ8. Bacteria.
COG1476. LUCA.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the nucleotide sequence of the Enterococcus faecalis conjugative virulence plasmid pAD1 and identification of a second transfer origin."
    Francia M.V., Haas W., Wirth R., Samberger E., Muscholl-Silberhorn A., Gilmore M.S., Ike Y., Weaver K.E., An F.Y., Clewell D.B.
    Plasmid 46:117-127(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DS16Imported.
    Plasmid: pAD1
  2. "Two-component regulator of Enterococcus faecalis cytolysin responds to quorum-sensing autoinduction."
    Haas W., Shepard B.D., Gilmore M.S.
    Nature 415:84-87(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Plasmid: pAD1
  3. "Structure and DNA-binding properties of the cytolysin regulator CylR2 from Enterococcus faecalis."
    Rumpel S., Razeto A., Pillar C.M., Vijayan V., Taylor A., Giller K., Gilmore M.S., Becker S., Zweckstetter M.
    EMBO J. 23:3632-3642(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
  4. "High-resolution structure determination of the CylR2 homodimer using paramagnetic relaxation enhancement and structure-based prediction of molecular alignment."
    Rumpel S., Becker S., Zweckstetter M.
    J. Biomol. NMR 40:1-13(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  5. "Integrated analysis of the conformation of a protein-linked spin label by crystallography, EPR and NMR spectroscopy."
    Gruene T., Cho M.K., Karyagina I., Kim H.Y., Grosse C., Giller K., Zweckstetter M., Becker S.
    J. Biomol. NMR 49:111-119(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.21 ANGSTROMS).
  6. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiQ8VL32_ENTFL
AccessioniPrimary (citable) accession number: Q8VL32
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.